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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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New Mixed Ligand Complexes; Synthesis, Spectral Analysis and Biological Activity Enaam Ismail Yousif
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The formation, structural characterization of mixed ligand complexes of Co II, Zn II, Cd II and Hg II metal ions with the Schiff base ligand (Z)-3,4,5-trihydroxy-N'-(4-hydroxybenzylidene) benzohydrazide and 8-hydroxyquinolineare reported. Ligand and complexes were characterized by analytical and spectroscopic analyses including; FTIR, electronic and 1H, 13C-NMR spectroscopy, microanalysis, chloride content, thermal analysis, magnetic susceptibility and conductance. Physico-chemical techniques indicated the formation of complexes with four-coordinated arrangement in the solid and solution state. Biological activity of the prepared ligand and their mixed complexes were screened for their antimicrobial activity against four bacterial species (Staphylococcus aureus and Bacillus subtitles (G+)), Enterobacter and Escherichia coli (G-)). Biological data showed that complexes become potentially more active against these tested bacteria compared with the free ligandsKeywords: Mixed ligand complexes, Structural characterization, Spectral analysis, Biological activity.
The Effectivity of Clonidine Addition to Levobupivacaine 0.25% for Scalp Block in Patients Underwent Craniotomy Surgery Tjokorda Gde Agung Senapathi
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: The scalp nerve block technique is a relatively simple and safe technique. Clonidine is well-known as an agent that extends the analgesia effect of local anesthetic drugs. The goal of this study was to evaluate the effectiveness of clonidine addition as adjuvants in levobupivacaine 0.25% in scalp nerve block in craniotomy procedures. Patients and Methods: This was a clinical trial with a double-blind, randomized study using consecutive sampling technique. Inclusion criteria include patients underwent craniotomy surgery due to brain tumor using general anesthesia with endotracheal tube in 18-60 years of age. As an addition to general anesthesia, group a received levobupivacaine 0.25% and clonidine 2 µg/kg as a regiment for scalp block. Group B received levobupivacaine only for the same purpose. All other treatments were similar for both groups. Results: The intraoperative fentanyl requirement (100 (50-150) vs. 150 (75-200) mcg, p <0.001), the period to the postoperative first PCA dose (822.5±129.7 vs. 387.8±69.6 minutes, p <0.001), and the total need of postoperative morphine by PCA (2.0 (1.0-3.0) vs. 3.0 (2.0-7.0) mg, p <0.001) were lower in the clonidine-added levobupivacaine groups compared to levobupivacaine alone. 3 Conclusions: The addition of clonidine to levobupivacaine 0.25% on scalp block is effective in reducing the need for intraoperative and postoperative opioids, reducing postoperative pain, extending the duration of scalp nerve block, and delaying the first PCA dose.Keywords: Clonidine, Levobupivacaine, Fentanyl, Morphine, Pain, Requirements.
Study of Some Histological and Biochemical Changes in Patients with Celiac Disease Ilham Abd Allah Ali Al-Saleem
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Introduction: Celiac disease (CD), a common heritable chronic inflammatory condition in the small intestine caused by permanent intolerance to gluten/gliadin. Aim of object: to investigate the disorders associated CD. Materials and methods: The present study carried out on the 30 patient’s and25 individuals as control group had been clinically diagnosed as celiac who underwent endoscopic examinations due to gastrointestinal symptoms. Blood samples were collected from the groups for determination of serum transaminase enzyme. The patients underwent upper gastrointestinal endoscopy. Three biopsies were taken from the second portion of the duodenum, fixed in 10% formalin embedded in paraffin. Marsh scores used for the histological evaluation of the intestinal mucosa damage that have been suggested .Results: This study demonstrated that 25(45.5%) in the total of 30(54.5%) of patients with celiac disease at the age under than 12 years old associated with Glutamic- pyruvic transaminase higher level. This study also demonstrated that 22(40.0%) from a total 27 of patients with celiac disease are associated with Glutamic- Oxaloacetic Transaminase higher level are under 12 years. From our results we found that 8(14.5%)of a type 3a and18(32.7%) of a type 3b,when we retain to the marsh classification .In the sections of duodenal mucosa in study group. we show increase intra epithelial lymphocytes and also the sections revealed crypt hyperplasia, focal partial villous atrophy and subtotal villous atrophy .Conclusions: this study demonstrated that there is a positive relationship between CD and hypertansaminase and the majority of them are of type3 of marsh classification.  Key words:  Biopsy-celiac disease scores- crypt hyperplasia- hypertransaminase- intraepithelial lymphocyte- mucosa damage- villous atrophy.
Environmental Analysis for Spreading Areas of Scleroderma Disease in Babylon Governorate Muthik A. Guda
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aimed of this study is to estimate Scleroderma infections in Babylon Governorate (2016). Locations and number of infected people were detected. The number of infected people reached 17. Those patients were admitted in the government hospitals. A statistical questionnaire was prepared for this study which includes patient's name, gender, age, occupation, address, date of admission to the hospital, date of discharge, and patient's condition. The results of this study found that female' infections were more than males. Scleroderma disease complications caused a change inside immune system, fibrosis, and damage in small blood vessels. It was also found that most of the infections are in Hilla district and less concentrated in the Kefel area. This may be correlated to the population density, lack of health awareness; municipal services, poor infrastructure as well as industrial activities were mostly concentrated inside the city. Further studies related geospatial and environmental variables could help our findings to detect a wide range of patients and related that with site variables.Keywords: Environmental Pollution, Hilla City, Air Pollution, Scleroderma Disease.
The Effect of Nimodipine on Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Activation in Neuron Cell Line SH-SY5Y Culture Exposed By Chronic Hyperglycemia Shahdevi NK
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Diabetes is a dysregulation of glucose metabolism due to defects in insulin secretion, decreased insulin sensitivity, or a combination of both that causes hyperglycemia. Diabetic neuropathy is induced by oxidative stress that results from excessive ROS production. When oxidative stress increases, it triggers a transcriptional response of antioxidant genes mediated by Nrf2. Based on the above mechanism, the researchers tried to use nimodipine as a calcium channel blocker which is neuroprotective to reduce Nrf2 activation. Objectives: This study aims to look at the effect of nimodipine on decreasing Nrf2 activation. Methods: This research was conducted in vitro using SH-SY5Y neuron cell culture induced hyperglycemia for 6 days with glucose concentrations of 5 mM, 25 mM, and 50 mM. Then the cell is harvested and given nimodipine for 30 minutes at a dose of 10 nM and 100 nM. Nrf2 expression was observed under a confocal microscope. Results: The results of nimodipine at doses of 10 nM and 100 nM were able to reduce the activation of Nrf2 in neuron cell culture that had been significantly induced by chronic hyperglycemia (p <0.05) at 50 mM glucose concentration. Conclusion: It can be concluded that the administration of nimodipine doses of 10 nM and 100 nM can reduce Nrf2 activation in neuron cell cultures exposed to chronic hyperglycemia with glucose concentrations of 50 Mm.Keyword: Hyperglycemia, SH-SY5Y Cell, Nimodipine, Nrf2.
Impact of TGF B1 level and single nucleotide polymorphism in gall bladder inflammation Abdalnabi J. Abid
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The current study was conducted to investigate the association of TGF B1levels in serum and polymorphism in cholecystitis patients. The study include 100 blood samples collected from patient undergoing cholecystectomy at the general teaching Hilla Hospital from September 2016 to June 2017. Tgf-B1 concentration pointed significantly increase in the patients compared  with control group with mean value (82. 2pg/ml) for chronic cholecystitis patient  and (46.1pg/ml) for acute cholecystitis patient with   high significant  differences  between patient  and control. p=0.007. The results revealed increased level of TGF-B1 concentration in patient had cholesterol stone with value (65.33  pg/ml) followed pigment stone(60.11pg/ml) and mixed stone(27.62 pg/ml). Single nucleotide polymorphism of  TGF-B1 (-869 T/C showed high appearance of  TC heterozygous With (64) (75.2%)  than others genotypes ,  TT  and CC homozygous and  with (13)( 15%) (8)(9.4%) respectively .there is no significant differences in alleles frequency with severity of disease  while the genotype association of TGF-B1 appeared significant differences ( p=0.04, OR=4.56)  for acute infection in over dominate model compare with chronic ,cholesterol, pigmented and mixed stone patients  shows high appearance of  TC heterozygous  than other genotypes. Keywords : gallbladder , Polymorphism ,SNPs, TGF B1, Gallstone     
Spectrophotometry UV-Vis Technique Combined with Chemometrics for Determination Phenylbutazone and Acetaminophen In Herbal Medicines Rollando Rollando
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Objective: Indonesia is known with its natural resources, one of them is abundant herbs. The herbs are basic ingredients of herbal medicine which is called jamu. Jamu started to develop since hundred years ago and passed through generation which is trusted to cure many diseases without giving any side effect. Lately, there are many cases of combining jamu with some chemical substances. The most common chemical substances used in jamu are acetaminophen and phenylbutazone. Methods: This research develops method to detect acetaminophen and phenylbutazone by using spektrofotometric UV-Vis which is combined with chemometrics. The most common chemometrics multivariate calibration used is Partial Least Square (PLS) and Principal Component Analysis (PCA). From this method, the data analysis used is R Studio software. This research generates a regression equation. Results: Based on this research, the regression equation indicates that the result is significance which can be seen from the value of P < 0.05. Besides that, the value of correlation coefficient of acetaminophen as 0.9889, and phenylbutazone as 0,9728. Conclusion:  This method can be considered as qualified and meet the requirement.
Synthesis and Characterization of New (2-(((5-(3, 5-Dinitrophenyl)-1, 3, 4-Thiadiazol-2-yl-2,5 Dihydroxy Benzalidine))) Metal Complexes Ali T. Bader
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

New  complexes  compounds of some metal ions such as [VO(IV)), Co(II) Ni(II),Cu(II),Zn(II) and Cd(II)] are synthesized with  ( 2-(((5-(3, 5-dinitrophenyl)-1, 3, 4-thiadiazol-2-yl-2,5dihydroxy benzalidine. The ligand Schiff base was synthesized by condensation of 2-amino -5-(3,5dinitro phenyl )1,3,4-thiadiazole with 2,5dihydroxy benzaldehyde .The suggested structures of new complexes are characterized by elemental micro analysis (C.H.N), FT-IR, UV-Vis spectra, Thermal gravimetric analysis (TGA-DTA), flame atomic absorption, molar conductivity, magnetic susceptibility and Mass Spectra.  The suggested theses complexes according to the results data the probable coordination geometries are octahedral complexes   excepted C1 was pyramidal. The all complexes were found to be non-electrolyte.Keywords: 1, 3, 4-thiadiazole, Schiff base and metal ions
Taxonomic Study of the Genus Phlomis L. (Lamiaceae) in Iraq Based on Trichome and Palynological Characters Shaemaa Muhi Hasson
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The current investigationincluded a comparative morphological study of the pollen grains of some Phlomis L species distributed in Iraq, as well as study of the Indumentum for species. The pollen grains and trichomes were examined under light and scanning electron microscope. The results showed that there is a limited variability in the characteristics of the pollen grains of the studied species, where the pollen grains were 3-zonocolpate, prolate-subprolate in the shape and the pattern of sculpture (ornamentation) grain surface was reticulate in all species under study, However, the present study showed variability in the dimensions of the pollen grains within the polar and equatorial view. There was also a contrast in indumentum characteristics, and each of these characteristics had a good taxonomic significance to distinguish between the species under study. The results of the current study were found to be taxonomic support to the morphological evidence. Keywords: Pollen grain, Phlomis, Lamiaceae, Indumentums.
Larvicidal Effect of Pure and Green-Synthesized Silver Nanoparticles against Tribolium castaneum (Herb.) and Callosobruchus maculatus (Fab.) Fatima S. Jafer
Journal of Global Pharma Technology .
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Silver nanoparticles seem to be an excellent alternative option to control insect’s pests due to their unique characteristics. In addition, the plant mediated synthesized silver nanoparticles have important applications in the field of biology, agriculture and environmental due to their safety. The present work aims to study the activity of pure and green-synthesized silver nanoparticles (Ag NP’s) against Tribolium castaneum and Callosobruchus maculatus. The biosynthesized Ag NP’s by N. olrander were characterized by UV-visible spectra, X-ray Diffraction (XRD), Energy dispersive spectroscopy (EDS) and Scanning electron microscope (SEM). Larvae of T.castaneum and C. maculates were exposed to different concentrations of pure and green-synthesized silver nanoparticles and Nerium oleander leaf extract (500, 1000, 1500 and 2000 ppm). Although the Larvicidal effect of pure silver nanoparticles against larvae of T. castaneum (mainly first larval instar with LC50 value 2.019) and C. maculates (with LC50 value 3.366) , the green-synthesized silver nanoparticles have more larvicidal effect. while Nerium extract have a less effect on all larval instars of T.castaneum (LC50 value against first instar 3.853) and larvae of C. maculates (LC50 value 4.332),  The green-synthesized silver nanoparticles have more Larvicidal effect than pure silver nanoparticles and N. oleander leaf extract.Keywords: Callosobruchus maculatus, Tribolium castaneum, silver nanoparticles, and Nerium oleander.

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