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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 10 Documents
 1 
Search results for , issue "VOLUME 11, NUMBER 3, December 2010" : 10 Documents clear
Cardiac Tamponade Due to Liver Amebiasis Rupture Birry Karim; Afifah Is; Ikhwan Rinaldi; Dono Antono; Cleopas Martin Rumende; Andri Sanityoso Sulaiman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010150-155

Abstract

Amebiasis is common cases in Asia, Africa, and South Africa. Liver amebiasis has become a serious problem worldwide especially in health and social aspect. The protozoa named Entamoeba histolytica was easily found in area with poor sanitation, low socioeconomic status, and poor nutrition status. The incidence of amebiasis in several hospitals in Indonesia is 5-15% per year. Epidemiological observation showed the comparison of incidence among male and female population and it was approximately 3 : 1 until 22 : 1 with male predominance. The potential age suffered from amebiasis is around 20 - 50 years old. The route of infection spread to oral-fecal and oral-anal-fecal. The most common complication is abscess rupture (5-15.6%). Rupture may be located in pleural cavity, pericardial cavity, lung, bowel, intraperitoneal, and skin. Rupture of liver amebias spread to pleural and pericardial cavity is a rare case and frequently under reported. This case report illustrates a 40-year-old male with cardiac tamponade due to rupture of liver amebiasis. Patient’s was admitted with chief complaint of shortness of breath, positive Beck’s triad, hepatomegaly, pleural effusion, liver abscess on sonography and swinging of heart on echocardiography. This patient was treated with metronidazole as a drug of choice, and pericardiocentesis for the cardiac tamponade.Keywords: cardiac tamponade, Entamoeba histolytica, oral-anal-fecal, metronidazole, pericardiocentesis
The Effectiveness of Emergency Endoscopic Retrograde Cholangiopancreatography in Patients with Severe Acute Cholangitis Muhammad Begawan Bestari; Nenny Agustanti; Yelica Rachmat; Dolvy Girawan; Ali Djumhana; Juke Roslia Saketi; Siti Aminah Abdurachman
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010128-131

Abstract

Background: The aim of this study was to assess the frequency, indications, yield and outcome of emergent endoscopy retrograde cholangiopancreatography (ERCP) in severe acute cholangitis patients. Method: Records of all cholangitis patients undergoing ERCP were reviewed over a six months period. Indications, findings, therapeutic interventions and survival were analyzed. Indications for urgent drainage were temperature greater than 38ºC, increasing abdominal pain, jaundice and any organ involvement. Results: Of 80 ERCPs, 19 (23.75%) were severe acute cholangitis patients underwent emergency ERCP. The common bile duct was the duct of interest in all patients and was cannulated in 100%. The most common findings were choledocholithiasis (42.1%) and pancreatic head cancer (42.1%), followed by cholangiocarcinoma (10.5%) and papil vater carcinoma (5.3%). There were 12 (63.2%) septic shock patients with systolic blood pressure less than 90 mmHg and heart rate greater than 90 beats/minute who required inotropic drugs. Endoscopic biliary drainage was performed using 8.5 F biliary stent (73.7%) or common bile duct (CDB) stones removal (26.3%). The overall 30 days mortality was 0. Conclusion: Emergency ERCP in severe acute cholangitis is associated with improvement of clinical and some laboratory parameters without a complication of acute pancreatitis. In cases of chIoledocholithiasis, it can be performed with stone extraction as well as stent insertion   Keywords: severe acute cholangitis, emergent ERCP, endoscopic stenting in difficult hilar biliary stricture
Papilla Vaterƒs Tumor in Elderly: an Interdisciplinary Issue Eric Daniel Tenda; Murdani Abdullah; Kuntjoro Harimurti; Edy Rizal Wahyudi; Czeresna Heriawan Soejono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010155-159

Abstract

Tumors of the papilla Vater are very rare. Papilla Vater’s tumors are benign or malignant tumors in the ampulla of Vater and periampullary region. Blockage of ampulla leads to the development of obstructive jaundice; intermittent cholangitis, epigastric discomfort and weight loss. Treatment possibilities include endoscopic ampulectomy, surgical transduodenal excision of tumors of the ampulla and pancreatoduodenectomy (PDE). Prognosis depends on histological typing of the tumor and their clinical stage. We report a case of papilla Vater’s tumor in elderly with comorbidities based on literature review. A 68-year-old female patient was referred for evaluation of intra and extra hepatic bile duct dilatation noted on abdominal ultrasonography. She complained of intermittent epigastric and right upper abdominal pain, with yellowish skin for two months. The laboratory findings showed leukocytosis, hyperbilirubinemia, abnormal liver function test, and high Ca 19-9. An endoscopic retrograde cholangiopancreatography (ERCP) revealed a distal obstruction caused by papilla Vater’s tumor. Abdominal computed tomography (CT) with contrast, revealed a dilated common bile duct and pancreatic duct. The histologic evaluation was highly suggestive for dysplasia. She is now on a schedule for a Whipple procedure. To make a true diagnosis and optimal treatment of papilla Vater’s tumor is multimodal. By doing a comprehensive geriatric assessment, with a careful modality selection, a Whipple procedure can be performed in elderly (65 years) safely. The post operative morbidity and mortality depends on their multi morbidity. Surgical, endoscopic, or radiologic biliary decompression; relief of gastric outlet obstruction; and adequate pain control may improve the quality of life but do not affect overall survival rate. By building a great interdisciplinary teamwork, the quality of life increased as follows.Keywords: papilla Vater tumor, elderly, Whipple procedure
Endoscopic Feature of Upper Gastrointestinal Bleeding Patient in Soedarso General Hospital Pontianak Yustar Mulyadi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010132-134

Abstract

Background: Gastrointestinal tract hemorrhage is an emergency condition most commonly caused by rupture of the esophageal varices with a mortality rate between 25-30% of cases. Gastrointestinal endoscopy is an accurate diagnostic used modality to identify lesions and locate bleeding in the upper gastrointestinal tract. The aims of this study were to determine the endoscopic features of upper gastrointestinal bleeding patients and distribution based on age and sex. Method: Retrospective study of endoscopic Results of upper gastrointestinal bleeding patients in Soedarso hospital, Pontianak, between January - June 2008. Results: There were 114 patients consisting of 75 (65.79%) male and 39 (34.21%) female. The findings from endoscopic examination were 46 (40.35%) cases of gastric ulcers, 23 (20.17%) cases of esophageal varices, 20 (17.54%) cases of errosive gastritis, 17 (14.91%) cases of duodenal ulcer, and 4 (3.5%) cases of esophageal mass/gastric mass. Conclusion: In this study the most common cause of upper gastrointestinal bleeding is gastric ulcer and it occurs more often in males compared to females.   Keywords: endoscopic feature, upper gastrointestinal, gastric bleeding
Colitis Tuberculosis Budi Tan Oto; Ahmad Fauzi; Ari Fahrial Syam; Marcellus Simadibrata; Murdani Abdullah; Dadang Makmun; Chudahman Manan; Abdul Aziz Rani; Daldiyono Daldiyono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010143-149

Abstract

Tuberculosis (TB) is a significant public health problem worldwide. Indonesia is a country with the third highest prevalence of TB in the world after China and India. TB infection can attack all organs of the human body. TB in digestive system is one of the extrapulmonary TB manifestations and comprises of 3- 16% of all extrapulmonary TB cases. This type of TB may affect digestive system, peritoneum, mesentery lymphatic glands, liver, and spleen. Digestive system is affected in 66-75% of patients with abdominal TB. The ileocaecal region is most commonly affected. The manifestation of abdominal TB is not specific. Precise diagnostic approach and supporting results are needed to determine final diagnosis. However, there is no single examination adequate enough to diagnose abdominal TB. If the diagnosis can be established early, this disease could then be managed with conventional anti-TB drugs. Treatment for both 6-9 months period and 18-24 months period has been proven effective in management of extrapulmonary TB. In countries with high abdominal TB prevalence, initiation of anti-TB therapy is allowed if there are the clinical features present. Diagnosis can be determined when the patient has therapeutic response against the the anti-TB treatment.   Keywords: tuberculosis, colitis, extrapulmonary, antituberculosis drugs
Effect of Conjugated Hyperbilirubinemia on the Prognosis of Patients Hospitalized in Intensive Care Unit at Kariadi Hospital Semarang Agung Prasetyo; Djallalluddin Djallalluddin; Hirlan Hirlan; Agus Suryanto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010108-111

Abstract

Background: In critically-ill patients, liver dysfunction plays a significant role on patient’s morbidity and mortality in the intensive care unit (ICU). Metabolic, hemodynamic and inflammatory factors also contribute in liver damage. Bilirubin is one of clinical markers for liver dysfunction. Some literatures indicated that patients with hyperbilirubinemia have higher mortality rate. The aim of this study was to assess the death prognosis of critically-ill patients with hyperbilirubinemia. Method: This study was an observational, prospective, and cohort study. All patients at the ICU of Kariadi hospital with hyperbilirubinemia were consecutively recruited over 8-month period from May 1st 2008 to January 31st 2009. Hyperbilirubinemia was defined as serum bilirubin levels ≥ 1.3 mg/dL for at least 72 hours and no hyperbilirubinemia was observed when the patients were admitted to the hospital. Results: Of 79 subjects who fulfilled inclusion criteria, the incidence of hyperbilirubinemia in critically-ill patients was 39.2%. About 56 subjects were enrolled in the study. Among them, 28 subjects showed hyperbilirubinemia and the other 28 subjects were included in the control group. There was no significant difference regarding the baseline characteristics of hyperbilirubinemia group and non- hyperbilirubinemia group. At the end of the study, the mortality rate in hyperbilirubinemia patients were 60.7% and 21.3% in the non-hyperbilirubinemia patients. The relative risk (RR) of death was 2.8; (95% CI = 1.3 - 6.1; p = 0.003). Conclusion: The incidence of hyperbilirubinemia was high in critically ill-patients hospitalized in the ICU of Kariadi hospital. The incidence of death between non-hyperbilirubinemia and hyperbilirubinemia subjects was significantly different. The significant relative risk of death indicates that hyperbilirubinemia may have influences on the mortality rate of critically-ill patients hospitalized in the ICU.   Keywords: liver dysfunction, hyperbilirubinemia, death
Correlation between Thrombopoietin Serum Level and Liver Fibrosis in Chronic Hepatitis Patients Juwita Sembiring
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010135-142

Abstract

Background: Thrombopoetin (TPO) is a cytokine mainly produced in the liver and is the principal regulator in the humoral control mechanism of thrombopoesis. Presumably TPO production is not adequate in patients suffering from severe necroinflammation and advanced liver fibrosis in chronic hepatitis. The aim of this study was to identify the correlation between serum TPO levels and the degree of liver fibrosis. Method: With analytical cross-sectional design, this sudy analyzed the relationship between the serum TPO level and the degree of liver fibrosis in 62 chronic hepatitis patients from June 2006 to March 2008. The serum level of TPO was examined using the Quantikine human TPO immunoassay, and liver biopsy was performed in accordance to the Metavir scoring system. Results: There were 22 female and 33 male, with age range from 18 to 70 years old. We found that serum TPO levels were negatively correlated with the degree of liver fibrosis in a very significant fashion (r = -0.284, p 0.05). At serum TPO level 16.01 pg/mL or lower, the sensitivity and specificity of serum TPO for diagnosing the severity of the fibrosis were the 64.1% and 70.3% respectively, when the disease process was at F3 or greater level (p = 0.003). There was a significant difference between the degree of liver fibrosis and platelet count (p 0.0001), and significant negative correlation between the degrees of fibrosis with platelet level (r = - 0.783; p = 0.001). Conclusion: There was a significant negative correlation between serum TPO levels and the degree of liver fibrosis in chronic hepatitis patients and significant negative correlation between the degree of liver fibrosis and platelet count.   Keywords: chronic hepatitis, liver fibrosis, thrombopoietin
Endoscopic Sclerotherapy and Band Ligation in Secondary Prophylaxis of Esophageal Variceal Treatment Catharina Triwikatmani; Putut Bayupurnama; Sutanto Maduseno; Neneng Ratnasari; Fahmi Indrarti; Siti Nurdjanah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010121-124

Abstract

Background: Variceal bleeding is the most severe outcome of portal hypertension. Endoscopic sclerotherapy and band ligation are endoscopic treatment modalities for both active variceal bleeding and secondary prophylaxis. Endoscopic sclerotherapy has been carried out in Sardjito hospital since 1998, while band ligation has only been carried out since 2007 year. The aim of this study was to evaluate the long-term Result of endoscopic sclerotherapy and endoscopic band ligation in secondary prophylaxis of esophageal variceal eradication. Method: This is not a prospective study and is not randomized. The Results of patients who underwent endoscopic sclerotherapy and endoscopic band ligation from July 2003 to June 2009 were compared. Patients were evaluated for re-bleeding and recurrence rates. Results: Two hundred and seventy seven patients underwent endoscopic sclerotherapy and endoscopic band ligation during the period. One hundred and nine patients with varices eradication data; 49 patients who underwent sclerotherapy and 60 patients who underwent band ligation were followed for 1-119 (15.54 ± 20.70) months. The numbers of sessions for eradication were 4.33 ± 1.16 and 2.23 ± 0.59 for endoscopic sclerotherapy and endoscopic band ligation respectively (p 0.001). Re-bleeding and recurrence rates were 38.64% and 84.21% for endoscopic sclerotherapy, and 25.93% and 70% for endoscopic band ligation (p 0.05). Conclusion: Endoscopic band ligation is more effective than sclerotherapy in the eradication of esophageal varices.   Keywords: esophageal varices, sclerotherapy, band ligation, secondary prophylaxis
Mucus as One of the Defensive Factors in the Stomach Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010107-107

Abstract

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HBeAg and Anti HBe Status in Patients with Chronic Hepatitis B Infection Haris Widita; Stephanus Gunawan; Baskoro Tri Laksono; Wenny Astuti Achwan; I Gusti Putu Wilusanta; Ketut Mahendra; Herman S Taufiq; Soewignjo Soemohardjo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010125-127

Abstract

Background: Data on HBeAg and anti HBe status in patients with chronic hepatitis B infection are not yet available in Indonesia. This study was done to acquire data on HBeAg and anti HBe status in patients with hepatitis B chronic infection. Method: The material of this study was sera, collected from 105 patients with chronic hepatitis B infection from June to November 2007, divided into four groups of hepatoma, liver cirrhosis, chronic hepatitis B and asymptomatic HBsAg carriers. All sera were examined for HBsAg, HbeAg, anti HBe aside from liver function examinations. The sera consisted of 23 sera of patients with hepatoma, 27 with liver cirrhosis, 12 with chronic hepatitis B, and 43 with HBsAg asymptomatic carriers. Results: From 105 samples, only 18.1% samples were in replicative phase, as shown with the positivity of HBeAg and the negativity of anti-HBe. Sera with negative HbeAg and positive anti-HBe were mainly found in liver cirrhosis (70.73%) and least in chronic hepatitis B (50.00%) Conclusion: The high frequency of HBeAg negative and anti-HBe positive in this study might indicate the possible high frequency of pre core mutation. A study using quantitative HBV DNA should be done to confirm it.   Keywords: HBeAg, anti HBe, chronic hepatitis B

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