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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 9 No 1 (January-April 2023)" : 9 Documents clear
ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD Nina Karlina; Aan Kunaedi; Didin Ahidin; Uzlifatul Jannah; Yasmin Zahiyah
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7912

Abstract

African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.
STUDY ON THE OPTIMIZATION OF MULBERRY LEAF EXTRACT BY MACERATING ETHANOL AND MICROWAVE ASSISTED EXTRACTION METHOD (MAE) WITH NATURAL DEEP EUTECTIC SOLVENTS (NADES) Kunaedi, Aan; Indawati, Iin; Karlina, Nina; Fadhillah, Zakie; Cantika, Citra Dhea; Khulfiah, Ade Ayu
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7915

Abstract

Ethanol extract from the leaves of Morus alba, an herb, has been widely used for medicine, including commercial formulations. This study aims to compare the characteristics of NADES extract using the MAE method and the maceration method. Mulberry leaf simplicia (Morus alba. L) ethanol extract was made with various ethanol concentrations of 50%, 60%, 70%, 80%, and 90%, and NADES (Natural Deep Eutectic Solvents) extract with a solvent ratio of 1:20 and 1: 30 on the MAE (Microwave Assisted Extraction) method with a time of 5 and 10 minutes. Measurement of total flavonoid content and total phenolic content was carried out by UV-vis spectrophotometry with quercetin and gallic acid as reference standards. The results showed that the ethanol extract with ethanol concentrations of 50%, 60%, 70%, 80%, and 90% had an average total flavonoid content; and total phenolic: 0.73%, 0.9%, 1.32%, 1.18%, 0.77%; total phenolic 96.789 mg/g, 71.262 mg/g, 126.465 mg/g, 116.643 mg/g, 93.366 mg/g. NADES extract with a solvent ratio of 1:20 at MAE 5" and 10" minutes obtained flavonoid levels of 0.36%, 0.4%, and total phenolic levels of 36.099 mg/g; 75.621 mg/g. While a ratio of 1:30 with an MAE time of 5" and 10" minutes, the flavonoid content was 0.44%; 0.48%, and the total phenolic content of 61.884 mg/g; 121.237 mg/g. Results of water-soluble essence of ethanol extract; NADES is 26%–31%; 21–24%. Result of ethanol soluble extract content of ethanol extract; NADES is in the range of 36%–42%; 85%–86%. Result of the specific gravity of ethanol extract; NADES is in the range of 0.82 g/mL–0.95 g/mL; 1.08 g/mL–1.18 g/mL. The ethanol extract pH test results were; NADES in the range 6.90–7.01; 7.59–7.89.
STUDY OF THE SEVERITY AND EARLY ANTIVIRAL TREATMENT FOR THE DURATION OF THE RECOVERY COVID-19 PATIENTS Susilo, Rinto; _, Tomi; Hidayati, Nur Rahmi; Asmarandani, Deani; Fadhilah, Daffa
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7916

Abstract

Late antiviral treatment can potentially cause the Covid-19 virus to replicate very quickly, so it is necessary to understand antiviral drugs and optimize treatment for Covid-19 patients. The study aimed to determine the correlation between the severity, speed of administration of antivirals, and the recovery time of Covid-19 patients. This type of research is an observational study with retrospective data collection on 94 Covid-19 medical records at “X” Hospital Cirebon from 316 populations in June-July 2021 according to inclusion criteria. The data analysis used was univariate and bivariate using Spearman's Rho. The 55–59-year age group (28.7%) was the most infected with Covid-19. There are more males than females (52.1% vs 47.9%). Favipiravir therapy (43.6%) was given the most. Moderate severity (74.5%) had the highest proportion. The speed of administration of antivirals was most initiated at 5-8 days (42.6%) after the onset of symptoms. The maximum recovery time for Covid-19 patients is 13-18 days (58.5%). A strong positive correlation between the speed of giving antivirals to the recovery time of Covid-19 patients (sig. 0.000) and the correlation coefficient of 0.659. Does not show a correlation between the severity of recovery time (sig. 0.113) and speed of antiviral administration to the severity of Covid-19 patients (sig. 0.297). There is a correlation between the early antiviral treatment and the recovery time of Covid-19 patients; the earlier antiviral therapy is given, the faster it will heal.
DIRECT MEDICAL COST AND LENGTH OF STAY OF HYPERTENSION PATIENTS AT PRIVATE HOSPITAL IN YOGYAKARTA Faridah Baroroh; Ridhaul Maghfiroh
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.6925

Abstract

The province that ranks fourth with the highest incidence of hypertension in Indonesia is the Special Region of Yogyakarta (DIY). Hypertension therapy is carried out in a not short period, so it becomes an economic burden for people with hypertension and the government. This study aims to determine the relationship between the length of hospitalization and direct medical costs—an analytical observational research method with retrospective data collection and data from class III inpatient hypertensive medical records. The calculation of costs is viewed from a payer's perspective—descriptive and analytical data analysis to determine the relationship between the length of hospitalization and direct medical costs. The study's results of 41 patients met the criteria; 53.65% were women aged 22-59 years (53.65%). The most widely used antihypertensive drug was the combination of amlodipine + candesartan (26.82%). The average direct medical costs for hypertensive patients were IDR 7,039,515. The highest direct medical cost component is the cost of other drugs and medical equipment. The component of direct medical costs is the lowest cost of antihypertensive drugs. The average length of hospitalization for hypertensive patients is 6.14 days. There was a significant relationship (p=0.000) between the length of hospitalization and direct medical costs. The conclusion of this study is a significant relationship (p = 0.000) between the length of hospitalization and direct medical costs
LITERATURE REVIEW OF THE PHARMACOLOGICAL ACTIVITIES OF THE EUPHORBIACEAE FAMILY PLANTS Maulana Isman Naki; Abulkhair Abdullah; Elis Susilawati
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.5990

Abstract

Euphorbiaceae family plants are spread in Indonesia and empirically, have been used for a long time as medicine. This article review aims to discuss the pharmacological activities of several plants from the Euphorbiaceae family. This research was conducted by conducting a literature review limited to research in the form of scientific articles. The scientific article in question results from research reviewed and published in Indonesian and English. The steps in the search are divided into several stages, starting from identification, screening, eligibility, and data grouping. The articles used in this article review were obtained by searching the internet from online data search media/search engines such as Google/Google Scholar and journal provider sites such as PubMed, NCBI, and SINTA with the keywords "Euphorbiaceae plants," "Ethnopharmacology, "Ethnobotany and Ethnopharmacy," "Plant Activity and Effectiveness," "Euphorbiaceae family activity," and "Pharmacological activity of Euphorbiaceae. After determining the keywords, the next step is filtering multiple data or duplications and filtering the article's title, abstract, and keywords so that data can be determined to be used or not for the following review.This study is a literature review based on several national or international scientific articles about the pharmacological activity of Euphorbiaceae plants. The literature study found that some plants from the Euphorbiaceae family have pharmacological activities, and the most dominant are antimicrobial, antioxidant, and anti-inflammatory. Moreover, many other activities include analgesic, antipyretic, antithrombotic, anti-hypercholesterolemia, antihyperglycemic, antihistamine, diuretic, and antiseptic.
HEALTH-RELATED QUALITY OF LIFE POST-SINOVAC VACCINE IN COMMUNITIES IN TAMPAN DISTRICT AND MARPOYAN DISTRICT, PEKANBARU CITY Seftika Sari; Rickha Octavia; Novelia Sukista
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.6924

Abstract

Giving the Sinovac vaccine for Covid 19 can cause several side effects. The existence of side effects that occur, of course, affect their lives, including a decrease in activity, productivity and quality of life. This study aims to determine the HRQoL score in the community after the Sinovac vaccine in Tampan District and Marpoyan District, Pekanbaru City. The research method is analytic observational with a cross-sectional design. The research sample was people who received the first vaccine recorded at the Puskesmas in Tampan District and Marpoyan District, Pekanbaru City, which was selected by purposive sampling technique according to inclusion and exclusion criteria and obtained a sample of 100 respondents. The instrument is a questionnaire EQ5D5L and EQ-VAS. The study results showed that there was little problem with the dimensions of pain (37%) and usual activities (14%), with a score of 0,944 (EQ5D5L) and 0,975 (EQ-VAS). In conclusion, the HRQoL scores on EQ5D5L and EQ-VAS are close to 1, which means close to perfect. This research is expected to be a reference for stakeholders in selecting preventive therapy for Covid 19 and can be used as initial data for cost-utility analysis research.
HPLC DETERMINATION OF BENZOXAZOLINONE ON JERUJU PLANT (ACANTHUS ILICIFOLIUS): NARRATIVE REVIEW Nurul Umi Salamah; Imron Wahyu Hidayat; Tiara Mega Kusuma; Heni Setyowati Esti Rahayu; Prasojo Pribadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7186

Abstract

Mangrove plants in Indonesia are the largest in the world, both in terms of area quantity (+42,550 km2) and number of species (+45 species). Mangroves are a diverse group of salt tolerant plants that grow in intertidal tropical and subtropical forests and represent a rich biodiversity of plants, animals and microorganisms. Acanthus ilicifolius is one of the true mangrove plants which is used as medicine. This literature review aims to determine the study of benzoxazolinone compounds in jeruju plants (Acanthus ilicifolius) from previous studies and to determine the methods, plant parts and solvents used. The literature review method related to the jeruju plant (Acanthus ilicifolius) uses an electronic data base google scholar. Nuclear Magnetic Resonance (NMR) spectroscopy analysis method is one of the spectroscopic methods widely used in previous studies, because NMR spectroscopy is useful in determining the structure of a chemical compound, both proton (1H) and carbon (13C) NMR. Jeruju leaf extract contains alkaloids, flavonoids, polyphenols, phenyletanoid glycosides and coumarin compounds. The methanol fraction of jeruju leaf extract has a pharmacological effect to inhibit edema (inflammation). The extraction method used is maceration, because this method is simple method and most widely used. Meanwhile, the solvents that are more widely used are methanol and ethanol solvents.
FACTORS ASSOCIATED WITH RATIONALITY OF ANTIMALARIA PRESCRIPTION IN PAPUA PROVINCE Irene Sondang Lingga; Sarhana Sarhana Rassya Aulyah Said; Dina Ayomi; Rusnaeni Rusnaeni; Elsye Gunawan; Nur Fadilah Bakri; Elfride Irawati Sianturi
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.8207

Abstract

Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted. Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.
THE ROLE OF THE E-PRESCRIBING SYSTEM IN HEALTHCARE: A SYSTEMATIC REVIEW Ayyoehan Tiara Annisa; Nanang Munif Yasin; Susi Ari Kristina
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.8257

Abstract

The electronic prescribing system has a good role in health services with the powerful features that this system has, when compared to manual prescribing. This systematic review aims to determine the role of the electronic prescribing system in health services. The literature search was conducted from 21 November 2022 using PubMed, ProQuest, Google Scholar, ScienceDirect, Scopus, and Sage PUB as literature search area databases. A literature search strategy using BOOLEAN Operator to help specify the search terms. Literature search based on inclusion criteria. After eliminating duplication, title, abstract and full text, 8 articles were obtained for analysis. The electronic prescribing system has a good role in health services, including reducing medication errors, improving the quality of communication and information both between staff and staff and patients, shortening service time, having an alert system that is able to detect allergies, drug interactions, and adverse drug reactions. desired, time and cost efficiency, effectiveness in terms of patient safety, providing satisfaction for users because with these qualified features they can help in terms of service when compared to manual prescriptions. Further research should be conduct to review the role of Clinical Decision Support System and the electronic Health Record in healthcare due to its limitation.

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