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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 104   105   106   107   108 
Synthesis and Characterization of 5- Amino-1, 3, 4-Thiadiazole-2-thiol and its Amine Group Derivatives Mustafa M. Shihab
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

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Abstract

This work includes preparation of 5-Amino-1,3,4-thiadiazole-2-thiol from thiosemicarbazide with Carbon disulfide (CS2) and KOH as catalyst. Also reaction of 5-Amino-1,3,4-thiadiazole-2-thiol with different aromatic aldehydes by using glacial acetic acid as catalyst to synthesis of some new Schiff bases derivatives that coupled with thioglycolic acid to synthesis five- member ring heterocyclic compounds derivatives. All synthetic compounds were definited by their melting point, FT-IR spectra and 1H-NMR spectra for some of them.Keywords: 5- Amino-1, 3, 4-thiadiazole-2-thiol, Thiosemicarbazide, Schiff bases, heterocyclic compounds, thiadiazole.
Advanced Oxidation Processes for Carmoisine (E122) Dye in UV-A/ZnO System: Influencing PH, Temperature and Oxidant Agents on Dye Solution Luma Majeed Ahmed
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

This paper aims to estimate the effects ofthree operating parameters such asinitial pH, temperature and oxidant agents (like H2O2 and Fe2+) on the stability of the food azocarmoisine dye under UV-A/ carmoisine/ ZnO system. The performed experiments in this work proved that the optimum initial pH is at zero point charge of ZnO and equal to 9.14 and with efficiency % equal to 90.936 at 8 min. The study of temperature was enhanced this photo reaction with activation energy equal to7.562 kJ mol-1.The addition of oxidant agents to an aqueous solution of carmoisine dye was declined the activity of decolorization, that referred to the addition of these compound will increase the resistance of carmoisine dye to light. The quantum yield ( ) for decolorization of carmoisine dye with the using ZnO without and with the using oxidant agent (H2O2 and Fe2+) was following to the sequences:  without the oxidant agent >  with the using oxidant agent (H2O2) > with the using oxidant agent (Fe2+) and equal to 0.485, 0.279 and 0.141 respectively.The physical deactivated process mostly was dominated on this photoreaction.From the other word, the addition of oxidant agents is useful to decrease the degradation of this dye when used it in food's industries.Keywords: Carmoisine dye, Food red 3, acid red 14 dye, Azorubine, Oxidant reagents, food's dye.
A Nobel Chemiluminescence and Fluorescence Energy Transfer Three Inlets Cell for the Determination of Hydrogen Peroxide via Continuous Flow Injection Analysis Nagam Shakir Turkie Al-Awadi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The study presents a sensitive, fast and easy assay method that was developed for determination of hydrogen peroxide  via continuous mode of FIA i.e. new noble chemiluminescence and fluorescence cell with specially designed unit cell of three inlets and  one outlet  to measure a total luminescence which include the chemiluminescence generated and the fluorescence that was created by the in situ radiation of the released chemiluminescence light using fluorescence molecule which gives an emission spectrum at 530 nm The method is based on the use of fluorescent molecule as an acceptor fluorophore where by it is irradiated internally and instantly when the generation of luminol chemiluminescence light is used as internal source for irradiation of fluorescein molecule to give fluorescence light , this reaction and analysis occur in a specially homemade  designed cell. Experimental parameters that lead to optimum concentrations of all chemicals and physicals variables .A sample volume of 75 μL was used throughout the whole work. It was found that the linear working range was between 20-500 μmol. L-1, with correlation coefficient of 0.9969 and limit of detection L.O.D. (S/N =3) 1.275ng/sample by using step wise dilution of the minimum concentration that was achieved by the calibration graph. Repeatability of less than 0.25% for ten successive injections of 250 μmol.L-1 & 400μmol .L-1 of hydrogen peroxide .The method was applied successively in determination of hydrogen peroxide in some pharmaceutical disinfectants.Keywords: Chemiluminescence, Flow injection analysis, Hydrogen peroxide, In situ fluorescence.
Antioxidant Activity, Formulation, and Evaluation of Roselle Seed Oil Extract Nanoemulsions Arpa Petchsomrit
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Roselle Hibiscus is a medicinal plant used in folk medicine. The parts of the flower, calyx, and bracts, are regularly used but the seed of roselle has not been used and studied for antioxidant activities. The objective of the present work was to determine the antioxidant activity of roselle seed oil extract extracted using dichloromethane maceration. The extraction then was formulated as nanoemulsions and evaluated for its physicochemical properties and stability. The oil obtained from Roselle Hibiscus seed demonstrated good antioxidant activity, according to the DPPH assays. Roselle seed oil extract nanoemulsions were developed using non-ionic surfactants and water by ultrasonic emulsification method and evaluated to achieve optimum stability. Nanoemulsions formulated using Tween 60 and Tween 80 had a relatively small droplet size ranging from 20-30 nm. After a seven-day stability test at the room temperature and a 6-cycle heating-cooling study, phase separation or creaming did not occur to the nanoemulsions formulated by Tween 60 and Tween 80. The ratio of roselle seed oil extract and Tween 60 that yielded the best physical properties for the nanoemulsions was 1% and 5%, respectively. The results indicated that nanoemulsions had nanoscale droplet size and were stable under the normal and stress storage condition.
The Relationship between Phylogenic Typing and Antimicrobial Susceptibility Patterns for Escherichia coli Isolated from UTIs in Many Hospitals at Baghdad City Eptisam Younam Pirko
Journal of Global Pharma Technology .
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Abstract

Escherichia coli are one of the most important pathogens, associated with urinary tract infections. Four phylogenetic groups were identified with locally isolates divided as follows: the phylogroups B2  43%, phylogroups D  28.25%, phylogroups A  24%  and B1  3.5%, so phylogenic group B1 was prevalent among  male patients of AL-Yarmouk hospital 14%, followed AL-Iskan  3.75 % as well, isolation rate of E.coli were higher among age 11-20 years  31.75 %, of which 11% were sensitivity to  antibiotics, while  75.25%  were classified as extensive drug resistance pathogens, but 13.75% were multidrug resistance and in Karkh areas, the frequency of phylogenetic B2 was 59.88%, followed phylogenetic A and D were 68.75 and 48.78%  respectively as compared to Rusafa areas were prevalence phylogenetic B2 40.12% , followed phylogenetic D and A were  51.22 and 31.25 %, as well as most of these phylogenetic groups occurred more frequently in both groups B2 or D  43, 28.25% respectively, also  2.75, 2.5% of phylogenic A were antibiotics sensitivity in both AL-Iskan hospital and Ghazi AL-Hariri hospital respectively whilst these phylogenic was multidrug resistance as percentage 9, 3.75  % Alternately in both AL-Yarmouk hospital and AL-Iskan hospital, Whilst in these hospital this phylogenic A was founded with extensive drug resistance 1, 0.75% respectively, also most of phylogenetic group B2 occurred more frequently in AL-Yarmouk hospital, so the sensitivity; multidrug resistance and extensive drug resistance as  2.25, 15 and 3.5%  respectively, also all  phylogenetic groups E. coli isolates from UTI patients of five hospital were grouped  in two or three major group as  A, B group contain major sub groups. The aim of this study is to explore the prevalence of in Escherichia coli from urinary tract infections in many Baghdad hospitals, investigate their phylogenic groups and evaluate the relationship of phylogenic groups of E. coli isolates with the antibiotic resistant patterns.
Venture Capital and Market Reaction to the Disclosure of Information Mosayeb Beyannejad
Journal of Global Pharma Technology Volume 08 Issue 01
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Abstract

The transaction volume behavior is closely related to the inhomogeneity of information among investors. Investors in financial markets are generally divided into two groups of informed and uninformed investors. To gain an abnormal return, informed investors make deals based on the confidential information of a security or the information they have and other market actors are lack of them. Uninformed investors, on the other hand, buy and sell stocks based on other reasons, including having liquidity. This carries with it the matter of unsecure choices according which uninformed investors are placed in an unpleasant condition. The leading question, thus, is that how the investors’ decisions, in the face of abnormal return and unexpected earnings, affect the unusual stock trading volume in the Tehran Stock Exchange. Given the research limitations, all companies listed in the Tehran Stock Exchange were sampled by the systematic elimination method (screening). The general purpose of this research is to study the effect of decisions made by venture capitalists on trading on the Tehran Stock Exchange. This is a practical research study, in terms of purpose, with an ex post facto design. Here, three hypotheses, including the effect of CGO investors on abnormal trading volume when companies’ financial information is disclosed, the correlation between unexpected earnings and trading volume and the abnormal return when companies’ financial information is disclosed, were assessed. Based on results, there is a positive and significant correlation between investors’ CGO and the abnormal trading volume when companies’ financial information is disclosed. Investors’ CGO has a strong impact on the relation between unexpected earnings and fluctuations in the stock prices and trading volume. There is a negative and significant correlation between investors’ CGO and the abnormal return when companies’ financial information is disclosed. Besides all factors affecting decision-making, investors check all overhangreturns. However, the stock returns have a trivial impact on this research. Keywords: Investors’ CGO, Unexpected Earnings, Abnormal Return, Trading Volume.
Synthesis and Characterization of Some New Pyrazole Derivatives Nisreen H. Kar
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work contain many steps starting from esterification of  isophthalic acid to yield diester compound [I] which was converted to their acid hydrazide [II], then the later compound reacted with ethylacetoacetate  to  yield pyrazol-5-one compound [III]. Afterword added acetyl chloride to give the compound [IV], the reaction of this compound with theiosemicarbazide led to produce a new carbothioamide compound [V], which was reacted with ethyl chloro acetate to yield the thioxoimidazolidin compound [VI]. The condensation reactions of this compound with different substituted aldehyde give new alkene derivatives [VII] a-d. The synthesized compounds were characterized by melting points, FT-IR, 1H-NMR and Mass spectroscopy.Keywords: Pyrazole, Heterocyclic, Isophthalic acid, Acid hydrazide, Alkene derivatives.
Efficacy of Drying and Stir-frying to Purple Rice Paddy Herb (Limnophila aromatica) Tea N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

In Vietnam, L. aromatica is easily cultivated in flooded rice fields. This herb has two very distinct flavours of lemon oil and cumin.  It is used in Vietnamese cuisine to add flavour in soup broths, sauces, and other foods. In order to create a new kind of functional herb tea, we have penetrated on various parameters such as drying and stir-frying the total phenolic and total flavonoid content in the dried stir-fried rice paddy herb tea. Our results revealed that drying raw purple rice paddy herb at 55oC to 8.5% moisture content and then stir-frying at 140oC in 6 minutes could produce the good organoleptic property while maintaining the best phenolic and flavonoid content in this functional beverage. These findings provided useful information for manufactures in processing of this herb to preserve potential sources of bioactive components for consumer and public health. Keywords: Rice paddy herb, Tea, Beverage, Drying, Stir-frying, Phenolic, Flavonoid, Organoleptic.
Determination of Clonazepam in Pharmaceutical Formulations by Normal and Reverse Flow Injection Analysis Coupled with Solid-Phase Reactor Containing MnO2 Immobilized Malik H. Alaloosh Alamri
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Clonazepam (CLO) is an anticonvulsant agent which has hypnotic properties and widely used in the treatment epilepsy. Rapid and sensitive flow injection (FI) spectrophotometric methods are proposed for determination of CLO in pure and pharmaceutical formulations. Method (A)  is normal flow injection which depend on oxidation coupling of reduced CLO with 4-methoxyphenol (MP) in presence of sodium periodate to give a colored product measured at 550 nm. While the method (B) was developed using reverse flow injection coupled with on line solid phase reactor containing MnO2 immobilized on cellulose acetate (CA) the method based on the coupling of reduced CLO with MP to give colored product which easily measured at 612 nm. The experimental conditions were optimized for both methods (A and B) and the linear range of CLO concentration was 5 – 300 and 1-250 μg.mL-1 with limits of detection of 4.312 and 0.822 μg.mL-1for methods A and B respectively. Both proposed spectrophotometric methods have been applied successfully for the determination of CLO in pure and pharmaceutical formulations.Keywords: Clonazepam, flow injection, solid phase reactor, immobilized MnO2.
New Record for Science Salvia margasurica Al-Musawi & Al-Hussaini, (Labiatae) in Iraq Aseel F. A. Al-Hussaini
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: The study covered thirty-three species which grown wildly in Iraq and a comparative study for all kinds of morphological characters were done. Principal Findings: The most stable and important taxonomic characters were pointed out, diagrams, illustrations, scheduals, micrographs were also documented. Stamens, nutlets, basal leaves, bracts, bracteoles, calyces, corollas and their trichomes were very important taxanomic characters. The trichomes were variable in variable species therefore used as a diagnostic characters for the species. Conclusions: New species Salvia margasurica Al-Musawi & Al-Hussaini was suggested to be new record for science.Keywords:  Salvia, Morphology, Spec. Nov.

Page 106 of 244 | Total Record : 2439

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