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Makara Journal of Science
Published by Universitas Indonesia
ISSN : 23391995     EISSN : 23560851     DOI : https://doi.org/10.7454/mss
Core Subject :
Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and Molecular Biology (including: microbiology, physiology, ecology, taxonomy and evolution); and Biotechnology.
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Articles 8 Documents
 1 
Search results for , issue "Vol. 25, No. 3" : 8 Documents clear
Effects of Different Extraction Solvents on the Extractive Removal and Properties of Oil Palm Empty-Fruit Bunch Cellulosic Nanofibers Solikhin, Achmad; Hadi, Yusuf Sudo; Massijaya, Muh Yusram; Nikmatin, Siti
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

In this study, the effect of different extraction solvents on the isolation and properties of cellulosic nanofibers (CNFs) were investigated. The unextracted and different solvent-extracted CNFs formed horn-like features and irregularly aggregated nanofibers after oven drying. Scanning electron microscopy at 10000× magnification revealed the smooth external surfaces of all extracted CNFs; this finding is attributed to the limited deposition of amorphous lignocellulosic components on the fibers. All resultant CNF solutions revealed aggregation, with a particle size distribution and zeta average of 21.39–513.00 nm and 162.26–342.13 nm, respectively. Extraction with different solvents and chemical treatment yielded CNF solutions with good transparency. Increases in crystallinity indices were generated by extractive removal and enhanced the delignification and bleaching processes. The atomic crystal size of untreated and different solvent-treated CNFs varied with the type of native cellulose. A dramatic decrease in organic (i.e., C, N, and O) and inorganic (i.e., Na, K, and Si) elements was observed following extractive removal and cellulose purification
Synthesis and Complexation of Monotosylated 4-Aminopyridine with Nickel (II) and Iron (II) Ions Orie, Kingsley John; Duru, Remy Ukachukwu; Ngochindo, Raphael I-oro
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Tosylated 4-aminopyridine and other sulfonylated compounds of amines comprise a substantial class of pharmaceutical drugs used as antibiotics in the field of medicine. This research aimed at the synthesis of tosylated 4-aminopyridine and the complexation of the tosyated 4-aminopyridine with Ni(II) and Fe(II) ions. The sulfonamide was prepared by the action of tosyl chloride on 4-aminopyridine in an aqueous alkaline medium. The complexes were synthesized by the reaction of Ni(NO3)2.6H2O /Fe(NO3)2.6H2O with sulfonamide derivative. These compounds were characterized through Ultraviolet Visible spectroscopy (UV–Vis), Fourier Transform Infer-Red (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance (1HNMR), Carbon-13 Nuclear Magnetic Resonance (13CNMR) and Electron Spray Ionisation-Mass Spectrometer (ESI-MS) and micro-analysis. The IR spectral data suggested that the sulfonamide derivative acts as a neutral ligand towards Ni (II) and Fe (II). In their complexes, the coordination frequency bands of 1665.55 and 1674.21 cm−1 were assigned to Ni−N and Fe−N bonds, and 1687.70 cm−1 was assigned to free tosylated 4-aminopyridine. This decrease in the frequency band of free imine to coordinated imine complexes indicates that electron transfer occurred from the ligand to the d-orbitals of the metals. The complexation of4-Methyl-N-(pyridin-4-yl)benzene sulfonamide can increase the biological and catalytic potential of the ligand in the pharmaceutical and chemical industries.
Analysis on the Crystal Structure of the Piezoelectric Nanocrystal Ceramic of Pr-doped Bi1/2Na1/2TiO3 using Molten-Salt Synthesis Ahda, Syahfandi; Ambarwati, Vita; Mardiyanto, Mardiyanto; Sukirman, Engkir; Sugeng, Bambang
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

One of the future technologies in nuclear reactors is the ability of piezoelectric materials to monitor reactor cores as sensors. Particularly, Pb-free piezoelectric materials, such as Bi1/2Na1/2TiO3, have been examined to improve the ability of their piezoelectric properties. In this study, we attempted to add Pr6O11 dopant material with mole ratios of 0, 0.3, 0.5, and 0.7 mol%. The synthesis process used in this study is the molten-salt synthesis method with a NaCl and KCl salt mole ratio of 1:1. The crystal structure analysis using the refinement process of the Rietveld method of the HighScore software was performed. Accordingly, a rhombohedral crystal structure system with lattice parameters of 3.8809(2), 3.8831(2), 3.8834(7), and 3.8816(2) angstroms and variations in the content of Pr6O11 was obtained. The optimal lattice parameter was discovered with the addition of 0.5 mol% of Pr6O11. The morphology of the synthesis product is still unclear for each addition of dopant material due to the large number of granular agglomerations.
Poly(2-Hydroxyethyl Methacrylate) Hydrogels for Contact Lens Applications–A Review Saptaji, Kushendarsyah; Iza, Nurlaely Rohmatul; Widianingrum, Sinta; Mulia, Vania Katherine; Setiawan, Iwan
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

The emerging technology in biomedical engineering requires biocompatible materials, which are also referred to as biomaterials. For a material to be considered biocompatible, it should not interact with human tissues in a harmful way, and vice versa. Various properties of biocompatible materials, such as mechanical and optical properties, have to be considered for different biomedical applications. One of the most popular applications of biomaterials is for contact lenses. Hydrogels, specifically poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels, are among the most popular ones in ophthalmologic applications, especially in soft contact lenses. This paper reviews the use of PHEMA hydrogels as one of the important biomaterials. The possible applications, properties, and manufacturing process of PHEMA hydrogels, especially in contact lens applications, are addressed. Many studies have shown that PHEMA hydrogels possess many advantages in contact lens applications and have promising development prospects.
Hemoglobin-Modified Core–Shell Fe3O4@Au Nanostructures for the Electrochemical Detection of Acrylamide Saepudin, Endang; Yuliani, Tri; Nasution, Mochammad Arfin Fardiansyah; Khalil, Munawar; Hong, Jong Wook; Ivandini, Tribidasari Anggraningrum
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

In this study, electrochemical detection of acrylamide using hemoglobin (Hb)-modified core–shell Fe3O4@Au nanostructures was conducted. Fe3O4 nanoparticles (~4.9 nm) and core–shell Fe3O4@Au (5.0–6.4 nm) nanostructures were successfully synthesized by the thermal decomposition method. Electrochemical investigation revealed that the optimum amount of Hb of 2 mg/mL could be immobilized in 0.1 M acetate buffer solution (pH = 6). Moreover, the detection of acrylamide using Fe3O4@Au/Hb was evaluated by the cyclic voltammetry technique. A linear calibration curve (R2 = 0.98) in the concentration range of 0.1 to 1.0 µM could be achieved with an estimated limit of detection, limit of quantification, and sensitivity of 0.136 µM, 0.453 µM, and 0.4411 µA/µM, respectively. Furthermore, the developed biosensor exhibited high selectivity in the presence of ascorbic acid, melamine, and caffeine. The developed biosensor was applied to the detection of acrylamide in coffee samples and validated using the standard high-performance liquid chromatography (HPLC) method. The concentration of acrylamide in coffee samples was determined to be 37.450 and 35.377 ppm using electrochemical measurement and HPLC, respectively.
Synthesis and Characterization of Cellulose Acetate Membrane from Cotton Spinning Waste Djayanti, Silvy; Kusumastuti, Syarifa Arum; Fatkhurrahman, Januar; Purwanto, Agus; Budiarto, Agung; Suherman, Alex Lukmanto
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

Cellulose acetate membrane (CAM) was successfully synthesized and characterized from the cotton spinning waste of the textile industry. The membrane was produced through the isolation, acetylation, and phase inversion stages. The highest yields of cellulose fiber and α-cellulose contents were obtained using 3.0% and 6.0% v/v NaClO, respectively. The C–O acetyl bond detected by Fourier Transform Infrared (FTIR) analysis indicates the formation of the CAM. The resulting membrane can be potentially applied as an ultrafiltration membrane for water desalination purposes in water and wastewater treatment facilities. Furthermore, the utilization of cotton spinning waste as raw material aims to produce inexpensive products and recycle solid waste from the textile industry.
COVID-19 In Silico Drug with Zingiber officinale Natural Product Compound Library Targeting the Mpro Protein Wijaya, Renadya Maulani; Hafidzhah, Muhammad Aldino; Kharisma, Viol Dhea; Ansori, Arif Nur Muhammad; Parikesit, Arli Aditya
Makara Journal of Science Vol. 25, No. 3
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Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a worldwide pandemic. Ginger (Zingiber officinale) is a rhizome, which is commonly used for culinary and medicinal purposes. In Indonesia, ginger is taken as traditional medicine by processing it into a drink known as jamu. The present study aimed to assess and evaluate the bioactive compounds in ginger that can be used in drug design for treating COVID-19. The crystal structure of the SARS-CoV-2 main protease (Mpro) was generated from a protein sequence database, i.e., Protein Data Bank, and the bioactive compounds in ginger were derived from the existing compounds library. Mpro is involved in polyprotein synthesis, including viral maturation and nonstructural protein gluing, making it a potential antiviral target. Furthermore, the bioactive compounds in ginger were analyzed using Lipinski’s rule of five to determine their drug-like molecular properties. Moreover, molecular docking analysis was conducted using the Python Prescription 0.8 (Virtual Screening Tool) software, and the interaction between SARS-CoV-2 Mpro and the bioactive compounds in ginger was extensively examined using the PyMOL software. Out all of the 16 bioactive compounds that were docked successfully, 4-gingerol, which has the lowest binding energy against SARS-CoV-2 Mpro, as per the virtual screening results, was proven to have the most potential as a viral inhibitor of SARS-CoV-2
Analysis of Total Acidity toward Bacterial and Endophytic Fungi Profile dur-ing Black Garlic Processing from Garlic (Allium sativum L.) and Shallot (Allium ascalonicum L.) Lestari, Ayu Rahmania; Wonorahardjo, Surjani; Suharti, Suharti
Makara Journal of Science Vol. 25, No. 3
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Abstract

Black garlic or shallot are products of processed garlic and shallots obtained through a heating process conducted over a certain period. Black garlic/shallots have a mild aroma with a sweet and sour taste. The heating process causes chemical compound transition in the garlic, including acidity. In addition to the chemical process, the garlic’s color and component changes are due to the role of microorganisms during black garlic processing. However, the presence and function of such microorganisms have not been identified. Therefore, this research explores the black garlic’s microorganisms, their role in black garlic processing, and their relation to the total acidity changes. Total acidity test was completed using the potentiometric titration method, while the onion’s microorganisms were explored through isolation and characterization. Data show that black garlic’s total acidity of both garlic and shallot increases during the heating period day by day. Endophytic microbes that were successfully isolated during black garlic processing were observed on days 0 and 6. According to the rough data, the bacteria that emerged on day 0 are presumed to come from genus Erwinia, Pseudomonas, Xanthomonas, Agrobacterium, Ralstonia, Xylophilus, Pantoea, Acidovorax, Burkholderia, Coryneform, and Streptomyces, while the bacteria observed on day 6 are assumed to be generated from genus Coryneform and Streptomyces.

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