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Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 224 Documents
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Kemangi (Ocimum basilicum L.): Kandungan Kimia, Teknik Ekstraksi, dan Uji Aktivitas Antibakteri Adithya Guntur; Monica Selena; Anastasia Bella; Giovanny Leonarda; Adelsiana Leda; Dewi Setyaningsih; Florentinus Dika Octa Riswanto
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3376

Abstract

Resistensi terhadap beberapa antibiotik disebabkan oleh adanya penggunaan antibiotik yang rasional masih sering diabaikan. Kemangi (Ocimum basilicum L.) merupakan salah satu tanaman yang memiliki aktivitas antibakteri. Salah satu kandungan kemangi yang diduga memiliki aktivitas antibakteri yaitu minyak atsiri. Penelitian terkait aktivitas antibakteri pada kemangi sebagian besar dilakukan dengan menggunakan sampel segar maupun simplisia dari daun kemangi yang kemudian diekstraksi, namun ada beberapa uji yang menggunakan bagian batang. Metode uji aktivitas antibakteri kemangi terhadap beberapa bakteri gram positif dan gram negatif dilakukan dengan metode difusi cakram agar, difusi cakram kertas, mikrodilusi broth, mikrodilusi dalam microtiter plates, difusi sumuran agar, dan macro-dilusi. Hasil uji aktivitas antibakteri menunjukkan bahwa kandungan minyak atsiri yang terdapat dalam kemangi memiliki aktivitas penghambat aktivitas bakteri.
The Effectiveness of the Halal Certification Process among the Community in Brunei Darussalam Sulaiman, Nor Surilawana; Hashim, Norkhairiah; Mohd Salleh, Nur Thaqifah Salihah; Mohd Raffi, Raihana; Mahalle, Norliza
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3373

Abstract

Realiti prestasi keberkesanan pensijilan halal dalam kalangan industri makanan bukan hanya boleh dipengaruhi oleh faktor luaran semata-mata, akan tetapi antara faktor yang menyumbang kepada keberkesanan tersebut juga adalah faktor pengguna dan pihak kerajaan yang melaksanakan pengurusan dalaman organisasi secara efektif dan berwibawa. Jesteru kajian dilaksanakan bertujuan untuk mengetahui tentang keberkesanan proses pensijilan halal di Negara Brunei Darussalam khasnya dari perspektif masyarakat. Kajian ini hanya membatasi respondan dari kalangan pemohon sijil halal. Seramai 154 respondan telah terlibat memberikan maklum balas terhadap soal selidik yang diedarkan secara rawak di ke empat-empat daerah di Negara Brunei Darussalam. Kajian rintis telah dijalankan bertujuan untuk menguji kebolehpercayaan soal selidik yang digunakan bagi kajian ini. Hasil analisis nilai Alpha Cronbach bagi item soal selidik yang diedarkan adalah berada pada nilai .975 . Dapatan kajian ini telah menunjukkan bahawa persepsi masyarakat terhadap keberkesanan proses pensijilan halal di Negara Brunei Darussalam adalah sangat tinggi dan sangat positif. Nilai min pada setiap konstruk soal selidik juga menunjukkan dapatan kajian ini adalah antara julat 3.68 hingga 4.61 iaitu pada tahap yang sangat signifikan. Secara umumnya kajian ini telah mendapati bahawa persepsi masyarakat terhadap keberkesanan pensijilan halal adalah pada tahap yang tinggi dan sangat positif walau bagaimanapun bagi meningkatkan lagi keberkesanan proses pensijilan halal pemeriksaan dan penilaian proses kerja secara dalaman perlulah dilaksanakan oleh pihak-pihak yang pengurusan, jesteru itu kajian ini mencadangkan langkah mengekalkan prestasi keberkesanan pemprosesan sijil halal adalah agar pihak-pihak yang berautoriti dalam pemprosesan sijil halal bertindak melaksanakan satu sistem audit dalaman tentang prosedur kerja bagi proses pensijilan halal di Negara Brunei Darussalam.
Fitokimia Dan Farmakologi Tanaman Empon-Empon Sebagai Imunomodulator Pada Penyakit Saluran Pernapasan: Systematic Review Ikbar Maulana Zuhri; Lailatul Mas'udah; Annisa’ Isyfi Faizati; Roihatul Muti'ah
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3378

Abstract

Sebagai upaya preventif terhadap Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV 2) maka sangat penting bagi masyarakat untuk meningkatkan imunitas tubuh secara mandiri. Berbagai tanaman asli Indonesia telah direkomendasikan oleh BPOM sebagai tanaman obat untuk peningkatan imunitas tubuh di masa pandemi, diantaranya adalah empon-empon. Tujuan systematic review ini adalah untuk membuat kesimpulan ilmiah dari empon-empon sebagai imunomodulator pada penyakit saluran pernapasan. Metode systematic review ini menggunakan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), dengan kriteria inklusi original artikel, artikel berbahasa Inggris dan bahasa Indosesia, artikel tahun 2011-2021. Sedangkan kriteria ekslusinya adalah artikel selain original artikel, artikel selain berbahasa inggris dan bahasa Indonesia, artikel selain rentang tahun 2011-2021. Pencarian dilakukan pada database Google Schoolar, Proquest, PubMed NCBI, Science Direct, dan Spriger dengan kata kunci yaitu zingiberaceae and immunomodulator and respiratory disease. Hasil searching database tersebut didapatkan 3553 artikel kemudian dilakukan skrining didapatkan 29 artikel yang memenuhi kriteria inklusi. Kesimpulan dari systematic review ini adalah Curcuma longa, Zingiber officinale Roscoe, Kaempferia galanga Linn, Curcuma mangga, Zingiber zerumbet, dan Alpinia galanga terbukti meningkatkan sistem imun dengan aktivitas imunomodulator, antiinflamasi, dan antivirus. Senyawa yang berperan sebagai imunomodulator tersebut adalah flavonoid atau fenilpropanoid.
Potensi Senyawa Nitazoxanide dan Arbidol sebagai Antivirus SARS-CoV-2 terhadap Reseptor NSP5 (7BQY dan 2GZ7) dan ACE2 (3D0G dan 1R4L) Ami Fini Faqiha; Yen Yen Ari Indrawijaya; Arief Suryadinata; Muhammad Amiruddin; Roihatul Mutiah
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3393

Abstract

Nitazoxanide merupakan obat pro-drug untuk tizoxanide. Obat tersebut diketahui memiliki aktivitas antivirus pada MERS-CoV. Arbidol memiliki aktivitas antivirus pada H3N2 HA yang memiliki kesamaan struktur dengan SARS-CoV-2. Reseptor target spesifik untuk obat-obat Anti SARS-CoV-2 saat ini adalah NSP5 (Nonstructural protein) dan ACE2 (Angiotensin-converting enzyme 2). NSP5 memediasi replikasi dan transkripsi protein-protein virus sedangkan ACE2 sebagai fasilitator transport asam amino dan reseptor tempat terikatnya SARS-CoV maupun SARS-CoV-2. Tujuan penelitian ini adalah untuk mengetahui aktivitas antivirus SARS-CoV-2 dari senyawa Nitazoxanide dan Arbidol secara in silico. Senyawa Nitazoxanide dan Arbidol dipreparasi terlebih dahulu dengan melakukan pengunduhan kode PDB ID, penyiapan struktur 2D dan 3D, penentuan minimal energy, pembuatan kode SMILES serta prediksi sifat fisikokimia dan toksisitas. Setelah dipreparasi, dilanjutkan proses penambatan molekul menggunakan aplikasi PyRx-Vina®. Hasil docking dianalisis dengan perangkat lunak PyMOL® dan Discovery Studio Visualizer®. Hasil profil fisikokimia menunjukkan bahwa senyawa Arbidol dan Nitazoxanide telah memenuhi hukum Lima Lipinski dan masing-masing memiliki nilai LD50 sebesar 1350 mg/kg dan 340 mg/kg. Hasil penambatan senyawa uji dengan reseptor menghasilkan interaksi yaitu ikatan hidrogen, interaksi hidrofobik dan interaksi elektrostatik. Interaksi Nitazoxanide pada reseptor 2GZ7 serta Arbidol pada reseptor 3D0G dan 1R4L menunjukkan perbedaan yang signifikan masing-masing terhadap Lopinavir dan Chloroquine dengan nilai p < 0.05, sehingga senyawa tersebut diprediksi memiliki potensi antivirus lebih baik.
The Study on Utilization of Grasshoppers Gelatine as Edible Film in Optimizing Environmentally Friendly Packaging Siwi Qoirinisa; Astri Arnamalia; Mutiara Eka Permata; Risma Nurohmah Ramdani
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3402

Abstract

The use of plastic packaging as food wrappers cannot be separated from everyday life. This will certainly cause many environmental problems because of the nature of plastics that are difficult to degrade naturally. One alternative to overcome the use of plastic in food products is edible film. The edible film is a thin layer that is used as a coating for food that can be consumed and is environmentally friendly. The edible film can be made from gelatin as raw material. Gelatin has properties that can form gels, foam emulsifiers, and can maintain the elasticity of a material. In the food industry, gelatin is widely used as a stabilizer, adhesive, binder, gelling agent, thickener, foamer, and viscosity enhancer. In Indonesia, the need for gelatin is met by importing from gelatin-producing countries, so the price becomes very expensive. According to international trade statistics, in 2016 Indonesia imported 54 tons of gelatin from America. Nearly 90% of American gelatin is derived from pork. This raises public concerns about the safety and halalness of their products. Grasshoppers have a fairly high protein content, which is about 24%. The method used in this study is the manufacture of edible films using grasshopper gelatin extracted by the acid method using HCl with varying concentrations of HCl levels of 2, 4, and 6% and soaking time of 1, 2, 3, and 4 hours. The potential of grasshoppers to be used as gelatin is considered suitable with Indonesia's natural resources in the manufacture of edible films as an effort to optimize environmentally friendly packaging.
In Silico Studies on The Potential of Green Tea Catechin Compounds (Camellia sinensis) as Antiviral of SARS CoV-2 Againts Spike Glycoprotein (6LZG) and Main Protease (5R7Y) Futna Naufa; Roihatul Mutiah; Yen Yen Ari Indrawijaya
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3580

Abstract

COVID-19 is a disease caused by SARS CoV-2 by producing structural proteins and non-structural proteins. SARS CoV-2 uses a spike glycoprotein to bind ACE-2 receptors in host cells and uses main protease to replicate. This research aims to screen green tea catechin derivates as an antiviral for SARS CoV-2 through inhibition of spike glycoprotein (6LZG) and main protease (5R7Y). In silico studies carried out are molecular docking, prediction of physicochemical properties, and prediction of toxicity. The potential inhibition was assessed based on binding affinity and interaction of amino acid residues. From the molecular docking process showed that epicatechin and epigallocatechin provide inhibition to spike glycoprotein better than nafamostat indicated by binding affinity of -5.2 kcal/mol and -4.5 kcal/mol, while epigallocatechin gallate and epicatechin gallate provide inhibiton to main protease better than lopinavir with binding affinity of -8.7 kcal/mol and -8.3 kcal/mol. The results of the physicochemical properties prediction showed that only epigallocatechin gallate that did not fulfill five Lipinski's rule. Based on the toxicity class LD50, the derivates of catechin belong to classes 4 and 6. In conclusion, it can be known that epicatechin and epigallocatechin can be developed as an antiviral for SARS CoV-2.
Analysis of Heavy Metals in Shellfish in Tanjung Balai Waters Reny Yuliana Siahaan; Jansen Silalahi; Zulkifli Lubis
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3734

Abstract

Abstract: Shellfish is a source of toxic heavy metals and the maximum levels of heavy metals allowed in shellfish by BPOM RI are Lead 1.5 mg/kg, Cadmium 1 mg/kg and Copper 20 mg/kg. Heavy metal content in shellfish is influenced by environmental pollution in which the shellfish live. The purpose of this study was to determine the levels of heavy metals in three types of shellfish in Tanjung Balai Asahan waters. Shellfish samples were taken from 3 different locations in Tanjung Balai in July 2021. Determination of the levels of heavy metals Pb, Cd and Cu in green mussels, mussels and blood clams was carried out using the AAS method with atomic absorption spectrophotometer. The results showed the levels of lead (Pb), cadmium (Cd) and copper (Cu) in Green mussels in Tanjung Balai, namely: Pb of 0.273 mg/kg – 0.406 mg/kg, Cd of 0.089 mg/kg – 0.106 mg/kg mg /kg, Cu is 1,864 mg/kg – 2,011 mg/kg. In oyster shells Pb was 0.051 – 0.095 mg/kg, Cd was 0.077 – 0.091 mg/kg, and Cu was 1.024 mg/kg – 1.064 mg/kg. It was concluded that green mussels had the highest heavy metal content. The levels of heavy metals in the analyzed shellfish samples were still below the maximum levels permitted by BPOM RI. Keywords: Lead, Cadmium, Copper,Atomic Absorption Spectrophotometry, Shells
The Role of Curcumin and Its Derivatives in Innate Immune Response of Macrophages Retno Murwanti; Anami Riastri; Andayana Puspitasari Gani
Journal of Food and Pharmaceutical Sciences Vol 10, No 1 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3942

Abstract

Curcumin, a diarylheptanoid, is the active compound isolated from the rhizomes of Curcuma species. Curcumin can modulate mechanisms in inflammatory-related immunomodulatory. The two methoxy groups in aromatic rings in the structure of curcumin play a role in the anti-inflammatory. Macrophages are crucial cellular components of innate immunity. For this reason, this review aims to assess the role of curcumin and its derivatives in the innate immune response of macrophage cells. Curcumin as anti-inflammatory releases inflammation mediators such as cytokines, nitric oxide, reactive oxygen species, and others. Curcumin regulates innate immune via NLRP3 inflammasomes, nuclear factor-kappa B, mitogen-activated protein kinase, and Janus kinase1/2‐signal transducer and activator of transcription protein1 signaling pathway. However, curcumin has limited clinical application, especially solubility and bioavailability. Therefore, a structure and formula modification of curcumin was developed. This review also discusses no evidence of curcumin's mutagenicity, genotoxicity, and toxicity. Thus, the brief information provided in this review investigates the role of curcumin in macrophage cells.
Physicochemical Characterization Patin Fish Oil (Pangasius micronema) Is Refined Using Bentonite and Activated Carbon. Indah Indah; Abdul Rohman; Lily Arsanti Lestari
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4682

Abstract

Abstract: This study aims to determine the physical and chemical quality of fish oil from the flesh of Pangasius microcinema. The quality of extracted fish oil can be improved through a refining process. Before and after the purification process, the quality of crude fish oil was analyzed, including acid value (AV), saponification value (SV), iodine value (IV), peroxide value (PV), and p-anisidine value (An-V). The results of the characterization of patin fish oil (PFO) in meat were carried out with 3 purifications, namely purification without activated carbon purification treatment with bentonite, the value of susceptibility to acid value, peroxide value, saponification value, iodine value, and p-anisidinee value, which ranged from 1.92-2.64 mg KOH/g, peroxide value 3.76-4.87 meq O2/kg, iodine value 80.46-81.39 g I2/100g, saponification value 189.48-196.75 mg KOH/g, and p-anisidinee value 5.95-8.93 meq/kg. The best refining process is the oil extracted from patin fish oil meat oil and distilled using bentonite from dry rendering because the processed fish oil is good in the standards set by the International Association of Fish Flour Producers, Indonesian Fish Oil Standards, and as food fish oil grades.
Review on Ethnomedicinal and Potential Effect of Antibacterial Plants against Halitosis Kintoko Kintoko; Astri Desmayanti
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4748

Abstract

Halitosis is an oral malodor condition in the oral cavity that comes from the breakdown of protein by anaerobic gram-negative and gram-positive bacteria. Some bacteria that are often found in cases of halitosis are Solobacterium moorei, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedia, Treponema denticola, dan Streptococcus mutans. Medicinal plants to treat various diseases have shown minimal side effects. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. As many as 7,000 species of medicinal plants in Indonesia have been studied to address health problems. Among the medicinal plants that have been studied are Green Betel (Piper betle L.), Cinnamon (Cinnamomum zeylanicum), Star Anise (Illicium verum), Mint (Mentha piperita) dan Oregano (Origanum vulgare) which have been shown to cure various diseases. This review article describes the potential of plants as an antibacterial against halitosis. The purpose of this review is to provide an overview of ethnomedicine and the potential effects of antibacterial medicinal plants that can be used in cases of halitosis.

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