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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Molecular Study for Association of ABCB1 Gene Polymorphism with Leukemia Patients Ali H. Al-Marzoqi
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Yield of ABCB1 quality diversions of the advocates as an efflux particle spat that ship a gigantic sort of substrates and is an escapement of single adaptable cell security against xenobiotics. An ontogenesis (prenominal), incremental tally of weigh have demonstrated that some ABCB1 polymorphisms may expand Pgp wording and agility, and in addition influencing the advancement and feeling to illnesses and pharmacologic answer. High gayety of Pgp has been finding in established myeloid Leukemia patients. Genotyping of outstanding 12 was impact by PCR examination utilizing particular ground works. The subsequent DNA parts were conceived on agarose gels.Keywords: ABCB1; MDR1; P-glycoprotein; Polymorphism; Exon26 & 21.
The Effect of Heat Shock on Anopheles Arabiensis Patton (Diptera: Culicidae) Larvae Muna Abd Al-Wahed Banian
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The objective of this study was to examine the effect of heat shock on Anopheles arabiensis larvae and for controlling mosquitoes. Samples of larvae were collected from Iraq. The larvae were exposed to various temperatures 30, 35, 40, 45 and 50°C for 10 minutes (as heat shock period). Larval mortality was recorded. The data was analyzed to calculate the quantity of heat (kj) that was added, the corrected mortality, the regression line and the correlation coefficient. It was found that heat shock of 30°C has no effect on larvae, but heat shock of 35, 40, 45 and 50°C produced mortality, while heat shock of 30 and 35°C has no effect on some aquatic organisms. The heat shock of 40.6°C and 48.94°C produced mortality in 50% and 95% of larval populations, respectively. The study showed that the heat shock of 40°C can be used to control the aquatic stages (Larvae) of mosquito (Anopheles arabiensis). The results of this work could be further tested in small pools, man- wholes of the bath rooms small containers used to keep drinking water and water pot, “zeer”
Effect of Storage Conditions on the Chemical Composition of Vietnamese Clove (Syzygium aromaticum) Essential Oil Mai Huynh Cang
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

In this study, changes in the composition of the oil from clove buds (Syzygium aromaticum) and their blends were investigated by mass gas chromatographic analysis during different storage under light and temperature conditions for a period of four months. Samples that were taken periodically were used to assess the chemical composition. Under these conditions, clove essential oil retains its main ingredients, including Eugenol, β-Caryophyllene and Acetyleugenol for four months. However, the oxidation rate of the essential oil under direct light and 45 ° C is rapid, contrasted by that essential oils stored in the dark and 4 ° C. The total Eugenol content in essential oils increased further at the end of the storage period under storage conditions. Changes in these compounds during storage can serve as an indicator of quality for clove essential oil.Keywords: Syzygium aromaticum, Essential oïl, Storage, Temperature, Light, Oxidation.
A Method for Tracking Eye Movements in the Study of Attention Selectivity in Social Anxiety Olga Sagalakova
Journal of Global Pharma Technology .
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Abstract

One of the key mechanisms of social anxiety is the distortion of the cognitive-perceptual activity. Cognitive-behavioral models of social anxiety, being the basis of anxiety disorder, determine the distortion of attention in regards to stimuli – social threats (by opposing types of disorders – vigilance or avoidance).. The eye movement tracking method enables assessing the bias of attention to stimuli – facial expressions in teenagers with a high and low level of social anxiety. The study included 30 test subjects aged 16-18. We used the eye tracker SMI RED 250 mobile tracking technology. The test subjects were divided into groups based on the results of the questionnaire of social anxiety and social phobia. We discovered signs of severer disorganization of the target activity during the perception of both presumptive positive and negative facial expressions (higher amplitude of saccadic movements as a deviation from target priorities and multitasking) and a prolonged fixation of attention on stimuli fragments with negative expression (average and maximum duration of fixations on the path of visual scanning). During the attribution of characteristics, we often found typical cognitive distortions, which are most significant in regards to the presumptive positive stimulus (the “happy face” condition was attributed negative characteristics and mistakes were made in determining the emotion).Eye movement registration would enable a more pinpoint and continuous measurement of attention. The eye-tracker method is very promising for the understanding of information processing in case of affective disorders. Eye movements are an indicator of clear attention and perception (zones of interest, fixation, duration and sustainability of fixations, saccadic movements, eye trajectory sequence, etc.).Keywords: Tracking eye movement method (“Eye Tracker”), Social anxiety disorder, Selectivity of attention, Vigilance and avoidance, Social threat, Facial expressions. 
Synthesis and Diagnosis of Nucleoside Analogues and Cytotoxic Effects against Normal Human Lymphocytes Najeeb Ibraheem Mohamed
Journal of Global Pharma Technology .
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Abstract

Synthesis of nucleoside analogues and investigated that cytotoxic effects on the Normal Human Lymphocyte by MTT assay. Preparation of Mannich bases that derivative from thymidine fainally obtain crystals and purify by using silica gel filled with gasoline. In the current study is to evaluate the cytotoxic effects for the four compounds of nucleoside analogues at concentrations of (0.15mg/ml, 0.31mg/ml, 0.62mg/ml, 1.25mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) alongside against the freshly isolated and cultured normal human lymphocyte in vitro. The result refer to that cytotoxic effects of each type of nucleoside analogues used in the study and the growth inhibition rate (%) was associated to the concentration of nucleoside analogues, so that a 20mg/ml concentration of gave the highest growth inhibition rate, followed by the 10mg/ml, 5mg/ml and 2.5mg/ml, 1.25mg/ml concentrations, therefore the cytotoxic effects was concentration dependent. There was a significant difference between the concentrations when compared between the four kinds of nucleoside analogues, also statistical analysis related between the effects of different kind of nucleoside analogues showed great difference and there was a significant relationship between the inhibition rate and the concentrations of the materials tested (P ˂ 0.05). The results visibly showed that nucleoside analogues have strong cytotoxic and cytostatic effects on studied the lymphocyte and the cytotoxic effects may be attributed to the role of these compounds in the DNA and RNA synthesis or play a role in the apoptosis. On the basis of these results we can conclude nucleoside analogues have potent cytotoxic effects against human lymphocytes in vito  and the pathways for how the cells dies need further studies in the future studies in more details and more advanced tests and techniques.Keywords: Nucleoside analogues; Cytotoxicity; Normal human lymphocyte.
Effect of Cutting Frequency and Potassium Levels on Seed Yield and its Components for Berseem (Trifolium alexandrium L.) Mahmood Abbas Abd Salama
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

A study was conducted at one locations in the AL-Jazeera region at north of Ramadi city for winter season (2017) to investigate the affect number of cutting and  different levels of potassium on seed yield and  its components in berseem. Four cutting treatments (once ,twice, three and four times ) with potassium levels included  (0,80,160 and 240 kg/he.-1).Were applied in a split plot design with three replication in which potassium levels were the main plots and cutting treatments were sub-plots . The results showed that significant effect on seed yield and its components, added potassium at levels (160) kg/ha produced significant higher means for all components higher seed yield (38.96 no. of seeds/flower, 2.90g. and 2.06 ton/ha.-1) was obtained from treatments received (160)kg/ha.-1 of potassium . Number of cutting stage had significant effect on seed yield and all components in winter season plants cut once gave higher seed yield (1.74 ton/ha.-1 )the 1st cut showed be don in 1st week of march  . It was concluded that addition of potassium at a rate of (160) kg/ha.-1 and cut the crop four times when the 1st cut showed be done in 1st week of March gave higher seed yield of berseem.Keywords: Berseem, Cutting treatments, Potassium levels, Head length, Grain yield. 
Synthesis of Some New Pyrazoline Compounds Derived from α-β Unsaturated Compounds and Study their biological and Biochemical Effect Wissam M. R. Al-Joboury
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

In this work Compounds Chalcones (w1-8) have been prepared from the reaction of acetophenone derivatives with appropriable aromatic aldehyde in presence of Noah (10%). The reaction of thiosemicarbazide with chalcones (w1-8) yielded compounds (W9-16) 5- (Aryl) -3- (4-sub. Phenyl) 4-5-dihro -1H-Pyrazole -1- Carbathiamide). All the new compounds have been characterized by using spectral (IR, H1-NMR, TLC) data. And physical methods. The antibacterial activity have been tested in vitro by the disk diffusion assay method against two kinds of bacteria gram positive and gram negative .The minimum inhibitory concentration [MIC] have been determined with the reference of standard drugs the results showed that the pyrazoline derivatives are better than growth of both types of bacteria (gram- positive and germ–negative compared to drug .The effect of hydrogen peroxide (0.1%) H2O2 drinking water through the mouth for about (15) days on white male rats shows significant increase (P˂0.01) at the level glucose and cholesterol and Triglyceride in the serum comparison with the control group, where as it shows a significant decrease(P˂0.01) in the level of ,glutathione, glutathione Peroxidase (GSH-Px), Superoxide dismutase (SOD), in serum. Whereas the prepared (W11) compound was injected, results show after (5) days of treatment that the organic compound of (7.14) mg/kg of body weight through the mouth for white male rats exposed to oxidation, with an associated significant decrease (P
Testosterone Replacement Protects Against Non-Alcoholic Fatty Liver Disease in Castrated Male Mice Liqaa Oday Ali
Journal of Global Pharma Technology .
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Abstract

The present work aimed to study histopathological, histochemical and biochemical changes in the liver of castrated male mice and effect of possible treatment with testosterone. For this purpose Forty five (45) male albino mice (3weeks) aged were divided into 3 groups (n = 15).The Group I was used as a control, Group II was castrated group, Group III was castrated treated with testosterone group .For 6 weeks from period February to June 2017, lipid profile was measured. There are significant p increased in (cholesterol, triglycerides, and low density lipoprotein LDL) levels, but there is no change in the level of HDL   in the castrated group as compared with the control group. In addition, histopathological changes of the liver were examined. Castration enhanced lipid accumulation liver (macrovesicular steatosis), ballooning degeneration in hepatocytes all these changes associated with inflammatory cellular infiltration. Histochemically accumulation of lipid in hepatocytes were strongly positive to Sudan Black B reaction in liver of castrated mice as compared with the control group and these structural changes were less pronounced in animals treated with testosterone. From the present results, it can be concluded that testosterone replacement ameliorates role in non alcoholic fatty liver disease. Keywords: Non-alcoholic fatty liver disease, Testosterone, mice, steatohepatitis, hepativ lipid accumulation.
Regularities of Organometric Characteristics of Cerebellum in Young and old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Background: The interest in morphological studies of cerebellum in different periods of postnatalontogenesis is steadily increasing. The most acute lack of age anatomy data exists for elderly patients.Since the information on structural peculiarities of cerebellum and its cortex at old age is poorlyrepresented in literature, being also contradictory in many ways, the study underlying the current paperwas dedicated to this issue. Aims: The purpose of the study was to find regularities of age-relatedchanges in organometric parameters of cerebellum and structural organization of its cortex at old age ascompared to the young age at old age as using necropsy material. Methods: The paper is based onmorphological study of cerebellums of 219 human corpses (108 male and 111 female) of young and oldages using organometric, histological and morphometric research methods. The study includedcomparative analysis of the mass, linear dimensions, thickness of the cerebellar cortex in young and oldages. Results: The regularities of age variability of organometric characteristics of cerebellum wereidentified, manifested in reduction of its weight and linear dimensions in people of senile age comparedto younger people. It was found that the thickness of molecular and granular layer of cerebellum ischaracterized by age-related decrease in parameters. Conclusions: The results of this morphologicalstudy can serve as a basis for identifying specific regularities of age anatomy of cerebellum and havepractical significance as standard indicators, which will allow using these data for diagnostic andtherapeutic purposes.
Effectiveness of Drying, Roasting and Preservation on Antioxidant of Dried Roasted Sunflower (Helianthus Annuus) Seed Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Antioxidants are considered important nutraceuticals on account of many health benefits. Due to the high antioxidant activity, Helianthus annuus seeds might be considered in the management and prevention of degenerative diseases associated with free radical damage. It is the rich source of vitamins specially vitamin E.  Drying and roasting are the most important processes giving neccessary alterations to the product.  Roasting can enhance flavour through caramelization on the surface of the food. There was no any research mentioned to varify the change of antioxidant (tocopherol) during heat pump drying as well as storage. So the objective of the present study was to identify the effect of temperature in heat pump drying, roasting condition, packaging and storage to antioxidant (tocopherol) in the dried Sunflower (Helianthus annuus) seed. Results demonstrated that drying temperature (40 oC), roasting (145 oC in 5 min), vaccum packing in polyethylen (PA) bag and keeping in 4 oC were recommended to maintain the tocopherol, total phenolic and antioxidant activity in the final products for 12 months. The effect of drying, roasting temperature and time were clearly demonstrated to produced dried roasted sunflower seed.Keywords: Sunflower, Drying, Roasting, Antioxidant, Tocopherol, Vaccum.

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