cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muammar Fawwaz
Contact Email
muammar.fawwaz@umi.ac.id
Phone
+6282125556303
Journal Mail Official
pharmaceutical.reports@umi.ac.id
Editorial Address
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia
Location
Kota makassar,
Sulawesi selatan
INDONESIA
Pharmaceutical Reports
Published by Universitas Muslim Indonesia
ISSN : 28286030     EISSN : 28288734     DOI : https://doi.org/10.33096/pharm%20rep.v1i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmaceutical Reports is a peer-reviewed journal published by the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, Universitas Muslim Indonesia, which was first published in 2022. We published two times a year in January-June and July-December. Our mission is to advance the science and practice of pharmaceutical research by working to develop and maintain competence, ethics, and integrity, and the highest professional standards in the specialty for the benefit of the public. Pharmaceutical Reports publishes studies that contribute to an understanding of some specific areas in pharmaceutical sciences including the following: - Analytical chemistry of organic and natural product compounds using instrumental analysis in pharmaceutical sciences including spectroscopy and chromatography method. - Design, synthesis, and biological evaluation of biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. - Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). - Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. - Pharmaceutics & Biopharmaceutics - Novel & Targeted Drug Delivery - Pharmacology & Toxicology - Pharmaceutical Biotechnology & Microbiology - Pharmacy Practice & Hospital Pharmacy - Drug Regulatory Affairs
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 53 Documents
 1   2   3   4   5 
Dose Optimization of Antihyperuricemia Effects of Matoa Leaf (Pometia pinnata J.R.Forst & G.Forst) in Rats Afiah, Nurul; Santi, Irma; Putra, Bayu
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.271

Abstract

Hyperuricemia is a condition of increased uric acid levels in the blood above normal limits that can cause pain or soreness, which if not treated immediately will cause chronic gout, the formation of tofus, and severe kidney function disorders. One plant that is thought to have anti-hyperuricemia effects is matoa leaves (Pometia pinnata J.R.Forst ; G.Forst) because they contain secondary metabolite compounds, namely flavonoids. This study is an experimental study using 25 male white rats divided into 5 treatment groups, namely group I (Na-CMC, negative control), group II (Allopurinol, positive control 100 mg), group III, IV, and V were given matoa leaf ethanol extract (EEDM) with successive doses of 200 mg/kg body weight (BW), 400 mg/kg BW, and 800 mg/kg BW for 4 days. Test animals were induced with fresh chicken liver juice orally for 7 consecutive days and potassium oxonate 250 mg/kg BW intraperitoneally on day 8. On the 9th to 12th day, EEDM therapy was carried out. Measurement of uric acid levels was carried out on days 0 (before treatment), 7, 8, and 12. The data were then processed statistically using Kruskal-Wallis and the Mann-Whitney follow-up test. From the results of the study, it can be concluded that ethanol extract of matoa leaves has an effect as anti-hyperuricemia with the most effective dose being 200 mg/kg BW.
Formulation and Evaluation of Anti-Acne Activity of Gel Pineapple Peel (Ananas comosus L.) Extract on the Growth of Propionibacterium acnes Latu, Saparuddin; Firman, Imran; Yaqkin-P, Andi Muh.; Musliani, Musliani
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.286

Abstract

Pineapple peel contains many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, alkaloids and bromelin enzymes. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acne. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the ethanol extract of pineapple peel (Ananas comosus L.) can be made into an anti-acne gel preparation and to find out at what concentration the ethanol extract of pineapple peel (Ananas comosus L.) in an anti-acne gel preparation can provide inhibitory activity on the development of Propionibacterium acne bacteria. This research method is true experimental by making anti-acne gel preparations of pineapple peel extract (Ananas Comosus L.) with various concentrations of 2%, 3%, 5% and testing the activity of the preparation against Propionibacterium acne using the agar well method. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the 5% concentration, namely 12.7 mm, which was in the strong category, while the 3% concentration, which was 11.03 mm, and the 2% concentration, which was 8.8 mm, was included in the moderate category.
Hydroquinone Levels in Whitening Body Lotion Circulating in Makassar City by the UV-Vis Spectrophotometry Method Rezky M, Mega; Suhaenah, Asriani; Baits, Muzakkir
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.272

Abstract

Hydroquinone is an active compound that is able to control pigment production to inhibit melanin formation and has activity as a skin whitening agent, so hydroquinone is widely used in cosmetic products. Hydroquinone has adverse side effects if used for a long time. BPOM RI has issued a regulation on the prohibition on the use of hydroquinone as a bleach in cosmetics. The purpose of this study was to identify the hydroquinone content in whitening handbody samples circulating in Makassar City and to find out the level of hydroquinone contained in the sample. Qualitative analysis is carried out using FeCl₃ reagents and quantitative analysis using the UV-VIS spectrophotometry method. The number of samples used in this study was as many as 4 samples that did not have a registration number from BPOM RI. The results showed that the 4 samples studied positively contained hydroquinone. The results of the sample test measured at a maximum wavelength of 292 nm, obtained hydroquinone levels at the sample code HB1 = 1.267%; sample code HB2 = 0.912%; sample code HB3 = 0.379% and sample code HB4 = 0.449%.
UV-Protection Activities of Labu Siam (Sechium edule) Extract Based on Sun Protection Factor (SPF) Anggraeni, Bella; Aminah, Aminah; Fawwaz, Muammar
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.287

Abstract

Exposure to sunlight has a negative effect on the skin. Sunscreens are used to protect the skin from the harmful effects caused by UV radiation. The ability of a sunscreen to protect the skin by delaying erythema is expressed by the value of the Sun Protection Factor (SPF). The purpose of this study was to analyze the UV protection activity of chayote (Sechium edule) based on the Sun Protection Factor (SPF) value, which was measured using UV-Vis spectrophotometry and calculated using the Mansyur equation. Based on the results of the study, it can be concluded that the SPF value of chayote (Sechium edule) extract has UV protection activity. At concentrations of 1%, 2%, and 3% there is activity as UV protection with SPF values of 7.487; 11.817; and 16,889. From the results obtained, it can be seen that the higher the concentration, the greater the SPF value obtained.UV-Protection Activities of Labu Siam (Sechium edule) Extract Based on Sun Protection Factor (SPF)
Determination of Antioxidant Activity of Stem Bark (Manihot esculenta Crantz) by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Scavenging Method Latu, Saparuddin; Jangga, Jangga; Mansur, Mansur; Gajali, Nurdila
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.273

Abstract

Cassava bark is a part of the cassava plant which is still underutilized besides being used as animal feed and wasted as waste. Each cassava can usually produce 10-15% cassava bark. The amount of waste produced can cause accumulation, resulting in environmental damage if not appropriately utilized. This research aims to determine the antioxidant activity of cassava bark (Manihot esculenta Crantz) using the DPPH (1,1-diphenyl-2-pikrihidrazil) method, measured using a UV-Vis spectrophotometer. Extraction used the maceration method of 96% ethanol as solvent. The determination of antioxidants in ethanol extract of cassava bark by the DPPH method and using vitamin C was used as a reference. Vitamin C was made in four series of concentrations, namely 2, 4, 6, and 8 ppm, while the ethanol extract of cassava bark was 20, 40, 60, and 80 ppm. From several concentration series, 2 ml was taken, and 1 ml of 50 ppm DPPH was added; then, the mixture obtained was incubated for 30 minutes in a place protected from light. The absorbance was measured at a wavelength of 515 nm. The results showed that the ethanol extract of cassava bark has a potent antioxidant activity based on the IC50 value obtained, which is 3.847 mg/L. Therefore, the ethanol extract of cassava bark can be developed as a natural antioxidant.
Antioxidant Activity Test of Ethyl Acetate Extract of Avocado Seeds (Persea americana Mill.) Using the 1,1-Diphenyl-2-Picrylhdrazyl Method Rahmat, Sri Rahayu; Pratama, Mamat
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.288

Abstract

Avocado is a plant that can thrive in tropical areas such as Indonesia and is one of the types of fruit that is popular with the public, however, avocado seeds have not been used optimally so that they are wasted as waste. Based on phytochemical experiments, avocados also contain phenolics, tannins and flavanoids which have antioxidant activity. Antioxidants are compounds that can be used to counteract free radicals. Dietary fiber and antioxidants are two types of components that are very useful in improving health and being able to prevent various diseases. The extraction method used in this study is reflux where the sample is heated for 6 hours with the solvent used to evaporate at high temperatures, but it will be cooled by the condenser so that the solvent which was in the form of vapor will condense in the condenser and fall again into the reaction vessel so that the solvent will still be there during the reaction. This study aims to analyze the antioxidant activity of the ethyl acetate extract of avocado seeds using the DPPH method. Quantitatively, the ethyl acetate extract of avocado seeds (Persea americana Mill.) was measured at a maximum wavelength of 516 nm using quercetin as a reference standard. The research results showed that the value was 903.08 μ/mL. Quantitatively, the ethyl acetate extract of avocado seeds (Persea americana Mill.) was measured at a maximum wavelength of 516 nm using quercetin as a reference standard. The research results showed that the value was 903.08 μ/mL. Quantitatively, the ethyl acetate extract of avocado seeds (Persea americana Mill.) was measured at a maximum wavelength of 516 nm using quercetin as a reference standard. The research results showed that the value was 903.08 μ/mL.
Formulation of Seaweed (Eucheuma cottonii Doty) Lotion Hamsinah, Hamsinah; Suhaenah, Asriani; Mulyana, Imam Dwiyan
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.274

Abstract

Seaweed (Eucheuma cottonii Doty) has potential as an antioxidant because it contains kappa-carrageenan which can counteract free radicals. Formulation of seaweed (Eucheuma cottonii Doty) into lotion preparations can minimize the negative effects of sun exposure, because it can reflect solar radiation or work as a physical sunscreen. To give the maximum effect, particle size reduction is carried out, so that the smaller the particle size of the seaweed powder, the surface area increases. This study aims to determine the formulation and evaluate the preparation of lotion from seaweed powder. This research was conducted using an experimental method. The lotion was made with three variations of seaweed powder concentration (Eucheuma cottonii Doty), namely 2.5%, 3% and 5%. Tests were carried out before and after accelerated conditions at 5oC and 35oC for 12 hours each for 12 cycles with test parameters including organoleptic, homogeneity, pH, spreadability, viscosity and flow type. The results obtained in the organoleptic test showed no change in the three formulas both before and after the accelerated condition. The pH test showed that Formula 2 and Formula 3 still showed that the preparation remained in the skin pH range for sunscreen. In the homogeneity test, all preparations were homogeneous, as well as the spreadability test met the test requirements criteria. Based on the tests carried out, it can be concluded that formulas 2 and 3 have optimum stability.
Antioxidant Activity of Ethanol Extract on Qust Al Hindi (Saussurea lappa) Roots Using the FRAP Method Putry, Dhevy Try; Syarif, Sukmawati; Rahmawati, Rahmawati
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.289

Abstract

Qust al hindi (Saussurea lappa) is a plant that has antioxidant activity, especially in the roots. Qust al hindi contains several chemical compounds including flavonoids, steroids, terpenes, alkaloids, sesquiterpenes, costunolide, dehydrococtus lactones, cynaropicrin, and chlorogenic acid. This study aims to determine the antioxidant activity of the ethanol extract of qust al hindi root using the FRAP method. Samples that had become powder were extracted using the soxhletation method with 96% ethanol and obtained a % rendition of 5.302%. The extract obtained was measured using a UV-Vis spectrophotometer at a maximum wavelength of 718 nm after being mixed with several FRAP reagents, using a quercetin standard. The results of the antioxidant analysis showed that the average antioxidant activity of the ethanol extract of the qust al hindi root (Saussurea lappa) using the Frap method was 10.3671 mgQE/g extract. Which means that the antioxidant activity of each g of extract is equivalent to the antioxidant activity of 10.3671 mg of quercetin.
Modulation Imaging Contrast Agent for Cancer Fawwaz, Muammar
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.283

Abstract

Molecular imaging, also known as molecular imaging, is a medical technique used to visualize and analyze biological molecules in the human or animal body. According to the Society of Nuclear Medicine and Molecular Imaging's website, "Molecular Imaging" is a type of medical imaging that provides a detailed picture of what is happening in the body at the molecular and cellular levels. This definition refers to the significant advancements researchers have made over the past two decades in applying the principles of molecular imaging in various areas, from basic and translational science to advanced patient diagnosis and therapy. Essentially, molecular imaging allows us to visualize biochemical processes and target localization patterns that are invisible at the level of anatomical imaging. The goal of molecular imaging is to obtain information about molecular activity and function in living tissue. The technologies commonly used in imaging modulation are Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
Analysis of Artificial Sweeteners, Sodium Cyclamate, in Packaged Beverages and Powders by the Gravimetric Method Pratama, Shinta Indah; Suhaenah, Asriani; Tahir, Masdiana
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.267

Abstract

Most people like instant beverage products because of their practical processing and superior taste and creative packaging, thus attracting consumers to consume them. One of the food additives that is often used in instant beverage products is artificial sweeteners such as sodium cyclamate which has a sweetness level of 3.94 kcal/g or 30 times that of sucrose. This study aims to determine the levels of sodium cyclamate in packaged and powdered drinks circulating on the campus of the Indonesian Muslim University using the gravimetric method. The sampling method used a purposive technique and obtained 6 test samples, qualitative analysis used the precipitation method and obtained all positive samples containing sodium cyclamate. The results of the quantitative analysis obtained the levels of sodium cyclamate for each sample A; B; C; D; E; F as much as 37.07 mg/kg; 30.17 mg/kg; 12.93 mg/kg; 4.31 mg/kg; 340 mg/kg; 258 mg/kg. Thus, these results indicate that all samples do not exceed the levels set by BPOM regulation No. 11 of 2019 concerning food additives, namely 350 mg/kg, so they are safe for consumption.

Page 3 of 6 | Total Record : 53

 1   2   3   4   5 

Filter by Year

2022 2025


Reset
Filter By Issues
All Issue Vol 4, No 2 (2025): (October) Pharmaceutical Reports Vol 4, No 1 (2025): (March) Pharmaceutical Reports Vol 3, No 2 (2024): (October) Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports