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All Journal AGRIVITA, Journal of Agricultural Science Jurnal Terapan Abdimas Berkala Kedokteran Jurnal Ilmiah Kedokteran Wijaya Kusuma The Indonesian Journal of Infectious Diseases Medika Kartika : Jurnal Kedokteran dan Kesehatan Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Abdidas Jurnal Pengabdian Masyarakat: Humanity and Medicine Berkala Penelitian Hayati Hang Tuah Medical Journal Calvaria Medical Journal Jurnal Pengabdian Masyarakat Prosiding Seminar Nasional Kusuma Prosiding Seminar Nasional COSMIC Kedokteran JI-KES (Jurnal Ilmu Kesehatan)
Noer Kumala Indahsari, Noer Kumala
Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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POTENTIAL EXTRACT OF Moringa Oleifera AS HEPATOPROTECTIVE IN WHITE RATS (Rattus novergicus) INDUCED TOXIC DOSES OF PARACETAMOL Indahsari, Noer Kumala; masfufatun, masfufatun; D.R, Emilia Devi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 1 (2016): Edisi Maret 2016
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Moringa Oleifera is a plant that contains chemical compounds that are useful, such as flavonoids. The ability of this flavonoid compound that can capture free radicals cause damage and hepatoprotektan hepar. Purpose of study was to determined levels of Moringa leaf extract which can overcome the effects of liver damage caused by toxic doses of paracetamol through MDA, SGOT and SGPT Method used in this laboratory experimental study is a Randomized Post Test Only Control Group Design with the following stages: 1. Moringa Leaf Extraction with Ethanol 96%; Try 2.Preparasi animals, 3. Treatment of Animals Try the extract of leaves of Moringa 3 dose is: 250mg / 200BB rat (dose of A), 500mg / 200BB mice (dose B), 1000mg / 200BB mice (dose C) for 14 days in combination with paracetamol 2 g / 200BB mice, compared to the negative control group (group given just paracetamol 2 g / 200BB rat) and the positive control group (the group who were given regular feed) for 14 days.Results : turned out to be no difference in the reduction in SGOT levels are statistically significant between the negative control group with high-dose treatment group ie the dose C with =0,016 smaller than 0.05, whereas a decrease in ALT levels were significantly decreased in the treatment group high dose is the dose C with =0,009 smaller than 0.05. While MDA group treated with the negative control group experienced an overall decline for the dose A with =0,05, dose B with =0,0011 and dose C with =0,001. Conclusion of this study showed that the extract of Moringa leaves can be potentially as an antioxidant in all doses at once can be as hepatoprotektor at high doses is 1000mg / 200BB Rattus Novergicus.
Characterization and Antioxidant Potential Albumin Protein of Canna striata Fish to Rattus Novergicus Induced by Isoniazid Toxic Dose Indahsari, Noer Kumala
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v14i1.4536

Abstract

Abstract: The Canna Striata fish is a potent source of albumin as an antioxidant. Albumin is a protein capable of binding to free radicals in plasma and has 17 disulfide bonds linking sulfur-containing amino acids. The existence of thiol group bonds in albumin extract of Canna Striata fish is possible to bind to diphenylphycril hydrazyl (DPPH), causing the antioxidant capacity of Canna Striata fish extract to be high. The accumulation of free radicals produced by the administration of antituberculosis drugs from the results of isoniazid metabolism can cause hepatic necrosis. So it requires antioxidants that can reduce free radical levels, which in this study was tested in white rats induced with isoniazid and then treated with albumin protein extract Canna Striata fish. This research method is the first experimental method done is the characterization of albumin protein extract Canna Striata fish with temperature 25˚C and 40˚C by Sodium Dodecyl Sulfate Polyacrilamide Gel Electrophoresis (SDS-PAGE). Then the antioxidant level was tested by measuring the levels of Malondialdehyde (MDA) after 2 last week treatment period in 5 groups of white rats are positive control group, negative control group and 3 treatment groups induced Isoniazid toxic dose are 37.8 mg accompanied by giving of albumin protein extract Canna Striata fish with content of 20ml/kg, 40 ml/kg and 60 ml/kg. The result of this study showed that there were ten albumin protein profiles with size 15,41 kDa, 19,74 kDa 28,6 kDa, 38,87 kDa, 46,08 kDa, 72,45 kDa, 94,42 kDa , 120.82 kDa, 142.80 kDa, and 155.97 kDa. Based on One Way ANOVA and Post Hoc Tukey statistic test, it were found that there was the significant influence and differentiation of Malondialdehyde (MDA) level on giving of albumin  protein extract in white rats induced by Isoniazid with p-value 0,002. The most effective decrease in MDA levels is high levels of albumin protein extract of 60 ml/kg. Keywords: Albumin Protein Extract of Canna Striata, Malondialdehyde, Isoniazid
Characterization and Antioxidant Potential Albumin Protein of Canna striata Fish to Rattus Novergicus Induced by Isoniazid Toxic Dose Noer Kumala Indahsari
Berkala Kedokteran Vol 14, No 1 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.398 KB) | DOI: 10.20527/jbk.v14i1.4536

Abstract

Abstract: The Canna Striata fish is a potent source of albumin as an antioxidant. Albumin is a protein capable of binding to free radicals in plasma and has 17 disulfide bonds linking sulfur-containing amino acids. The existence of thiol group bonds in albumin extract of Canna Striata fish is possible to bind to diphenylphycril hydrazyl (DPPH), causing the antioxidant capacity of Canna Striata fish extract to be high. The accumulation of free radicals produced by the administration of antituberculosis drugs from the results of isoniazid metabolism can cause hepatic necrosis. So it requires antioxidants that can reduce free radical levels, which in this study was tested in white rats induced with isoniazid and then treated with albumin protein extract Canna Striata fish. This research method is the first experimental method done is the characterization of albumin protein extract Canna Striata fish with temperature 25˚C and 40˚C by Sodium Dodecyl Sulfate Polyacrilamide Gel Electrophoresis (SDS-PAGE). Then the antioxidant level was tested by measuring the levels of Malondialdehyde (MDA) after 2 last week treatment period in 5 groups of white rats are positive control group, negative control group and 3 treatment groups induced Isoniazid toxic dose are 37.8 mg accompanied by giving of albumin protein extract Canna Striata fish with content of 20ml/kg, 40 ml/kg and 60 ml/kg. The result of this study showed that there were ten albumin protein profiles with size 15,41 kDa, 19,74 kDa 28,6 kDa, 38,87 kDa, 46,08 kDa, 72,45 kDa, 94,42 kDa , 120.82 kDa, 142.80 kDa, and 155.97 kDa. Based on One Way ANOVA and Post Hoc Tukey statistic test, it were found that there was the significant influence and differentiation of Malondialdehyde (MDA) level on giving of albumin  protein extract in white rats induced by Isoniazid with p-value 0,002. The most effective decrease in MDA levels is high levels of albumin protein extract of 60 ml/kg. Keywords: Albumin Protein Extract of Canna Striata, Malondialdehyde, Isoniazid
Potential of Pectin in Lemon’s and Bali Orange’s Peel as Antidislipidemia and Antioxidant in Hypercholesterolemia Rats (Rattus novergicus) Noer Kumala Indahsari; Aristanto Aristanto; Rio Rio
Berkala Kedokteran Vol 16, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.916 KB) | DOI: 10.20527/jbk.v16i2.9275

Abstract

Abstract: Dyslipidemia is a lipid metabolism disorder characterized by an increase or decrease in plasma lipid fractions. Lemon’s and Bali Orange’s Peels, which are usually discarded, can be used because they contain pectin compounds. The presence of pectin compounds contained in the Lemon and Bali oranges Peels is expected to potentially reduce the risk factors for cardiovascular disease. This research method was conducted with pure experimental, namely One Group Pre-Test-Post Test Design. With 5 groups of white rats, the first was a positive control group which was only given normal food, the second was a negative control group which was given hypercholesterolemia and the third group was the treatment group who were given Lemon orange peel extract 10%, Bali orange peels extract 10% and a mixture Lemon and Bali orange peel extract 10%. The results of this study were obtained that the administration of Lemon orange peel ethanol extract and Balinese orange peel can effectively reduce total cholesterol levels, from 181.87 mg / dL to 69.29 mg / dL, down around 61.91%, HDL levels are almost the same, levels LDL decreased from 56.76 mg / dL to 45.71 mg / dl, meaning around 19.47%, Triglyceride levels decreased from 192.50 mg / dL to 77.83 mg / dL, which was around 59.57%, levels MDA decreased from 8.19 mg / dL to 6.37 mg / dL, which is down about 22.22% in white rats (Rattus novergicus) made hypercholesteroalmia. Ethanol extract of Lemon and Bali orangse peels containing pectin can effectively reduce total cholesterol, LDL, HDL, Trygliceryde, and Malodialdehyd (MDA) Levels Keywords: Hypercholesterolamia, Pectin, Antidislipidemia, and Antioxidant
Comparative Literature Study of Bligo Fruit Extract (Benincasa hispida (Thunb) Cogn) and Bitter Melon (Momordica charantia L.) Extract on the Minimum Inhibition of Salmonella typhi Bacteria Mei Rizqi Putri Afifah; Noer Kumala Indahsari
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.556 KB) | DOI: 10.20527/jbk.v17i2.11679

Abstract

Abstract: Salmonella typhi is a gram-negative bacteria species that causes typhoid fever. Salmonella typhi is sensitive to antibiotics such as amoxicillin, chloramphenicol, ciprofloxacin, and cotrimoxazole. However, there has been some increase in antibiotic resistance, so there is a need for new antibacterials that do not have a resistance effect to treat infection. Bligo fruit (Benincasa hispida (Thunb) Cogn) and bitter melon (Momordica charantia L.) contain saponins, tannins, flavonoids, alkaloids, and triterpenoids which have antibacterial power. The purpose of this study was to compare the effectiveness of the bligo fruit extract (Benincasa hispida (Thunb) Cogn) and bitter melon extract (Momordica charantia L.) on the minimum inhibition of Salmonella typhi bacteria. The method used is narrative literature review. The results of the journal study showed that the extract of bitter melon (Momordica charantia L.) was more effective in inhibiting Salmonella typhi bacteria than the extract of bligo (Benincasa hispida (Thunb) Cogn) with a minimum inhibitory power at a concentration of 20%, namely 8.5 mm. Keywords: Bligo Fruit (Benincasa hispida (Thunb) Cogn), Bitter Melon (Momordica charantia L.), Salmonella typhi.
Effects of Curcumin on Stability and Efficacy of Neem Leaves Extract as Botanical Insecticides Elika Joeniarti; Masfufatun Masfufatun; Noer Kumala Indahsari; Endang Noerhartati
AGRIVITA, Journal of Agricultural Science Vol 42, No 2 (2020)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v42i2.2651

Abstract

Botanical insecticides are considered biodegradable, environmentally compatible, and less toxic to non-target organisms than synthetic insecticides. Unfortunately, they are not attractive to Indonesian farmers due to its instability against light, temperature, and microbes, as well as they, have short storage time. This research was intended to produce a distinctive botanical insecticide that is resilient against the light, microbes, and durable. The role of curcumin in the stability and efficacy of neem (Azadirachta indica) leaves extract as a botanical insecticide against soybean pod sucking bug, Riptortus linearis was evaluated in the laboratory. This research was conducted at the Organic Chemistry Laboratory of Chemistry Department, Faculty of Science and Technology Airlangga University and the Plant Protection Laboratory, Faculty of Agriculture University of Wijaya Kusuma Surabaya, Indonesia, from March to October 2016. The results explained that curcumin is no effect on increase the stability of neem leaves extract solution towards UV light irradiation. However, it can increase the insecticide activity of neem leaves extract solution up to 96% mortality against soybean pod sucking bug, R. linearis. The increase of the bioactivity refers to the anti insecticidal activity of ferulic acid formed from the degradation of curcumin.
Antibacterial and antibiofilm effect of silver and gold nanoparticles in Uropathogenic Escherichia coli Rini Purbowati; Sugiharto; Agusniar Furkani Listyawati; Masfufatun; Lusiani Tjandra; Noer Kumala Indahsari
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 27 No 2 (2022): June 2022
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.27.2.20222

Abstract

Nosocomial infections of the urinary tract are the most common nosocomial infections. Infectious diseases currently pose a life threatening due to the increasing phenomenon of infectious agent resistance. One of the factors known to cause resistance to broad-spectrum antimicrobials agent is the susceptibility to biofilm formation. The use of silver nanoparticles (NPs) is now regarded as one of the most promising strategies to target infections associated with biofilms. This study aims to determine the application of nanotechnology in the form of metal nanoparticles in targeting the formation of biofilms on infectious agents. The antibacterial and antibiofilm activity test was performed on a 96-well microtiter plate on uropathogenic Escherichia coli (UPEC) at concentrations of 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100 ppm. The results showed the addition of silver and gold nanoparticles at different concentrations affected and inhibited the growth of UPEC and prevented the formation of biofilms, as indicated by a decrease in the OD value. In conclusion, silver and gold nanoparticles have antibacterial and antibiofilm effects on UPEC.
The Effect of Broken Home (Household Crisis) on Depression Anxiety Stress Scales (Dass 42) in Students of Sma X Lumajang NOER KUMALA INDAHSARI; RIZKI AMALIA MEGA FITRIANI
HANG TUAH MEDICAL JOURNAL Vol 19 No 1 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i1.67

Abstract

Abstract: Background : Children or teenagers who are facing Broken homes in their master person directly or indirectly can have an impact on mental health disorders, namely stress, anxiety, and depression, which adversely affect children.  This condition can be said to be a trigger and can make the child moody, sad or long because both parents are divorced. The cause of broken homes is due to several factors, namely: the factor of divorced parents, ugliness, economic period, busy period, and the last is the period of education. Method: This study is a type of observational analytic research with the design of cross-sectional study research and the taking until this research using the method of probability sampling that is random, to find out the level of Broken Home aam this study using a questionnaire made by the research-based on various sources obtained and for stress, anxiety, and depression itself using the questionnaire Depression Anxiety Stress Scale (DASS 42). Result : From the results of the following research can be drawn the doubt that a broken home does not significantly cause high school students in this study to experience stress and anxiety. However, it is known that it can cause depression in high school students in this study significantly. Conclusion: the broken home did not significantly cause high school students to experience stress and anxiety but it can cause depression in high school students is significantly
Hubungan Antara Kebiasaan Aktivitas Fisik dengan Indeks Massa Tubuh (Imt) pada Mahasiswa Fk-Uwks Angkatan 2016 dan 2017 NOER KUMALA INDAHSARI; MOCH. IRFAN MAHALI
HANG TUAH MEDICAL JOURNAL Vol 17 No 1 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract

Abstract Background: Being overweight in a person increases the risk of developing degenerative diseases, including diabetes mellitus which is still the most common cause of death, thus maintaining a normal weight allows a person to reach a longer life expectancy. One of the activities that can make normal weight is physical activity. The Body Mass Index (BMI) is a simple, inexpensive and easy method of assessing a person's nutritional status, but BMI can’t measure body fat directly. So that in this study activities will be carried out to get a relationship between physical activity with BMI for FK-UWKS students 2016-2017. Methode: 124 respondents from the 2016 and 2017 FK-UWKS students and taken randomly. The research method used was an analytic observational study with a cross sectional study. Data taken includes BMI, and physical activity. Statistical test with Spearman correlation test (x2). In the early stages of the study anthropometric measurements were carried out to determine Student BMI. Physical activity is measured by recalling activities that students do every day. Results: groups that always carried out physical activity were 24 respondents who had a normal body mass index, while the group that had never carried out physical activity had 57 respondents with a body mass index with details (3 respondents with less BMI, 11 respondents with normal BMI, 30 respondents with excessive BMI and 13 respondents with Obesity BMI)as well as groups that sometimes carried out physical activities totaling 43 respondents had a relatively normal body mass index. Conclution: There is a relationship between physical activity and the Body Mass Index in the 2016 and 2017 FK-UWKS students
Edukasi dan Pelayanan Kesehatan tentang Pemeriksaan Kadar Kolesterol dan Glukosa Darah Terkait Pencegahan Penyakit Jantung Koroner dan Diabetes Melitus di SMA Ta’miriyah Surabaya Noer Kumala Indahsari; Masfufatun Masfufatun; Olivia Herliani
Jurnal Abdidas Vol. 3 No. 6 (2022): December Pages 944 - 1124
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdidas.v3i6.709

Abstract

Angka mortalitas Penyakit Tidak Menular (PTM), terutama Penyakit Jantung Koroner (PJK) dan Diabetes Melitus (DM), masih cukup tinggi di negara-negara berkembang. Etiologinya bersifat multifaktorial, ada yang tidak dapat dihindari namun juga ada yang dapat dihindari, oleh karena itu sejatinya dapat dilakukan langkah prevensi terhadap kejadian PTM. Kesadaran hidup sehat, seperti mengubah pola makan, aktivitas fisik dan menghentikan kebiasaan merokok, diharapkan dapat dibangkitkan melalui hasil pemeriksaan laboratorium yang nyata. Hal tersebut mendorong pengabdi untuk melakukan penyuluhan dan pelayanan kesehatan untuk meningkatkan pemahaman dan kesadaran masyarakat tentang pemeriksaan kadar glukosa darah dan kolesterol untuk menghindari PJK dan DM. Kegiatan dilakukan selama 2 hari dimana hari pertama dilakukan penyuluhan untuk memberikan edukasi dan hari kedua dilakukan pelayanan berupa pemeriksaan kesehatan dan laboratorium kepada kurang lebih 70 orang peserta dari kalangan guru dan karyawan di SMA Tamiriyah Surabaya. Hasil yang didapatkan berupa rata-rata nilai pre dan post test yang diberikan sebelum dan sesudah penyuluhan. Uji statistik Paired Sample T Test diperoleh harga sig (2-tailed) = 0,000, yaitu < 0,05 berarti ada perbedaan antara sebelum dan sesudah perlakuan. Kegiatan ini menyimpulkan bahwa penyuluhan yang diberikan dapat meningkatkan pemahaman dan kesadaran peserta tentang pentingnya pencegahan PJK dan DM.
Co-Authors 'Aqiilah O, Firyal Andriani, Chenny Aniba Alvu Zahra Anisa Rindatus Sholihah Aristanto Aristanto Aritania, Putu Oky Arya N.R, Ganing Atik Sri Wulandari Ayly Soekanto Aynul Z., Abdillah Ayu Cahyani Noviana Bagasya I.K.A, Cheka Chenny Andriani Wiyono Chenny Andriani Wiyono Devi Dwi Rianti, Emilia Dewa Gede Leonda Zeppalin Karsan Dina Meiliawati Emilia Devi D.R Emilia Devi D.R, Emilia Devi Febtarini Rahmawati Haru Setiawan Herliani, Olivia I Made Subhawa Harsa Joeniarti, Elika Kartika Ishartadiati Keysha C, Nashita Listyawati, Agusniar Furkani Lusiani Tjandra Masfufatun Masfufatun Masfufatun masfufatun masfufatun Mei Rizqi Putri Afifah MOCH. IRFAN MAHALI Mokhammad Navycia AL Ghozali Muhammad Dody Ihsan Mukhlatul Ainiah Nafla Dzikrina Qolbiyanti Narotama, Harya Nashita Keysha Chaniago Nursanti, Paramitha Dwi Okky Abimanyu Okta O, Yasfina Olivia Herliani Pramita Laksitarahmi Isrianto Pratika Yuhyi Hernanda PRIMA WIBISONO Putri, Febri S.K Putri, Ni Putu Kharisma Ardiana Putu Oky Ari Tania Qoid Izza Rasyad Ratnasari, Diana Tri Rini Purbowati Rio Rio RIZKI AMALIA MEGA FITRIANI Santika D, Windy Sasmita D, Agatha Silitonga, Evanri Matthew Sugiharto Suhartati Suhartati Suhartati Suhartati Suhartati Sutanur, Lutfiafirliana Tri Ratnasari, Diana Warini Ayu Safitri Wiyono, Chenny A Yaniari, Roethmia