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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Latent Membrane Protein 1 Gene of Epstein - Barr virus: 30-Base-Pair Deletion in Indonesian Nasopharyngeal Carcinoma Patients Yurnadi Hanafi Midoen
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Introduction: Epstein Barr Virus (EBV), a member of the Herpesviridae family, is a dsDNA virus. Nasopharyngeal carcinoma (NPC) patients express EBV latent genes EBERs, EBNA1, LMP1, LMP2A, and LMP2B. The LMP1 gene, in particular, plays important roles in epithelial oncogenesis and B-lymphocyte transformation. Several epidemiological studies found a specific variant of LMP gene detectable as a 30-bpdeletion in NPC patients and it is still unclear whether this deletion is associated with NPC pathogenesis in Indonesian population. The aim of this research is to understand the existence of the deletion of the 30-bp LMP1 gene in Indonesian NPC patients and to determine the frequency of 30-bp deletion of LMP1 gene and its association with the pathological status. Methods: The 30-bp deletion in LMP1 gene was identified by nested PCR and subsequent electrophoresis in 2% agarose gel. The results were determined as 162-bp DNA band of the LMP1 gene (without 30-bp deletion) and 132-bp DNA band of the LMP1 gene (with 30-bp deletion). Results: Among 100 identified samples from Jakarta, 8 samples were found to have the 30-bp deletion, 71 samples did not have 30-bp deletion and 21 samples carried coexistence variants. Conclusion: In Indonesia, especially in Jakarta, EBV variant of 30-bp deletion of LMP1 gene was found at low frequency (8%) in comparison with variant without deletion (71%). There is a variant of LMP1 gene mixtures (21% coexistence with and without deletion). Analysis of data using Fisher's exact test shows that there is no significant relationship between 30-bp deletion of LMP1 gene and NPC pathological status (p> 0.05).Key words: 30-bp deletion, NPC, EBV, LMP1, Coexistence
Telemedicine Medical Image Compression based on ROI (A Case Study of Spine Medical Images) Abd Abrahim Mosslah
Journal of Global Pharma Technology .
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Abstract

In recent years, telemedical need arose, as a result of the increasing numbers of patients significantly, where using image compression is one of the most important techniques in the field processing research field, as well as in multiple applications such as medicine, reconnaissance, aerial surveillance, and space. Image compression necessary to reduce transport costs due to rising transport prices and distances In this method, we divide the original image into two separate sub-images called ROI and non-ROI. Region of interest (ROI) is the decisive area in a medical image, which is very important. This area may indicate a disease and must result in a right diagnosis. We use the spread spectrum-embedding algorithm to embed a binary mark into DCT transform of non-ROI part of an image.  In this search review the compression of the medical images and encoded and then decoder with no distort medical images was taken for sections of the spine for sick people.  Used in the field of telemedicine, Medical images encoded works with LSK through use WT (wavelet transform), During the user interaction (encryption) obtained of the ROI regions that lead us to get high compression ratio.The method used in this technology decompress on the block and like-minded countries on the basis of the value stored, note that the time of implementation of this method is low when compared with other methods.Keywords: Telemedicine, Medical Image Compressing, ROI, fractal image compression, LSK.
Control and Management of Distribution System Using MAS Mahdi Mozaffari Legha
Journal of Global Pharma Technology Volume 08 Issue 07
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Abstract

In this paper, application of MAS for the frequency & Voltage control of islanded Micro grid by Load shedding method is presented. Frequency & Voltage stability of micro grids under islanded operation attracts particular attention recently. The islanded micro grid makes its frequence & Voltage control more difficult than the conventional grids. On This strategy, agents sent data and furthermore each component has its own to center operating decisions (MGCC). The simulation results show the promising performance of the proposed structure of the controller based on multi agent systems. Keywords: Control and Management, Distribution System.
Knowledge, Awareness and Practices Regarding Dengue Fever among the Rural and Urban Populations of Salem District Mohamed Yasir Arafath
Journal of Global Pharma Technology Volume 11 Issue 03 (2019) March. 2019
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Abstract

Objective: The objectives of the study were to assess how many people have knowledge and level of awareness on dengue, to know about most prevalent preventive measure, to ascertain the source of information regarding dengue and to enquire about the diagnostic measures and treatment strategies used by affected individuals.Methods: A cross-sectional observational study was conducted on 1000 respondents in Rural and Urban areas of Salem district, Tamilnadu to evaluate the knowledge, awareness and practices regarding dengue fever.Results: The results showed that only 52% of the rural respondents and 96% of urban respondents were aware about dengue fever.53% of the rural respondents and 97% urban respondents identified the vector as mosquito. The overall knowledge of dengue specific symptoms was much lower, in rural as compared to urban areas. The knowledge about the preventive measures was inadequate among the rural respondents when compared to that of urban respondents. Majority of the rural respondents (30%) had no source of information about dengue fever. While among the urban respondents, 29% had information about dengue fever from T.V/radio.Conclusion: The overall knowledge, awareness and practices regarding dengue fever were found to be inadequate among the rural populations when compared to urban populations. There is a need to make rural people aware of different preventive practices and reduce this knowledge application gap.Keywords: Dengue Fever; Knowledge; Awareness; Practices; Rural; Urban
Evaluation of Enzymes Liver and Kidney Function in Serum People the Exposures at Risk of Chemicals Volatile in the Lab Pharmaceutical Samarra Methaq N. Mahmood
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Included the present examination procedure of making sense of the value, sum, or nature of something  of certain numbers that change identified with the synthetic substances in living things in the squandering almost no while working or delivering something of the functions of the liver represented by the enzymes ALT and AST and organ that creates urine represented by the creatinine and the Uric acidin blood of people workers in the public company for medicine Samarra from exposure at risk of materials chemical dangerous and unstable used in the making of medicine compared of people non-workers as a group control in the city of Samarra, a total of 60samples 30samples from workers in the public company for medicine Samarra from exposure at risk of materials chemical dangerous and unstable 30 control non-workers group their ages ranged from 30 to 45 years, and after the separation of serum managed and did/done tests (related to the chemicals in living things) own research. Results showed big increased(P˂0.05) at levels of the enzymes ALT and AST in the group exposure at risk of materials chemical dangerous and unstable as compared with the control group, As showedresults increased (a lot)( P˂0.05) at levels of the creatinine in the group exposure at risk of materials chemical dangerous and unstable as compared with the control group, Whereas the Uric acid had a big drop in group exposure at risk of materials chemical dangerous and unstable as compared with the control group.Keywords: Exposed volatile chemical, ALT, AST, Creatinine, Uric acid
Probiotics - A Review Kamala Kumari
Journal of Global Pharma Technology Volume 13 Issue 02 (2021) Feb. 2021
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Abstract

Probiotic bacteria are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. While this beneficial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefits by modulating immune functions. Scientists continue to work on elucidation of the mechanisms of the most common probiotic strains. The results that might arise from could be extremely important because the use of probiotics to maintain health must be considered promising, although much remains to be elucidated. The universal use of some strains seems less reasonable from an ecological point of view than selection of strains from their natural habitat were they are adapted to the ecological niche. It is important to understand that all probiotic strains are unique and different and their properties and characteristics should be well defined.
DFT Study for Characterization the Biological Activity of New Derivatives of Titanium (IV) Budotitane Complex Ahmed Abdul Sattar Ali
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The official use of organometallic complexes in chemotherapy dating back to 1969 when cis-platin "cis-diamminedichloroplatinum(II)" showed to have properties against tumors such as“ human testicular, ovarian, bladder, head and neck carcinomas” Titanium (IV) compounds are one of the promising alternatives and candidates drugs to anti-cancer treatments that have a wide spectrum of activity against tumors. These compounds are more effective and have less side effects than platinum compounds. In this work, we characterization the building and designing geometrical shape and crystal structure of six titanium complexes "titanium budotitane complexes (IV)" depending on the DFT "density functional theory" method survey of the title complexes were performed using the Gaussian 03 (2003) program. The study also include discuss "crystal structure information, Mulliken charges allocation, complex biological effectiveness, frontier molecular orbital energies (HOMO, LUMO) of the complexes, ionization energy (IE), hardness (η), electron affinity (EA), stability, and polarity" of titanium complexes with comparition. The results show that best one of the building complexes as anticancer activity is complex 5 (C5), then complex 6 (C6)are gave lower activity than (C5) and higher when compared with other complexes, while the other complexes (C2, C1, C3, C4) respectively gave lower activity than (C5,C6) complexesKeywords: Tumors; Budotitane; Titanium (IV) metallodrug; Titanocene; Density functional theory (DFT);(HOMO, LUMO) energies.
Effectiveness of Impulse Control Training in Self-Efficacy of High School Students Shahrbanoo Ghahari
Journal of Global Pharma Technology .
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Abstract

Introduction and Objective impulsive behaviors are dysfunctional behaviors that harm others; hence, it is essential to teach some methods to control impulses. In this regard, this study was conducted to examine effectiveness of impulse control training on self-efficacy among high school students. Materials and Methods this is an experimental with pretest-posttest plan. Statistical population of study consisted of all students educating at first grade of high school in Roodsar, Iran; in this regard, 60 students that were not able to control impulse were selected as sample size form several schools through purposeful method then were assigned into two 30-members groups (control and experimental). Then, Sherer Self-efficacy Questionnaire was distributed among members in both groups within pretest then experimental groups received the protocol of impulse control training and control group remained in waiting list; ultimately, self-efficacy questionnaire was again distributed among members in both groups to examine effect of impulse control training protocol as posttest. The obtained data were analyzed using ANCOVA through SPSS22 Software. Findings the obtained results showed that impulses control training could affect self-efficacy of students (P<0.005). Conclusion it is concluded in accordance with obtained findings that impulse control training can increases self-efficacy among students.Keywords: Impulse Control, Self-Efficacy, High School Students.
Organ Index, Toxicological, and Bioaccumulation Study of Sub chronic Intraperitoneal Injected Silver Nanoparticles in Albino Mice Males Sarab Mohammed M. Razooki
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

To investigate the sub chronic toxicity effects of intraperitoneal injected silver nanoparticles (Ag NPs) (24.52 nm), Albino mice males repeatedly exposed to three different doses (12.5, 25, and 50 mg/kg) of Ag NPs for 4 weeks. The accumulations of injected doses in different organs were evaluated. The results showed a significant changes in organs indexes with a good relations to the histopathological effects were noted which ranges between infiltration of inflammatory cells to coagulative necrosis in liver, multiple hemorrhage and cast forming in kidney, and amyloid deposition in spleen, thickening of intestinal villi, and sever interstitial broncho pneumonia as adverse effects in studied organs with dose related manner. Significant changes in hematological and biochemical parameters were detected combined with a considerable increasing in antioxidant enzymes in a dose dependent manner.   The reduction in thyroid hormones levels T3, T4, and thyroid stimulating hormone (TSH). The  highest accumulated Ag means values were recorded in liver, spleen, lung, and kidney respectively followed by brain, heart, small intestine, and testes in the order  with dose depended manner which express the toxicological effects were recorded.Keywords: Ag NPs, Accumulation, Organ index, Biochemical parameters, Histopathology.
Three Novel Transition Metal with Ethylenediamine Complex Template Polyborates [Pt(en)3]4 [B5O6 (OH)4] Cl15, [Rh(en)3][B5O6 (OH)4]3∙ 10H2O, and [Zn(en)3] [B6O7 (OH) 6]· 2H2O have been Synthesized and Characterized by Elemental Analysis, FT-IR, H, 13C, 11B - NMR, TGA-DSC, Powder X-ray Diffraction and Magnetic Properties Mohammed A. Altahan
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Three new polyborate compounds [Pt(en)3]4[B5O6(OH)4]Cl15(1), [Rh(en)3][B5O6(OH)4]3∙10H2O(2), and [Zn(en)3][B6O7(OH)6]·2H2O (3)have been prepared. The new compounds have been identified by elemental analysis, FT-IR, H, 13C, 11B - NMR, TGA-DSC, powder X-ray diffraction and magnetic properties. The three new compounds are consisting of transition metals (platinum (IV), rhodium (III), and zinc (II)) cations, polyborate ([B5O6 (OH)4]-and [B6O7(OH)6]2-) anions, and lattice water molecules.Keywords: polyborate, zinc (II), platinum (IV), rhodium (III).

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