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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
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Search results for , issue "Vol 17 No 1 (2019): Hang Tuah Medical Journal" : 10 Documents clear
Hubungan antara Usia, Jenis Kelamin dan Indeks Massa Tubuh dengan Kejadian Hipertensi di Rumkital Dr.Ramelan Surabaya MARIA INGGRIT BELA THESMAN
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background : Hypertension or high blood pressure is heart and blood vessel disorder marked by increasing of blood pressure. The risk factors of high blood pressure are age, sex difference, body mass index, genetic, smoke, stress, physical activity, patterrn of natrium intake and dietary, consumption of alcohol and caffeine. Purpose : This observation purpose is to aknowledge the relations between age, sex difference and body mass index with incident of Hypertension. Method : The study design is observational analytic with cross sectional design, using secondary data recorded in the medical record in poly heart sub department intern at Rumkital Dr. Ramelan Surabaya in November 2017 . Technique sampling is using consecutive = purposive sampling method. Used 96 samples that meet the criteria for inclusion and exclusion. Data analysis of this research using statistic test Cramer's V Result : 54 person hypertension patient from 96 of the total sample. Result of this study showed there is correlation between age and hypertension incident, with value of p=0,031, < α=0,05. There is correlation between sex difference and hypertension incident with value of p=0,025 < α=0,05. There is correlation between Body mass index and hypertension incident with value of p= 0,000 < α=0.05. Conclution : Age, sex difference, body mass index (BMI) have a significant effect on the incidence of Hypertension.
Pengaruh Pemberian Ekstrak Daun Mahkota Dewa(Phaleria Macrocarpa) pada Gambaran Histopatologi Paru Tikus Putih (Rattus Norvegicus) Galur Wistar yang Dipapar Asap Rokok NGURAH BAGUS RADITYA SRI DAMAR; EDIJONO; JANTO POERNOMO HADI; TROEF SOEMARNO
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background Smoking and getting exposed to cigarette smoke in a long period of time can cause inflammatory response on respiratory tract. Mahkota dewa leaf contains beneficial biological component, such as flavonoid, alkaloid, and saponin that have anti-inflammatory, anti-cancer, and many others. Aim : to determine the effect of administration of mahkota dewa leaf (Phaleria macrocarpa) extract of inflamatory cells on lung histopathology in white male Wistar rats (Rattus norvegicus) exposed to cigarette smoke. Methods : experimental research using Post-Test Only Control Group Design. The subject in this research were 30 male Wistar Rats (Rattus norvegicus) which were divided into 4 groups, a group without given any treatment (K-), a group where they only getting exposed to cigarette smoke (K+), a group where they exposed to cigarette smoke and given mahkota dewa leaf extract at 1500 mg/kgBW/day dose (K1), and the group exposed to cigarette smoke and a mahkota dewa leaf extract at a 2500 mg/kgBW/day dose (K2). , then the rats sacrificed to be made lung histological preparats to count the number of inflamatory cells Result : There was a significant difference on lung histopathology between K- and K+, P1, and P2. There was no significant difference infiltration cells on lung histopathology between K+, K1 and K2. Conclusion : Exposure to 5 cigarette smoke in 21 days caused lung histopathology changes. However, there was no effect of the administration of mahkota dewa leaves extract at 1500 mg/kgBW/day and 2500 mg/kgBW/day on lung histopathology of white male Wistar rats exposed to 5 cigarette smoke in 21 days
Autoimmune Hemolytic Anemia (AIHA) and Hypereosinophillia in Multiple Myeloma Patients in Saiful Anwar Hospital, Malang RAHADIANTO; MAIMUN Z. ARTHAMIN
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Multiple myeloma (MM) is a plasma cell dyscrasias characterized by five clinical signs namely anemia, monoclonal protein in serum and / or urine, bone radiology and abnormal bone pain, hypercalcemia and insufficiency and / or kidney failure. Autoimmune hemolytic anemia (AIHA) is a clinical condition where Ig G and or Ig M antibodies bind to the red blood cell surface antigen and destruction of red blood cells through the complement system and the reticuloendothelial system. Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directly against red blood cells. Autoimmune hemolytic anemia (AIHA) is characterized by the production of antibodies directly against red blood cells. AIHA is a disorder that does not occur frequently, with an estimated incidence of 1-3 cases per 100,000 per year. A patient of Multiple Myeloma with AIHA who is likely to occur because of a non-specific bond that occurs due to high levels of protein M or some abnormalities of the patient's red blood cells, also has an eosinophillia. Eosinophilia from peripheral blood is defined as absolute eosinophil count ≥ 0.5 x 109 / L. In general, eosinophilia is divided into familial type and acquired type. To find out the causes of eosifillia from these patients, it needs more in-depth observation and examination
PENGARUH PEMBERIAN EKSTRAK DAUN KELOR (Moringa oleifera) TERHADAP KADAR KOLESTEROL HDL TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR HIPERGLIKEMIA DENGAN INDUKSI ALOKSAN Lybelary Dewi Satrianawaty; Tri Martini Sumarno; Sulistiana Prabowo
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background : Diabetes mellitus (DM) is a chronic metabolic syndrome characterized by an increase in blood glucose levels due to a lack of insulin, less effective insulin action or both. Hyperglycemia can cause a decrease in HDL cholesterol. Alloxan can reduce HDL cholesterol due to the mechanism of ROS formation. Moringa contains antioxidants that can prevent oxidative stress so that it is expected to increase HDL cholesterol levels. Method : This study used 24 male Wistar rats divided into 3 groups. The first group was given standard feed without alloxan induction, the second group was induced by 150 mg/kgBW intraperitoneal alloxan in the first day, and the third group was induced by alloxan in the first day and given 600 mg/kgBW Moringa leaf extract for 14 days begining at the fourth day. At the end of the study a serum HDL cholesterol levels were measured in each group.Result : One Way Anova test results showed significant decrease of serum HDL cholesterol (p = 0.024) in the alloxan-induced animal group (x = 26.88 mg/dL) compared to the group of rats fed with standard feed without alloxan induction (x = 33.13 mg/dL). There was no significant increase (p = 0.174) of HDL cholesterol in the group of rats that were induced by alloxan and given Moringa leaf extract (x = 29.25 mg/dL) compared to the group of rats that were induced by alloxan without being given Moringa leaf extract (x = 26, 88 mg/gL).Conclusion : this study showed that alloxan significantly reduced serum HDL cholesterol levels and the administration of Moringa leaf extract tended to increase serum HDL cholesterol levels in white rats induced by alloxan because flavonoids and phenols in Moringa leaves acted as antioxidants, but the increase was not statistically significant.
Pengaruh Ekstrak Daun Dan Buah Ketapang Terhadap Malondialdehida Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan dan Diet Tinggi Lemak LYBELARY DEWI SATRIANAWATY; FRANSISKA CHRISTELA; ANTHONY ANUGERAH JOSHUA; SULISTIANA PRABOWO
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background : Diabetes mellitus is a chronic disease caused by high levels of blood glucose. Hyperglycemia will cause the formation of free radicals which can damage cells. To reduce this effect, antioxidants are needed. Aloksan is a chemical that can damage beta cells, resulting in decreased insulin production. Ketapang (Terminalia catappa) is a plant that can be used because of its antioxidant content. The administration of ketapang extract is thought to reduce levels of malondialdehyde. Malondialdehyde is a biomarker for the occurrence of lipid peroxidation in the body caused by an increase in free radicals due to the occurrence of oxidative stress. Metode : 32 male rats divided into 4 groups. Three groups will be given high-fat diet for 7 days followed by induced alloxan at a dose of 90 mg / kgBW to increase blood glucose levels and pancreatic malondialdehyde levels. Then 2 groups will be given treatment for 14 days. The first treatment group was given Ketapang extract with a dose of 600 mg / kgBW and the second treatment group which was given glibenclamide using a dose of 0.09 mg / kgBW. Results: administration of ketapang leaf and fruit extract reduced the levels of molondialdehyde in Wistar rats given a high fat diet and induced by alloxan, but did not significant (p = 0.916). There was a significant reduction in malondialdehyde in Wistar rats given glibenclamide (p = 0.016). Conclusions: the administration of ketapang leaf and fruit extract were able to reduce the levels of pancreatic malondialdehyde given a high-fat diet and induced by alloxan.
Efek Ekstrak Kulit Pisang Kepok Terhadap Kadar Kolestrol LDL Tikus Putih Jantan Galur Wistar yang diinduksi Diet Tinggi Lemak ERIC HARTONO
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Obese people can experience dyslipidemia which is a disorder of lipid metabolism characterized by an increase or decrease in lipid fraction in the plasma. This condition if left unchecked can lead to atherosclerotic plaques which later lead to coronary heart disease. Control of dyslipidemia can be done by consuming foods that contain antioxidants. Method: Using 24 male Wistar rats, divided into 3 groups. The first group of rats fed with standard food, the second group of rats was given fat diet orally, and the third group of rats was given kepok banana skin extract and fat diet orally. At the end of experiment all animals were sacrificed and LDL levels were measured on the 30th day. Result: There was also signifficant difference (p = 0,011) of LDL levels between group of rats fed with high dose fat diet and group of rats fed with high dose fat diet and kepok banana skin extract. Conclussion: kepok banana skin extract decreased significantly the LDL levels because its flavonoid, saponin, and tanin which act as anti oxidant.
THE EFFECT OF STARFRUIT (Averrhoa bilimbi L.)JUICE ON THE BLOOD TOTAL CHOLESTEROL LEVEL OF WISTAR RATS (Rattus norvegicus) FED WITH HIGH-FAT DIET Putri Diana Mauliyah Ulfa; IGM. Antara Hambarsika; Indri Ngesti Rahayu
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background: Hypercholesterolemia is a condition in which increased cholesterol concentration in the blood exceeds normal values. Consuming fats and foods rich in cholesterol can increase total cholesterol levels in the blood and cause cholesterol buildup in the arteries. Starfruit (Averrhoa bilimbi L.) has saponin and flavonoid compounds which are expected to play a role in reducing total cholesterol levels. The aim of this study is to determine the effect of star fruit juice (Averrhoa bilimbi L.) to total cholesterol blood levels of male Wistar strain (Rattus norvegicus) with a high-fat diet. Method: Experimental study with post-test only control group design. Twenty-four male white rats (Rattus norvegicus) of the Wistar strain are divided into 3 groups: the experimental group which is given standard diet for 28 days; group of experimental animals who were given a high-fat diet for 28 days; the experimental group treated with a high-fat diet for 28 days and on the 15th until 28th days were given starfruit juice (Averrhoa bilimbi L.) with a dose of 4ml/200grwieght/day. On the 29th day, it is measuredtotal cholesterol levels for all groups of experimental animals. Results: The One-Way ANOVA test shows a significant increase in the average of total cholesterol levels (p = 0,009) in group of experimental animals that are given a high-fat diet (x = 60,625± 3,462mg/dL) compared to groups of experimental animals given standard diet (x = 50± 8,468mg/dL). There is a increase in the average in cholesterol level of the experimental group given a high-fat diet and the starfruit juice (Averrhoa bilimbi L.) (x = 65,5 ± 8,960) compared to the mean total cholesterol level of group of animals given a high-fat diet (x = 60,625± 3,462). However, there is no significant increase (p = 0,201). Conclusion: Administration of starfruit juice (Averrhoa bilimbi L.) was not significantly difference in statistics on average of cholesterol level to male wistar rat (Rattus norvegicus) induced by high fat diet
Hubungan Pengetahuan terhadap Kepatuhan Minum Obat Anti Hipertensi pada Pasien Hipertensi Usia Lanjut di Puskesmas Krian Kabupaten Sidoarjo SUKMA SAHADEWA; NOVA NOVITA; KADEK DWIPA; GEDE ABI YOGA; MANDASARI DWI PERTIWI
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
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Introduction: Hypertension is persistent abnormal high artery pressure. Patient with hypertension should have knowledge about the disease especially the cause, symptoms and how important to take the medicine regularly in long term periode and the dangerous if it is not taken regularly. The purpose of these study is to observe the role of The Role Of Knowledge In The Compliances For Taking Hypertension Medicine among Geriatric Patient At Krian Primary Health Care Sidoarjo District. Method : The population of the study were patient who came to geriatric clinic at Krian primary health care Sidoarjo district as much 332 patient with sampel 75 people and were analyzed using Spearman Correlation. Results: There is role of knowledge in the obediences for taking hypertension medicine among geriatric patient at Krian Primary Health Care Sidoarjo district with p< 0.05 (p = 0.000) Keywords : Knowledge, Compliances, Hypertension
Pemberian Ekstrak Buah Pare dan Diet Tinggi Lemak pada Penurunan Berat Badan Tikus Putih Jantan I MADE SUBHAWA HARSA
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background : Obesity is an energy balance disorder, ketogenic diet can reduce body weight. Bitter melon (Momordica charantia L.) is a type of vegetable material that is often used as an antioxidant, hypocholesterolemia and hypotriglyceridemia drug. Cucurbitasin is a substance produced by bitter melon (Momordica charantia L.) with a bitter taste which causes in decreasing appetite, resulting in a decrease in triglycerides. This is caused by the bioactivity of bitter melon (Momordica charantia L.) which can increase lipid oxidation, which causes the accumulation of decreased fat tissue which can reduce weight. Methods: This research using pre and post test randomized controlled group design with sample size of 30 male white rats (Rattus norvegicus) wistar lines divided into 3 groups, group 1 as negative control group given standard feed, group 2 as positive control group given high-fat diet with a dose of 2.5 ml and group 3 as a treatment group given a high-fat feed with dose of 2.5 ml and extract of bitter melon (Momordica charantia L.) at dose of 37.5 mg / 150 gBB by feeding tube every morning for 28 days. Data were analyzed by T-paired tests. Result: The T-paired test in each group found a significantly different result of p = 0,000. Conclusion: given bitter melon (Momordica charantia L.) extract and high-fat diet can reduce weight in male white rats (Rattus norvegicus). Keywords:Bitter molon extract, high fat feed, weight loss
Hubungan Antara Kebiasaan Aktivitas Fisik dengan Indeks Massa Tubuh (Imt) pada Mahasiswa Fk-Uwks Angkatan 2016 dan 2017 NOER KUMALA INDAHSARI; MOCH. IRFAN MAHALI
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
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Abstract Background: Being overweight in a person increases the risk of developing degenerative diseases, including diabetes mellitus which is still the most common cause of death, thus maintaining a normal weight allows a person to reach a longer life expectancy. One of the activities that can make normal weight is physical activity. The Body Mass Index (BMI) is a simple, inexpensive and easy method of assessing a person's nutritional status, but BMI can’t measure body fat directly. So that in this study activities will be carried out to get a relationship between physical activity with BMI for FK-UWKS students 2016-2017. Methode: 124 respondents from the 2016 and 2017 FK-UWKS students and taken randomly. The research method used was an analytic observational study with a cross sectional study. Data taken includes BMI, and physical activity. Statistical test with Spearman correlation test (x2). In the early stages of the study anthropometric measurements were carried out to determine Student BMI. Physical activity is measured by recalling activities that students do every day. Results: groups that always carried out physical activity were 24 respondents who had a normal body mass index, while the group that had never carried out physical activity had 57 respondents with a body mass index with details (3 respondents with less BMI, 11 respondents with normal BMI, 30 respondents with excessive BMI and 13 respondents with Obesity BMI)as well as groups that sometimes carried out physical activities totaling 43 respondents had a relatively normal body mass index. Conclution: There is a relationship between physical activity and the Body Mass Index in the 2016 and 2017 FK-UWKS students

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