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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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Formulation And Physical Properties Evaluation Of Beach Morning Glory (Ipomoea Pescaprae) Leaves Ointment Meddo Lorenza Garnida; Delladari Mayefis; Habibie Deswilyaz; Mega Sari, Diani; Arie Vonikartika
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 1 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i1.30572

Abstract

Background: Sea kangkung is one of the plants used as traditional medicine which is widely used as a topical medicine, one of which is to treat jellyfish stings and ulcers. This study aims to determine how to formulate ointment preparations from sea kangkung extract and to test the physical properties of sea kangkung preparations. Methods: Sea kangkung leaves were extracted using the maceration method using methanol as a solvent and then made preparations in the form of an ointment using concentration variations, namely (F1) - , (F2) 1 % , (F3), 3 % (F4), 5 % (F5) 10 %. Furthermore, the physical stability test of the ointment was carried out, namely the Cycling Test including organoleptic test, homogeneity test, pH test and spreadability. Results: The results obtained that sea kangkung extract ointment has a fairly good stability based on the stability test of the third formula, which is the most stable preparation.
Antibacterial effectiveness of belimbing wuluh leaf extract (Averrhoa bilimbi L.) and meniran herb (Phyllanthus niruri L.) against Staphylococcus epidermidis Ariaditya Wibowo; Agnes Yuliana; Dwi Puspita Sari
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33127

Abstract

Acne is an inflammatory condition of the skin which is commonly called polysebaceous which is caused by the Staphylococcus epidermidis bacteria. Meniran herbs and starfruit leaves contain compounds that are used as antibacterials, namely tannins, flavonoids and saponins. The purpose of this study was to determine the effectiveness of the antibacterial combination of star fruit wuluh leaf extract (Averrhoa bilimbi L.) and meniran herb (Phyllanthus niruri L.) as an antibacterial in inhibiting the growth of the Staphylococcus epidermidis bacteria that causes acne. The research was an experimental study by conducting an antibacterial effectiveness test against Staphylococcus epidermidis bacteria. The results of this research are that the combination of meniran herb extract and starfruit can inhibit the growth of Staphylococcus bacteria. A 1:3 combination of starfruit leaf extract (Averrhoa bilimbi L.) and meniran herb (Phyllanthus niruri L.) is effective in inhibiting the growth of Staphylococcus epidermidis bacteria 8.568 mm (Medium).
Analysis Descriptive of Anosmia and Dysgeusia in SARS CoV-2 Patients: Overview of Epidemiology, Pathogenesis, Prognosis, and Treatment Options Muhammad, Izbikavik; Prasetyo, Yohannes Eddy; Nur, Rifqi Misbahuddin
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 1 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i1.33644

Abstract

Introduction: SARS CoV-2 (COVID-19) is a respiratory infectious disease whose cause has been identified as the seventh type of the coronavirus family that attacks humans. Common symptoms among patients with COVID-19 include fever, dry cough, shortness of breath (dyspnea), muscle aches (myalgia), confusion, headache, sore throat, rhinorrhea, chest pain, diarrhea, nausea / vomiting, conjunctival congestion, nose. congestion, sputum production, fatigue (malaise), hemoptysis, and shivering. However, the spread of COVID-19 infection has shown new symptoms of the disease: patients with dysfunction of smell, taste and indigestion. Methods: Literature review by taking libraries from 34 journals and 2 textbook. The journal obtained from the Google, NCBI and Pubmed search engine, as well as processing research materials into new information related to the research objectives. Results: One hypothesis currently developing is that SARS-CoV-2 will cause olfactory changes through direct access and damage to the CNS through its penetration by the cribriform plate. Another hypothesis that is also developing suggests direct viral damage to olfactory cells and taste receptors. Glial cells, neurons, and the oral cavity present the ACE-2 receptor which appears to be a mechanism of cell invasion by viruses. Conclusion: People who have lost their smell or taste are six times more likely to become positive for COVID-19. Likewise, people who have anosmia have a 10-fold higher chance of being diagnosed with COVID-19. Taste and smell disorders with ageusia have a 10 times higher chance of catching COVID-19.
A Comprehensive Review of the Current Understanding and Future Directions in Biofilms and Antibiotic Resistance in Chronic Rhinosinusitis Indra Setiawan; Miftha Churochman
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 1 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i1.33659

Abstract

This paper aims to analyze and evaluate the impact of social media on society. The study examines about Chronic Rhinosinusitis (CRS) that is the multifactorial inflammatory disease of the nasal and paranasal mucosae for more than 12 weeks. Chronic Rhinosinusitis (CRS) is a highly widespread condition that has a significant impact on a large population around the globe. There has been a notable increase in the focus on the significance of biofilms and antibiotic resistance in the pathophysiology of chronic rhinosinusitis (CRS). The objective of this review is to consolidate existing scholarly literature on the aforementioned subjects, drawing from a selection of five prominent peer-reviewed works, while also suggesting potential avenues for further research. The objective of this study is to consolidate existing information regarding the involvement of biofilms and antibiotic resistance in the etiology and treatment of Chronic Rhinosinusitis (CRS), and to suggest potential avenues for future research. The study utilized a qualitative research methodology, integrating data from five primary scholarly papers that centered on topics such as chronic rhinosinusitis (CRS), biofilms, antibiotic resistance, and therapeutic approaches. The process involved the extraction and analysis of data in order to discover prevalent themes, inconsistencies, and areas of research that have not been adequately addressed in the current body of literature. In conclusion, it can be inferred that the given information supports the notion that biofilms have been found to have a substantial impact on the pathophysiology of chronic rhinosinusitis (CRS), leading to increased disease severity and posing difficulties in its management. Gaining comprehension of the underlying mechanisms involved in the process of biofilm formation and the development of antibiotic resistance might provide valuable diagnostic and therapeutic perspectives. Subsequent investigations ought to prioritize the advancement of therapeutic interventions targeting biofilm formation and the acquisition of a more comprehensive comprehension of the microbiome in chronic rhinosinusitis (CRS).
Determination of Phenolic Total, Flavonoid Total, Antioxidant Assay and Inhibition of Xanthine Oxidase Enzyme Activity Kemloko Fruits Extract (Phyllanthus Embilica. L) Wirasti Wirasti; Khusna Santika Rahmasari; Isyti'aroh
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33737

Abstract

People use Kemloko Fruits as sweets and some also use it as a herbal medicine to reduce uric acid. The sour-tasting Kemloko fruit contains a lot of ascorbic acid. Ascorbic acid and ingredients contained in it have the effect of preventing or reducing uric acid levels. The aim of this research was to treat the antioxidant effect and inhibitory of the xanthine oxidase enzyme Kemloko Fruit extract, as well as determine the phenolic total and flavonoid total levels. The method used to make Kemloko fruit extract uses maceration with ethanol 96% solvent. The phytochemical screening method uses an in-tube reaction for flavonoid content using the Shinoda test, alkaloids using the Dregendorf reagent, saponins using the foam test and terpenoids/steroids using the Liebermann Burchard reagent. Meanwhile, the methods for determining phenolics and flavonoids total are the colorimetric used spectrophotometry UV-Vis, the DPPH methods for antioxidant assay, and measurenment of inhibiting xanthin oxidase activity using a microplate at a wavelength of 375 nm. Qualitative data produced by the ethanol extract of Kemloko fruit contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides. Meanwhile, Quantitative data showed that the phenolic and flavonoid total levels were 1465.63±0.003 mgGAE/g extract and 9.52±0.001 µg/mL, respectively, as well as the IC50 for xanthin oxidase enzyme inhibition of 20.65 µg/mL and the IC50 antioxidant power of 9.49 ±0.0007 µg/mL. Kemloko fruit ethanol extract contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides has inhibitor activity against xanthine oxidase and antioxidant is a strong.
Formulation And Evaluation Sunflower Seed Oil With Sappan Wood Extract (Caesalpinia Sappan) Lip Balm Anugerah Suciati; Diah Ayu Mutmaina; Nurul Marfu’ah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33765

Abstract

Lip balm preparations can be used to prevent and treat chapped lips due to UV exposure and synthetic ingredients. Natural ingredients such as sappan wood extract and sunflower seed oil can be used to reduce the use of synthetic ingredients. The brazilin compound in sappan wood has anti-free radical, antibacterial, and anti-inflammatory abilities. While chlorogenic type polyphenol compounds in sunflower seeds have potential as antioxidants. The purpose of this study was to make a lip balm preparation of a combination of sunflower seed oil with sappan wood extract. This research is an experimental research by extracting sappan wood using the socletation method and 70% ethanol solvent. Lip balm preparations were made from a combination of sunflower seed oil: secang wood extract in the ratio of 5%:1,25% (F1), 10%:2.5% (F2) and 15%:3,75% (F3). Evaluation of the preparation includes organoleptic test, homogeneity, pH, spreadability, adhesiveness, melting point, and moisture capacity. While the results of the stability test were analyzed using the paired t-test parametric test with SPSS 24.0 and a significance level of 95%. The results showed that the characteristics of the lip balm preparation of a combination of sunflower seeds and sappan wood extract showed results in organoleptic testing, namely having a yellowish beige and yellow color. The aroma is typical of beeswax with an oily semi-solid texture. The lip balm preparation shows that all preparations are homogeneous, with pH test results of 4.90-6.12; leachability of the lip balm.
Physicochemical Characteristics and SPF Value of Kepok Banana Corm Extract Cream Andini; Mega Rilen; Viona Masakana; Ellyvina Dini
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33835

Abstract

Banana Corm is banana plant waste that has not been utilized optimally and contains flavonoids which have the potential as natural UV repellents. This study aims to determined the physical-chemical characteristics and preferences of respondents as well as the SPF value of kepok banana corm extract creams. Three cream formulations were carried out using concentration variants of 10% (F1), 20% (F2) and 30% (F3) with physical property tests including organoleptic tests, cream type tests, homogeneity tests, spreadability tests, centrifugation tests and SPF value. The test results show that the three formulations have different colors and aromas and are o/w cream types and have a homogeneous texture. All formulas meet the skin's pH range. In the test results there was a significant difference (p<0.05) in the order of highest spreading power in diameter F3 (5.725 ± 0.01 cm) × F2 (5.24 ± 0.2 cm) × F1 (5.24 ± 0.092 cm ), whereas for the centrifugation test results there was no phase separation in the supply. The results of respondents' preferences for cream showed that the overall cream preparation formula is acceptable and liked by respondents. Based on the research results, it can be concluded that the banana bongol extract cream meets the physical quality requirements based on predetermined parameters and the banana bongol extract cream can be accepted by respondents. Cream with variations in banana weevil concentration of 10%, 20% and 30%, obtained an SPF value in the maximum protection category
Organoleptic and Chemical Properties of SERANGI Herbal Drink: A Blend of Lemongrass (Cymbopogon nardus L.) and Holy Basil (Ocimum sanctum L.) as Immune Booster. Ambar Fidyasari; Ayu Ristamaya Yusuf; Nafila Nada Dzikri
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33968

Abstract

Herbal drinks have therapeutic and refreshing properties. Some plethora of botanicals are used as herbal drink ingredients, including simplicia from lemongrass (Cymbopogon nardus L.) and holy basil  (Ocinum sanctum L.). This research was performed to assess the organoleptic and chemical characteristics of lemongrass and holy basil simplicia herbal drink named Serangi.  The research underwent two phases: organoleptic testing in the first stage and chemical analysis in the second stage to evaluate pH, vitamin C levels, and total phenols in Serangi herbal drink. Three repetitions had been performed to gain data mean values and standard deviation before being analyzed using General Linear ANOVA model (GLM) on the Minitab 20 software. Results revealed panelists' preferences for F3 in terms of color, aroma, and taste, with ratings of 4.12, 4.02, and 4.05, respectively. All Serangi drink samples met the pH requirements, falling within the 3-8 range, where F3 exhibited the highest vitamin C content of 1.224% and total phenol content of 122.10 mg GAE/100g/ml. Serangi herbal drink is rich in vitamin C and secondary metabolites and it offers immune-boosting benefits.
Factors Abssociated With Occupational Irritant Contact Dermatitis In Cleaning Service Dwi Nurwulan Pravitasari; Raihan Fatihka Devi; Probo Yudha Pratama Putra
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 8 No. 2 (2023)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v8i2.34815

Abstract

Occupational contact dermatitis is one of the occupational diseases which often arises due to contact with materials in the work environment. Cleaning service (CS) is an example of a job exposed to daily irritants that can cause skin irritation. The study used an analytic observational method with a cross-sectional approach. The population of CS throughout the University of Muhammadiyah Malang is 42 people with simple random sampling. The research data used a questionnaire from the Health and Safety Executive UK (HSE UK). The analytical technique used is the Fisher Exact and Kruskal Wallis test (alternative chi-square) in the bivariate test and logistic regression in the multivariate test. Bivariate analysis showed there was no specific relationship between the length of work (p= 0.178), duration of exposure (p= 0.068), and length of exposure (p= 1,000) in CS employees at the University of Muhammadiyah Malang, while in multivariate analysis it was not influenced by the same effect, significance (sig wald duration of exposure 0.851 and length of work 0.070). The incidence of occupational contact dermatitis caused by irritants often occurs after exposure, so there is no conclusion on the length of work, duration of exposure, and length of exposure.
Knowledge level of mothers of toddlers diagnosed with acute respiratory infection at Dinoyo Community Health Center, Malang City Rusdiana, Husna; Atmadani, Rizka Novia
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 7 No. 2 (2022)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v7i2.29379

Abstract

Acute Respiratory Infection (ARI) is an attack by viruses and bacteria in the upper and lower respiratory tract. The cause of the increase in the number of ARI sufferers can also be influenced by the level of parents' own knowledge of information about ARI. This study aims to analyze the level of knowledge of mothers of toddlers diagnosed with ARI. This research uses quantitative research methods which are observational research using cross-sectional studies by giving questionnaires to respondents. The sample in this study were 65 mothers of toddlers who were diagnosed with ARI at the Dinoyo Community Health Center, Malang City. The results showed that the knowledge level was found to be 89.2% good, 10.85% adequate, and 0% poor. Based on the results of the chi-square test analysis, it shows that in this study, mother's age, domicile, employment, health insurance, family income, and age of toddlers have a significance value of more than 0.05 so that it can be said that they do not have a relationship with the level of knowledge of mothers of toddlers diagnosed with ARI. There is no relationship between sociodemographic factors and the level of knowledge of mothers of toddlers.

Page 16 of 17 | Total Record : 170

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