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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
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Articles 106 Documents
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Search results for , issue "Volume 12 Issue 06 (2020) June 2020" : 106 Documents clear
Increasing of Early High-Risk Pregnancy Detection with Proactive Intervention in Bangkalan District, Madura Indonesi Budi Prasetyo
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Maternal Mortality Rate (MMR) in Indonesia remains high despite various initiatives had been done to decrease. Factors that correlate with it are culture and referral. In this study, a proactive intervention was conducted to improve cultural and referral issues in a rural area. Aim: to explain the improvement of the early detection of high-risk pregnancy after a proactive intervention. Method: This study is an experimental design by implemented proactive intervention complemented antenatal care programs in the primary health care center. Midwifery students were enlisted to conduct a maternal assistance program to raise awareness of the importance of antenatal care visits, childbirth by health workers, and family planning programs. Results: The proactive intervention showed the increasing of early detection of high-risk pregnancy by skilled health personnel (p =
Analysis of Factors Affecting the Participation of Women of Childbearing Age in Visual Inspection with Acetic Acid (VIA) in The Community Health Center of Bangkalan Uswatun Khasanah; Siti Anisak; Nurlailis Saadah; Esyuananik Esyuananik; Anis Nurlaili
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Nurlailis Saadah1, Esyuananik1, Anis Nurlaili1 1Midwifery Department, Poltekkes Kemenkes Surabaya; Jl. Pucang Jajar Tengah 56 Surabaya (yusa_0510@yahoo.com) *Corresponding Author: Uswatun Khasanah Abstract Cervical cancer is a malignant disease that it is possible to cause death. Unfortunately, the community still has a very low awareness to check themselves.More than 70% of sufferers come to the hospital at an advanced stage that is difficult tocure. This study aims to analyze the factors that influence the participation of women of childbearing age in visual inspection using acetic acid in the community health center of Bangkalan. The study was conducted in March-June 2019 with a cross sectional study design. The number of research subjects was 104 women of childbearing age taken by cluster random sampling.The dependent variable included predisposing factors (knowledge, motivation, culture), supporting factors (distance to health facilities and income) and reinforcing factors (midwife counseling). The independent variable included the participation of women in childbearing age in the VIA test. Data analysis was performed using the chi square test and logistic regression with a significance level of α = 5%. The results showed that knowledge had an influence on the participation of women in childbearing age in VIA tests (p value 0.047 0.05).Knowledge is the initial factor of a behavior that is expected to be positively correlated with behavior. In addition, environmental influences (including culture) also shape the behavior. However,not all people are aware and ready to implement behavioral changes. The existence of socio-cultural influences with gender bias, as well as the lack of information and the ability to receive and absorb information can influence the norms and beliefs of the community in utilizing health services including the effort to take part in VIA tests. For this reason, it is necessary to conduct socialization to targets related to VIA inspection through printed and electronic media. In addition, health workers need to improve their skills in counseling based on VIA counseling standards. Keywords: Predisposing Factor, Reinforcing Factor, Enabling Factor, Women of Childbearing Age Participation, VIA Test
Male Infertility: An Epidemiological and Clinical Profile at the Andrology Unit of Dr. Soetomo Hospital, Surabaya, Indonesia Antonius Wahyudi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: To discover and to lay out epidemiological features and clinical characteristics of patients with infertility problems who seek treatment at the Andrology Unit of Dr. Soetomo Hospital. Methods: A cross sectional study was conducted to men with infertility who sought treatment in the Andrology Unit of Dr. Soetomo Hospital ranging from January to December 2017. Only patients who lived together with their spouses were included as research subjects. Results: The average age of the patients was 33.76 years (age ranged from 25 to 46 years) and the average age of their spouses was 30.4 years (age ranged from 19 to 42 years). The average duration of infertility is 4.25 years (between 1 year and 13 years). Average age of puberty was 14.5 years old. First consultations were late with average of 4.46 years. From overall infertile patients, 90% of them were categorized as primary infertility. History of smoking was found in 84 people (68.29%), history of wearing tight pants 27 people (21.95%). In terms of Body Mass Index(BMI), we found that underweighted patients comprise 7% (9 patients) from total liable subjects, while 55 people (55%) were in the area of ideal body mass, 46 people were overweight (35%), whereas obesity was found in 13 subjects (10%). The results of semen analysis showed that the most case were asthenoteratozoospermia 34 people (27.6%). A careful history, physical examination and semen analysis can determine the cause of male infertility. The cause of male infertility in Surabaya, Indonesia is very complex, which involves older age, delayed consultation and background as risk factors that cause abnormalities in semen analysis. Keywords: Male infertility, epidemiology, andrology, Dr. Soetomo Hospital, Surabaya, Indonesia.
Clinical Correlates of the Severity of Diabetic Foot Ulcers Rahadyan Magetsari; Meirizal Hasan; Yossie Atyandhari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

OBJECTIVE Severe diabetic foot ulcer leads to amputation and is associated with higher risk of mortality. The purpose of this study is to identify clinical correlates of severe diabetic foot ulcers. METHODS The design of the study was cross-sectional survey of medical records on patients treated in Sardjito Hospital from 1 January to 31 July, 2014. Severe foot ulcer was measured as grade 4 and 5 according to Wagner classification. ABI (Ankle Brachial Index) to estimate blood flow to lower extremities and Semmes-Weinstein test using monofilament to detect neuropathy, classified as positive or negative, were done in all patients. HbA1C, serum sodium and creatinine levels were measured during the latest hospital visit. RESULTS The results of this study showed that 77 (36.5%) among 211 patients had severe foot ulcers (grade 4 and 5, Wagner classification). ABI and Semmes-Weinstein monofilament test failed to predict severity of diabetic foot ulcers. HbA1c increased the odds of severe ulcers while higher serum sodium level and higher diastolic blood pressure protected patients against severe ulcers. CONCLUSION Better glycemic control and caution against excessive reduction of diastolic blood pressure, usually due to anti-hypertension medication, should be recommended to prevent the development of severe foot ulcer. KEYWORDS: diabetic foot ulcers, severity, glycemic control, hypertension, poor circulation, neuropathy
Different Molecular Methods to Determine Genetic Diversity in Pseudomonas aeruginosa Clinical Isolates Reem Akram Naji
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

A total of (210) clinical specimens were collected from patients suffering from different infections such as burns, wounds, ear infections, diabetic foot, and urinary infections, cultured on differential media. All clinical specimens were cultured on different media. The results indicated that 22 (10 %) of the isolates were belong to P. aeruginosa. It was found that six isolates (27.27%) were isolated from wounds, five isolates (22.72%) from burns, six isolates (27.27%) from ear infections, two isolate (9%) from urine and three isolates (13.63%) from diabetic foot infections. In this study, used RAPD, BOX, and ERIC-PCR for the detection of phylogenetic diversity of pseudomonas aeruginosa isolated from different samples, In general, 18 isolates characterized using the three molecular techniques had comparable number of bands with some degree of polymorphism. P. aeruginosa isolates from the same source were clustered in to different groups. The three molecular techniques generated 2 main clusters, and the results of dendrogram of these techniques reveals that two isolates number(11,12) were similarity 100% in three methods techniques this suggest that this give the more discrimination power. While the pattern of others recorded some difference in the distribution. Keywords: Genotyping, Phenotyping, Pseudomonas aeruginosa, Molecular detection, RAPD, BOX, ERIC.
In Silico Study of Anti-Inflammatory Potential of 1.8-Cineole against Cox-2 and TLR-2 Sianiwati Goenharto
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: To determine the anti-inflammatory activity of 1.8-cineole against COX-2 and TLR-2 using an in silico approach. Methods: In silico studies were conducted using the Molegro Virtual Docker (MolDoc) program to predict the anti-inflammatory potency of 1.8-cineole against COX-2 and TLR-2 receptors. Results: MolDoc score showed that 1,8-cineole (-49.1236) could be predicted to be an anti-inflammatory ligand demonstrating lower activity than diclofenac or COX-2 (-106.8010) ligand. 1,8-cineole (-42.7930) can also be predicted to be an anti-inflammatory ligand with lower activity than TLR-2 / CAS_673 ligand (-56.5640). Conclusion: 1.8-cineole possesses anti-inflammatory potential against COX-2 and TLR-2 receptors based on an in silico predictive study.
Results of the Comparative Analysis of the Willingness-To-Pay Threshold Indicators for Introduction of Innovative Technologies in Healthcare Calculated on the Basis of the Purchasing Power Parity of the Population in Ukraine, Azerbaijan, Armenia, and Georgia Hanna Panfilova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: To conduct a comparative analysis of the dynamics of changes in the willingness-to-pay indicators concerning introduction of the innovative technology in the national healthcare systems of Azerbaijan, Armenia, Georgia and Ukraine. Methods: The studies used the “Willingness-to-pay” calculation method proposed by the WHO Commission on Health Macroeconomics and Economics. Calculation and comparison of willingness-to-pay indicators in the reference countries was carried out on the basis of the purchasing power parity (PPP) of the population. Results: It was found that during 2010-2017 Azerbaijan consistently held the leading position when introducing the innovative technology in healthcare by the willingness-to-pay value. By the average value of willingness-to-pay indicators (in 2010-2017) the reference countries were distributed in ascending order of indicators in the following way: Armenia (24, 28 USD Thousand); Ukraine (25,02 USD Thousand); Georgia (26,30 USD Thousand); Azerbaijan (50,61 USD Thousand). Therefore, the average value of the willingness-to-pay indicator in Azerbaijan was approximately twice as much as in other reference countries. Іn ascending order of the average growth rate values (%) of the willingness-to-pay indicator the countries were distributed as follows: Azerbaijan (101.69%); Ukraine (102.02%); Armenia (105.4%); Georgia (107.2%). Azerbaijan demonstrated the highest willingness-to-pay indicators, but it showed the lowest average growth rates (%) within 2010-2017. The highest growth rate (%) of the willingness-to-pay indicator was observed in Georgia. Conclusion: The results of the studies conducted can be used to form an objective assessment of the threshold values of national healthcare systems in Azerbaijan, Armenia, Georgia and Ukraine. Keywords: Innovative drug, Innovative health technology, Health technology assessment, Pharmaceutical provision of the population, Willingness-to-pay indicator.
Application of Surgical Safety Checklist (WHO) at Al- Diwaneyah Teaching Hospital Ali Jawad Hamza Al-Shammari
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Surgery have been considered as one of the global health care important part, however the surgical complications are still common, but can be prevented. Till now, surgery is an essential component of public health and its role is increasing rapidly. Aims: Present study aims to use a safety checklist items to improve team surgical care which will reduce complications and deaths associated with surgery. Patient and Methods: This prospective study enrolled 162 patients using checklist of surgical safety consist of 19 items with different types of operations at Al-Diwaneyah Teaching Hospital in Iraq during the period 1st of February 2018 until 1st of February 2019. We follow the patients until 30 days after surgical intervention. Results: After applying the 19 items of surgical safety checklist to 162 patients, the risk of the surgical site infection(SSI), respiratory complications, missed gauze and risk of blood loss (3.7%, 2.4%, 0.6% and 1.85%) respectively were comparable to the results of the World Health Organization. Pulse oximeter was used in 92.5% and site marking in 65.4%. In 61.73% of patients received antibiotic prophylaxis in which just 3.7% developed surgical site infection, while the extended regime in 38.27%, there is 9.8% with SSI. No mortality reported during the collection of the data. Conclusions: The surgical checklist is a simple and effective method in reducing surgical complications. WHO recommends use of the checklist in all surgical operations and encourages clinicians to modify the list for different specialty and hospitals. Keywords: Safety check list, Surgical site infection, Surgical complications, Basic surgical care.
Determination of Potential Compounds of Stevia Leaves (Stevia rebaudiana Bertoni) Against DPP4 as Candidates for Antidiabetic Drugs Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Diabetes mellitus is a metabolic disorder due to abnormalities in insulin secretion, insulin action, or both. Around 200 million people worldwide suffer from diabetes, most of which is type 2 diabetes. One of the targets of diabetes treatment is the DPP-4 enzyme which works to degrade incretin from the body. Sitagliptin, a DPP-4 inhibitor that has been approved for the treatment of type 2 diabetes. Besides using synthetic drugs, a biochemical compound can also be used for diabetes therapy, one of which is stevia leaf. This research was conducted to select compounds contained in stevia leaves based on their interaction with DPP4 in silico. The purpose of this study was to determine potential compounds from stevia leaves to be a candidate for antidiabetic drugs. Tests were carried out on DPP4 inhibitors, namely sitagliptin, and 10 compounds contained in stevia leaves. The results showed that there were three potential compounds namely isosteviol, steviol, and steviolmonoside. Testing the Lipinski's rule of five and pre-ADMET parameters implied that the three compounds had the potential to be used as candidates for antidiabetic drugs. Keywords: Stevia leaf, Stevia rebaudiana, Diabetes mellitus, DPP4, Molecular modeling.
Assessment of Pregnancy Complications among Internally Displaced Women in Karbala Governorate Ridha M. lefta
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Pregnant women face increased risks of complications as they exposure to displaced conflict zones with damaged and destroyed health facilities in out conflict zones. Objectives: To determine the pregnancy complications among displaced women, and to find out the relationship between dietary habits for displaced pregnancy and complication of pregnancy. Methodology: A descriptive analytic study has been conducted on non-probability purposive sample of (200) displaced pregnant women select AL-Hussein Teaching Hospital in Karbala governorate .This study has been conducted during the period of 1st December until (30)th December 2017. A questionnaire is used as a tool of data collection to fulfill the study. A content validity, which is carried out through 13 panel of experts. Validity is determined by a panel of experts while the reliability utilization its split half. A descriptive and inferential statistics are used to analyze the data. Results: This table shows that the study result for demographic data the majority of the study samples 21-25 years old are 32% and the most the sample related level of education have secondary school 38% and housewife are 93% and resident in urban. The study results indicate that the economic status sufficient to some extend and living at camp are 53%. This table depict that the complication among pregnancy displaced that indicate majority of pregnancy suffer from anemia is 49%. This table depict that the there is a non- significant between complication among pregnancy displace women and diatery habit domain at p. value more than 0.05. While there is a significant between complication pregnancy displaced and (dental problems and prenatal vitamin) at p. value less than 0.05, also the correlation between fregin food and complication pregnancy displaced women is high significant at p. value less than 0.01. Conclusion: Anemia is the major pregnancy complication among IDPs women. Recommendations: A special education programs focused on improvement the women knowledge and practices about the prevention and management of pregnancy complications. Keywords: Internally displacement, Pregnancy complications, Anemia, Prenatal vitamins, Dental problems.

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