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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effectiveness of Edible Coating, Preservation Temperature and Packaging to the Rancidity and Proteolytic Activity in Dried Mudskipper (Pseudapocryptes Elongatus) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Mudskipper (Pseudapocryptes elongatus) has become a high value species in the markets of Mekong Delta, Viet Nam. Mudskipper aquaculture has potential for coastal aquaculture development and is an alternative to shrimp farming in the Mekong Delta. In terms of nutritional quality of fish, sometimes dry fish have higher quality standards compared to fresh fish. P. elongatus aquaculture has developed rapidly to supply the high demand of domestic consumers. Consumption of dried mudskippers fishes has increased during recent years as consumers have become more aware of its nutritional benefits and of the health concerns associated with other meat products. However the dry-salted mudskippers are not stable at normal preservation by rancidity and proteolytic activity because they have too much oil as well as protease enzyme in their abdomen. Edible coating provide a replacement and fortification of the natural layers at the product surfaces to prevent moisture losses, gas aromas and solute movements out of the food, while selectively allowing for controlled exchange of important gases. Biodegradability, barrier properties, biocompatibility, and edibility as well as being nontoxic and non-polluting are a few advantages of edible films and coatings over plastic packages. Preservation temperature and packaging method also influenced to rancidity and proteolytic activity in the dried mudskippers (Pseudapocryptes elongatus). Objective of the current research studied the feasibility of sodium alginate coating in preservation of dried mudskipper (Pseudapocryptes elongatus). The dried mudskippers were treated by different concentration of sodium alginate (1.0%, 1.5%, 2.0%, 2.5%, 3. 0%). The effectiveness of sodium alginate coating was based on quality changes of dried mudskippers such as lipid oxidation: Peroxide value (mEqO2/ kg), Thiobarbituric acid (mg maloaldehyde/ kg); proteolytic changes: total volatile base (TVB-N, mg N/100 g) nitrogen content and trimethylamine (TMA, mg N/100 g). All treated samples were monitored during 12 months of storage at ambient temperature in 3 months of interval sampling. Results revealed that the coating of 2.5% w/w sodium alginate, 4oC in vaccum bag could control microbial spoilage and lipid oxidation of the dried mudskippers. By this approach, the dried mudskippers (Pseudapocryptes elongatus) are stable at normal environment for 12 months. The study indicated that the edible coating could be commercially utilized to prolong the shelf‐life of this oil fish. The improvement in the quality of the seafood products is achieved through inhibition of proteolytic reaction, reduction of lipid oxidation reduction and enhancement of sensorial attributes. Keywords: Pseudapocryptes elongatus, Sodium alginate, Proteolytic reaction, Lipid oxidation, Shelf-Life.
Immunomodulator Activity and Antirheumatoid Arthritis Extract of Ethyl Acetate Ginseng Bugis Talinum Paniculatum (jacq.) Gaertn) Andi Emelda
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The Immunomodulator is one of the compounds that can improve immune system. Chemical compounds work through the immune system to prevent and treat disease. Rheumatoid arthritis is an autoimmune disease that is chronic-systemic inflammation. The purpose of this study was to determine the effects of imonomodulator and antirheumatoid arthritis of ethyl acetate extracts of ginseng bugis leaves (Talinum Paniculatum (Jacq.) Gaertn). This study was divided into 2 groups, namely the immunomodulatory testing using sheep red blood cells and CFA-induced antirhematoid. This study used wistar rats which divided into 6 groups for immunomodulatory activity and 5 groups for antirematoid arthritis. The dose of ethyl acetate extract used was 0.05 g/KgBW; 0.1 g/KgBW, and 0.15 g/KgBW. Statistical test results for immunomodulatory activity showed significantly different results between the extract group doses of 0.05 g/KgBW; 0.1 g/KgBW, and 0.15 g/KgBW (p <0.05) with a negative control group. Rheumatoid arthritis testing showed (p <0.05) to the foot volume and arthritis index. The results showed that ethyl acetate extract of ginseng bugis leaves have immunomodulatory and antirheumatoid arthritis activity.Keywords: Immunomodulator, Anti Rheumatoid arthritis, Ethyl acetate, Talinum Paniculatum (Jacq.) Gaertn.
Synthesis of New Organic Compounds Via Three Components Reaction with Studying of (Identification ,Thermal Behavior, Bioactivity on Bacteria of Teeth) Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

All  compounds  in  this  work  prepared  via  mannich   reaction   through  various  starting  materials  like  (  furan , thiophene ,  benzothiazole  derivatives  )  with   functional  groups  in   terminals  of  compounds  like ( hydroxyl  group , carboxyl  group ) ., our  method  involved  reaction  between  diamine  compounds   with  aromatic  aldehyde. then  identification  of  synthesized compounds  via  identification  techniques  ( FT.IR , H.NMR , Mass ) – spectrophotometric , studying  of  thermal   behavior   , studying  of  bioactivity  behavior  for  our  compounds  toward  types   of  bacteria  ( bacteria  of  Mouth like  ( Streptococcus  Mutans   ,   Streptococcus  Salivarius ) . Keywords: three components, bacteria, activity.
Constant Attention and its Correlation with Case Anxiety for Students of the Faculty of Physical Education and Sports Sciences Jameel Hamid Kadhim
Journal of Global Pharma Technology .
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Abstract

Students' responses to rapid and changing situations need to be swift, predictable, well-behaved, and control over different attitudes in the course of a lesson, based mainly on higher mental processes (such as attention, perception, perception, thinking and sense). The objective of the search is to learn about the correlation between the constant attention and the anxiety of the case for the students of the Faculty of Physical Education and Sports Sciences for the academic year 2017-2018. The researchers use the descriptive method in the relational relationships to fit and the nature of the search procedures. the research community is the fourth-stage students at the Faculty of Physical Education and Sports Sciences/University of Babylon, of which there are 120 students, while the research sample was the fourth phase students of the (60) divisions (C,D), who were randomly selected from the research community. Through the collection of data and the results obtained, researchers have reached the following conclusions:Students owning a moderate level of attention and anxiety caseHaving a significant correlation between the anxiety of the case and the attention of the research sample.Keywords: Constant attention, Case anxiety and Sports Sciences.
Comparison of the Training Skills of the Handball Trainers for the First and Second Classes in Iraq Ahmed Kadhim Abdulkareem
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The research consisted of two axes: the level of communication skills and their comparison among the handball trainers for the category of applicants in Iraq. The training communication skills standard was developed and the descriptive method was used in a comparative manner to suit the nature of the research. The research sample included (20) trainers, and the comparisons between training skills were obtained using statistical means.Keywords: Training skills and handball trainers.
Walking Analysis Using the Angles around the Midpoint between Print Length and Toe Spread by Four Different Color Footprints and SFI in Sciatic Nerve-Injured Rat Model Treated With Curcumin Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

SFI, the sciatic function index, has been applied as an evaluation method in walking analysis over a long period. It is a method that addresses the functionality of nerves using footprints during walking analysis. Other techniques developed previously make use of one-color ink. The method has difficulties in interpretation due to footprints mingled among the mice specimen's four legs. There exists a possibility of the rats not walking straight, and this leads to overlapping, and the result is complicated measurements. SFI, as a method, entails the application of a mathematical formula that is special. Researchers have questioned this method since it is affected by muscles' contraction, automatic mutilation, and rat motion speed. During this study, the idea is to use four different colors, allowing easier and faster interpretation of the footprints results. Moreover, the study will also modify tools based on the already existing available tools in pre-existing literature. The modified tool gives a measurement of print leg denoted as PL, toe spread TS, and inter- toe spread IT’S, all belonging to the SFI component. The tool's validity and reliability are essential when applied in the measurement of components used in the functional analysis of nerves. Confirmation from the study is that results from SFI and TOA (toe out of angle) all describe footprint. Toe out of angle is an essential measurement in the walking analysis as it has an impact on the alteration of abduction-adduction as well as the internal-external navigation of the hind legs. The study will help develop a method that assesses nerves' functional analysis using the sciatic functional analysis and total out of angle spread. The angle at the intersection point of the print length and the toe spread. Keywords: SFI, TOA and ITS.
Purification and Characterization of Laccase Extracted from Cladophora sp. and Its Role in Decolonization of Dyes Bahjat Fakhri Mahmood
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The Laccase enzyme belongs to the oxidoreductases containing copper atoms, and it has an ability to oxidize a wide range of phenolic compounds. Laccase was extracted from local green algae Cladophora sp. and partially purified using 80% ammonium sulfate and ion exchange chromatography. The specific activity of Laccase in precipitation step was 11583.1 unit /mg protein, and was 33733.5 unit /mg protein after the washing step of ion exchange chromatography technique using DEAE- cellulose ion exchanger. The optimal pH of the partially purified enzyme was 5.5 and for the stability was 6.0 . The optimal temperature of the activity was 35 °C and the enzyme remained at full activity at temperatures ranging from 25-45 °C. The enzyme also had a large tendency towards the Orthotolidine compared to the other reaction materials (Catechol, Guaiacol and Para ansidine). It was observed that the activity significantly reduced when the partially purified enzyme was incubated with substrates of reaction (EDTA, L-Cysteine and 2- Merecaptoethanol) at concentrations of 5mM and 10mM separately. While, the enzyme was still active after the incubation with SDS solution. The enzyme activity increased in the case of incubation of the partially purified enzyme with solutions containing ions of Cu, Fe and Zn at concentrations of 5mM and 10mM individually. The enzyme has retained its activity with ions of Na and Ca, while the enzyme inhibited with ions of Ag, Hg and Mn. The partially purified enzyme has a suitable ability to decolorize four types of textile dyes compared with the crude enzyme, especially the black dye. The percentage of decolorization of the black dye was 91.6% after incubation of the partially purified enzyme for 28 hours at 35 °C.Keywords: Oxidoreductases, Algae, Orthotolidine, Temperature, PH.
Red Piper Crocatum Leaves Extract Ethanol Lowering Malondialdehyde (MDA) and Blood Glucose Level In Hyperglycemic Wistar Rat Sri Wahjuni; I Made Sukadana; dan Luh Putu Arisanti
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Changes in fast-food behavior became one cause of diabetes. Potential of the red betel leaf (Piper crocatum) can lower blood sugar levels allegedly because it contains antioxidant-potent compounds inductively induce certain organs to produce insulin hormones that play a role in lowering glucose levels in the blood.The aim of the study is to determine the effectiveness of Piper crocatum leaf ethanol extract in fixing the pancreas β-cell damage rate in alloxan induced hyperglycemic Wistar Rat. Methods: This study used randomized pre-and posttest control group design. Twenty-four (24) male Wistar rats divided into 6 groups namely P0 positive control (P0), P1 as a negative control (allowance 125 mg Kg -1BW), P2 (alloxan and extract dose 50 mgKg-1 BW), P3 (alloxan and extract dose 100 mg Kg -1 BW), P4 (alloxan and extract dose 150 mg Kg - 1 BW), P5 (alloxan and glibenclamide 0.18 mg/day 200g -1BW). Blood glucose measurement was taken through a vein tail performed by the glucose test method. Measurement of MDA levels, blood was taken from the jugular vein and analyzed by the TBARS method. The yield of Piper crocatum extraction with ethanol solvent was 13,1%.  The most significant results were shown by dosing of 150 mg Kg -1BW and extract of 50 mg Kg -1 BW gave a comparable effect to glibenclamide as a blood sugar-lowering drug. The results of phytochemical tests showed that Piper crocatum contains phenolic, alkaloid, and steroid. The results of GC-MS analysis of extracts active Piper crocatum were suspected to contain 29 compounds of 13 compounds known as phytol, neophytadiene, β-bisabolene, germacrene-D, α-humulene, sulfamethoxazole, caryophyllene, nandrolone phenylpropionate, thiamin, linalool, β-ocimene, Anthocyanin, and β-myrcene.Keyword: Red Piper crocatum leaf, Blood glucose, MDA (Malondialdehyde).
Isolation and Characterization of Alkaloids in Peganum Harmala. L Seeds and Detect their Antibacterial Activity against Multidrug-Resistant Acinetobacter Baumanii Bacteria Zainab J. Qasim
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Objectives: The recent emergence of multidrug resistance (MDR) in Acinetobacter baumannii (A. baumanii) has raised concern in health care settings in Iraq. Peganum harmala  Linn. (P. harmala) is a small genus of Zygophyllaceae family which widely grows widely in Iraq, Middle East, North Africa, Australia and America. One of the important features of P. harmala alkaloids is their bactericidal activity that is comparable with that of common antibiotics, which have many adverse effects. This study aimed to investigate the antimicrobial effect of methanol extract of P. harmala and its derived alkaloids like harmine and harmaline against A. baumanii. Also their synergism activity in combination with synthetic antibiotic was evaluated. In addition, the cytotoxicity of this extract in its derived active compound was evaluated on human lymphocyte. Methods The primary antibacterial activity were assessed using agar well diffusion method for crude extract and total alkaloids. Minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were also detected of crude extract, total alkaloids, harmine and harmaline, by using checkerboard method, the present study investigated the combination of harmala seed active compounds with available antibiotics namely: tigecycline, colistin, meropenem, amikacin and levofloxacin against ten of A. baumanii strains. Moreover, the cytotoxicity of methanolic crude extract of P. harmala and its derived alkaloids were studied on human lymphocyte by MTT (thiazolyl blue tetrazolium dye) colorimetric method. Results: For the two tested compounds, methanolic crude extract and total alkaloids within the range of 50 mg/ml to 10 mg/ml concentrations, the total alkaloids exhibited the most potent antibacterial activity against A. baumanii in a dose-dependent manner. the total alkaloids also exhibited the lowest level of MIC and MBC medians 32, 64 μg/ml respectively, whereas harmine and methanolic crude extract showed relatively moderate activity with MIC and MBC medians (96 and 256) (256 and 512) μg/ml respectively, and harmaline had the least inhibitory effect with MIC and MBC median 256 and 768 μg/ml respectively. According to the result of MTT colorimetric method, all concentrations of ≥ 256 μg /ml for harmine, harmaline and total alkaloids and of ≥ 512 μg /ml for methanolic crude extract caused lymphocyte cell death over 50%. For the combinations between harmala seed active compounds and available synthetic antibiotics, the best results were found in the combination between total alkaloids with tigecycline, it was found that 8 out of 10 had synergistic effect (FIC ≤ 0.5) against bacteria while only two had additive effect (FIC= 0.75); combination with colistin showed that only 4 out of 10 had synergistic effect (FIC ≤ 0.5) while 6 out of 10 had additive effect (>0.5-≤1). However, in the combinations with amikacin, meropenem and levofloxacin, all the samples showed indifference effect. Conclusion: Despite the strong antimicrobial effects of high concentrations of P. harmala seeds on A. baumanii, high cell toxicity of this plant would restrict its in vivo therapeutic use. However combination therapy such as the one resulted from synergism between antibiotic and plant extract can be used to minimize the possible toxic effects.Keywords:  Acinetobacter baumanii, Peganum Harmala seeds, Alkaloids, Harmine, Harmaline, antibacterial activity, and synergism.
Diorganotin (IV) Complexes Aid Switch to Protect the Photodecomposition of PVC in Outdoor Buildings Emad Yousif
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Three organotin (IV) complexes with different R-groups were used as additives for PVC. The photo-degradation rate constant of poly (vinyl chloride) upon irradiation with an ultraviolet light were investigated in the presence of Organotin(IV) complexes as photo stabilizers. Poly (vinyl chloride) photo-degradation rate constant was lower for the films containing Organotin (IV) complexes (5.6-1.5 × 10-3 sec-1) compared to the blank film (9.0 × 10-3 sec-1).Keywords: Organotin(IV), Photo stabilizers, UV irradiation, Poly(vinyl chloride), Photo degradation rate constant (kd).

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