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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Genotyping of Human Cytomegalo Virus Envelop Glycoprotein B in Iraqi Immunocopromised and immunosupresser Patients Raghad Harbi Mahdi Al-Azzawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Envelope glycoprotein B is a surface protein of CMV which plays an important role in the pathogenesis of the virus, polymorphism in the gB gene may interfere with transmission of infection. This study was aimed to investigate the HCMV glycoprotein B genotypes in immunosupressed and immunocompromised Iraqi patients. A total of 362 Iraqi patients were collected from immunosupressed (pregnant women and infants) and immunocompromised (renal transplant and malignancies patients) that have been tested for the presence of acute infection of HCMV, during the period from November 2014 to February 2015. While another 20 individuals with negative serum IgM/IgG were included as negative control. The blood samples were positive for CMV-IgM and both IgM /IgG by ELISA and ELFA were found to be present in 85 (23.48 %) out of 362 blood samples. Five PCR confirmed isolates were chosen randomly for DNA sequences and similarity. Searches were carried out with the Basic Local Alignment Search Tool (BLAST) in National Center of Biotechnology Information (NCBI). The data showed that the glycoprotein B type 2 was the most common genotypes among the studied immunocoprimised and immunosupressed Iraqi patients. The nucleotide sequences of the glycoprotein B UL55 region from HCMV in this study have been deposited in the Gen Bank sequence database of HCMV under the following accession numbers: M17209.1, KP745721.1 and X17403.1.
The Effect of Nimodipine towards Calcium Ion (Ca2+) Expression in SH-SY5Y Neuron Cell Culture Exposed By Chronic Hyperglycaemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Diabetic neuropathy is a complication of diabetes mellitus which forms clinical or subclinical that affecting the peripheral nervous system. In diabetes condition, changes in calcium ion signalling contribute to the development of distal symmetrical sensorimotor polyneuropathy (DSN) and pain. Increasing of cytosolic calcium involved in neuron degenerative and cell apoptotic process. This study discusses the effect of nimodipine, an L-type calcium channel blocker, on calcium ions (Ca2+) in SH-SY5Y culture cell line exposed to chronic hyperglycemia. This study, using in vitro research model. Before measuring calcium ions (Ca2+), the study sample was divided into three groups with 6 days of glucose administration; 5 mM noromoglycemia, 25 mM hyperglycemia, and 50 mM hyperglycemia. Each group was given different treatment; without nimodipine, nimodipine 10 nM and nimodipine 100 nM for 30 minutes, then proceed to observe of Ca2+ concentration parameters by fluo-3 dye using confocal laser scanning microscopy (CLSM). The results showed that higher dose of glucose could increase the calcium ion significantly. The administration of nimodipine at 10 nM and 100 nM doses significantly reduced calcium ions in the 25 mM and 50 mM glucose groups. In the 5 mM glucose group with administration of 10 nM and 100 nM nimodipine, Ca2+ has shown increased. The conclusion of this study is the administration of nimodipine could decrease calcium ions in SH-SY5Y cells exposed to chronic hyperglycemia. Keyword: Nimodipine, Calcium Ion (Ca2+), Diabetic Neuropathy.
The Exploratory Orientations of the Brain and Correlated with the Performance of Some Tennis Skills for Students Rawaa Allawi Kadhim
Journal of Global Pharma Technology .
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Abstract

The exploratory orientation of the brain is an important self-motivation. The importance of this motivation is attributed to its obvious impact on the learning process because it enables learners to learn more about themselves, their abilities and their learning environment and to support them in persevering in the search for knowledge. The researchers noted the lack of interest by students motivated by the exploratory directions of the brain and the desire to keep pace with the wide changes in different areas of learning and knowledge and the relationship of that motivation results in their skilled performance, So deliberately researchers to study the trends of exploratory brain students and its relationship to the results of the performance of some skills in the game of tennis. The aim of the research was to identify the exploratory orientations of the brain and the technical performance of the sample of the students of the third stage of the morning study in the Faculty of Physical Education and Sports Sciences at Babylon University for the academic year 2016-2017. The researchers used the descriptive approach in their methods of surveying and correlative studies to suit the nature of the problem. The research community identified the students of the third stage of the morning study in the Faculty of Physical Education and Sports Sciences at Babel University for the academic year 2016-2017 (96), while the sample size (50) (52,083) were randomly selected by lottery. To achieve the objectives of the research, the researchers used the measure of the exploratory directions of the brain designed by the researcher (Maha Hadi Hussein) and the equivalent of (30) paragraphs, as well as the use of technical performance tests for tennis skills covered by the research and concluded the following: There is a significant correlation between the exploratory attitudes of the brain in the research sample of the students and their performance of some of the technical skills in the game of tennis.Keywords: Exploratory orientations, Brain and tennis skills.
Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
Journal of Global Pharma Technology .
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Abstract

Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol  extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.
Child Protection and Development of Child Abuse Pediatrics Hamdiyah Abdul Ameer, Kadhim Al-Dahhan
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

The history about teenagers reflects toddler misbehavior the development on medication as much a walk of life is influenced through social actions up to expectation engage together with poverty, economic exploitation, or infant abuse. When docs began in imitation of specialize between childcare, bold cases born in accordance with the awareness to that amount youth have been affected via special scientific issues and ailments so had been angry through bad conditions, abuse, yet neglect. They hold promoted pediatric pedophilia or toddler misbehavior in accordance with advocate because their needs in courts and communities. Using the records of medical practitioner then distinguished cases, the objectives about this treatise are: (1) in imitation of re-discover the establishment concerning pediatrics of the surroundings as served as much an instruction for its development; (2) in imitation of highlight our promptly appreciation concerning medical issues encirclement child abuse, Increasing the medical ponder able regarding children; yet (3) exploring the development on pediatric misuse between the mild of outstanding medical doctors perform large contributions in accordance with baby protection. The schedules exhibit shortly interplay between communal problems, reported cases, personal or government agencies, and the improvement concerning pediatrics. The essay concludes with feasible training according to stay discovered then greater questions as regards it interaction of toddler safety structures and toddler improvement.Keywords: Child Abuse and Neglect, Child Protection, Abuse Pediatrics
The Role of Cowmilk’s Colostrum as the Source of Passive Immunity and Growth Factor for Improving the Haematological Status and Titre of Antibody against Hog Cholera in Pre-Weaning Piglets Ida Bagus Komang Ardana
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: pre-weaning piglets often suffer from anemia, and infected with the bacteria so as growth slows even death. Aim: The purpose of this study was to determine the effect of cow colostrum administration on hematology profile and anti-body titers as an immunomodulatory effect to prevent germ infection. Methods: Seventy two piglets were divided in 4 groups in this research. Group who were not given bovine colostrum as a control, group who were given cow colostrum dose of 3 ml per animal, groups of piglet given bovine colostrum dose of 6 ml per animal, and a group of bovine colostrum piglet given a dose of 9 ml per animal. At the age of 7 days vaccinated against Hog Cholera and repeated at 14 days. Besides, at the period of 20 days all the piglets to have blood drawn and then accommodated in a vacuum tube which already contains anticoagulant (EDTA) for examination hematological profile is checked with Automated Manual VET ABC Blood Counter, made in Germany. Finally at the age of 30 days all piglet blood drawn and then accommodated in the tube for examination Hog Cholera antibody titer by ELISA. The data were analyzed with statistical test. Result: The results showed bovine colostrum supplementation at a dose of 1-5 days of age piglet 3-9 ml/piglet can raise the profile hematology and Hog cholera antibody titer. Conclusion: Addition of cowmilk’s colostrum in pre-weaning for the first five days of life could improve both the hematological profile and immunomodulatory set.Keywords: Piglet, Bovine colostrum, Hematology.
Production of Gooseberry (Phyllanthus Acidus) Jam Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Gooseberry (Phyllanthus  acidus) tree has been widely cultivated in Mekong region (Vietnam). The fruits of the plant have been used as an astringent. This fruit is eaten fresh, fruit juice, candied in sugar or pickled in salt. The potential for gooseberry extract as a food ingredient is increasing substantially, owing to the growing global nutraceuticals and functional food market. In order to improve its value by keeping for a stable duration,  we examined different technical factors such as a mixture of components (sugar 45%, 50%, 55%; carrageen an 5%, 10%, 15% and fruit juice 10%, 12% 4%); the effect of temperature (60oC, 70oC, 80oC) and time (3, 5, 7 minutes) in concentration (boiling), preservatives (potassium sorbate 0.05%, 0.1% and sodium benzoate 0.05%, 0.1%) affecting to production and preservation of gooseberry jam. Our results showed that with an optimal mixture of sugar 50%, carrageenan 10%, and fruit juice 12% concentrated at 70oC in 5 minutes we got a pleasant taste, bright color and elastic texture. With an addition of sodium benzoate 0.1%, we realized the gooseberry jam could be maintained until 60 days.Keywords: Gooseberry, Jam, Carrageenan, Concentration, Preservative, Sodium benzoate.
Synthesis and Characterization of Some Heterocyclic Compounds from Chalcone Derivatives and Studying of their Biological Activity Lina Saadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

In this work a preliminary step was preparation of 1-(3-((1H-imidazol-2-yl)diazenyl)phenyl)ethan-1-one (1) via coupling of diazonium salt of m-amino acetophenone with imidazole in alkaline alcoholic media which is followed to condensation with different aromatic aldehydes (p-tolualdehyde ,4-dimethyl amino benzaldehyde ) by aldol condensation in the presence of base in ethanol to give chalcones derivatives (2,3), that consider as excellent starting material for synthesis of many heterocyclic derivatives through its reaction with (hydrazine ,phenyl hydrazine ,2,4 dinitrophenyl hydrazine) to get pyrazol derivatives (4-9), likewise (2,3) react with hydroxylamine hydrochloride to get isoxazole (10,11), also (2,3) react with (urea, tiourea) to get oxazine and thiazine derivatives (12-15) , as well (2,3) react with (ethyl cyanoacetate, malononitrile) to get pyridine derivatives (16-19) ,too (2,3) react with guanidine hydrochloride to get pyrimidine derivatives (20,21). All these compounds characterized by means of FT- IR, 1H-NMR, and 13C-NMR, and follow reaction by Rf- TLC and measurements melting points. After that we studied the biological activity for all prepared compounds to ward two types of bacteria.Keywords: Azo, Chalcone, Pyrazole, Isoxzazole , Oxazine, Thiazine,  Pyridine , Pyrimidine, Biological activity.
Characterization of Silver Nano Particles Synthesized by Leaves Green Tea Extract Neeran Obied Jasim
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Background and Objective: Plant extract contain biomolecules which can be a reduce metal, ions, to nanoparticles in one step n synthesis process.. Materials and Methods: green synthesis of silver nanoparticles using aqueous leaves extract of green tea and study the characters of this particles using UV -VIS spectrophotometer and SEM .Also, Investigation the antifungal activity of it. Results : silver nanoparticles were synthesized using leaf extract of green tea in present of silver nitrate and the color change to brown .UV-Vis spectrophotometer appear peak in wavelength at 420nm which is prescribed for silver nanoparticles . the microscope images by SEM, showing the size of Ag nanoparticles in range 3.6-5.3nm.Antifungal activity explain the ability of biosynthesis silver nanoparticles to inhibition the growth of yeast, C. neoformans with zone of inhibition 2.7mm compare with leaves extract in diameter 7mm.Conclusion: An extract of leaves green tea at room temperature act as reducing agent and can be used in synthesis of silver nanoparticles which have antifungal activity.Keywords: Green synthesis, Nanoparticles, Silver nanoparticles, C. neoformans.
Bentonite as an Adsorption Surface for Bromothymol Blue Dye from Aqueous Solution Kawther Ahmed Sadiq
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Accomplishment of Adsorption of dye from aqueous solution on the surface of bentonite was done under the following optimized conditions: temperature, initial concentration, contact time and weight surface. Via utilizing the technique of UV-Vis spectophotometry at (λmax= 432 nm) the quantitative estimation of the dye adsorption has been performed. this study has demonstrated that the more increasing of  adsorption with the more increasing of temperature from 25 ˚C to 45 ˚C also increasing of clay weight (0.1-1.1 g).calculating thermodynamic parameters like change in the free energy (∆G), the enthalpy (∆H), the entropy (∆S). Results of adsorption isotherms obtained in this study were inconsitence with fitted with Freund lich adsorption isotherm.Keywords: Adsorption, Bentonite, Bromothymol blue.

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