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INDONESIA
eJournal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23381426     EISSN : 23386037     DOI : http://doi.org/10.23886/ejki
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
eJournal Kedokteran Indonesia (eJKI) is a general medical journal, published quadrimester (April, August, December) by Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. eJKI aims to published the manuscript of students (Bachelor of Medicine (S.Ked), study Program of Medical Profession, magister/specialist, doctoral, and fellow). The journal is a general medical journal that covering all areas of biomedical science, basic medical science, clinical science, medical technology, and medical education. The journal accepts editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. This work was supported by Faculty of Medicine, Universitas Indonesia.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "Vol. 11 No. 2 - Agustus 2023" : 10 Documents clear
Autopsy Discoveries in Severe Malaria Mohammad Tegar Indrayana; Dedi Afandi; Ilhami Romus; Suri D. Lesmana
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.174.175-80

Abstract

Severe malaria is a disease caused by Plasmodium falciparum as the main cause of death in malaria. As autopsy examinations on malaria are rare in Indonesia, we report a nineteen-year-old male from Dumai, Indonesia, who died of severe malaria on November 10th 2018, at Dumai Regional General Hospital of Riau Province. The diagnosis was concluded from autopsy, histopathology and toxicology. This case report aimed to explain autopsy findings in severe malaria. As the result of external examination, we found some bruises on the right earlobe, lip mucosa and lower leg; excoriations on the neck, both arms and right lower leg; excoriations on the right lower leg and blood infiltration in the connective tissue on the right intercostal space. The autopsy and histopathology examination showed signs of congestion and hemozoin pigment in the brain, small intestine, liver, lung, heart, kidney, stomach and spleen. On toxicology examination, there was no narcotic substance found. Based on autopsy findings, histopathology and toxicological findings, we conclude that the cause of death, in this case, was severe malaria. Blunt violence to the ears, lips, neck, arms, and legs did not significantly cause death.
Pneumoperitoneum with Muyo Hook on Laparoscopic Cholecystectomy Fadli Robby Amsriza; Rizka Fakhriani; Sagiran Sagiran
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.205.170-4

Abstract

Gallstone migration into the cystic duct aperture can prevent bile from exiting the gallbladder during contraction. Gallbladder wall strain increases due to a distinct form of pain (biliary colic). A more prolonged cystic duct obstruction can cause acute gallbladder inflammation (acute cholecystitis). Cholecystectomy is a popular treatment for gallstone-related illnesses. We present a 49-year-old male with heartburn, nausea, and vomiting for one month, worsening in the last week. On general examination, vital signs and urine output are expected. On clinical examination, he had tenderness on the upper right quadrant abdomen, and Murphy's sign was positive. An abdominal ultrasound (US) showed multiple cholelithiasis. The patient was performed elective laparoscopic cholecystectomy with pneumoperitoneum by Muyo hook. The patient was discharged on the third day after surgery. Recent research has highlighted this unusual method. In this unique and challenging situation, Muyo Hook may be an option.
Diagnosis dan Tata Laksana Metastasis Tulang Rahmat Cahyanur; Thariqah Salamah
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.214.181-8

Abstract

Tulang merupakan salah satu organ yang sering menjadi lokasi metastasis kanker, misalnya kanker payudara, prostat, dan paru. Metastasis tulang berpotensi memicu peningkatan mortalitas dan morbiditas, serta penurunan kualitas hidup. Gejala dan tanda klinis metastasis tulang mencakup nyeri, fraktur patologis, hiperkalsemia, serta kompresi medula spinalis. Oleh karena itu, deteksi dini dan tata laksana metastasis tulang yang tepat diperlukan untuk mencegah komplikasi lebih lanjut. Pertimbangan dalam memilih modalitas pemeriksaan radiologi, sebagai langkah utama dalam diagnosis, harus dilakukan secara rasional berdasarkan lokasi lesi metastasis tulang. Selain itu, pemeriksaan alkalin fosfatase dan biopsi juga dapat menjadi pilihan pemeriksaan penunjang. Tata laksana metastasis tulang mencakup terapi suportif, seperti kontrol nyeri, pemberian bifosfonat, pemberian denosumab atau terapi sistemik, penggunaan radiofarmaka, dan kontrol lokal, yaitu radiasi eksterna atau pembedahan.
Work Stressors Before and During COVID-19 Pandemic and Factors Related to Workers in the Heavy Equipment Manufacturing Industry of PT.X Yunianti Lafau; Nuri Purwito Adi; Amilya Agustina; Muhammad Ilyas; Agus Sugiharto
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.221.133-42

Abstract

Psychosocial hazards are a major public health problem, so it is necessary to prevent and manage them so as not to cause mental and physical harm to workers. This study aims to determine changes in work stressors before and during the COVID-19 pandemic and related factors to workers in the PT.X Heavy equipment manufacturing industry. The study used a retrospective cohort design from 2018 and 2021 Medical Check-Up (MCU) data with a Stress Diagnosis Survey (SDS) questionnaire. Research was conducted from October 2021 until July 2022 with samples of 146 obtained. Bivariate analysis using proportion and mean test. The research found that the increase in moderate-severe stressors before and during the pandemic was role ambiguity, role conflict, quantitative workload, and career development. On the other hand, qualitative workloads and responsibility for others decreased during the pandemic. The most worsened was role ambiguity and responsibility for others. Based on the type of production and non-production work, there was a significant relationship to quantitative workload before the pandemic (p=0.043), and not significant during the pandemic. Furthermore, there is a significant relationship with qualitative workload during the pandemic (p = 0.043), and it was not significant before the pandemic. It can be concluded that the Pandemic conditions caused an increase and decrease in work stressors analysed in workers in the heavy equipment manufacturing industry.
Efek Pemberian Tetes Mata Diquafosol Sodium 3% Sebelum Kegiatan Tatap Layar terhadap Kejadian Mata Kering pada Laki-laki Muda Chalid Kurniawan; Bayu Ewangga; Mey M. Karyana
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.254.143-8

Abstract

Kegiatan tatap layar yang lama akan meningkatkan kemungkinan terjadinya sindrom mata kering karena stabilitas komponen air mata berkurang. Penggunaan air mata buatan seperti diquafosol sodium dapat membantu mengatasi masalah mata kering. Tujuan penelitian adalah menilai perbedaan gejala subjektif dan tanda objektif mata kering pada kelompok pengguna diquafosol sodium sebelum melakukan kegiatan tatap layar dibandingkan kelompok kontrol. Penelitian ini menggunakan desain potong lingkang dengan subjek laki-laki muda 44 orang yang memenuhi kriteria inklusi dan tidak memenuhi kriteria eksklusi. Subjek dipilih secara acak kemudian dibagi dua kelompok. Penelitian dilakukan di Garut dari Oktober hingga Desember 2022. Dilakukan pemeriksaan Schirmer sebelum dan sesudah kegiatan tatap layar serta pengisian kuesioner mata kering. Kelompok intervensi mendapatkan diquafosol sodium sebelum kegiatan tatap layar sedangkan kelompok kontrol tidak mendapatkan. Data dianalisis dengan t-test atau Mann Whitney. Hasil penelitian menunjukkan  terdapat perbedaan bermakna uji Schirmer setelah kegiatan tatap layar antar dua kelompok dan perbedaan bermakna hasil selisih uji Schirmer sebelum dan setelah kegiatan tatap layar. Analisis kuesioner menunjukkan hanya satu responden mengalami gejala mata kering pada kelompok intervensi dibandingkan 7 orang  pada kelompok kontrol. Penelitian ini menunjukkan bahwa penggunaan air mata buatan diquafosol sodium efektif mencegah terjadinya sindrom mata kering sebelum kegiatan tatap layar.  
Studi In-Vitro Efektifitas Grain Kefir dengan Kombinasi Sorbitol Terhadap Pertumbuhan Streptococcus mutans Viranda Sutanti; Yuanita Lely Rachmawati; Bintang Vallentino Nugraha Putra; Herlambang Pangestu
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.259.156-62

Abstract

Karies gigi adalah penyakit kronis jaringan keras gigi yang disebabkan oleh Streptococcus mutans (S.mutans). Berbagai metode termasuk aplikasi pasta gigi, senyawa antibakteri dan obat kumur yang mengandung fluoride bersama dengan penggunaan pemanis yang tidak dapat difermentasi seperti sorbitol telah disarankan untuk mengurangi aktivitas bakteri ini. Pada studi ekologi mulut telah mengkonfirmasi efektifitas bakteri probiotik dalam mengurangi jumlah S. mutans. Grain kefir merupakan salah satu produk probiotik. Tujuan penelitian ini adalah untuk melihat efektifitas grain kefir murni dan kombinasi dengan sorbitol terhadap pertumbuhan S. mutans secara in vitro. Penelitian dilakukan di laboratorium Biologi Oral Fakultas Kedokteran Gigi Universitas Brawijaya pada bulan Januari-Februari 2023. Dilakukan uji KHM (Konsentrasi Hambat Minimum) menggunakan uji tabung dan KBM (Konsentrasi Bakterisidal Minimum) menggunakan colony counter. Penentuan konstrasi perlakukan diawali dengan uji pendahuluan grain kefir murni konsentrasi 3,125% dan 6,25%, 12,5%, 25%, 50% dan 100%. Nilai KHM grain kefir murni uji pendahuluan terhadap S.mutans pada konsentrasi 12,5%. Pada konsentrasi perlakuan didapatkan nilai KHM grain kefir murni adalah 15% dan kombinasi grain kefir-sorbitol terhadap S.mutans yaitu pada konsentrasi 12,5%. Nilai KBM grain kefir murni didapatkan pada konsentrasi 15% dan kombinasi grain kefir-sorbitol pada konsentrasi 12,5%. Kombinasi grain kefir-sorbitol dapat menurunkan pertumbuhan S. mutans pada konsentrasi 12,5%.
Correlation between Atherogenic Index of Plasma and Lipid Profile with Cognitive Function and Their Effect on Outcome in Ischemic Stroke Patients Fasihah Irfani Fitri; Muhammad Zulfikri
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.264.102-8

Abstract

Dyslipidemia is one of the main risk factors for both ischemic stroke and cognitive impairment. Atherogenic index of plasma (AIP) has been shown to correlate with mortality and clinical outcomes in stroke, but studies about its association with cognitive impairment in ischemic stroke is still limited. We aimed to determine the correlation between AIP and lipid profile and cognitive function and their effect on outcome in ischemic stroke patients. A cross-sectional study involving 50 ischemic stroke patients in the Haji Adam Malik General Hospital was conducted from August 2021 to March 2022. We measured the cholesterol level and calculated the AIP then divided them into 3 risk categories which were high (AIP>0.21); intermediate (AIP>0.11and ≤0.21) and low (≤0.11). We performed cognitive assessment and stroke outcome at the 7th day of stroke onset. Data analysis was conducted with Spearman correlation test. The subjects were predominantly male (60%) with median age of 55 (34-68) years. Most of the subjects had AIP level of high risk (54%) and were cognitively impaired (66%). There was no significant association between AIP and both global cognition and each cognitive domain. However, there were significant negative correlations between total cholesterol (r=-0.31, p=0.03) and LDL-C level (r=-0.30, p=0.03) and attention. There was also a significant negative correlation between cognitive function and stroke outcome (r=-0.61, p=0.01). Higher total cholesterol and LDL-C levels showed negative correlation with cognitive function, mainly attention. Poorer cognitive function correlated with worse outcome in ischemic stroke patients.
Adaptasi Lintas Budaya Kuesioner STOP-Bang Versi Indonesia Putri Anggilina Manullang; Muhammad Arfiza Putra Saragih; Adlin Adnan; Ester Lantika Ronauli Silaen
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.335.126-32

Abstract

Obstructive Sleep Apnea (OSA) merupakan obstruksi saluran napas atas saat tidur yang mengakibatkan penurunan saturasi oksigen. Di Indonesia, data prevalensi OSA masih sangat minim. Dari beberapa alat penapisan OSA, hanya BQ dan ESS yang memiliki versi Bahasa Indonesia, sementara STOP-Bang belum terdapat versi Bahasa Indonesia. Melakukan penapisan terhadap tanda dan gejala sangat penting dalam proses perencanaan dan evaluasi. Suatu alat ukur harus memenuhi unsur psikometrik dan mampu menyesuaikan dengan karakteristik sosial dan budaya setempat. Untuk menghasilkan alat ukur kuesioner STOP-Bang versi Indonesia dengan metode adaptasi lintas budaya yang reliabel dan tervalidasi. Penelitian ini merupakan penelitian observasional analitik menggunakan metode cross sectional. Setelah kuesioner STOP-Bang diadaptasikan ke Indonesia, kuesioner diberikan kepada 500 orang masyarakat Indonesia, kemudian setelah 14 hari akan dilakukan pengisian ulang terhadap 20 responden. Penelitian dilakukan pada bulan Juli sampai September 2023 di Kota Medan dan Binjai. Pengambilan sampel memakai metode purposive sampling. Dari 500 responden penelitian dan validitas diolah menggunakan Spearman correlation didapatkan (p<0.001 dan r=0.422±0.118) berarti ada korelasi bermakna dan cukup valid. Analisis reliabilitas menggunakan Cronbach’s-alpha (r=0,694) dan nilai Interclass Correlation Coefficient menggunakan Spearman correlation coefficient (r=0,886). Adaptasi lintas budaya kuesioner STOP-Bang versi Indonesia memiliki nilai validitas dan reliabilitas yang baik.
Efektivitas Injeksi Intra-Artikular Sekretom Sel Punca Jaringan Adiposa terhadap Regenerasi Tulang Rawan pada Osteoartritis Sendi Lutut: Penelitian pada Domba Andri Lubis; Andra Hendriarto; Bambang Pontjo Priosoeryanto; Tri Isyani Tungga Dewi; Ziad Alaztha; Anissa Canintika
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.386.109-17

Abstract

Saat ini tidak terdapat terapi efektif untuk mencegah osteoartritis lutut. Sel punca mesenkimal (SPM) telah mendapat banyak perhatian karena kapasitas regeneratifnya.Namun, penggunaan SPM berkaitan dengan berbagai kekurangan seperti biaya yang besar, sulitnya penanganan dan manufaktur sel, serta prosedur pengambilan yang invasif.  SPM memperbaiki osteoartritis lutut melalui aksi parakrin faktor pertumbuhan dan sitokin yang disekresi oleh SPM yang  disebut sekretom. Penelitian ini bertujuan untuk menguji efektivitas pemberian injeksi intra-artikular sekretom sel punca jaringan adiposa terhadap regenerasi tulang rawan pada osteoarthritis sendi lutut menggunakan metode post-test only control group experimental di Rumah Sakit Hewan Pendidikan Fakultas Kedokteran Hewan Institut Pertanian Bogor pada bulan Juli hingga Oktober 2019. Sebanyak 15 domba dibagi menjadi tiga kelompok. Kelompok pertama mendapat sekretom SPM jaringan adiposa, kelompok kedua mendapat asam hyaluronat (AH), dan kelompok ketiga mendapat sekretom danAH.  Empat minggu setelah injeksi, seluruh domba dikorbankan. Lutut dari ketiga kelompok dibandingkan secara makroskopik dan mikroskopik menggunakan skor OARSI. Dalam 4 minggu setelah injeksi, terdapat fibrosis pada kelompok sekretom dan AH yang tidak terdapat di kelompok lainnya. Skor osteofit pada kelompok sekretom lebih rendah dibandingkan kelompok lainnya (p=0,031). Skor osteofit secara bermakna lebih rendah pada model domba yang diinjeksi sekretom asal SPM jaringan adiposa. Tidak terdapat perbedaan bermakna pada parameter lainnya, baik makroskopik mikroskopik, 4 minggu setelah injeksi.
Evaluation of Safety and Anti-RBD IgG Sars Cov-2 after Indovac Administration in Depok Kuntjoro Harimurti; Harningtyas Jasmin; Rini Sekartini; Muhammad Aini; Irene Yuniar; Wahyuni Indawati; Angga Wirahmadi
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.393.118-25

Abstract

The WHO declared the COVID-19 pandemic on March 11, 2020, then several centres developed Covid-19 vaccines. The Indovac vaccine contains SARS-CoV-2 RBD antigen adjuvanted with Alum and CpG1018. This article reported Jakarta Centre Phase 1 trial results of the safety and immunogenicity of Indovac in Kota Depok. This study is a randomised, observer-blinded, active-control (Sinovac) clinical trial. The study included 175 healthy adults aged 18–70 and 75 participants were enrolled by the Jakarta centre. Two vaccine doses were given 28 days apart. Four vaccine formulas were tested. Safety evaluations included solicited and unsolicited adverse events (AE) up to 28 days post-injection. SARS-CoV-2 anti-RBD IgG was tested before, 14, and 28 days after second injection to determine immunogenicity. Most solicited AEs were injection site pain. Local pain was highest in the RLCL group after the first dose (38.62%) and RHCH after the second dose (23.08%). 13.33% and 6.67% of control group subjects experienced local pain after the first and second injections, respectively. RHCL has the highest seroconversion (100%) after two injections. Anti-RBD IgG responses increased (p<0.005) in all groups and plateaued 28 days after the second dose injection. In conclusion, Indovac was safe and immunogenic in Jakarta.

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