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All Journal Pharmaceutical Sciences and Research (PSR) Jurnal Permata Indonesia Jurnal Pengabdian Masyarakat Permata Indonesia Kunir: Jurnal Farmasi Indonesia (KJFI)
Laila, Wahyu Kumil
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antioxidant, Tyrosinase Inhibition Activity, and In Vitro SPF Evaluation of Pepino Fruit Extract (Solanum muricatum Aiton) in Different Solvent Types and Concentrations Sugihartini, Nining; Firsty, Girly Risma; Laila, Wahyu Kumil; Mulyaningsih, Sri; Rais, Ichwan Ridwan
Pharmaceutical Sciences and Research Vol. 11, No. 1
Publisher : UI Scholars Hub

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Abstract

Solvent is a key factor that affects the effectiveness of active compound extraction from plant materials (simplisia). This study aimed to determine the optimal type and concentration of solvent used in the extraction of pepino fruit based on the parameter of antioxidant and tyrosinase inhibition activity, as well as Sun Protection Factor (SPF) value. The extraction was carried out using the maceration method with ethanol or ethyl acetate as the solvent, each at concentrations of 50%, 70%, and 96%, respectively. The antioxidant activity of the extracts was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The inhibition of tyrosinase and the determination of the SPF value were carried out using in vitro test. The results showed that the ethyl acetate extract was better than that of the ethanol extract in terms of antioxidant activity, tyrosinase inhibition, and SPF value. In the ethyl acetate solvent, a concentration of 96% provided the strongest antioxidant, tyrosinase inhibition activity, and the second highest in SPF test. It can be concluded that the optimal solvent for extracting pepino fruit as promising compound for sunscreen formulation is 96% ethyl acetate.
Review Artikel: Potensi Talas sebagai Obat Luka Laila, Wahyu Kumil; Firsty, Girly Risma; Sunardi, Kartika Setyaningsih
KUNIR: JURNAL FARMASI INDONESIA Vol 3 No 1 (2025): JULI
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v3i1.808

Abstract

Latar belakang: Luka insisi merupakan luka goresan pada kulit yang disebabkan oleh benda tajam. Umum terjadinya luka insisi pada masyarakat dan minimnya pemanfaatan tanaman obat menjadi fokus utama dalam review ini. Umbi secara empiris telah digunakan masyarakat sebagai pembalut luka dan secara ilmiah mengandung saponin, tanin, dan flavonoid untuk meningkatkan reepitalisasi luka insisi. Tujuan: bukti ilmiah tentang penggunaan ekstrak umbi talas dalam meningkatkan reepitelisasi luka insisi, jumlah fibroblas dan ketebalan kolagen. Metode: studi literature jurnal dilakukan secara sistematis melalui penelusuran hasil publikasi ilmiah menggunakan database PubMed, Google Scholardan Scientdirect. Hasil: tanaman umbi talas memliki kandungan yang dapat mempercepat penyembuhan luka dengan membantu reepitalisasi sel kulit. Kata kunci : Colocasia esculenta, talas, luka Introduction: Incision wounds are scratches on the skin caused by sharp objects. The common occurrence of incision wounds in society and the minimal use of medicinal plants are the main focus of this review. Tubers have been empirically used by the community as wound dressings and scientifically contain saponins, tannins, and flavonoids to increase reepithelialization of incision wounds. Objective: scientific evidence on the use of taro tuber extract in increasing reepithelialization of incision wounds, the number of fibroblasts and collagen thickness. Methods: a systematic journal literature study was conducted through searching for scientific publication results using the PubMed, Google Scholar and Scientdirect databases. Results: taro tuber plants have content that can accelerate wound healing by helping skin cell reepithelialization. Keywords : Colocasia esculenta, taro, wound
Edukasi Swamedikasi Rasional melalui Gerakan Masyarakat Cerdas Menggunakan Obat (GeMa CerMat) pada Komunitas Keluarga Alumni Pondok Pesantren Inayatullah di Sleman Dilalah, Idlohatud; Christiandari, Hanita; Hernawan, Jarot Yogi; Suprasetya, Edy; Laila, Wahyu Kumil; Nugraheni, Nadzifa
Jurnal Pengabdian Masyarakat Permata Indonesia Vol 5 No 2 (2025): Volume 5, Nomor 2, Oktober 2025
Publisher : Permata Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpmpi.v5i2.358

Abstract

Self-medication refers to an individual’s effort to treat their own health complaints based on symptoms they experience. This practice commonly involves purchasing over-the-counter drugs, using leftover prescribed medicines, or taking medications recommended by family members, friends, or the media without medical supervision. Such self-treatment carries the risk of irrational drug use; therefore, education is essential to enhance public literacy regarding the proper use of medicines. The Inayatullah Islamic Boarding School Alumni Family Community consists of former students and their families, most of whom are in the 25–35 age range and have recently started families. This community service program aims to improve participants’ knowledge and attitudes toward self-medication through a community-based educational approach. The activity was implemented through the Smart Community Movement for the Rational Use of Medicines (GeMa CerMat), conducted in the form of interactive lectures and discussions during a regular monthly gathering at one of the alumni’s residences in Dukuh Nandan, Sariharjo Village, Ngaglik District, Sleman Regency. Participants actively engaged in discussions about appropriate and rational self-medication practices. It is expected that this educational initiative will enhance the community’s understanding of responsible self-medication, enabling them to make wiser decisions in treating minor health problems and to prevent irrational drug use.
Pengembangan Sabun Padat Transparan Berbasis Ekstrak Rimpang Bangle (Zingiber cassumunar Roxb.): Formulasi dan Uji Mutu Fisik Hernawan, Jarot Yogi; Laila, Wahyu Kumil; Wahyu Ika Lestari, Nur; Dilalah, Idlohatud; Christiandari, Hanita; Nugraheni, Nadzifa
Jurnal Permata Indonesia Vol 16 No 2 (2025): Volume 16 Nomor 2, November 2025
Publisher : Politeknik Kesehatan Permata Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59737/jpi.v16i2.372

Abstract

Rimpang bangle (Zingiber cassumunar Roxb.) merupakan bahan alam yang memiliki efek antibakteri dan antioksidan untuk kulit. Penelitian ini bertujuan mengembangkan sabun padat transparan berbasis ekstrak rimpang bangle serta mengevaluasi mutu fisiknya. Ekstrak bangle diperoleh melalui metode maserasi menggunakan etanol 96% dengan rendemen 10,50%. Ekstrak diformulasikan ke dalam empat formula sabun (F0–F3) dengan konsentrasi 0%, 3%, 6%, dan 9%. Evaluasi mutu fisik meliputi uji organoleptis, homogenitas, tinggi busa, pH, dan kadar alkali bebas. Hasil menunjukkan bahwa semua formula memiliki bentuk padat oval, sementara penambahan ekstrak memengaruhi warna dari putih transparan (F0) menjadi oranye hingga oranye kecoklatan (F1–F3), disertai munculnya aroma khas bangle. Seluruh sediaan homogen tanpa terlihat adanya gumpalan. Tinggi busa menurun seiring peningkatan konsentrasi ekstrak, dari 115 mm (F0) menjadi 98,3 mm (F3), namun tetap memenuhi persyaratan SNI (13–220 mm). Nilai pH berada pada rentang 9,45–10,65 dan seluruhnya sesuai standar SNI (9–11). Kadar alkali bebas meningkat seiring peningkatan ekstrak, tetapi tetap berada di bawah batas SNI (<0,1%), sehingga aman digunakan. Secara keseluruhan, penambahan ekstrak bangle memengaruhi warna, aroma, tinggi busa, pH, dan kadar alkali bebas, namun seluruh formula tetap memenuhi standar mutu fisik, sehingga ekstrak bangle berpotensi sebagai bahan aktif alami dalam formulasi sabun transparan.
Co-Authors Christiandari, Hanita Dilalah, Idlohatud Edi Suprasetya Firsty, Girly Risma Hernawan, Jarot Yogi Ichwan Ridwan Rais Nining Sugihartini Nugraheni, Nadzifa Sri Mulyaningsih Sunardi, Kartika Setyaningsih Wahyu Ika Lestari, Nur