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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Inhibitory Activity Evaluation of Two Medicinal Plant Extracts (Rosmarinus officinalis & Alhagi maurorum) against Adult of Tribolium Castaneum Meison Abdulbary
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Medicinal plants (Rosmarinus officinalis and Alhagi maurorum) alcoholic extracts inhibitory effect against Tribolium castaneum adults were examined with concentrations 50, 75 and 100 mg/ml through 24, 48 and 72 hours respectively. The total results indicate that the two plants can be used as insecticides for T. castaneum.  However ,The results indicated a significant difference between the two plants in the adult mortality rate, where were adults mortality rate of treatment with plant extract Alhagi maurorum (2.37) in contrast to the plant Rosmarinus officinalis which amounted to (1.19) after 72 hours of treatment. The results showed non-significant differences between concentrations of the plant extract Rosmarinus officinalis  in the adult mortality  Tribolium castaneum in 24 and 48 hours , while there was a significant difference between concentrations in 72 hours where was the adult mortality rate 5.67 with concentration 100 mg/ml and 1 with concentration 50 and 75 mg/ml  respectively. In addition, there were significant differences with extract of Alhagi maurorum between the concentrations in the adult mortality rate at 24 and 48 hours, but the results showed significant differences between the concentrations of the extract in 72 hours reaching 1.33, 4.33 and 5.67 respectively with the concentrations 50, 75 and 100 mg/ml respectively.                                                                                                              Keywords: Rosmarinus officinalis, Alhagi maurorum, Tribolium castaneum.
Synthesis, Characterization and Antimicrobial Evaluation of Some New 1, 3, 4-oxadiazoline Compounds Khaldoon S. Alhadad
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

This study involve synthesis of some new 1,3,4-oxadiazoline compounds and screening the antibacterial activity against Staphylococcus aureus , Escherichia coli and pseudomonas aeruginosa bacteria and the antifungal activity against  Aspergillus flavus and Candida albicans.  The structures of newly prepared compounds (5a-5f) were confirmed by spectroscopic methods like elemental analysis (CHN), FT-IR and 1H-NMR spectroscopy. All the compounds showed good antibacterial activity as compared with the standard drugs (cefepime and amoxicillin) against Staphylococcus aureus , Escherichia coli and pseudomonas aeruginosa while the compounds (5a, 5b, 5c and 5d) displayed a good inhibition zone of growth against Aspergillus flavus and Candida albicans.Keywords: 1, 3, 4-oxadiazoline, Antimicrobial, Heterocyclic compounds, Hydrazone derivatives.
High Frequency of Hemolysin Associated Genes among Staphylococcus Aureus Clinical Isolates in Iraq Ali Jaffar Saleem
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

AbstractIn current study, 120 clinical isolates of Staphylococcus aureus were collected from different hospitals in Diyala. In addtion of phenotypic method, all isolates diagnosed as S. aureus by genotypic method was done by Polymerase Chain Reaction (PCR) technique to detection nuc gene. PCR technique has been used to investigate hemolysin associated genes that encoding for hla, hlb, hlg and hld by using specific primers which showed the prevalence in percentage (95%, 79.17%, 90% and 96.67%) respectively. All isolates were found to be positive for at least two or more hemolysin genes and 69.17% of isolates were carrying all hemolysin genes.Keywords: Staphylococcus aureus, Thermo nuclease gene, Virulence genes, Alpha, Beta, Gamma and delta hemolysin.
Effect of Sonication to Protein Extraction from Jackfruit Seed (Artocarpus Heterophyllus) Flour Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Ultrasound technology is growing rapidly in the field of research and development of non-thermal food processing methods. Jackfruit seeds are not only nutritive, but also tasty. The flour from seeds is a fruit residue featuring alternative protein, carbohydrate and fiber source. A wide range of ultrasound power, treatment temperature, treatment time, ratio of liquid: solid have been investigated. Optimum conditions for the extraction of protein were found to be: sonication power of 30 W/g, sonication time 3 min, sonication temperature 45oC and solid-liquid ratio of 2.0: 1.0, and the extraction time of 30 min. Ultrasound is one of the emerging technologies that were developed to reduce the cost and time of processing. It ensures the quality and safety of food products. The use of ultrasound can enhance the extraction process by increasing the mass transfer between the solvent and plant material. Ultrasound in the use of plant extraction has benefits in increased mass transfer, better solvent penetration, less dependence on solvent used, extraction at lower temperatures, faster extraction rates and greater yields of product.Keywords: Jackfruit, Protein, Extraction, Sonication.
Study of Some Optical Properties of Poly Methylmethacrylate Copper Nanocomposites Films Nahida B. Hasan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The addition effect of nano Cu on some optical properties for poly methyl-methacrylate has been investigated. Poly methyl-methacrylate with different weight percentages of nano Cu content and different thickness have been prepared. The wavelength range for which absorption spectra have been recorded is (200-800) nm. For indirect allowed and forbidden transition the absorption coefficient, extinction coefficient and energy gap have been determined. Results show an increasing in absorption coefficient and extinction coefficient and decreasing in the energy gap with the Wt.% concentration of nano Copper. Scanning Electron Microscope (SEM) Measurements certificates the compatibility between various components of the polymers and nano materials through the detection of phase separations and interfaces. All figures show the very detailed three-dimensional images at very high magnifications for all films.Keywords: Polymethyl-methacrylate, Nanoparticles, Nano-composites.
The Effect of Ethanol on the Fetal Heart Muscle Galina Zhanaidarova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The survey goal was to study the effect of antenatal intoxication with ethanol on embryogenesis of the fetal cardiac muscle. The experiment was conducted on 48 female rats weighing 180-200 grams. To study the embryotoxic effect of ethanol, 2 groups were created. In group I, 18 rats throughout the pregnancy received a 15% ethanol solution daily instead of water. 18 animals of the control group were kept under normal vivarium conditions. On the 13th, 18th and 21st day of pregnancy, the females were killed, removed from the cauls of living fetuses, their length, body weight and heart weight were measured.Histological preparations stained with hematoxylin and eosin were prepared from the hearts of the fetuses. The nuclear cytoplasmic ratio, capillarydensity of the capillary network and cardiomyoblasts, procardiomyocytes and cardiomyocytes were measured. The data obtained were statistically processed. In group II, 6 animals during pregnancy (from 6 to 21 days) were injected daily with an endogastric solution of 30% ethanol at a dose of 5 g / kg of body weight, and 6 animals of the control group received physiological salt solution in equivalent amounts.On the 18th day of pregnancy, the females were killed, the material taken (cardiac muscle of the fetus) was studied by electron microscopy. Our study showed that antenatal intoxication with ethanol has a pronounced embryotoxic effect on the heart muscle, which manifests itself at the cellular and subcellular levels. The value of the obtained results lies in the fact that for the first time at the electron microscopic level, ultrastructural changes in the fetal cardiac muscle during prenatal intoxication with ethanol are shown. Keywords: Fetal alcohol spectrum disorder, Cardiac muscle, Electron microscopy.
Synthesis, Characterization and Biological Study of Mixed Ligand Complexes Derived from Dithiocarbamate and Azo Enaam I. Yousif
Journal of Global Pharma Technology .
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Abstract

The formation, structural characterisation of mixed ligand complexes of Co II, Zn II and Cd II metal ions with dithiocarbamate, azo and 1, 10-phenanthroline are reported. Ligands and complexes were characterised by analytical and spectroscopic analyses including; FTIR, electronic and 1H, 13C-NMR spectroscopy, microanalysis, chloride content, thermal analysis, magnetic susceptibility and conductance. Physico-chemical techniques indicated complexes demonstrated six coordinate structures in the solid and solution state. Biological activity of the prepared ligands and their mixed metal complexes were screened for their antimicrobial activity against four bacterial species ((Bacillus stubtilis and Staphylococcus aureus (G+)), Escherichia coli and Enterobacter (G-)). Biological data showed that complexes become potentially more active against these tested bacteria compared with the free ligandsKeywords:  Mixed ligand complexes; Structural characterization; Thermal analysis; Biological activity.
The Vermicidal Effectivity of Wudani Leaf Extract (Quisqualis indica Linn) in Treating Infection caused by Gastrointestinal Worms in Cattle Ida Bagus Komang Ardana; Made Suma Anthara; Dan Anak Agung Gde Oka Dharmayudha; DK Harya Putra
Journal of Global Pharma Technology .
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Abstract

The present study was aimed to study whether application of 100% extract of wudani leaf (Quisqualis indica Linn) was able to kill gastrointestinal worms Strongylus Sp. (vermicidal effect). In order to make comparation with commercial drug commonly used, one group was treated with Rheindazol (100 ml of Rheindazol contain 10 gram of albendazol) at a single dose of 10 mg/kg of body weight (BW). The other 3 groups were subjected to a single treatment with 100% wudani leaf extract at 10 mg, 15 mg, and 20 mg/kg of BW, respectively. Assessment on its vermicidal effect was carried out by conducting fecal egg count reduction (FECR). The results showed that the vermicidal property of 100% wudani leaf extract given at 10mg/kg BW was 100% and this was significantly (P < 0.01) higher than that of dose of 15 kg/kg BW (92.4%), 20 mg/kg BW (96%) and even compared to that of albendazol treatment (96%). Thus, from the present in vivo study, it can be concluded that 100% wudani leaf extract due to its vermicidal property can be effectively used to cure gastrointestinal worm infection and, therefore, can be subsequently applied to overcome worm infection in cattle. Keywords: Gastrointestinal worm, Wudani leaf extract, Vermicidal property.
Seroprevalance of Torch Infection in Pregnant Women in Basra City Southern of Iraq Ali. F. Hussein
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background torch infection (toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus) the causative agent for congenital infections in infants and abortion in pregnant women. Objectives the goal of the study was to determine the rates of infection of the toxoplasmosis and viruses that cause abortion in pregnant women. Methods kit (torch) igm, elisa technique. Result: a total of 50 serological samples were collected from adult pregnant women from 2018 -10 to 2018-oct-12. The number of qurna samples was 25 positive infection counts 15 and the estimated infection was 15/25 which accounted for 60%.while the infection rate in abi al-khasib district of the total 25 samples of the number of infection 8 and estimated the proportion of infection 8/25, which constitutes 32% of the toxoplasmosis. the results of the current epidemiological study confirmed that the viruses that cause abortion in the qurnah& abe al-khasib district of rubella were 4of the 50 blood samples (serum) showing that the percentage of infection is4/50, which is 8% and the rate of infection of cytomegalovirus 8/50 which is 16% the results showed that herpes virus was more infected than the virus above 24/50 and that the percentage was estimated to be 48%. these results indicate that the most common percentage among pregnant women toxoplasmosis& herpes virus cytomegalovirus, rubella).)60%, 48%, 16%, and 8%, respectively. The results have been confirmed by using a technique elisa. Conclusion: we concluded from the study the two most common cause's abortion in pregnant women in basra city southern of Iraq t gondi 60%, herpes virus 48%  Keywords: TORCHT- Toxoplasmosis, R –Rubella C- Cytomegalovirus. H- Herpes simplex virus.
The Difference of Intelligence Quotient (IQ) Score Before and After Temporal Lobe Epilepsy (TLE) Surgery: A Quasi-Experimental Study in Indonesia Muhamad Thohar Arifin
Journal of Global Pharma Technology Volume 11 Issue 11 (2019) November 2019
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Abstract

Background: Epilepsy is a serious disorder of the brain, affects almost fifty million people in the world. About 40% of the patients finally became refractory to epileptic drugs, especially those with temporal lobe epilepsy (TLE). Surgical therapy has an important role in stopping further damage to brain cells caused by repeated seizures. The elimination of the seizure after surgery will hopefully result in better intelligence score. This study aims to find out the effect of surgical therapy in TLE patients on the Intelligence Quotient (IQ) score. Method: A quasi-experimental study with pre-test and post-test group design was conducted among 15 respondents. The respondents were taken with consecutive sampling method that underwent anterior temporal lobectomy and have passed at least one-year postoperative period, and also had done an intelligence quotient (IQ) test before surgery. IQ before and after surgery were measured with WAIS and WISC-R method. The statistical tests used were paired t-test by SPSS version 20 for Windows. Result: Most of the respondents were males (66.7%), average age 24.3±7.17 years-old, and 7.7±4.70 year’s duration of seizures. The verbal IQ score after surgery was 98.8±9.88 significantly higher (p=0.01) compared with preoperative verbal IQ (92.7±9.60) score. On the other hand, the performance IQ score after surgery was higher (98.2±8.64) compared with preoperative performance IQ (96.0±9.39), however not statistically significant (p=0.5). A total IQ score after surgery tends to be higher (97.8 ±7.69) compared with preoperative total IQ (93.9±9.28) but not statistically significant (p=0.08).  Conclusion: Our study suggests that postoperative verbal IQ improvement was found to be significantly different compared to the preoperative verbal IQ. However, there was no significant difference in the performance and total IQ score after TLE surgeryKeywords: IQ, Epilepsy, Temporal lobe epilepsy, Surgery.

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