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Nailis Syifa
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INDONESIA
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 182 Documents
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Synergistic Formulation and Activity of Earthworm-Aloe Gel for Bruise Healing : An In Vivo Study in a Murine Model Mercya, Yovita; Oktavia Lauda; Ana Ratnasih; Whisnu Trie Seno Ajie
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44551

Abstract

Bruise is a common soft tissue injury characterized by prolonged inflammation and fibrin deposition. Topical heparin sodium demonstrates limited efficacy and potential side effects, warranting exploration of natural alternatives. This study formulated and evaluated a combination gel of earthworm powder (Lumbricus rubellus) and Aloe vera for topical bruise treatment. An experimental post-test only control group design was employed. Phase I involved formulation and physical evaluation of earthworm powder 5% (GEL-E), Aloe vera 100% (GEL-A), and combination gel (GEL-C). Phase II assessed in vivo efficacy using 25 male BALB/c mice (Mus musculus), aged 8–12 weeks (n=5/group), with cupping-induced bruise (1.5 cm, 60 kPa, 10 minutes). Bruise area was measured using WoundGenius® (H0–H12). Kruskal-Wallis and Mann-Whitney U tests were applied (α=0.05). All formulations met pharmaceutical specifications (CV <10%). GEL-C achieved the fastest healing (7.2 ± 1.10 days) versus GEL-E (7.6 days), GEL-A (8.8 days), heparin (8.6 days), and negative control (10.0 days), with significant differences at H3–H5 (p=0.008–0.043). GEL-C reduced healing time by 28% versus negative control and 16% versus heparin. The combination gel demonstrated a pharmacologically complementary effect and represents a promising topical alternative; however, clinical translation requires further pharmacokinetic evaluation and controlled human studies.
Adulterated Meat Processed Products Detection using Combination of FTIR and Chemometrics Agustin Rafikasari; Any Guntarti; Anton Yudhana
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia has the world's largest Muslim population in 2025 and high demand for halal food products, including sausage. Differences in meat prices increase the risk of adulteration, which is wild boar or pork can adulterate beef or chicken. The adulteration can be detected using FTIR combined with chemometrics. The aim of this study was to investigate the adulteration in sausages by analyzed the fingerprint FTIR spectra combining with chemometrics. This study conducted by physicochemical analysis and scanning the extracted fat at the mid-infrared region using FTIR to collect spectral data. Qualitative and quantitative analyses were performed on the fingerprint region using chemometrics of Partial Least Square (PLS) and Principal Component Analysis (PCA), respectively to provide best modeling. The PLS calibration model for the relationship between actual values and predicted value of three binary mixed meats obtained from 1399 – 1321 cm-1, 1770 – 1681 cm-1, 780 – 650 cm-1. The calibration models demonstrated strong linearity, with R² values ranging from 0.9367 to 0.9884. The chicken–beef model exhibited the lowest RMSEC (5.85), indicating superior predictive accuracy. Although the chicken–pork model showed the highest R² (0.9884), its higher RMSEC (7.32) suggests reduced prediction precision. The chicken–wild boar model displayed the lowest R² and highest RMSEC, indicating greater model uncertainty, likely due to increased spectral similarity and matrix complexity. Fifteen marketed products analyzed. PCA of FTIR data demonstrated clear discrimination between halal-labeled and pork-containing sausages based on lipid profile differences, highlighting its potential as a rapid screening tool for halal authentication.  

Page 19 of 19 | Total Record : 182

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