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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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The Alteration of SNAIL2 and MMP-9 Protein Expression of JEG-3 Choriocarcinoma Cell by Methanolic Extract of Tamarindus Indica Fruit Candra Rini Hasanah Putri; Sutiman Bambang Sumitro; Setyawati Soeharto; Karyono MIntaroem
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Tamarindus indica is one of the famous natural plant that has various effects on health. Recent research has begun to examine the effect of Tamarindus indica on cell malignancy. One of the things that happens in cell malignancy is an increasing ability of cell migration, which is characterized by increasing expression of Snail2 and MMP-9. This study was conducted to determine the effect of extract of Tamarindus indica Fruit Extract (TIFE) towards Snail2 and MMP-9 expression in JEG-3 cells.Methods :.TIFE were extracted by using methanol. JEG-3 cells were grown in culture medium treated with TIFE (at 0, 25, 50 and 100 µg/ml). Immunofluorescence staining was carried out, and observed under Confocal Laser Scanning Microscope.Result: Snail2 expression after treatment with TIFE 50 and 100 µg/ml higher than control- (P=0.015 ; P=0.001) whereas at MMP-9 expression there was a biphasic pattern, in which the MMP-9 expression peaked at concentration of 50 µg/ml (P=0.002), then MMP-9 expression decreased at 100 µg/ml concentration. Conclusion : The expression of Snail2 influence MMP-2 expression after treat with TIFE, so it might increase the potential for JEG-3 cell migration Keywords : Methanolic extract, Tamarindus indica, Snail2, MMP-9
Molecular Modeling of Anti-Alopecia Compounds Found in Sauropus Androgynus Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

People in the village of Mak Kemas, Malaysia use the katuk leaves (Sauropus androgynus) to prevent anti-alopecia. It was thought that katuk leaves have secondary metabolites which could accelerate the growth of new hair. The objective of this study was to determine the molecular modeling of compounds contained in katuk leaves (Sauropus androgynous) providing docking and ADMET information in silico as anti-alopecia drugs. In this study, receptors were used (PDB code: 4K7A) derived from protein data banks (http://www.rscb.org/pdb) and visualized with Discovery Studio and tested 10 compounds that had the potential as ligands to prevent baldness. Molecular modeling of bioactive compounds was carried out by molecular docking computation using AutodockTools 1.5.6 and Pre-Admet to determine absorption, distribution, and toxicity. The results were an amino acid residue that showed the place-bound to the receptor, inhibitory constant (Ki), and free energy bonds (∆ G). Of the 11 compounds studied, 3 were 5-Alpha-Dihydrotestosterone; Finasteride; and Pyrene interacts well so that it could prevent baldness. From the results of docking and pre-admet that had been done, it concluded that the compounds contained in katuk leaves could be used as candidates for anti-alopecia drugs.Keywords: Anti-alopecia, ADMET, In-silico, Katuk Leaf, Sauropus androgynus.
Molecular Identification and Phenotypic Detection of Some Virulence Factors among Aeromonas hydrophila Isolated from Diarrhea Cases (Iraq) Ilham A. Bunyan
Journal of Global Pharma Technology .
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Abstract

The present study included the detection of Aeromonas hydrophila in clinical samples were taken from patients suffering from diarrhea during the period from July (2017) to October (2017). A. hydrophila isolates which were diagnosed by four different methods (Culture media, biochemical tests, Api20E system and Polymerase chain reaction (PCR). Api20E kit was the important method for diagnosis of bacteria, which has led to isolate and, diagnosis of (35) isolates of A. hydrophila, but the PCR method of gene (16S rRNA) was more accurate method for diagnosis, which has led to isolate and diagnosis as (16) clinical isolates. The virulence factors of bacteria were detected, and showed that all isolates have ability to produce, heamolysin, protease, lipase, and capsule formation but have no ability to produce siderophores. In addition, A. hydrophila have the ability to adhere to uroepithelial cells of human and have strong biofilm formation.Keywords: Aeromonas hydrophila, 16S rRNA gene Capsule, Sidrophore, hemolysin, and Lipase.
Different Ferroxidases Activities in Sera and Saliva of Iraqi Patients with β-thalassemia Major Muhtada Ali
Journal of Global Pharma Technology .
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Abstract

Background and aim: β-thalassemia is the most common recessive hemoglobin disease, caused by defective in normal hemoglobin β-globin chain production. It results in large number of red blood cells being destroyed, which leads to anemia. We conducted this study to investigate the different ferroxidases activities in sera and saliva samples of these patients. Materials and methods: Serum and saliva specimens were collected from 91 males, 51 of them were β-thalassemia major patients, aged 11 to 26 years (mean= 15.28 ± 4.45 years) and 40 of them were age and gender-matched healthy controls. Results: The obtained results were as follows: in sera samples the activity and the specific activity of: total ferroxidase, and non-ceruloplasmin ferroxidase, were highly significantly decreased (P<0.001), with a significant increase in the activity and specific activity of ceruloplasmin ferroxidase (p<0.05) were found in the patients compared with the control. Meantime the results in saliva of the patients group, showed a none-significant increase (p>0.05) in the activity of non-ceruloplasmin ferroxidase and the specific activity of total ferroxidase in comparison with that of the control group, this was accompanied with none significant increase in ceruloplasmin activity and specific activity (p>0.05). Conclusion: According to our results, it can be suggested that the reduction in ferroxidase activities other than ceruloplasmin ones contributes in the oxidative stress that was measured previously in β-thalassemia patients. Furthermore, saliva cannot be served as an alternative diagnostic fluid for this disease instead of serum as far as the present study measured parameters are concerned.Key words: Ferroxidase, Thalassemia, Deferasirox, Ceruloplasmin.
In Vitro Evaluation of Antibacterial Activity from Nephelium lappaceum L. Leaf Ethanolic Extract and Fraction against Some Foodborne Pathogens Imam Adi Wicaksono; Raden Bayu Indradi; Danni Ramdhani; Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 11 (2020) Nov. 2020
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Abstract

Fooborne pathogens are causing foodborne illness with significant effects on human health. Some of the most common foodborne bacteria that cause foodborne illness are Bacillus cereus and Shigella dysenteriae. Nephelium lappaceum L. is known to have antibacterial potential because of these plants have secondary metabolites such as flavonoid and polyphenols. The ethanolic extract and fractions of Nephelium lappaceum L. was investigated for antibacterial activities including determine of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against foodborne pathogens. The extraction of N. lappaceum L. was done by maceration method with 70% ethanol and fractionationed by liquid-liquid extraction to obtain ethyl acetate, water, and n-hexane fractions. Secondary metabolite content and profile determination of N. lappaceum L. was done by phytochemical screening and thin layer chromatography. The antibacterial activities were determined using the agar diffusion method, MIC and MBC value determined by dilution method using the test tube. The results showed that the ethanolic extract, ethyl acetate fraction and water fraction of N. lappaceum L. had antibacterial activity against Bacillus cereus isolate and Shigella dysenteriae bacteria. The value of MIC and MBC of the extract in the concentration range between 0.08%(w/v) – 0.15%(w/v) against B. cereus isolate and 2.5%(w/v) – 5%(w/v) against S. dysenteriae, which the ethyl acetate fraction in concentration range between 0.04%(w/v) - 0.08%(w/v) against B. cereus isolate and 1.25%(w/v) – 2.50%(w/v) against S. dysenteriae bacteria. The ethyl acetate fraction is the most active fraction because it had the best activity, MIC and MBC values when compared to the results against both of test bacteria.
PASSAGE INFLUENCE ON THE AGING PROFILE AFTER SUCCESSIVE CRYOPRESERVATION OF BONE MARROW MESENCHYMAL STEM CELLS Ismail Hadisoebroto Dilogo; Starifulkani Arif; Jeanne Adiwinata Pawitan; Ria Anggraeni; Yogi Ismail Gani
Journal of Global Pharma Technology Volume. 9 Issue 6
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Abstract

Objective: Bone marrow mesenchymal stem cells are promising in cell therapy but the low frequency of this subpopulation necessitates their in vitro expansion and cryopreservation prior to clinical use. The aim of this study was to analyze the passage effect on the aging profile of previously successive cryopreserved bone marrow mesenchymal stem cells.  Methods: The samples of this in-vitro observational analytic study (April - September 2016) were iliac crest bone marrow mesenchymal stem cells that were cryopreserved in passage one and a second group was cryopreserved after being subcultured. It was obtained from UPT TK Sel Punca RSCM-FKUI. Samples were analyzed for each passage in terms of cell size, viability, population doubling time (PDT), and percentage of senescent cells by ANOVA test and independent t-test for the inter-cryopreservation group.Results: The remarkable manifestation of senescence appeared at passage six in both cryopreserved groups, but tend to appear earlier in the twice cryopreservation group. The senescent positive cell size became bigger along with the increasing number of passage. There were significant differences in PDT, 30% confluent cell size, viability, in passage six between the two cryopreservation groups (p<0.001, p<0.001, p=0.022), respectively, but no significant difference in percentage of senescent cells (p= 0.052). The cells became senescent in P6 in both groups (P=0.000).Conclusion: The onset of senescence of bone marrow mesenchymal stem cells was in passage six, while PDT, cell size and viability differ significantly due to successive cryopreservation.
Pulmonary Function Test among Asymptomatic Male's Smokers and Non-smokers: A Community Study in Denpasar City, Bali I Made Muliarta
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Smoking chronically affects lung function, The effect and severity changes differ between individuals. It is estimated that six million adults and ~100,000 adolescents died each year from tobacco-related health issues. Active smoking by healthy adults has been reported to cause declines in lung function. These differences between cigarette smokers and non-smokers are in direct proportion to the quantity of smoking. Study-related factor associated with pulmonary function in Indonesia, especially in Bali still limited. Aim: This study aims to examine the factor that may be associated with pulmonary function among smokers and non-smokers in Denpasar. All participants were males. Method: This is an analytical study using a case-control method conducted in Denpasar City represented by 592 male respondents. Data collection is done through interviews with structured questionnaires. Demographic data, occupation, residence, body mass index, smoking habit, spirometry examination were documented. Data were analyzed using SPSS IBM 25.0 with univariate and bivariate analysis. Results: Spirometry examination showed 0.2% respondent had obstructive lung disease, 8.3% had restrictive lung disease, and 0.3% combines. This study found the association between smoking status and impaired lung with p-value <0.0001 (3.334 (CI95% 1.898-7.204). Association between pack years above 1.9 also significant with p-value <0.05 4.020 (CI95% 2.638-8.558). Conclusion: A significant association was found between the status of smoking and lungfunction parameters. Pack years also affect towards lung function parameter, especially FEV1%. Keywords: Smoking status, Packyears, Spirometry, Pulmonary functions.
The Effect of a Variety of Anaerobic Exercises on the Ability and Anaerobic Capacity and Rapid Individual Attack of Young Players in Handball Reza Talib Hilail
Journal of Global Pharma Technology .
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Abstract

The importance of research lies in the preparation of a variety of anaerobic exercises and their impact on anaerobic ability and capacity that directly participate in the performance of the individual handball rapid attack of young players. The problem of research: focused on the lack of use of trainers for the various anaerobic exercises based on the overlap in energy production systems, there is a weakness in the use of anaerobic exercises.It is necessary to study the effect of the various anaerobic exercises on the basis of the proper scientific connection between science and science. And training in order to achieve the desired objectives of the training process.The objective of the research is to:Preparing a variety of anaerobic exercises in handball.To recognize the effect of the various anaerobic exercises on the anaerobic ability and capacity and individual quick attack of young players in handball.The research hypotheses included the following:The various anaerobic exercises have an impact on the anaerobic ability and capacity and individual quick attack of young players in handball.There is a preference for influencing the various anaerobic exercises in the anaerobic ability and capacity and individual rapid attack of young players in handball between the experimental and control groups in the posttest tests and for the benefit of the experimental group.As for the research methodology and field procedures:The researchers used the experimental method to solve the research problem. The research community was identified by 16 young Kufa youth handball players and they were divided into two groups (experimental and control) equally by random method (drawing method). After preparing the training curriculum the pilot group underwent training on the use of a variety of anaerobic exercises, while the control group used the usual training method for the trainer. After eight weeks, the tests were carried out. And then the data using appropriate statistical methods address.As for the most important conclusions and recommendations, the most important conclusions were the following:Various anaerobic exercises have helped to develop anaerobic capacity.The various anaerobic exercises have helped to develop anaerobic capacity.The development of anaerobic capacity and anaerobic capacity has been positively reflected on the development of individual rapid handball attack.Keywords: Anaerobic exercises, Ability, Anaerobic capacity, Rapid individual and handball.
Effectiveness of Drying Methods to Callisia Fragrans Tea Production Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Herbal tea is a polyherbal formulation of different medicinal plants that is a rich source of antioxidant. Tea manufacturing processes can greatly affect the oxidation of tea polyphenols. Callisia fragrans is an herbaceous plant with small white fragrant flowers and waxy leaves. Its leaves are used for treatment of different skin diseases, burns and join disorders owing to its biologically active flavonoids, neutral glycol and phospholipids and fatty-acid. In order to better utilization of Callisia fragrans was functional herbal tea, the effect of different drying methods such as sun drying, microwave drying and oven drying to the total phenolic, total flavonoid and antioxidant capacity was investigated. Results revealed that microwave drying was the best option to stabilize the valuable components in this plant during drying.Keywords: Callisia fragrans, Total phenolic, Total flavonoid, Antioxidant, Drying, Herbal.
Evaluation of Risk Factors affects Length of Hospitalization in Patients with Transient Ischemic Attack or Ischemic Stroke Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction: Cerebral artery diseases are the most prevalent neural disorder leading to serious diseases and death. Stroke is the third cause of death in the U.S. and is the most prevalent neurological disabling disease. This study aims to evaluate the influential factors of the duration of hospital stay in transient ischemic attack (TIA) or ischemic stroke   patients. Method of study This is re retrospective study. The population of study consists of all patients diagnosed as TIA or ischemic stroke who admitted in the neurology department of Urmia Imam Khomeini hospital from August, 2014 to August 2015. Data was collected from the cases’ records and analyzed using SPSS 22.\0 results A total number of 349 TIA and ischemic stroke cases was included in the study of whom, 322 (95.1%) and 17 (4.9%) cases were diagnosed and studied as ischemic stroke and TIA cases, respectively. In 258 cases (73.9%), the involved area was anterior circulation while in 91 cases (26.1%), it was posterior circulation. Considering relevant risk factors, hypertension with 212 cases (60.7%) was the most frequent risk factor followed by past medical history of stroke in 115 cases (33%), congestive heart failure in 113 cases (32.4%), diabetes mellitus in 86 cases (24.4%) and smoking in 72 cases (20.6%), respectively. Conclusion: According to our results, AF rhythm and anterior circulation involvement apparently affects the duration of hospital stay and increases it. This agrees with medicinal literature where AF has been introduced as a risk factor for cerebral embolic diseases and can be considered as a cause of TIA or ischemic stroke.  Keywords: Duration of hospital stay, Ischemic brain stroke, TIA.

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