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Muammar Fawwaz
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muammar.fawwaz@umi.ac.id
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pharmaceutical.reports@umi.ac.id
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Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia
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INDONESIA
Pharmaceutical Reports
Published by Universitas Muslim Indonesia
ISSN : 28286030     EISSN : 28288734     DOI : https://doi.org/10.33096/pharm%20rep.v1i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmaceutical Reports is a peer-reviewed journal published by the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, Universitas Muslim Indonesia, which was first published in 2022. We published two times a year in January-June and July-December. Our mission is to advance the science and practice of pharmaceutical research by working to develop and maintain competence, ethics, and integrity, and the highest professional standards in the specialty for the benefit of the public. Pharmaceutical Reports publishes studies that contribute to an understanding of some specific areas in pharmaceutical sciences including the following: - Analytical chemistry of organic and natural product compounds using instrumental analysis in pharmaceutical sciences including spectroscopy and chromatography method. - Design, synthesis, and biological evaluation of biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. - Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). - Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. - Pharmaceutics & Biopharmaceutics - Novel & Targeted Drug Delivery - Pharmacology & Toxicology - Pharmaceutical Biotechnology & Microbiology - Pharmacy Practice & Hospital Pharmacy - Drug Regulatory Affairs
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 63 Documents
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Antiplasmodial Activity of Psidium guajava L. Leaf Fractions against Plasmodium falciparum Saidu, Ahmad; Hassan, Yusuf; Sani, Abubakar
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.402

Abstract

Malaria remains a major global health challenge, particularly in sub-Saharan Africa, where resistance to conventional antimalarial drugs continues to rise. This study aimed to evaluate the in vitro antiplasmodial activity of Psidium guajavaL. leaf fractions against Plasmodium falciparum. Dried leaves were extracted using ethanol and subsequently fractionated into n-hexane, chloroform, ethyl acetate, and ethanol fractions. Phytochemical screening using standard reagents revealed the presence of alkaloids, flavonoids, terpenoids, and saponins in all fractions, while tannins were detected only in the ethyl acetate and ethanol fractions. Antiplasmodial activity was assessed using the Giemsa staining method. All fractions demonstrated concentration-dependent inhibition of parasite growth, with the ethanol fraction exhibiting the highest activity, achieving 84.38% inhibition at a concentration of 10.5 mg/mL. This activity was comparable, although slightly lower, than that of the standard drug artemether/lumefantrine, which showed 95.31% inhibition. The superior activity of the ethanol fraction is likely attributed to its higher content of polar bioactive compounds, particularly flavonoids and tannins, which are known for their antiplasmodial properties. In conclusion, P. guajava leaf fractions, especially the ethanol fraction, exhibit significant antiplasmodial activity, supporting their traditional use in malaria treatment. These findings highlight the potential of P. guajava as a promising source of natural antimalarial agents and warrant further pharmacological and mechanistic studies.
In Silico Evaluation of Bioactive Compounds from Caesalpinia sappan L. as Lipase and Penicillin-Binding Protein Inhibitors for Antibacterial Therapy Kusuma, Andi Trihadi; Arsal, Andi Sitti Fahirah
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.404

Abstract

The increasing prevalence of antibiotic-resistant bacteria has created an urgent demand for alternative antibacterial agents with distinct molecular targets. Natural compounds derived from medicinal plants continue to play an important role in early drug discovery. Caesalpinia sappan contains diverse phenolic and flavonoid constituents with potential pharmacological activity. This study investigated selected bioactive compounds from sappan wood, excluding brazilein, as potential inhibitors of bacterial lipase and penicillin-binding protein (PBP) through computational analysis. Molecular docking was employed to examine binding affinity and protein–ligand interactions, while pharmacokinetic and toxicity properties were predicted using pkCSM. The docking results revealed that sappanchalcone showed the strongest interaction with bacterial lipase, whereas protosappanin A demonstrated the highest affinity toward PBP. Both compounds formed stable interactions with important active-site residues associated with enzymatic function. In addition, ADMET prediction indicated favorable pharmacokinetic characteristics, including adequate intestinal absorption, minimal toxicity, and low potential for cytochrome P450 inhibition. Overall, the findings indicate that sappanchalcone and protosappanin A may serve as promising multi-target antibacterial candidates and provide a computational basis for future experimental validation and antibacterial drug development.
Abstract Book: Interdisciplinary Innovation in Drug Development: Challenges and Opportunities for Indonesia Group, Molecular Probes Discovery
Pharmaceutical Reports Vol 4, No 2 (2025): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i2.405

Abstract

It is a great pleasure and honor for me, on behalf of the organizing committee, to welcome you to the International Conference on Interdisciplinary Innovation in Drug Development: Challenges and Opportunities for Indonesia. We are truly delighted to host this important gathering of scientists, professionals, and scholars in the field of pharmaceutical sciences and drug discovery. This conference aims to serve as a dynamic platform for the exchange of ideas, research findings, and collaboration opportunities across disciplines, with a focus on the innovation and transformation of drug development, especially in response to global health challenges. I would like to express our deepest appreciation to Prof. Kazuma Ogawa from Kanazawa University, Japan for his gracious presence here with us today. We are truly honored by his participation, and we look forward to his insightful presentation. Our sincere thanks also go to all our invited speakers from various institutions who are joining us virtually:Prof. Bambang Purwono, Ph.D. (Universitas Gadjah Mada, Yogyakarta)Prof. apt. Muchtaridi, Ph.D. (Universitas Padjajaran, Bandung)Assoc. Prof. apt. Muammar Fawwaz, Ph.D. (Universitas Muslim Indonesia, Makassar)Dr. rer.nat. Rien Ritawidya, M.Farm (National Research Center, BRIN, Serpong.Though distance separates us physically, your knowledge and contributions are invaluable and help to enrich the depth and scope of this conference. We also extend our heartfelt gratitude to all participants, sponsors, reviewers, moderators, and the organizing team who have worked tirelessly to make this event a success. Total participants are 160 participants divided into offline 75, and online 85 participants.

Page 7 of 7 | Total Record : 63

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