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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 5 Documents
 1 
Search results for , issue "Vol. 10, No. 1" : 5 Documents clear
Interaction between Fluoxetine and Risperidone and Its Association with Clinical Outcomes in Schizophrenic Patients Rachmaini, Fitri; Ayu Juwita, Dian; Abdillah, Rahmad; Dwi Afrianti, Rezy; Sri Wahyuni, Fatma
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data were collected from direct observation and notes from medical records. To provide an overview of the frequency distribution and percentage of the variables evaluated, the data were analysed through descriptive statistics and a chi-square test using SPSS v.22. Symptoms due to risperidone-fluoxetine interaction were found in four patients (10%). The symptoms experienced are categorised as extrapyramidal syndrome (EPS). The results of the clinical outcomes showed that 38 patients (88%) having recovered and five patients (12%) were in remission. The PANSS-EC in male patient (6.24±1.12) was higher than female (5.88±1.12). The length of hospitalization was higher in patient with age 36-45 years (23.72). This study showed no significant relationship between fluoxetine-risperidone interaction on the outcome of therapy (p>0.05). It can be concluded that EPS was found in 10% of schizophrenic patients. However, there was no significant association between EPS due to fluoxetine-risperidone interaction with clinical outcomes.
Utilization of Spent Arabica Coffee Grounds as Raw Material for Activated Charcoal in Liquid Bath Soap Formulation Maysarah, Hilda; Desiyana, Lydia Septa; Nurzuhra, Siti; Illian, Didi Nurhadi
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Arabica coffee (Coffea arabica) is one of the most popular coffees among Acehnese, an ethnic group from Aceh, Indonesia. The amount of coffee consumed is directly proportional to the amount of coffee waste produced. Spent coffee grounds are the residue obtained during the brewing process. Spent coffee grounds can be utilized by converting them into active charcoal adsorbents. This study aimed to produce activated charcoal from spent arabica coffee grounds (SACG), to utilize it as an active ingredient in the liquid bath soap formulations, and to determine the best formula. The characterization of activated charcoal was conducted and compared to the Indonesian National Standard (SNI). The liquid bath soap contains activated charcoal from SACG was divided into five formulas with various concentrations of cocamidopropyl betaine (CAPB) and sodium lauryl sulphate (SLS) surfactants. Furthermore, the evaluation of liquid bath soap formula was performed. The characterization results showed that activated charcoal produced from SACG met the SNI requirements with a yield of 86.3%, volatile substance content of 10.67%, water content of 5.67%, ash content of 1.7%, pure carbon content of 81.96%, and iodium absorption of 1522.8 mg/g. The evaluation results revealed that liquid bath soap formula with activated charcoal from SACG containing a combination of 5% CAPB and 5% SLS (F5) was the best formula that met the requirements. SACG can be used as an excellent raw material for activated charcoal in liquid bath soap formulations.
Beyond Use Date (BUD) Determination of Ambroxol Hydrochloride Syrup by High-Performance Liquid Chromatography – UV/VIS Detector Jatmika, Catur; Iswandana, Raditya; Lestari, Indah Dewi
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug content using High-Performance Liquid Chromatography (HPLC) – UV/Vis detector. The HPLC conditions were reversed-phase with a C18 column, mobile phase containing acetonitrile - phosphate buffer 0.05 M pH 4.5 (60:40) at a flow rate of 1.0 ml/min using UV detection at 248 nm. To determine BUD, five syrup preparations (brands) obtained from the Jakarta area were analyzed in triplicate. The retention time for ambroxol HCl was 4.62 minutes. In the validation, ambroxol HCl showed good linearity with r = 0.99985 in the 6 to 36 µg/ml. LOD and LOQ for ambroxol HCl were 0.74 µg/ml and 2.25 µg/ml, respectively. It is also fulfilled the accuracy and precision parameters with a % recovery from 99.04% to 100.94% and CV<2%. This method meets the requirements according to the ICH Q2(R1) guidelines and can be used for the assay of ambroxol HCl syrup. The ambroxol HCl level on all samples was still higher than 90% (until the 36th day). Normality test data result indicated that data must be divided into two groups that are sample A and B, and sample C, D, and E. In conclusion, the extrapolation result showed that the BUD ambroxol HCl syrup was 83 days for sample A and B, and 49 days for sample C, D, and E.
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs Butar-Butar, Maria Elvina Tresia; Wathoni, Nasrul; Ratih, Hestiary; Wardhana, Yoga Windhu
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in which polymers and surfactants can trap drug molecules that are in the amorphous phase. Drugs in a hydrophilic carrier will increase wettability, water absorption capacity, and porosity of particles, so that the drug is released better. This review article will discuss the development of technology in solid-state, how solid dispersion overcomes the lack of solubility and the rate of dissolution of antiviral drugs, and solid dispersion preparation techniques. We also discuss some examples of successful applications of solid dispersion methods to antiviral drugs that have been circulating on the market. Overall, this review article offers information of innovation in the development of antiviral drugs to provide more solid dispersion antiviral drug products.
Synthesis of Ferrous Fumarate from Indonesian Iron Sand and In Vivo Body Weight Gain Test in Rats Rukmana, Taufiq Indra; Kurniadi, Felicia Natalia; Harmita, Harmita
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand in Indonesia. This study aims to synthesize ferrous fumarate from Indonesian iron sand, which is from Malang, Sukabumi, and Cianjur area, and to determine its absorption through in vivo body weight gain test in male Wistar white rats (Rattus norvegicus). First, ferrous fumarate was synthesized through reaction of ferrous sulfate, which was made from Indonesian iron sand with the highest iron content, which was from Sukabumi area, and disodium fumarate. Second, in vivo body weight gain test was conducted to 3 rat groups (negative control, ferrous sulfate group, and ferrous fumarate group, respectively) and monitored for two weeks. The results showed that ferrous fumarate was successfully obtained as brownish red-orange fine powder with yield of 62.17 ± 1.66 %. In addition, the in vivo body weight test suggested that the rats from ferrous fumarate group showed similar weight gain (35.1%) compared to those from the ferrous sulfate group (30.6%), indicating a possibility of iron absorption from ferrous fumarate.

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