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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Some Natural Plant Extracts can be used as Leishmania Stains Nidaa Mohammed Sulaiman
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Visceral leishmaniasi is a chronic disease caused by Leishmania donovani. Staining method is an effective way for identification of parasites by using synthetic or natural dyes. In this study Morus nigra, Punica granatum and Quercus infectoria extracts were used as natural dyes to investigate their staining activity to stain L. donovani promastigote in comparison with geimsa stain. Results: the three extracts showed a good staining ability, M.nigra was the best followed by P. granatum and Q. infectoria. Conclusion: according to the results, dying with natural dyes is cheap, safe and could be alternative for synthetic dyes.                                   Keywords: Natural dyes, Synthetic dyes, L. donovani, Extrac.
Salivary Alpha Amylase Enzyme and Calcium Changes with the Age and Their Effect on Dental Caries Haider A Naji
Journal of Global Pharma Technology .
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Abstract

Introduction: Saliva is a clear, slightly acidic oral secretion, mainly produced by the major and minor salivary glands. Saliva plays an important role in the oral health and the levels of its constituents alter with age [1]. The study comprise α-amylase enzyme and Ca in saliva , and follow the changes occured in their levels according to age changes, and explain the effect of these changes on dental and periodontal tissue health. Materials &Methods: Ninety samples of saliva were collected from different age groups, which are divided into three study groups; group I (20-35 years), group II ( 36-50 years) and group III (51years and above) Amylase Alpha I and Calcium are analyzed by ELISA technique. Results: Results show that Mean ± S.D of Amylase Alpha I of the Age group I is (110.35±66.42), while that in the age group II is (71.19±58.53) and in age group III is (85.87±56.62). The level of α-amylase I among study groups is decreasing with the age, but not significant (P≥0.05). For salivary Ca, Mean & S.D of salivary calcium  for the age group I  is (6.04±1.87), Mean & S.D for age group II is (5.67±0.79), and for age group III is (8.07±0.56) which shows significant increasing with the age (P≤0.05). Conclusion: The level of salivary Amylase Alpha I enzyme is decreasing with age, therefore there is less adhesion of bacteria to tooth surface, while the level of salivary Ca, is increasing with age, which aid in remineralization process and reduce development of dental caries with age.Keywords: Saliva, Α-amylase enzyme, Ca.
A Midwife: Professional Ethics in Midwifery Practices, Managing Pregnancy and Childbirth Complications, and Legal Rights for Nursing Mothers Ayesha Hendriana Ngestiningrum; siska diana sari; Rizka Rizka; Taadi Taadi; Sofyan Wimbo agung Pradnyawan; Sigit Sapto Nugroho; Dewi Iriani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

This study aims to discuss a midwife as a health professional, professional ethics in midwifery practices, the management of pregnancy and childbirth complication, and legal rights for nursing mothers. This qualitative research utilizes interview as a main instrument. The data are collected from interviews conducted with: 1.) pregnant women who gave premature birth, 2.) nursing women and families supporting breastfeeding program, and 3.) Public Health Office staffs. The study reveals that legal ethics between midwives and patients is significantly crucial. There is a need for effective communication between midwives and patients. Patients have the right to obtain information as clearly as possible and midwives also have the right to get the trust of patients to perform medical procedures without any interventions. In addition to the aforementioned result, this study reports that there is pregnancy and premature childbirth complication. It is a maternal health issue occurred during pregnancy causing premature birth. This study also highlights a breach of guarantee to nursing mothers who breastfeed up to 2 years of age. The results of study conclude three points. First, it reports informed consent. It is a process for getting permission before conducting a healthcare intervention on a person, or on disclosing personal information. Second, legal practice regulating rights for nursing mothers and its legal sanctions for someone who prohibits breastfeeding for working women or health workers who provide formula milk to newborns without medical indication. Third, the authorized party will conduct an investigative audit of cases of complications of pregnancy and childbirth that cause infant mortality.
The Effect of 12 Weeks of Using Stability Ball in Working Environment on the Intensity of Pain and Disability in the People with Chronic Low Back Pain Jafar Ketabchi
Journal of Global Pharma Technology .
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Abstract

Introduction: low back pain is common among the employees who sit at the table for long hours. Comparing to sitting on office chair, sitting on stability balls causes activation of the core muscles of the body. Increasing the activity of core muscles in the central part of the body causes the increase of stability in Lumbo-pelvic-Hip complex which can be efficient in improving the pain, signs and symptoms of the patients with chronic low back pain. The objective of the present study was the transitional use of 12 weeks of stability ball instead of office chairs on pain indexes and disability in the patients with chronic low back pain. Material and methods: 28 men suffering from chronic low back pain (mean± standard deviation of age 4/2±5/39،BMI,  9/1±2/24) were selected to take part in the study through convenient method. The participants of the present study used stability ball for 12 weeks instead of office chair during some hours of their working (maximum two hours) at the office. The pain intensity and disability of the subjects were measured through applying QUEBEC and OSWERTRY questionnaires. Dependent sample t-test was used at 0.05 levels to analyze the data. Findings: a significant difference was observed in the relationship between pain intensity and disability in the participant people (P<0.05). The mean of pain intensity and disability in the people participating in the pretest were 26.4±5.0 and 24.2±5.4 respectively. After administering therapeutic protocol, the mean of pain intensity and disability decreased to 18.6±4.7 and 21.2±4.7 which showed an improvement of 29% and 12% in the pain intensity and disability in these patients. Conclusion: sitting on stability ball leads to more activation of core muscles of the body especially deep stabilizers in this part. Activating deep stabilizers in the core part leads to the improvement of the condition of patients suffering from chronic low back pain. According to the results of the current study, sitting on stability ball instead of office chair in working hours can cause more activation of core muscles. Therefore it is recommended to use stability balls instead of office chairs. although just the improvement of working environment cannot lead to the treatment and improvement, so making such changes along with other therapy modalities can cause more effectiveness on the condition of the patients suffering from chronic low back pain.Keywords: Chronic low back pain, Stability ball, Quebec questionnaire, Core stability, Oswertry questionnaire.
Porphyromonas Gingivalis fim A Type I, II, III, IV, V and Ib Genotypes Distribution among Malay Chronic Periodontitis Patients Tara Bai Taiyeb Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

III, IV, V and Ib genotypes in the Malay ethnic group and to relate their presence to chronic periodontitis. Design: A total of 30 Malay subjects (15 periodontitis and 15 periodontally healthy subjects) aged 25 years and above were selected. Clinical periodontal parameters were recorded for each subject. Subgingival plaque samples were collected from the deep pockets ≥5mm in periodontitis subjects and from subgingival areas in healthy subjects. Presence of P. gingivalis fimA types I, II, III, IV, V and Ib genotypes were identified by polymerase chain reaction followed by agarose gel electrophoresis.  Results: P. gingivalis was more prevalent in periodontitis subjects (53.33%) as compared to periodontally healthy subjects (13.33%). In periodontitis subjects, P. gingivalis fimA I, II, IV, V and Ib genotypes were detected in of 20%, 33.33% 20%, 6.67% and 13.33% respectively among periodontitis subjects. The frequency of genotype fimA type II was greater where plaque accumulation was >1. However, P. gingivalis fimA IV genotype followed by fimA Ib genotype were detected in higher percentages. Conclusion: P. gingivalis was detected in periodontally diseased and healthy subjects. P. gingivalis fimA genotype II, IV and Ib was identified in diseased subjects only. In conclusion, the prevalence of P. gingivalis especially fimA genotype II, IV and Ib can be used as indicator to differentiate between diseased and healthy subjects.Keywords: P. gingivalis, Chronic periodontitis, Genotypes.
The Influence of the Musical Rhythm according to the Interactive Method of Learning the Top-down Passing Skills in the Volleyball for Students Saeed Gheni Noori
Journal of Global Pharma Technology .
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The objective of the search is to identify the effectiveness of the use of musical tunes in the interactive method of learning the top-down passing skills in the volleyball, and the experimental method has been used to suit the nature of the problem. The research community has identified the fourth grade students of the Dar Al Salaam boys school in Misan governorate for the 2018-2017 school year, which totaled (72) students. (60) Students were randomly selected from the research community, who accounted for (83.3) of the community, and were divided into two groups, the control group was (30) students and the experimental group was (30) students. Thus, the researchers conducted parity between the two groups, and it took (5) weeks to implement the program by two educational units per week, and at a time of (45 minutes) per educational unit. The researchers used the method of application (SPSS) and some other statistical means. The researchers concluded the effectiveness of the program using the rhythms of music according to the method of exchange in learning the skills of passing up and down in the volleyball, and also concluded the speed in the acquisition of skills because of the adaptation of students with the program prepared for the duty sheet and feedback.Keywords: Music rhythm, Interactive mode, Skills of passing top and skill of passing from down.
Phytochemical Analysis and In Vitro Cytotoxicity of n-Hexane Extract of Kaempferia pandurata and its Nanoparticle to Breast Cancer MCF-7 Cells Fadilah Fadilah
Journal of Global Pharma Technology Volume 11 Issue 05.
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Background: Finger root (Kaempferia pandurata) is a medicinal herb which has shown anticancer activity as potential targeted-therapy towards estrogen receptor positive breast cancer. Objective: This research was conducted to analyze the phytochemical contents of n-hexane extract of Kaempferia pandurata and its nanoparticle to the growth of estrogen positive breast cancer MCF-7 cells. Methods: Kaempferia pandurata rhizome was extracted in n-hexane, and its phytochemical contents was analyzed by simple phytochemical test and thin layer chromatography. Nanoparticle was then synthesized from n-hexane extract of Kaempferia pandurata. Finally, the n-hexane extract of Kaempferia pandurata and its nanoparticle were then tested using MTT Assay to MCF-7 cells in order to determine their inhibition rate and IC50. Results:. The extraction of Kaempferia pandurata rhizome in n-hexane extract was conducted successfully. Through simple phytochemical testing, n-hexane extract of Kaempferia pandurata contained flavonoids, triterpenoids, and tannins. Thin layer chromatography using non-polar eluent (n-hexane : ethyl acetate = 5 :1) showed eight spots with Rf values of 0,12; 0,18; 0,23; 0,29; 0,41; 0,55; 0,62; 0,80. MTT assay resulted in IC50 value of 94.387 ± 11.667 μg/mL and 31,298 ± 0,242 μg/mL for n-hexane extract of Kaempferia pandurata and its nanoparticle respectively. Discussion: The phytochemical contents of n-hexane extract of Kaempferia pandurata (flavonoid, triterpenoid, tannin) was shown to have anticancer activities on breast cancer cells n-hexane extract of Kaempferia pandurata and its nanoparticle has moderately active anticancer activities towards estrogen positive breast cancer MCF-7 cells. Nanoparticle enhances n-hexane extract of Kaempferia pandurata’s entry to cancer cells. Conclusion: N-hexane extract of Kaempferia pandurata and its nanoparticle can be a potenial anticancer agent towards estrogen positive breast cancer.
Antibacterial Evaluation of Quassia Indica (Gaertn.) Nooteb. in Steenis Towards Bacteria Involved in Skin Diseases Kassim Ajeena P; Thomas Toji
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Quassia indica has been used as medication for a number of diseases in traditional systems of medicine. Leaves of Quassia indica evaluated for its antibacterial potential and phytochemical contents in various solvent extracts of the plant in increasing polarity towards pathogenic bacterial species involved in skin diseases in human beings. Antibacterial activity was evaluated by disc diffusion method. Petroleum ether and ethanol extracts were found to be active against Pseudomonas aeruginosa. The results indicated that the plant exhibited antibacterial activity especially towards single pathogen, Pseudomonas aeruginosa. Phytochemical analyses were performed to analyse the nature of compounds contained in the active extracts. Flavonoids, phenols, steroids were detected in petroleum ether and ethanol extracts. Alkaloids were not detected in any of the extracts. Active ethanol extract of the plant exhibited minimum inhibitory concentration as well as minimum bactericidal concentration of 31.25mg/ml towards Pseudomonas aeruginosa. The study revealed that the active ethanol extract possessed some antibacterial compounds, which could be isolated from the ethanol extract. Keywords: Quassia indica,Simaroubaceae, antibacterial, disc diffusion, MIC
Effects Cytokinin in Seed Germination Indexes Psyllium Plantago Psyllium Mohammad Amin Noorani
Journal of Global Pharma Technology .
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Seed priming technique by which seeds under controlled conditions before being placed in their original context and this treatment before planting the exposure seeds ecological condition of the environment, physiological andbiochemical preparations not find germination This improves germination, initial establishment of the plant,earliness quality and as defense mechanisms of plants conditions. Seed dormancy treatments include the use concentrations (100, 50, 0) and kinetin concentrations (100, 50, 0) ppm. Percentage and speed of germination, germination efficiency, mean germination time, germination index, vigor index, the value germination, seedling length were measured. The results showed that in the psyllium for 100 with Kinetin Minimum germination in the passion is the same treatments. The lowest percentage in the psyllium kinetin 50.Keywords: seed dormancy, gibberellic acid, kinetin
Factor Analysis of Patient with Hypertension on Self-Regulation Based on Self-Belief Riza Fikriana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Objective: The purpose of this study was to analyze the factors that influence self-regulation based on the self-beliefs of hypertension patients. Methods: The design of the study used observational analytics with a cross-sectional study approach. The sample size consisted of 108 patients with hypertension in health centers in Malang Regency, East Java, Indonesia. The independent variables were physical activity, food consumption, medication adherence, control in health care and stress management. The dependent variable was self-regulation. Data were collected using a questionnaire tested for validity and reliability. Logistic regression was used to analyze the results. Results: Age (p = 0.014) and support of health workers (p = 0.004) had an effect on the self-regulation of food consumption. Age (p = 0.008), gender (p = 0.006), family history (p = 0.004), family support (p = 0.014) and health insurance (p = 0.028) had an effect on the self-regulation of medication adherence. Age (p = 0.022) affected the self-regulation of control to health services. Peer support (p = 0.008) was significantly associated with stress management. Conclusion: The consolidation of social support and health services is important to improve self-regulation based on self-beliefs in patients with hypertension.Keywords: Self-regulation, Confidence, Hypertension.

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