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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis of New Five-Membered Hetrocyclic Compounds from 2-Furfuryl Mercaptan Derivative and Evaluation of their Biological Activity Luma S. Ahamed
Journal of Global Pharma Technology .
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Abstract

Sixteen compounds were synthesized from 2- furfuryl mercaptan as starting material which was reacted with ethyl chloroacetate to produce 2-furfuryl mercaptan ester derivative. The later was reacted  with hydrazine hydrate to  produce hydrazide derivative(2)which was introduced in different synthetic methods by using either cyclization reactions or  using  different reagents to produce biheterocyclic  systems(3-16).Keyword: Five-membered heterocycles, 2-furfuryl mercaptan, Biological activity.
Incidence of Lesions of Organs and Systems in Iron Deficiency Anemia in Children and Its Predictive Significance in the Development of Diseases of Internal Organs Albert Giliazev
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

This article deals with the study of the incidence of somatic pathology in children with iron deficiency anemia. It is shown that children with anemia more often have respiratory pathology, and less often - endocrine diseases. Somatic pathology is almost equally diagnosed in boys and girls and predominates in young children. The authors established the importance of iron deficiency anemia in the development of diseases of internal organs, determining the time of formation and nature of the disease, as well as increasing the risk of involvement of a number of organs and systems in the pathological process.     Keywords: Iron deficiency anemia, children.
Synthesis and Characterization of New Heterocyclic Compounds and Studying the Biological Activity Wisam Khalifa Jassim
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

New series of some of synthesized compounds derived of the compound (2- (5-(3,5-dinitrophenyl)-1,3,4-thiadiazol-2-yl-substituted benzalidine .The starting material was prepared by the reaction of 3,5-dinitro benzoic acid with thiosemicarbazide in presence of POCl3. The derivatives of Schiff bases were prepared by reaction of 2-amino -5-(3,5dinitro phenyl) 1, 3, 4-thiadiazole with appropriate aldehydes (m-nitro, p-N, N-dimethylamino, p-bromo, o-hydroxy, p-hydroxy) benzaldehydes. These Schiff base were synthesized in order to prepare more important compounds which are the quinazolines and oxazepins. These compounds were synthesized from the reaction of Schiff bases (2- 6) with o-amino benzoic acid (anthranilic acid) and phthalic anhydride respectively. The structures of the new compounds were characterized by FT-IR, 1H-NMR spectroscopy besides the melting points and other properties. The biological activity (antibacterial activity) in-vitro are investigated for the derivatives at prepared concentration (1*10-3 M) and showed inhibition ability against growth of the two types of pathogenic bacteria: [Staphylococcus aurous.] as gram positive and [Escherichia coli] as gram negative and showed inhibition ability against bacteria. The most of these compounds are effective against both types of bacteria in varying degree, with high activity for quinazolines and oxazepines. Keywords: Quinazolines, Oxazepines, Biological activity of 1, 3, 4-thiadiazole, Schiff base.
The Effectiveness of Different Teaching Methods According to the Kolb Theory in Performance Accuracy of Some Basic Skills and Neuralgic Inhibition in Tennis Aqeel Yahya Hashim Abdulaziz
Journal of Global Pharma Technology .
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Abstract

In an attempt to use modern techniques in learning skills and believing that there is a need to re-examine the method used and provide the potential for the student to obtain information from them to ensure the process of education and to change the methods that are widespread based on memorization and conservation and literal application and replace them with modern methods to ensure the development of thinking and creativity capabilities of teachers and students And to benefit from modern information and techniques ,And experimenting through the effectiveness of different teaching methods in accordance with the patterns of the theory of the circle Kolb in the performance of the accuracy of some basic skills in tennis. The aim of the research was to identify the classification of students according to the Kolb theory and the different teaching methods suitable for each classification, and to identify the best groups that were used according to Kolb's theory of performing some basic skills in tennis .The researchers hypothesized that the use of various teaching methods according to "Kolb theory is positively effective in learning some basic skills in tennis .he fields of research were the human field: students of the Department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa, class III / for the academic year (2016-2017) .The period field from 1/11/2016until 1/8/2017, and the spatial field ,in the internal gymnasium of the department of Physical Education and Sports Sciences - Faculty of Education for Girls - University of Kufa .The researchers used the experimental method in the two groups (experimental) method. On this basis, the researchers selected the sample of the students from the third stage of the Department of Physical Education and Sports Sciences / Faculty of Education for Girls / University of Kufa with (25) .After excluding (7) female students from the original society for their participation in the exploratory experiment, the sample was selected by 18 female students in the simple random way ,Which was divided into two experimental groups according to the classification form of the theory of Kolb, which classified the sample to the practical and theoretical and according to the qualifications of each student, the first experimental group (the practical) (10) students and applied the method of solving problems in teaching basic skills in tennis ,And the second experimental group (theorists) (8) students. The method of mental training in teaching was applied to the basic skills of the tennis game. The special units were prepared for each group after presentation to the experts and the preparation of the tools for experimental procedures such as computer use ,video clips and strips educational, rackets and tennis balls, and form evaluating the performance of accuracy, was applied (8) educational units on the two sets of research experimental, by one unit for each week, as it has been implementing the teaching style of solving problems with the first experimental group (practically) and the style of mental training with the second experimental group (theorists), and the conclusions obtained between the results of tribal tests and dimensionality and there is a significant moral differences and in the interest posteriori tests and both sets, and either posteriori tests results were the absence of significant differences between the two groups differences The pilot, and the researchers recommended that the need to use Kolb's theory circle in teaching.
Study of Characterization and Concentration of Trace Element in Human Hair of Radiation Workers Zahraa Abbas Rasheed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Human hairs experience damage and restoration processes consistently because of various external and internal factors. To analyze degrees of hair damage, morphological studies based on scanning electron microscopy (SEM).The present study aims to analyze degrees of hair damage, morphological and structural changes in human hair shaft and effect concentration of trace element under SEM and ICP-OES respectively in a sample of male radiation workers who worked in Al-Tuwaitha nuclear site.  The descriptive statistics of grade of hair damage, hair diameter, cell length under SEM. A statistically significant difference was found between the radiation worker and control group with respect to the SEM scores with the extent of damage being more in the radiation workers as compared to the control groups. The present study showed high percentage of grading damage under SEM for both Radiation worker& control group in grade 1(56%) and grade 0(60%), respectively. To validate the analytical of levels of Sr and U in scalp hair of radiation workers and control groups. U levels in of radiation workers was  significantly higher in radiation workers compared to control groups, whereas, Sr was significantly lower in radiation workers as compared to the control group. In conclusion, the obtained results occupationally exposed to low levels of ionizing radiation may be associated with increased deposits on the hair shaft surface; these findings may be consistent with those obtained in other studies, confirming that the deficiency and efficiency of trace elements play a role in clinical disorders and the pathogenesis of many diseases. Furthermore, to prove that human hairs are useful in the studies pertaining to chronic body exposure and good biomarkers in clinical studies for radiation worker.Keywords: Human hair, SEM, ICP: OES, Uranium, Strontium.
The Impact of Special Exercises for the Development of a Deep Sense of Block Skill Accuracy in Volleyball for Player's Focal Youth Bassem Hassan Ghazi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The Aim of Research: Preparation of special exercises to develop the deep sense and the accuracy of block in the volleyball for focal young players and Learn the effect of special exercises in the development of deep sense and the accuracy of the block of the volleyball of focal young players. Hypothesis: Special exercises have a significant effect on the development of the deep sense and the accuracy of block of the volleyball of the focal young players. As for the research methodology, the researcher chose the experimental method as the appropriate method to solve the problem of research in the design of a single group with the pre and posttests. The sample of the research was chosen from the research community represented by the young players (17-19) years for the Kufa and Al Rawdatain 2016-2017 clubs. The number of players was chosen from them. The number of players was 4 players in each team. The total number of players was 8. The Researcher Concluded: An evolution in the deep sense of the young players for the movement of the parties to the experimental group, Exercises for deep sense and accuracy contributed to increase the accuracy of the wall of the ball of the volleyball players, The various special exercises developed by the researcher contributed to the development of deep sense and accuracy of the wall barrier.The Recommendations Were: The need to use special exercises in the development of deep sense and the accuracy of the wall of the block of the volleyball of young players, The need to develop a deep sense and accuracy of the skill of the wall of the young players to defeat the importance. The need to use exercises for the deep sense of other skills.Keywords: Special exercises, Deep sense, Block skill and Focal youth.
Genetic Diversity of Human Leishmania spp. Isolated from an Endemic Area in the Middle of Iraq Amany Mohamed Al-Kasy
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

This study aimed to the possible characterization of cutaneous leishmaniasis species isolated from cutaneous tissue imprints from patients in an endemic area in the middle of Iraq. Samples were taken by skin scraping and dermal tissue aspiration. Direct examination and polymerase chain reaction, two types of primers used (CL for L. major, Lin R for L. tropica) for detection. DNA Sequencing and phylogenetic analysis were also used for detection. In this study, 48 patients with Cutaneous leishmaniasis were enrolled, 32 (66.7 %) of them were males and 16 (33.3%) were females. Giemsa staining results showed presence of 25 amastigote forms inside and outside the macrophages, while 25 (53 %) and 23 (47 %) were positive to direct test, 26 (54.2 %) patients had multiple lesions and 22(45.8%) had single lesions in a different locations of the body. More than 68.8% of patients had dry lesions, while 27.1% had moist and 4.2 % had mixed lesions. The results showed that 8 isolates (16.7 %) were L. tropica and 4 cases were L. major (8.3 %). Most L. tropica lesions were located on the face and other parts of the body, while lesions of L. major were located on foot. In addition, new species of Leishmania were identified as L. infantum 3 (6.3 %). Four PCR products of L. major isolates were prepared and sequenced by Macrogen Company, USA. The sequence of the isolates was recorded in the gene bank and the accession numbers of L. major were LC369673, LC369674, LC369675 and LC369676. The phylogenetic tree constructed from these sequences and the polygenetic tree of the L. major. The Iraqi isolates were close to French and Russian isolates.Keywords: Cutaneous leishmaniasis, PCR, Sequencing, Phylogenetic.
Investigation Structural Properties of Cu2ZnSnS4Thin Films Prepared by Pulse Laser Deposition Ali J. Khalaf
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The prepared samples of thin-film by laser ablation method were achieved. Powders of (CZTS) copper (Cu), zinc (Zn), tin (Sn) and Sulfur (S) of and   then compressing by approximately 3 tons in Pellets form.  The samples were ablated by using Neodymium-YAG laser with different laser energies (400mJ, 500mJ, 600mJ, 700mJ, 800mJ) and number of pulses (300) pulse, frequency (6Hz) and wavelength (1064) nm obtained the plasma plume at 10-5mbar pressure. Results indicate by using XRD, AFM , SEM and EDX devices.by x-ray diffraction study of Cu2ZnSnS4 compound films prepared are proven to be  polycrystalline tetragonal as noted when the laser energy is increased when the process of ablation of the target CZTS  The grain size increases while the strain, the dislocation density  and the lattice constants (ao, co) decrease. Through the images of the atomic force microscope (AFM) it was observed that the grain size decreases from (CZTS400mJ-CZTS700mJ) and then increases. There is also an increase in the surface roughness rate and the square root rate (CZTS600mJ - CZTS800mJ) by increasing the laser energy when the process of ablation of the target CZTS with constant other laser parameters. Through scanning electron microscopy (SEM) images, the spherical shape of the nanoparticles is observed by increasing the laser energy when the process of ablation of the target CZTS with constant other laser parameters with irregular forms. The EDX test showed that the films contained Cu, Zn, Sn, S elements as expected, indicating the formation of high-purity CZTS films.Keywords: Structural, Thin film, Nanoparticle, CZTS, Composite, XRD, AFM, SEM, EDX, laser ablation.
Molecular and Biochemical Changes of Some Algae Used in the Biological Removal of Heavy Metals in Industrial Waste Water Treatments Kareem Talib Kahashan
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The current study examined the susceptibility of three types of algae, including Oscillatoria sp., Westiellopsis prolifica, Stigonemasp in reducing the values of some heavy metals in industrial wastewater. These algae were used as unialgal culture and the wastewater was used from the industrial wastewater disposed by the State Company for Textile Industries as a growth culture for the development of these algae by cultivating each algae alone in wastewater under constant laboratory conditions at 25 ± 20 ° C and in a light system 16: 8 hours Illumination: Darkness.  The results showed that the Oscillatoria sp has the ability to reduce heavy metals in high ratios reduction of (100.3%) for Iron and (29.1%) for Copper and (66.2%) for Zinc and (33.5%) for Cadmium and (99.5%) for Lead. The results also indicated that W. prolifica showed the ability to reduce heavy metals by (99.7%) for Iron and (29.1%) for Copper and (56.4%) for Zinc and (40.2%) for Cadmium and (99.5%) for lead. Stigonemasp showed higher efficiency than the rest of algae in reduction of some heavy metals with ratio of (100%) for Iron and (44.3%) for Copper and (73.8%) for Zinc and (22.3%) for Cadmium and (100%) for lead .As for the current algae physiological status, Glutathione (GSH) content in  Oscillatoria sp was decreased after treatment, while its content was increased in W. prolifica, Stigonema sp. after treatment. The content of the Cytochrome p450 in the algae appears to have decreased after treatment in Oscillatoria sp. And W. Prolific and increased in Stigonema sp. The results indicate that the Metalothionine content has not increased significantly and the values remain similar to the algae shown for control. On the other hand, bioremediation showed a clear effect on molecular properties of algae, this was demonstrated by the high values of Comet assay indicators, which include tail length, Comet length, tail moment which indicate the effect of treatment on DNA after completion of the treatment.
Concordance and Validity of Urinalysis Using Sysmex UX-2000, Cobas U411 and Manual Microscopic Examination Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Urinalysis is important in screening, diagnosing, and monitoring the progress of certain diseases. However, the procedure takes time to finish, special skill, and lack of standardization in certain labs. This study evaluates the concordance between manual microscopic examination results to Sysmex UX-2000, and urinalysis chemical results between Sysmex UX-2000 and Cobas U411 (Roche Diagnostic), and the validity of urine sediment results between Sysmex UX-2000 and manual microscopic examination.  Methods: Eighty urine samples were analyzed using Sysmex UX-2000, Cobas u411, and manual microscopic examination. Concordance level was measured using kappa coefficient. Then we calculated the validity of Sysmex UX-2000 in sediment tests to manual microscopic examination. Results: Chemical urinalysis of Sysmex UX-2000 possesses good and very good concordance level to Cobas u411 (*weighted κ 0.65-0.91). Urine sediment tests of Sysmes UX-2000 possesses good concordance to manual microscopic examination (**weighted κ 0.76-0.77), with 86-100% sensitivity and 73-78% specificity. Conclusion: Sysmex UX-2000 has good concordance level to Cobas u411 for chemical tests urinalysis, and also good concordance and validity between Sysmex UX-2000 to microscopic examination for erythrocyte and leucocyte sediment tests.Keywords: Analytical System, Renal Diseases, Quality Assurance and Control.

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