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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 5 Documents
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Search results for , issue "Vol. 11, No. 1" : 5 Documents clear
Current Update of Clinical Therapeutic Strategies for Colon-Targeted Delivery Systems Widiani Batubara, Risa; Chany Saputri, Fadlina; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Oral colon-targeted drug delivery systems represent a significant advancement offering both systemic and local therapeutic effects for a range of intestinal diseases, including irritable bowel syndrome, inflammatory bowel disease, colonic bacterial infections, and colorectal cancer. These systems facilitate the delivery of both small molecules and macromolecular compounds such as peptides, proteins, antibodies, oligonucleotides, RNA, and probiotics. This review provides an up-to-date exploration of the critical factors crucial for the effective design and development of drug delivery systems targeting the colon. The chosen strategy takes into account various aspects of colon physiology that influences the profile of drug release, absorption, dissolution, and stability in the colon, including pH, retention time, presence of enzymes, pressure, presence of reactive oxygen species due to inflammation, and specific receptors. Site-targeted drug release allows for high concentrations in the colon while minimizing systemic adverse effects by reducing or preventing drug absorption in the small intestine.
Transdermal Delivery of Ketoprofen for Osteoarthritis Treatment and Management: A Literature Review on Current Progression Ramadhani, Dwi Asih; Harahap, Yahdiana; Sagita, Erny; Permata Sari, Kartika Citra Dewi; Andranilla, Rr. Kirana; Trisina, Jessica; Punu, Gabriella Frederika; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Arthritis, a diverse spectrum of joint disorders, is characterized by chronic pain and inflammation. Osteoarthritis (OA), the most prevalent form, leads to disabling pain, functional limitations, and reduced mobility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for managing OA pain, with ketoprofen recognized as one of the effective options. However, oral administration of ketoprofen may cause gastrointestinal irritation. Addressing this issue, Transdermal Drug Delivery Systems (TDDS) emerge as a promising alternative route of administration. TDDS facilitates delivery of various drugs through the skin without undergoing first-pass metabolism. Recent studies have centered on enhancing ketoprofen’s transdermal delivery, particularly focusing on different methods (such as patches, gels, electroporation technology, and stratum corneum bypass methods), with microneedles emerging as a promising approach for delivering anti-inflammatory drugs through transdermal routes. This review aims to explore recent advancements in transdermal drug delivery systems for managing OA. The utilization of transdermal ketoprofen presents innovative opportunities for future research and development in novel drug delivery systems.
Antioxidant, Tyrosinase Inhibition Activity, and In Vitro SPF Evaluation of Pepino Fruit Extract (Solanum muricatum Aiton) in Different Solvent Types and Concentrations Sugihartini, Nining; Firsty, Girly Risma; Laila, Wahyu Kumil; Mulyaningsih, Sri; Rais, Ichwan Ridwan
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition activity, as well as Sun Protection Factor (SPF) value. The extraction was carried out using the maceration method with ethanol or ethyl acetate as the solvent, each at concentrations of 50%, 70%, and 96%, respectively. The antioxidant activity of the extracts was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition of tyrosinase and the determination of the SPF value were carried out using in vitro test. The results showed that the ethyl acetate extract was better than that of the ethanol extract in terms of antioxidant activity, tyrosinase inhibition, and SPF value. In the ethyl acetate solvent, a concentration of 96% provided the strongest antioxidant, tyrosinase inhibition activity, and the second highest in SPF test. It can be concluded that the optimal solvent for extracting pepino fruit as promising compound for sunscreen formulation is 96% ethyl acetate.
Antioxidant Activities and Protective Effects of Shorea macrophylla Leaf and Bark Extracts Ramli, Salfarina; Sukri, Nik Nor Sabrina; Zulkifli, Nur Adhwa’ Faqihah; Ariestanti, Donna Maretta; Choo, Chee Yan; Halim, Hasseri; Manshoor, Nurhuda; James, Richard Johari
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Shorea macrophylla, also known as the ‘Engkabang’ tree or Light Red Meranti, is renowned for its role in reforestation efforts. Despite lacking records of traditional use, the reported biological activities of other species within the Shorea genus spark curiosity about the potential biological activities of this plant. Therefore, this study aims to explore the antioxidant capabilities of S. macrophylla leaf and bark extracts, along with their protective effects against oxidative stress using a brine shrimp model. In the evaluation of antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays were employed. Extracts were incubated in DPPH and FRAP solutions, and absorbances were measured at 517 and 593 nm, respectively. The brine shrimp lethality assay (BSLT) involved exposing brine shrimps (Artemia salina) to various concentrations of the extract, with LC50 values determined through probit regression analysis. Oxidative stress protection assays entailed treating brine shrimps with safe doses of S. macrophylla extracts before exposure to H2O2, with subsequent observation of survival rates. The DPPH assay unveiled IC50 values of 1.025 and 0.693 mg/mL for S. macrophylla leaf and bark extracts, respectively, while FRAP values exhibited a concentration-dependent relationship. BSLT demonstrated concentration-dependent mortality, with LC50 values of 0.93 and 0.6455 mg/mL for S. macrophylla leaf and bark extracts, respectively. Pre-treatment with S. macrophylla extracts significantly increased brine shrimp survival against H2O2-induced oxidative stress. In conclusion, both S. macrophylla leaf and bark water extracts demonstrated noteworthy antioxidant activities and exhibited protective effects against oxidative stress in brine shrimps. These findings provide insights into the antioxidant activities and protective effects of S. macrophylla Leaf and Bark extracts.
Physico-Chemical, Organoleptic, and Antioxidant Properties of Black Soybean Flour (Glycine soja (L.) Merrit) Flakes with the Addition of Bangle (Zingiber purpureum Roxb.) Kumalasari, Ika Dyah; Nurkhasanah, Nurkhasanah; Sepitriani, Sepitriani
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Flakes are products that are generally made from cereals. In this study, we are interested to use black soybean (Glycine soja (L) Merrit) and bangle (Zingiber purpureum Roxb.) as flakes ingredients. Black soybeans have high antioxidant components, while bangle contains high antioxidant and fiber components, which enables it to capture free radicals. This study aimed to find the most favorable formula with good physical, chemical, and organoleptic characteristics, which also has the highest antioxidant activity. We used the Completely Randomized Design (CRD) method and the variation of formulation used was the ratio of black soybean flour to bangle as follows: T1 (100%:0%), T2 (95%:5%), T3 (90%:10%), T4 (85%:15%), and T5 (80%:20%). The parameters analyzed included physical properties (color, texture, and water absorption), chemical properties (moisture content, ash content, fat content, protein content, carbohydrate content, crude fiber content, and antioxidant activity, as well as total plate count), and organoleptic properties (color, texture, taste, aroma, and overall acceptance). The research data were analyzed using One-Way Analysis of Variance (ANOVA) at a significance level of 5% and Duncan’s multiple range test. The results showed that the best formula for color and texture is T5 L* 54.57, a*-4.22, color b*31.42, hardness 0.74N, and water absorption 30.01%. The best treatment for chemical properties is T5 (moisture: 4.26%, ash: 3.68%, fat: 18.16%, protein: 16.92%, carbohydrate: 56.98%). All formulations meet the total plate count of <2,500. The highest antioxidant activity was in the T5 formulation (49.59 %). The results of the organoleptic properties showed that the most favorable overall organoleptic reception was T1. Flakes based on black soybean flour with the addition of bangle in formulation T5 (80% black soybean flour: 20% bangle) have the potential to be a functional food high in fiber and antioxidants.

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