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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 10 Documents
 1 
Search results for , issue "Vol. 3, No. 2" : 10 Documents clear
Avian Influenza A (H5N1) : Patogenesis, Pencegahan Dan Penyebaran Pada Manusia Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Avian influenza A (H5N1), or highly pathogenic avian influenza (HPAI), has become the worldÂ’s attention because of possibility of global pandemic. This review describes the features of human infection, pathogenesis, transmission, and clinical management of avian influenza A (H5N1).
Hubungan Antara Kualifikasi Dokter Dengan Kerasionalan Penulisan Resep Obat Oral Kardiovaskuler Pasien Dewasa Ditinjau Dari Sudut Interaksi Obat (Studi Kasus di Apotek “x” Jakarta Timur) Harianto, Harianto; Kurnia, Ridwan; Siregar, Syafrida
Majalah Ilmu Kefarmasian Vol. 3, No. 2
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Abstract

The aim of this research is to reveal the relationship between the physicianÂ’s qualification and the rationality of the prescribing oral cardiovascular drugs to adult patients from drugs interactions point of view. This research is classified into descriptive analitic retrospectif survey. Data was collected from a dispensary located in East Jakarta. The result showed that rate of the rationality of prescribing cardiovascular agents by the physicianÂ’s is 89,86%. From total prescribing, 56,45% among them was prescribed by specialist whereas the rest 43,55% was prescribed by general practitioners. The rate of the irrational prescribing is 10,14%. From total prescribing, 78,57% among them was prescribed by general practitioners whereas the rest 21,43% was prescribed by specialist. Based on Chi square testÂ’s result, there is a relationship between physicianÂ’s qualification and the rationality of the prescribing oral cardiovascular drug. Specialist physicians more rational compare to general practitioners in prescribing oral cardiovascular drug
Studi Kemampuan Pati Biji Durian Sebagai Bahan Pengikat Dalam Tablet Ketoprofen Secara Granulasi Basah Jufri, Mahdi; Dewi, Rosmala; Firli, Akhmad Ridwan
Majalah Ilmu Kefarmasian Vol. 3, No. 2
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Many type of starch from various plants can be exploited as an alternative for additional materials in tablet formulation. One of the source that have been developed as a pharmaceutical excipient is durian seed starch, which relatively easy to find in tropic area such as Indonesia. The objective of this research was to observe the ability of durio seed starch as binder in wet granulation of ketoprofen tablet formulation. Durio seed starch obtained by extraction and drying methode. Starch as a paste used in wet granulation as a binder. Tablet made by wet granulation with ketoprofen (25%) as a drug model; calcium phosphate dihidrate as a diluent; Avicel® PH 102 as a disintegrant; magnesium stearat (1%) and talc (2%) as a lubricant. Placebo formula with various durio seed starch concentration (5%, 6%, 8%, 10%) in tablet compared to other binder that is cassava starch. Placebo tablet formula with better hardness and friability used in ketoprofen tablet formula and compared to cassava starch as a binder with the same concentration. Formula with durio seed starch as binder have smaller hardness and more friable than cassava starch as a binder. Thereby tablet with durio seed starch as binder have faster disintegration time than tablet with cassava starch as a binder. The dissolution test for both ketoprofen formula did not meet the pharmacopeial requirements.
Pengaruh Waktu Praperlakuan Sari Buah Mengkudu Terhadap Wujud Efek Toksik Teofilin Pada Tikus Putih Jantan Sari, Sant Purna; Donatus, Imono A
Majalah Ilmu Kefarmasian Vol. 3, No. 2
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The use of traditional medicine in Indonesia as the substitution and complementary of modern medicine for the treatment of disease may cause interactions to other therapeutic drugs in the body. This research was aimed to observe the effect of Morinda juice on theophyllin toxicity in white rats. This research was initiated by checking sample of Morinda juice including organoleptic, density and thin layer chromatography analysis. The effect of pre-treatment time of Morinda juice to theophyllin toxicity was done by taking randomized completely design using 60 male Sprague Dawley rats that were devided randomly into 5 groups. First group (control) was given 225 mg/kg BW theophyllin suspension, second to fourth groups were given 5.5 g/kg BW Morinda juice on 2, 6, 12, and 24 hours before treatment of theophyllin, then all were observed the toxic effect that appeared. The results of interaction effect have shown that the pre-treatment of Morinda juice which was given 2, 6, 12, and 24 hours before 225 mg/kg BW theophyllin increased number of rats death for 40, 60, 60, and 100%.
Penetapan Kadar Triprolidina Hidroklorida dan Pseudoefedrina Hidroklorida Dalam Tablet Anti Influenza Secara Spektrofotometri Derivatif Hayun, Hayun; Harianto, Harianto; Yenti, Yenti
Majalah Ilmu Kefarmasian Vol. 3, No. 2
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The determination of triprolidine hydrochloride and pseudoephedrine hydrochloride in anti influenza tablet has been performed using derivative spectrophotometry method. Triprolidine hydrochloride and pseudoephedrine hydrochloride were determined by measuring the first derivative ratio amplitudes, at 227,6 nm (zero crossing for pseudoephedrine hydrochloride) and at 230,0 nm (zero crossing for triprolidine hydrochloride) respectively. The linear calibration graphs were obtained for 5-50 ppm of triprolidine hydrochloride and for 100-800 ppm of pseudoephedrine hydrochloride. The results showed that the method is rapid, simple and can be applied successfully to assay simultaneously of two components in tablet preparation.
Skrining Aktivitas Antibakteri Bakteriosin dari MinumanCe Hun Tiau Sari, Rafika; Deslianri, Lia; Apridamayanti, Pratiwi
Pharmaceutical Sciences and Research Vol. 3, No. 2
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Lactic acid bacteria is one of the beneficial bacteria because it can produce an antimicrobial peptide called bacteriocin. Bacteriocin has been applied as a natural food preservative because it effectively prevents the growth of pathogenic bacteria in food or drink. This study aims to identify the lactic acid bacteria as producers of bacteriocin from Ce hun tiau which have inhibitory activity againts pathogenic bacteria such as Escherichia coli, Staphylococus aureus and Salmonella typhi. In this study, Lactic acid bacteria were isolated from Ce Hun Tiau using streak plate method on media deMan Rogose Sharpe. Screening bacteriocin using disc diffusion method to find out the inhibitory activity of isolates against Escherichia coli, Staphylococus aureus and Salmonella typhi and for confirmation test using proteolytic enzymes. The results showed 1 isolate of lactid acid bacteria was succesfully isolated from Ce hun tiau, identified as Lactobacillus plantarum. This isolate could inhibit the growth of pathogenic bacteria Escherichia coli, Staphylococus aureus and Salmonella typhi which is a bacteriocin activity.
Validasi Metode Analisis Ofloksasin dalam Plasma In Vitro secara Kromatografi Cair Kinerja Tinggi-Fluoresensi Mengacu pada European Medicines Agency Guideline Tania, Letitia; Sitepu, Eme Stepani; Harahap, Yahdiana
Pharmaceutical Sciences and Research Vol. 3, No. 2
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Abstract

Ofloxacin is an antibiotic from second generation of fluoroquinolones group. Concentration of ofloxacin in human plasma is in low level, and due to that fact, it requires a selective, accurate, sensitive method of analysis. In this study, the optimization and validation of ofloxacin analysis in human plasma using high performance liquid chromatography-fluorescence with ciprofloxacin-HCl as an internal standard were carried out. Separation of ofloxacin was performed using C18 (Waters, SunfireTM 5 µm; 250 x 4.6 mm) column with an isocratic mobile phase consisted of triethylamine 1% in water pH 3.0–acetonitrile (84:16) in the flow rate of 1.0 mL/min, 40oC column temperature whereas the detection was carried out at excitation of 300 nm and emission of 500 nm. Plasma extraction was done by deproteination using methanol, through the process of vortex and centrifugation (10000 rpm) for 2 minutes and 10 minutes consecutively. The method was valid and linear within the concentration ranged from 21,4 ng/mL to 4280 ng/mL with LLOQ of 21,4 ng/mL. Intra-day and inter-day accuracy and presicion was not more than + 20% for LLOQ and not more than + 15% for QCL, QCM, and QCH samples in both % diff and coefficient of variation. Ofloxacin was stable in human plasma at least three freeze and thaw cycle, for at least 24 hours in room temperature and 28 days at -20oC. This bioanalytical method fulfilled the acceptance criteria following EMEA guideline.
Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design Sari, Rafika; Nurbaeti, Siti Nani; Pratiwi, Liza
Pharmaceutical Sciences and Research Vol. 3, No. 2
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Abstract

Indonesia especially Kalimantan Barat well known by its biodiversity, one of the potential resource is Kesum leaves. Kesum leaves are potential by its antibacterial effect, so that it can be formulated into pharmaceutical dosage form, especially gel. This research aims to know the best comparison between Carbopol 940 and Hydroxypropyl methylcellulose (HPMC) gel base affecting the physical stability of methanol extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD) method. Gels were prepared into three variation base such as gel A (100% Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol – 50% HPMC). According to SLD method, the optimum combination obtained among the basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and 10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Then , the gels were tested their physical stability including adhesive ability spreadability and pH. Results were analyzed using One sample t- test and was known there was no difference of the physical stability between Kesum leaves methanol extract gel and Kesum leaves methanol fraction gel.
Antibiotic Sensitivity in Pseudomonas aeruginosa of DiabeticPatient’s Foot Ulcer Apridamayanti, Pratiwi; Meilinasary, Khairunnisa Azani; Sari, Rafika
Pharmaceutical Sciences and Research Vol. 3, No. 2
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Abstract

Diabetes Mellitus (DM) patients are at risk to have the diabetic ulcer. The main reason for DM’s patient with ulcer complication to be treated and healed in hospital is bacterial infection. One of many bacteria that infects diabetic ulcer is Pseudomonas aeruginosa. The effort to treat this infection is by using antibiotic. The use of antibiotic unfortunately, is often found inaccurate causing the microbe resistance to occur. To choose the right antibiotic, it needs to test the antibiotic’s sensitivity towards Pseudomonas aeruginosa. The aim of this study is to determine the sensitivity of antibiotics against Pseudomonas aeruginosa. Sample used was taken from diabetic ulcers swab with grade III and IV Wagner. The identification of bacteria was managed using the biochemical test and Gram staining test. Antibiotic sensitivity was determined by Kirby Bauer method. Antibiotics that were found still sensitive towards Pseudomonas aeruginosa included ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime, whereas cefadroxil and amikacin were resistant. Antibiotics that can be used for Pseudomonas aeruginosa in diabetic foot ulcer patients are ciprofloxacin, norfloxacin, imipenem, levofloxacin, meropenem, ceftriaxone, and cefotaxime.
Potensi Ekstrak Etanol Daun Petai (Parkia speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (SOD) Pada Plasma Tikus yang Mengalami Stres Oksidatif Butarbutar, Ruth Haryati; Robiyanto, Robiyanto; Untari, Eka Kartika
Pharmaceutical Sciences and Research Vol. 3, No. 2
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Abstract

Cigarette smoke is free radicals superoxide resources that contains, hydrogen peroxide, hidrosil and peroksil. Superoxide dismutase (SOD) is an enzymatic antioxidants that protect cells from oxidative stress by catalyzing superoxide dismutase (O2 *) into O2 and H2O2 . This study aims to determine the potential of ethanolic extract petai leaves against plasma SOD enzyme activity in animals exposed by cigarette smoke. The simplicia extracted by maseration using ethanol 96%. Thirty-six rats Sprague Dawley strain were divided into six groups: normal group was not given treatment, negative group received 10% CMC-Na, positive control group received vitamin E, and treatment group received ethanolic extract petai leaves of 50; 100; 250 mg / kgBW of mice. All rats were treated for 14 days. SOD activity was measured by UV-Visible spectrophotometer at a wavelength of 505 nm. Statistical analysis using One Way ANOVA. The mean value of SOD activity to the normal, negative control, positive control and the group receiving the ethanolic extract petai leaves dose of 50; 100; 250 mg/kg in a row is 37 979 ± 3708; 59 932 ± 3085; 48 552 ± 1234; 57 239 ± 2102; 50 774 ± 1632; 59 124 ± 4849. The results show ethanolic extract petai leaves the most influence on the activity of SOD is a dose of 100 mg/kg.

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