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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Impact of the use of Innovative Aids to Improve Some of the Kinetic Abilities and Learn the Skill of Receiving the Service of Volleyball Hamida Obaid Abdulamir
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Volleyball is a group of games that have spread widely and evolved from a game of recreation and leisure time to a game of competition for the higher levels and require the highest degrees of performance and skill and also require high fitness for the coach or the teacher to strive to achieve a good level of performance must To prepare the learner from all aspects of physical and skill, as well as to pay attention to the development of physical and motor abilities through the use of innovative aids to improve the level of learning to the good performance and level required. The sample of the study consisted of (30) female students who were randomly selected by drawing lots of (38) female students after the exclusion of female students of the game and the students of the experimental experiment were divided into two equal groups by lottery method, the control group and the number of (15) students and the experimental group (15).Before the implementation of the vocabulary of the educational curriculum, the researchers investigated the homogeneity of the research sample in the variables related to the morphological measurements (height, weight, age) as well as the motor abilities and technical performance of the volleyball receiver reception skill. The skewness value is limited to (± 1), which means that the sample is distributed naturally, indicating its homogeneity.Through the results, the most important conclusions were reached:Innovative assistive devices have a positive impact on the improvement of motor abilities (flexibility, balance, agility, accuracy) of the skill of receiving female students' volleyball.Innovative aids have a positive impact on learning the skill of receiving female students' volleyballExercise using innovative aids has had a greater impact than the teacher's approach to improving motor abilities (flexibility, balance, agility, accuracy) and learning the skill of receiving volleyball for female students.The chosen methods are commensurate with the nature of the sample, which helps to learn the skills in question.Keywords: Innovative aids, Kinetic abilities, Learn the skill of receiving the service and volleyball.
Studies on Anti-Inflammatory, Antioxidant and Free Radical Scavenging of Cu (Ii)-N-Acetyl-Para-Aminophenol (APAP) Based Complex Ouiza HAMRANI
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

N-acetyl-para-aminophenol (APAP) or paracetamol–copper based complex with [Cu(APAP)2(OH)2.H2O] formula and noted Cu-APAP has been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), NMR and electronic spectral studies. The value of molar conductance of the complex indicates a non-electrolyte nature.The antimicrobial activity of the complex was evaluated against several pathogenic microorganisms to assess its potential. The copper complex was found to be more active against Gram-positive than Gram-negative bacteria. The pharmacological and toxicological ability of the complex were equally explored. The results are compared to those obtained with the unbound drug molecule.The metal complex has been tested for antioxidant and catalase-like activity in order to assess its catalytic properties. The results are encouraging.
A Thermodynamic Study of Adsorption 2-(4-Antipyriyl azo) Orcinol [APAO] on Zincoxide as Adsorbent Nuha Abdul-Saheb Ridha
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

We can remove Organic materials contaminated from their solutions in several methods, for examples the Adsorption. In this research was studies adsorption APAO which dissolved in 2.5% ethanol/water by the Zinc Oxide as adsorbent. The adsorption isotherms it was found similar to L4-shape according to Gilles classification. Also it studied the influence of adsorbent weight and adsorption time on removal% of APAO; it was 0.35gm best weight and 35 min. best time. The impact of changing the function of the acidic PH on removal% of APAO was found as follows (PH=4> PH=10> PH=7). The thermodynamic values were calculated (∆H, ∆G, ∆S) depending on changing temperature with concentration were (+24.74002KJ/mol, +9.4256KJ/mol, +51.390J/mol.K).
Isolation, Purification and Structural elucidation of bioactive constituents from root bark of Crataeva magna Lour (DC) RADHA krishnan meera
Journal of Global Pharma Technology Volume 10 Issue 02: (2018) Feb 2018
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Abstract

Objective: The study was to isolate and characterize the bioactive phytoconstituents from Crataeva magna Lour (DC).Materials and methods: For isolation of the compounds, ethanolic extract of Crataeva magna Lour (DC) isolated first with petroleum ether, increasing amounts of EtOAc in petroleum ether and finally with methanol yielded a number of fractions. The proportion of solvent systems used to obtain CM-01 and CM-02 were hexane-EtOAc (80: 20) and EtOAc –methanol (98:2) from fractions 5 and 8.Results: The subsequent structures of isolated compounds were elucidated by various spectrophotometric analysis. Mass spectrum of CM-01 and CM-02 showed a parent molecular ion (M+) peak at 382 gm/mol and 614 gm/mol respectively. In the 1H- NMR spectrum of CM-01  has 0.728 (methyl H), 2.439 (OH ), 2.764 (long chain CH2), 3.953(H in CH2 adjacent to OH ) where as in the 1H- NMR spectrum of CM-02, 3.9-4.2 (CH3 protons), 5.7 (OH group), 6.2-7.2 (Aromatic protons)Conclusion: From the physical, chemical and spectral characteristic CM-01 and CM-02 were concluded as phytosterols (Ceryl alcohol (Hexacosan -1-ol)) and macropolyphenol (Tannic acid).Keywords: Crataeva magna Lour (DC), phytosterols, macropolyphenol.  
Synthesis, Structure and Antibacterial Activity of 1, 4-bis (1-benzimidazolyl) butane Complexes with some Transition Metal Salts Abbas Washeel Salman
Journal of Global Pharma Technology .
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Abstract

This study presents the synthesis, characterization and antibacterial activity of Mn2+, Co2+, Ni2+, Cu2+, Zn2+ and Ag+ complexes derived from the ligand 1,4-bis(1-benzimidazolyl) butane (Dbz). The ligand and its complexes were characterized by using different techniques including IR, Uv-Vis, 1H and 13C NMR and elemental analysis CHN. According to the abovementioned techniques, a polymeric structure was proposed to the prepared complexes. Further, the structure of Ag(I) complex was confirmed by single crystal X-ray diffraction technique which reveals the polymeric structure trigonal geometry around the Ag+ center. The in vitro antibacterial activity of the prepared ligand and complexes were tested against the standard Escherichia coli (E. coli ATCC 25922), environmental Bacillus sp. and 16 clinical bacterial isolates (both Gram-positive and Gram-negative bacteria) by using amikacin as a standard antibiotic. All the tested compounds except the Zn(II) complex showed antibacterial activities at minimum inhibition concentration (MIC) level, particularly, the silver complex which shows a significant activity with MIC = 15- 250 µg/ml.Keywords: Benzimidazole; Synthesis; Crystal structure; Metal complexes; Antibacterial; Silver.
The Impact of FLG Mutation and TRBV Insertion/deletion Gene Polymorphism in Molluscum Contagiosum and Papillomavirus Iraqi Patients Saba Amer Mughir Al-Ammar
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objective: Filaggrin (FLG) has very important role in the skin terminal differentiation and formation, which encoded by FLG gene. TRBV4-3, TRBV3-2 are an insertion/deletion polymorphism in human T cell receptor beta locus (TRBV).The polymorphisms in these genes have been reported in several diseases. To evaluate the impact of FLG (R501X), TRBV (I/D) polymorphisms in Molluscum contagiosum(MCV) and Papillomavirus (HPV) Iraqi patients. Material and Method: thirty one blood samples from each MCV and HPV patients and  healthy control group was collected, then DNA was extracted and analyzed for FLG and TRBV genotypes and Alleles frequencies with (PCR) and by Gel electrophoreses using 1.5%, 2% Agarose concentration (respectively) was examined. Results : FLG mutations have been detected in 35% of MCV patients and in 26% of HPV patients while only 10% in the control group , in addition mutant allele (T allele) has been detected in 18% in MCV patients , 13% in HPV patients and only in 5% in the control group ,when we compared with the control group, we found that the genotype and allele frequency have significant association with MCV infection group P<0.05 , and have no significant relation with HPV infection group. For TRBV (TRBV4-3, TRBV3-2) gene polymorphism has no significant association with MCV and HPV infection groups when compared with the control group P>0.05.Conclusion: FLG mutations are associated with MCV infection while there is no significant associated with the HPV. Moreover the TRBV gene polymorphisms have no significant association with the MCV and HPV infection.Keywords Molluscum contagiosum, Human Papillomavirus, FLG (R501X), TRBV Polymorphism.
Antioxidant Activity Assay of Combination of Purified Extract of Banana Peel (Musa Paradisiaca Sapientum) and Andrographis Paniculata Leaves Jastria Pusmarani M.Sc., Apt.
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Antioxidant is a compound that able to postpone, slowdown and prevent free radical reaction which able to postpone degenerative disease. Banana peel (Musa Paradisiaca Sapientum) and Andrographis paniculata contain flavonoid compound which have antioxidant activity. The aim of this study is to measure antioxidant activity of the combination of banana peel extract and Andrographis paniculata to DPPH free radical (2,2-difenil-1-pikrilhidrazil). Extraction process of banana peel using methanol, meanwhile Andrographis paniculata using ethanol 70%. Extract purification conducted using n-hexan and ethyl acetate. This study using combination of the purified extract of banana peel and Andrographis paniculata with the following comparison consecutively (1:10) (1:1) (2:1) (1:2) (0:1) concentration of  20,40, 60, 80 and 100 ppm, measured their antioxidant activity with DPPH method using visible spectrophotometry, thus resulted in IC50value. IC50value for the combination of purified extract of banana peel and Andrographis paniculata (0:1) as many as 256.76 ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:1) as many as 140.33 ppm, the combination of purified extract of banana peel and Andrographis paniculata leaves (1:2) as many as 110.05 ppm, the combination of purified extract of banana peel and Andrographis paniculata (2:1) as many as ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:0) as many as 184.13 ppm. The result can be concluded that combination of purified extract of banana peel and Andrographis paniculata have an antioxidant activity even though in moderate category included purified extract of combination of of banana peel and Andrographis paniculata with comparison (0:1) (1:2), (2:1), (1:1) and (1:0) have medium antioxidant activity.
Study the HLA Genotyping in Pulmonary Tuberculosis Patients in Babylon Province-Iraq Mohammed A. K. Al-Saadi
Journal of Global Pharma Technology .
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Abstract

This study aimed to investigate the role of Human Leucocyte Antigen (HLA-DRB1) alleles in susceptibility to pulmonary tuberculosis in Babylon/ Iraq population. Whole blood samples collected from 50 pulmonary tuberculosis patients who are admitting to consultant clinic for respiratory diseases in Hilla – Babylon province during the period from February 2016 to February 2017. Out of the pTB patients, there were 27 males and 23 females, the patients age range was 12-80 years. Sequence specific oligonucleotide (SSO) was used to genotyping HLA-DRB1.The distribution of HLA-DRB1 genotypes in 50 patients with pulmonary tuberculosis and 50 healthy controls studied. HLA-DRB1*13 was a significantly increased in pulmonary tuberculosis patients 48% as compared with healthy controls 16% while HLA-DRB1*15 was a significantly increased in healthy controls 24% as compared with pulmonary tuberculosis patients 6%.The genotyping of all HLA-DRB1alleles found more common in females 77% than males 23% from total number of patients. Also, HLA-DRB1*13 was more common in females 75% than males 25% with pulmonary tuberculosis patients while HLA-DRB1*15 was common in females 100% and no appeared in males.Keywords: Pulmonary Tuberculosis, HLA-DRB1, SSO.
PCR Detection for Epstein-Bar Virus Associated with Leukemia Patients in Babylon Province of Iraq Mohammed T. Al-Tameemi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The first virus to be implicated in the causation of a human cancer was the Epstein–Barr virus (EBV), discovered in 1964 by Epstein, and Barr in a lymphoid cell line established from a biopsy of an African Burkitt lymphoma. The present study establish  for detection Epstein-Bar virus  in thirty serum samples  collected from Marjan hospital in Babylon Province of Iraq. Detection of this virus conducted by polymerase chain reaction for blood diagnosed firstly as having Epstein-Bar virus with leukemia by ELISA technique. Twenty three from thirty samples are positive for EBV association with leukemia patients according to PCR produced 161 bp band referred to EBV gene noticed at gel electrophoresis technique. Keywords: Epstein–Barr virus, Leukemia, PCR.
The Effect of Special Visual Exercises in the Development of Visual Tracking and the Accuracy of Spike in the Volleyball for Young Players Bassem Hassan Ghazi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The Aims of Research to: Preparation of visual exercises, especially in the development of visual tracking and the accuracy of the spike of the volleyball young players. To identify the impact of exercise visual especially in the development of visual tracking and the accuracy of the spike of the volleyball of young players. The Hypothesis: Special visual exercises have a positive effect on the development of visual tracking and the accuracy of the volleyball spiking of young players. As for the research method, the researchers chose the experimental approach as the appropriate method to solve the research problem by designing the experimental and control groups with the tribal and remote tests as it fits the nature of the research problem. The sample of the research was chosen from the research community represented by the young players in the volleyball of the middle region (3 clubs) in Iraq at the age of 17-19 years and the number of (36) player has been selected two clubs, including the number of (20) player after the expulsion of the player prepared randomly by lot to represent the two groups Experimental and control of the sample of the search and the reality of (10) player for each group. The Researchers Concluded: An evolution in visual tracking and accuracy of the volleyball team's spike in volleyball skill, There is a preference for the experimental group in the tests of the dimension of visual tracking and the accuracy of spiking in the volleyball, The various special exercises developed by the researchers contributed to the development of visual tracking and the accuracy of the spiking skill. The Recommendations Were: The need to use special visual exercises to develop the visual tracking of players, especially young people, The need to use special visual exercises to increase the accuracy of the skill of spiking, The need to use special visual exercises to increase the excitement and excitement of young people and increase their motivation for training.Keywords: Visual exercises, Accuracy, Spike and volleyball.

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