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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Evaluation of Phenol Removal from Aqueous Solution by Banana Leaf Ash Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Several industries such as crude oil refineries, petrochemical plants, processing of olive oil, pesticide manufacturing, and oil and sewage activities produce significant amounts of phenol and its derivatives that are among the most important toxic compounds present in industrial wastewater. The present study was conducted to evaluate the absorption potential of phenol from aqueous solutions using the banana leaf ash (BLA). In this basic-applied research, the banana leaf ash (0.1- 1 g) was used as an absorbent according to the purposes intended in laboratory scale and in batch system, and then changes of phenol concentration effect, pH, contact time and Freundlich and Langmuir adsorption equations were investigated. The removal efficiency was 88.93% at pH of four, initial concentration of 10 mg/L and the contact time of 75 minutes. The Langmuir and Freundlich adsorption isotherms were studied to assess the adsorption equilibrium reactions, which the results demonstrated better compliance of adsorption equilibrium reactions with the Freundlich adsorption isotherm (R2 0.900) compared to the Langmuir adsorption isotherm (R2 0.758). Based on the findings of the present study, the banana leaf ash is an inexpensive absorbent with high absorption potential and appropriate ability to the removal of phenol from water and wastewater samples. Keywords: Phenol removal, Banana Leaf Ash, Aqueous Solution, Adsorption, Adsorbent 
Water Quality Assessment of Some Rivers in Al-Qadisiyah Province, Middle Euphrates/ Iraq Hazim A. Walli
Journal of Global Pharma Technology .
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Abstract

The assessment of water quality of some rivers has been intensively studied, however, a number of problems remain to be solved in order to enhance the assessment. The Present study was undertaken with aim of obtaining information about Hamza River, Diwaniya River, and Al-Shamyia River. The investigations were carried out to understand the present status of Rivers-water quality. The primary objective of the study is to find out quality of water from different sampling stations regarding composition of water from Rivers of Al-Qadisiyah city. The quality of determination by making the measurements and physical - chemical testing was examined. The study area consists of following Rivers located in different parts of the metropolis. The current study basically examines some physical and chemicals parameters for various samples that were taken from AL-Shamyia, Hamza, and Al-Diwaniya Rivers for various characteristics including: Temperature, pH, Electrical, Conductivity, Chloride, Sulphate, Phosphate, Turbidity, Hardness, total alkalinity, Dissolve oxygen, Chemical oxygen demand, and Biological oxygen demand. All samples had been collected in three locations: south of Shamyia River, Hamza River, and Al-Diwaniya River in November, December, January and February of 2016. In general, the pollution of Hamza River was more than Al-Diwaniya, Shmyia Rivers in terms of Temperature, PO4, SO4 and Chloride. While Al-Diwaniya River shows high value more than Hamza and Shamyia represented in pH and Chemical oxygen demand.Keywords: Water Quality Assessment, Temperature, pH, Electrical, Conductivity, Chloride, Sulphate, Phosphate, Turbidity, Hardness.
Synthesis and Characterization of Some New Derivatives of Thiourea and Study of Their Biological Activity Miad Hassan Jebur
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Some new derivatives of Suberyl Chloride  synthesized by reacting with ammonium  thiocyanate then the product is reacting with some amino acids to prepare thioureio-amino acid,  as well as react with two amino hetrocyclic compounds are 2-aminobenzo[d]thiozole-6-carboxylic acid and thiophen-2-amine to prepare thiourea derivatives. This reaction was checked by thin‐layer chromatography (TLC) method. All new compounds were characterized by melting points, elemental analysis, FT‐IR and 1H&13C-NMR. The antibacterial action of these derivatives was also determined as well as study three of these derivatives as anti-breast cancer. Keywords: Suberyl Chloride, thioureio-amino acid, antibacterial, thiourea derivatives, anti-breast cancer.
Formulation and Evaluation of Herbal Antiperspirant and Deodorant Foot Powder from Mulberry Leaves Extract Ravindran Muthukumarasamy
Journal of Global Pharma Technology Volume 10 Issue 09: (2018) September 2018
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Abstract

Background: Sweating is a normal physiological process occurs in the body, but excessive sweating (hyperhidrosis) indicates a significant adverse impact on the quality of life for individuals. Sweating can be considered to have stressful experience, reduces self-confidence and social acceptance as it interferes with daily activities. Excessive sweating on the foot provides optimum conditions for bacterial growth and subsequently leads to smelly foot. Objective: The objective of the current study was to formulate and evaluate antiperspirant and deodorant foot powder from mulberry leaves extract.  Methods: The formulated powder was tested for its antiperspirant and deodorant activity against Staphylococcus epidermidis by measuring its zone of inhibition using disk diffusion method. Furthermore, the formulated powder was tested for its physiochemical parameters as per standard procedures. Results: The study results proved that mulberry leaf extract showed considerable antibacterial activity against Staphylococcus epidermidis bacteria in concentration of 200 mg/ml and 400 mg/ml. Phytochemical screening on the extract confirmed the presence of alkaloids, reducing sugars, phenols, flavanoids, carbohydrates, proteins, etc... The invitro evaluation of  the formulated herbal foot powder was tested on the micrometric test parameters like angle of repose, bulk density, tapped density, hausner ratio, carrs compressibility index and sterility test. The results on the micrometric properties was found to have poor flow property. Conclusion:However, the formulated herbal foot powder from mulberry leaves extract can be used as a potential herbal antiperspirant and deodorant foot powder with further studies on improving the flow property of the powder and toxicity testing using suitable models.
Comparison of Three Phenotypic Methods for Detection of Extended-Spectrum β-Lactamase (ESBL) Producing Klebsiella Pneumoniae Jumaah Dakel Hussein
Journal of Global Pharma Technology .
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Abstract

Through a period extended from October to December, 2016. Fifty six of Klebsiella pneumonia isolates were collected from some hospitals in Baghdad. The isolates of K. pneumonia were obtained from various clinical specimens including: 39(69.65%) isolates from blood, 6(10.71%) isolates from urine,6(10.71%) isolate from burns, 3(5.36%) isolate from sputum and 2(3.57%) isolates from ear swabs. Our result shows a high level resistance of K. pneumonia clinical isolates towards most of the antibiotics under test, all K. pneumonia isolates had the highest resistance rate 100% to Ampicillin followed by (87.6%) to Cefazolin, while the lowest level resistance of K. pneumonia isolates was to Imipenem which had 17.86% resistance rate. Three methods were used for phenotypic detection of ESβL producing Klebsiella pneumoniae, first one was done by Vitek-2 system and the results showed that out of 56 isolates, 45 (80.35%) isolates were gave positive results for ESβL producing while 11(19. 65%) isolates of K. pneumonie were gave negative results. While in second method (disc combination method) the results showed that out of the 56 K. pneumonia isolates, 48(80.35%) isolates were positive ESβL producing, while 8(19. 65%) isolates of K. pneumonie were negative by two sets of cartridges (D52C) discs. In the third method the results of CHRO Magar technique, 51(91.07%) of the 56 isolates gave positive result which suspected ESBL producers while only 5(8.93%) isolates gave negative result. Eventually, CHRO Magar technique was recorded a high percent of ESBL detection while method by using Vitek-2 system was recorded a low percent of ESBL detection. From study we noticed that a high percent of ESBL producing K. pneumoniae isolates compared with non ESBL producing K. pneumoniae isolates under test by all previous confirmatory methods used in this study.Keywords: Klebsiella pneumoniae, Extended-Spectrum β-Lactamases (ESBL), phenotypic detection
Cervical Caries: Modern Methods of Diagnosis and Treatment Alexei Yumashev
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: The purpose of this study is to study the effectiveness of the cervical caries treatment when filling with different materials in the short and long term.  Methods: To study the elemental composition, electron probe microanalysis method was used. The quality of fillings from NC, GC, CM was evaluated in the following terms: a week after restoration, six months, a year, two years.  Results: Features of the anatomical structure of the cervical region indicate an increased risk of caries here. Areas with increased tissue hardness, as well as hardness, stability and mineralization may form in the dental tissue. These foci are able to withstand the demineralization of the tooth for some time. Conclusions: When filling NC and CM in the intermediate layer between dentin and material, the structure is homogeneous. The hard tissues of the tooth are enriched due to the contained fluorides. Scanning microscopy data confirmed the opening of the dentinal tubules. The first group of patients (low resistance to caries) improved 1.4 times the performance of the marginal fit of the fillings, provided that ozonation was present (p≤0.05). For the second group, the safety of fillings was established for 2 years in 95% of cases, but subject to the presence of ozonation.Keywords: Cervical caries, Ozonation, Nanocomposites, Glass ion cements, Nanoglassionomer, compomer.
Comparing the Gene ACE Variant with Some Cardiac Muscle Variables for Handball Players Nagham Salman Kareem
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The study objective to recognize the diversity of the gene ACE and the heart variables and the researcher used the descriptive research in the survey method to identify the majority of players who have cardiac functions that distinguish them from others according to genetic diversity where the dominant gene types were identified in the sample research (DD, ID , ii) The search sample was identified and chosen in the intentional manner, the 12-player handball players of the Diwaniya Governorate, divided by shapes into DD (6) players and (II) were (3) players and finally (ID) were (3) players and a blood withdrawal test was performed for the sample P Date on Monday (5 \ 3 \ 2018) and after which the checks were performed on the ACE gene and all the players have appeared to have the gene where the genes were dominant in the sample then the gene forms were detected to know the differences between groups through any group delayed to reach fatigue and the group. The gene structure (DD) is the most delayed to reach the anaerobic threshold where the researcher attributes that the genetic structure (DD) is what distinguished this group from others and the objectives of the search is to identify the types of the ACE as well as to identify the differences between the totals of the shapes according to the variables of the heart muscle In the fields of research, the human field was the handball players of the Diwaniya Sports and Spatial club, the sports hall in the Ramadan district and the period of time between (5 \03 \ 2018) – (8 \05 \ 2018) The statistical means were used (arithmetic mean, standard deviation, Variance test (p) for the differences between totals, the Law (LSD) is the least significant difference, Simple link.Keywords: ACE I, D gene and cardiac muscle.
Morus alba and Morus rubra alleviate hepatic disorder, oxidative DNA damage and gene expression profile change in obese rats Howaida Ibrahim Abd-Alla
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: To examine the impact of Morus rubra and Morus alba extracts on physiological and metabolic functions of obese male rats induced by high fat diet. Methods: Orlistat was used as standard drug. Seventy Wistar male rats (weighing 150-160 g) were fed for 12 weeks with high fat diet to induce obesity. The obese rats were randomly assigned to three groups (10 rats each) and treated with Morus rubra and Morus alba extracts or orlistat for 6 consecutive weeks. The level of visfatin was measured by enzyme-linked-immunosorbent. The suppression impact of extracts against DNA adducts 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 2-deoxyguanosine (2-dG) generation was measured by high-performance liquid chromatography. Expression of genes including ATP- citrate-lyase, peroxisome-proliferator-activated receptor-γ and HMG CoA reductase in liver tissues were also measured by quantitative real time-polymerase chain reaction. Results: Treatment with the Morus rubra and Morus alba extracts and orlistat significantly decreased visfatin level. Morus rubra and Morus alba extracts significantly decreased the levels of mRNA expression of ATP-citrate-lyase, HMG CoA reductase genes, and peroxisome-proliferator-activated receptor-γ compared with high fat diet rats. In addition, Morus rubra and Morus alba extracts decreased the level of 8-OHdG/2-dG ratio. Conclusions: The ameliorating effect of Morus rubra and Morus alba extracts on visfatin levels  reducing fat may be attributed to the rich content of polyphenolic which suppresses lipid synthesis in liver tissues. Moreover, anti-DNA damage effect of Morus rubra and Morus alba extracts suggests their role as natural antioxidants against diseases such as obesity associated with genetic damage.
Obestatin (OB), Calprotectin (FCP) and (SIgA) in Patients Infected with Entamoeba Histolytica in Al-Najaf Governorate, Iraq Raja Jawad Mohamed Al-Saeedi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The study included the identification of changes in biomarkers to determine the effect of E. histolytica on the level of calabrotectin, obstobestatin and SIgA in patients parasites, 250 patients were collected from AL-Hakeem Hospital in Najaf from (May 2018) to (October 2018), The number of  patients with amoeba was 115(46%), 65(26%) males and 50 (20%). females and compared with a control group of 50 healthy subjects The results showed sig significant increase(p≤ 0.05) in the level of obestatin, calprotectin, SIgA control groub.
Genotype and Phenotype Detection of E. coli Isolated from Children Suffering from Urinary Tract Infection Zahraa Hameed Oda Alquraishi
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

One hundred clinical urine samples were obtained from patients suffering from UTI during the period from 1, August, 2017 to 9, October, 2017. Methodology: The identification of the E. coli isolates was depended on colonial morphology, microscopic examination and biochemical tests as a primary identification. The final identification was performed by PCR technique with Mdh. In addition antibiotic genes were used such as (bla-CTM, blatem-1, aac (6) - Ib-crandsul-1). Result: Rendering  to  the  results  obtained  according to the morphological ,cultural and biochemical characters from 100 sample  only   80 (80%) isolate was  identify as  E. coli. According  to  the  results  obtained  by  PCR, Mdh gene  that  encode  was found in 56 (70%) isolates in  E. coli. The results of PCR revealed that the percentage of bla-CTX-M gene among tested isolates reached to 30/56(53.57%), 10/56(17.85%)   for blaTEM-1, 13/56(23.2%) for aac (6’)-Ib –cr and 33/42 (78.57%) for Sul-1gene. Conclusion: The  study  investigated  the  antibiotic resistance genes  of  E. coli which  play a major  role  in pathogen city .Keywords: E. coli, Urinary tract infection and antibiotic resistance genes.

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