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MEDICINUS

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Published by PT Dexa Medica

ISSN : 1979391X EISSN : 29638399 DOI : 10.56951

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol. 33 No. 3 (2020): MEDICINUS" : 8 Documents clear

Hemangioma Verukosa Rinandari, Ummi; Yustin Ellista Sari, Endra
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Verrucous hemangioma (VH) is a localized verrucous venous malformation comprising a capillary or cavernous hemangioma with proliferation reactions such as epidermal hyperkeratosis, acanthosis or papillomatosis also vascular proliferation and widening in the dermis to subcutaneous tissue. This disorder is usually found in the lower extremities and unilateral. It is often misdiagnosed as venous or lymphatic malformations. An 11 year-old boy presented with rough patches and blackish-red lumps on the right leg since birth. Four months prior, the lesion bled after being hit by ball and became rougher, thickened and darker thereafter. He was initially diagnosed with hemangioma and cryotherapy was performed, but there was no improvement after 6 cryotherapy treatment. A diagnosis of VH should be considered in the presence of erythematous papules, nodules, and plaques, especially those that are hyperkeratotic, present at birth, located at the lower extremities, and progressively enlarge after trauma or infection. Based on patient history, physical examination and laboratory results, the patient was diagnosed with VH. Excision surgery is the gold standard of VH management. The excision of the lesion must be deep and wide with a margin of 1 cm, to minimize recurrence. Treatment consists of combination of clobetasol propionate 0.05% and salicylic acid 5% ointment before excision was performed.

Acute Mesentric Venous Thrombosis with a History Recurrent DVT in Young Age: A Case Report Z. A. Haldis; B. A. Kuncoro
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Acute mesenteric ischemia (AMI) may be defined as a sudden interruption of the blood supply to a segment of the small intestine, leading to ischemia, cellular damage, intestinal necrosis, and eventually patient death if left untreated. Mesenteric venous thrombosis (MVT) is an emergency condition that is rarely found as a cause of AMI compared to arterial thrombosis, and accounts for only 16% of all mesenteric ischemia cases. The overall incidence is low (0.09-0.2% of all acute admissions to emergency department), prompt diagnostic and intervention are essential in order to reduce the high mortality rate (50-80%).

Pubertas Prekoks Perifer Isoseksual akibat Juvenille Granulosa Cell Tumor Santosa, Putu Adi; Widijanti, Anik; Susianti, Hani; Engli, Katherina Alfa
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

A 16-month-old girl with peripheral isosexual precocious puberty due to juvenile granulosa cell tumor underwent unilateral salpingo-oophorectomy procedure to stop the symptoms of precocious puberty. The diagnosis was established based on the patient’s medical history, physical findings, laboratory and other examinations which demonstrated secondary sexual characteristics according to Tanner scale M3P2, presence of abdominal mass, elevated serum estradiol, and a histological finding of juvenile granulosa cell tumor. Karyotyping results was normal. Left salpingo-oophorectomy successfully reduced estradiol concentration and stop the menstruation, while the other secondary sexual characteristics is monthly assessed at the clinic.

Diagnosis dan Terapi Terkini Multiple Myeloma Savitri, Merlyna
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Multiple myeloma (MM) merupakan keganasan sel plasma yang ditandai oleh proliferasi klonal sel plasma ganas di sumsum tulang dengan protein monoklonal dalam serum dan/atau urine, serta disfungsi organ terkait disertai dengan morbiditas dan mortalitas substansial, berupa end-organ damage: gangguan ginjal, hiperkalsemia, lesi tulang litik, dan anemia. Dengan perkembangan terapi yang lebih baik, MM telah berubah dari penyakit yang tidak dapat diobati ke salah satu penyakit yang masih belum dapat disembuhkan, namun highly treatable dengan kebanyakan pasien dapat berobat rawat jalan. Kelangsungan hidup pada MM telah meningkat secara signifikan dalam 15 tahun terakhir. Hal ini disebabkan oleh adanya terapi terkini seperti bortezomib, thalidomide, dan lenalidomide. Dalam dekade terakhir, carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, daratumumab, isatuximab, dan selinexor juga telah disetujui oleh Food and Drug Administration (FDA) untuk pengobatan MM yang mengalami kekambuhan. Selain itu, adanya terapi autologous stem cell transplantation (ASCT) dapat meningkatkan median overall survival (OS) pasien MM sekitar 12 bulan dan sudah dapat dilakukan di Indonesia, khususnya di Surabaya (FK Unair- RSUD Dr. Soetomo-RS Unair).

Inflamasi dalam Patologi Penyaki Alzheimer Jan S. Purba
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

The worldwide incidence of Alzheimer's disease (AD) in 2006 was estimated to be 26.6 million; and is expected to quadruple by 2050 because of the increasing life expectancy in many countries. The main cause of AD is generally attributed to increased production and accumulation of β-amyloid (Aβ), in association with neurofibrillary tangles (NFT) formation and synaptic degeneration. Increased levels of proinflammatory factors such as cytokines and chemokines, and the activation of complement cascade that occurs in the brains of AD patients contributes to local inflammatory response triggered by amyloid plaque. The same type of amyloid beta proteins which is the hallmark of Alzheimer's when found in the brain are also found in the lens and ocular fluid. These proteins produce an unusual type of cataract in a different part of the eye than common cataracts. Studies showed that after the release of Aβ, synaptic activity in the neurons is increased through a positive feedback loop, and disrupting this positive feedback loop might be the key for the prevention of the earliest signs of Alzheimer's. Epidemiological findings show reduced prevalence of AD upon long-term medication with nonsteroid antiinflammatory drugs (NSAID). On the other hand, neuronal-type nicotinic acetylcholine receptors (nAChRs), peroxisomal proliferator-activated receptors (PPARs) are involved in AD-induced neuroinflammation and in this regard, future therapy may focus on their specific targeting in the AD brain.

Tata Laksana Gastroesophageal Reflux Disease dalam Masa Pandemi Covid Surya, Haryanto
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Gastroesophageal reflux disease (GERD) merupakan gejala atau komplikasi dari aliran balik isi lambung ke arah esofagus sampai ke rongga mulut, dan dapat juga mengiritasi saluran pernapasan. Tingkat keparahan dari GERD ditentukan oleh durasi paparan esofagus dan organ lainnya oleh asam lambung. Durasi paparan tersebut dipengaruhi oleh kemampuan pengosongan esofagus. Proton pump inhibitor (PPI) masih dianggap sebagai terapi empiris yang superior dibandingkan terapi lain untuk mengatasi gejala GERD. Terdapat beberapa isu terkait penggunaan PPI yang menyebabkan kekhawatiran dalam pemberian terapi PPI di masa pandemi Covid-19, seperti yang menyatakan bahwa penggunaan PPI berisiko meningkatkan keparahan pneumonia, berpotensi menyebabkan terjadinya secondary infection, hingga terjadinya ARDS. Sejauh terapi dengan PPI telah dinilai dengan saksama melalui penilaian risiko yang menyeluruh, penggunaan PPI selama masa pandemi Covid-19 dapat dilakukan pada indikasi yang sesuai menggunakan dosis efektif terendah untuk mencapai kontrol pH lambung dan kualitas hidup yang baik pada penderita GERD.

Pengaruh Astaxantine Oral terhadap Kadar Serum Tumor Necrosis Factor Alpha pada Pasien Akne Vulgaris-lores Reti Anggraeni; Niluh Widjayanti; Harijono Kariosentono; Indah Julianto; Endra Yustin; Muhammad Eko Irawanto; Prasetyadi Mawardi
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Background: Acne vulgaris (AV) is chronic inflammatory disease affecting the pilosebaceous unit manifested as closed and open comedones, papules, pustules, and nodules. Treatment of AV generally involves more than one drug due to multifactorial pathogenesis. Objective: This study aims to determine the efficacy of 4 mg oral astaxanthin as an adjuvant AV therapy in decreasing serum level of inflammatory marker tumor necrosis factor alpha (TNF-α). Method: This is a double-blind randomized controlled trial. Subjects were 34 patients with mild and moderate AV (Global Acne Grading System/GAGS 1-30) that were treated with combination of tretinoin 0.025% and clindamycin phosphate 1.2%. Astaxanthin was added to the treatment group and lactulose as placebo was added to the control groups, given for 4 weeks. The pretest and posttest results in both groups were analyzed statistically using nonparametric test. Results: Decrease in TNF-α serum levels occurred in both groups but significant difference compared to baseline were only found in treatment group (p=0.015). There was no significant difference in the reduction of TNF-α levels between both groups (p=0.459). Conclusion: Although the results did not show a significant difference overall, but in the treatment group, astaxanthin can significantly lower TNF-α serum levels compared to baseline.

Analisis In Silico pada VCO untuk Terapi Dermatitis Atopik Mardiana; Primadhanty B; Adniana N; Halim PK; Didik H. Utomo; Endra Yustin Ellistasari; Suci Widhiati
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Introduction: In silico analysis is used in the early stages of drug discovery to speed the rate of discovery that is considered cost and time-efficient. Virgin Coconut Oil (VCO) is a treatment option for atopic dermatitis because it has function to repair skin barrier and as anti-inflammation. Objective: To evaluate the VCO content using computational in silico analysis for the treatment of atopic dermatitis. Methods: The active compounds of Cocos nucifera extracted from KNApSAcK database were predicted experimentally and analyzed computationally using Simple Molecular-Input Line-Entry System (SMILES), Prediction of Activity Spectra for biologically active Substances (PASS) server, and Search Tool for Interactions of Chemicals (STITCH). Results: There are 19 active compounds found in VCO. The analysis shows that VCO has free fatty acid (FFA) protein which acts as a receptor for long and medium chain saturated and unsaturated fatty acids. The highest potential bioactivity of active VCO compounds was as antieczema, with the most important component was linoleic acid, with an average value of probable to be active (Pa) = 0.872, predicted to be highly potential in computational and laboratory tests. Conclusion: Based on this study, we recommend the use of VCO as treatment for atopic dermatitis because VCO has anti-inflammatory potential bioactivity, histamine inhibitor, improves skin barrier function and antieczema which could improve the outcome of atopic dermatitis.

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Ratna Kumalasari

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medicinus@dexagroup.com

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Ratna Kumalasari

Contact Email medicinus@dexagroup.com

Phone +6287808191388

Journal Mail Official medicinus@dexagroup.com

Editorial Address Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224

Location Kota tangerang selatan, Banten INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Ratna Kumalasari

Contact Email
medicinus@dexagroup.com

Phone
+6287808191388

Journal Mail Official
medicinus@dexagroup.com

Editorial Address
Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224

Location
Kota tangerang selatan,

Banten

INDONESIA