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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Effect of Using Pain Management Techniques in the Rehabilitation of Chronic Lower Back Injury in Athletes and Non-athletes Haider Jumaah Asree Ktaiman
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

In the past few days increased chronic lower back pain, where today is a disease of the era due to the high effort and continuous and disproportionate exercise of the athlete and loads of low back, and the fact that chronic lower back pain is a disease of the modern era and through the experience and work of researchers in medicine Physical therapy and physiotherapy have found that there is little or no use of pain management techniques to treat chronic low back pain and that chronic low back pain is a disease of the modern age. Therefore, researchers considered this study as the first study in Iraq in terms of Techniques in pain management to treat chronic lower back pain. The researchers used the experimental method was the sample included the 12 players injured who suffer from the bottom of the chronic back pain represented by convulsions and muscle cramps, chronic where formed the experimental group of 6 players used pain management techniques within the program consists of 16 weeks either the control group used its traditional 16 week. Search Results showed superiority of the experimental group on the control group in the test Schober to measure the degree of pain where he showed differences (0.021 (in the test side flexibility differences emerged (0.01).Keywords: Pain management techniques, Rehabilitation, Lower back injury.
INCLUSION OF IMMUNOTROPIC DRUGS INTO THE PHARMACOLOGICAL THERAPY OF ORAL LICHEN PLANUS DS Tishkov
Journal of Global Pharma Technology Volume 08 Issue 08
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Abstract

Lichen planus (LP) is one of the most common diseases of oral mucosa (OM). It is characterized by recurrent, persistent course and a great variety of forms.
Silver Nanoparticles Synthesis by Hamza's Khubdat (A.S.) (Kombucha) Tea and used in Burn Wounds Treatment Esam J. Al-Kalifawi
Journal of Global Pharma Technology .
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Abstract

In the present study, silver nanoparticles were synthesized using Hamza's Khubdat (A.S.) tea as the reducing and capping agent. The nanoparticles were characterized using UV-visible, FT-IR, XRD, and SEM methods. The surface plasmon resonance peaks in absorption spectra for silver colloidal solution showed an absorption peak at 340 nm in a UV-visible spectrum. Several peaks were observed indicating the Hamza's Khubdat (A.S.) tea is composed of various functional groups which include vibration of amine groups responsible for the silver nanoparticles formation were characterized by FT-IR. The XRD results suggested that the crystallization of the bio-organic phase occurs on the surface of the silver nanoparticles or vice versa. The broadening of peaks in the XRD patterns was attributed to particle size effects and the average particles size about 29.15 nm. The silver nanoparticles synthesized by using Hamza's Khubdat (A.S.) tea were scanned using SEM. It reveals that a silver nanoparticle seems to be spherical in morphology. In addition, antimicrobial packaging was prepared by mixing colloidal silver nanoparticles synthesized by Hamza's Khubdat (A.S.) tea with nanocellulose pellicle of Hamza's Khubdat (A.S.) and depositing this hybrid coating (NCP/Ag) as a layer. The NCP/Ag coated layer were then characterized by scanning electron microscopy (SEM), furthermore study their antimicrobial activity. SEM showed deposition of Ag nanoparticles on the surface of NCP and formation of a relatively smooth, dense coating layer on the pellicle surface. The results also demonstrated that the NCP /Ag coating exhibited good antibacterial activity against four Gram-negative and four Gram-positive bacteria which causing burn wounds inflammation.Keywords: Hamza's Khubdat (A.S.), Silver nanoparticles, Nanocellulose pellicle, Antimicrobial activity, pathogenic bacteria.
Serum Monoamine Oxidase (A and B) Activities and Oxidative Stress Status in Iraqi Infertile Women Undergoing In Vitro Fertilization Shatha Abdul Wadood Al- Shammaree
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Serum monoamine oxidase (MAO-A and B) activities were measured in 98 infertile women undergoing in vitro fertilization (Intracytoplasmic Sperm Injection ICSI) attending Kamal AL-Samaree Hospital for Infertility and In Vitro Fertilization at Baghdad after treatment with standard long protocol. Methods: Participants in the study were 98 infertile women subdivide according to infertility cause into PCOS, Unknown cause, and Male factor cause. The activities of MAOs, some antioxidant, and oxidant parameters (catalase, thiol levels, and lipid peroxidation product (MDA) were measured. Luteinizing hormone (LH), Follicle stimulating hormone (FSH), LH/FSH ratio, TSH and prolactin were measured. Results: The activities show significant variations among the three infertility groups. Serum MAOs activities (MAO-A, MAO-B) in sera of PCOS (P<0.01), as well, MDA, and total thiol levels were higher significantly when compared with other groups .While, the activity of catalase was lower significantly (p<0.001). Conclusion: Our study reveals the existence of an imbalance between serum oxidant and antioxidant status in infertile women with PCOS undergoing IVF.Keywords: Monoamine Oxidase Activity, Ovary Polycystic Syndrome, Unknown Infertility, Oxidative Stress.
Determination of Standard Parameters of Acorn Squash Leaves Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

One of the priority tasks of pharmacy is to find new sources of raw materials for the medicinal products. The purpose of this work is to determine a number of indicators of the quality of promising medicinal raw materials that are the leaves of acorn squash Cucurbita pepo (Cucurbitaceae) for the creation of regulatory and technical documentation. For our research one of the most competitive kind - "Ukrainian multi-plant" was chosen. This kind is not sensitive to climatic conditions (drought-resistant). It has been grown in many countries with moderate climate and the most parts of Ukraine (Polissya, forest-steppe, steppe) and other since 1950. In this way, for the first time, 7 series of acorn squash leaves of "Ukrainian multi-plant" were studied. The main diagnostic features of morphological structure, including morphometric indicators, the main diagnostic microscopic features of the powder of acorn squash leaves were determined. The work presents the limit values of the main figures of 7 series of raw materials: weight loss during drying (not more than 8.5 %), total ash content (not more than 3.7 %,), extractive substances content (not less than 20.0%), phenolic compounds content (not less than 2.0 %). According to the results obtained the regulatory and technical documentation “Methods of quality control of” Acorn squash leaves “has been developed. Keywords: Acorn squash, Leaf, Morphological structure, Microscopic diagnostic signs, Plant raw materials.
Formation of Bis Oxadiazole- Azo Ligands and Studying of (Spectral Analysis, Thermal Behavior, Bacterial Behavior, Chemical Properties) Nagham Mahmood Aljamali
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Bis oxadiazole – azo   ligands  were synthesized   via  many  chemical  reactions  and   steps  represented  by  reaction  between  diamine  aromatic  compound  with concentration  hydrochloric acid  and sodium nitrite   in azotation  reaction as  a first  step , then  the  second  step  involved  coupling   step  to  yield  mainly  compound  containing  di active  groups , which  will  react  with  semicarbazide  in  cyclization  step  to  formation  first  ligand , after  that  preparation  other  ligands    through  various  reaction  like  insertion  reaction  to  yield  second  ligand , azotation  reaction  to  yield  third  ligand  and  substitution  reaction  like  fourth  and  fifth  ligands.  The  prepared   ligands  have  been   identified   by  spectral  techniques  like (1H NMR , FT.IR  and  UV-Visible  spectra)  with  chemical  studies   like  thermal  behavior , physical properties , TLC – Paper , and  biological  studying  like   microbial  assay. Keywords: Oxadiazole, Semicarbazide, amide, Cyclization , Azo, Insertion , Thiazane.
Effect of Atorvastatin on Cerebral Vasomotor Reactivity in Patients with Ischemic Stroke Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Background and Objectives: statins are effective in the prevention of atherosclerotic plaques formation. According to the observed effects of statins in improving regional blood flow and their protective role against brain stroke, it seems that some of these effects are involved in improving the cerebrovascular reactivity in patients. The objective of this study was to evaluate the effect of statins on cerebrovascular reactivity in patients with ischemic stroke. Methods: This study is a single-blinded randomized clinical trial conducted on 180 patients referred to Imam Khomeini Hospital of Urmia in Iran. The patients were hospitalized due to ischemic stroke and they were included in study based on inclusion and exclusion criteria. Then, they were randomly assigned into control and intervention groups. Intervention group patients, in addition to receiving common drug treatments, were treated with daily atorvastatin 80 mg for three consecutive months and their cerebrovascular reactivity was measured and compared on the arrival, seventh and ninetieth days by Transcranial Doppler(TCD). Finally, results were analyzed using spss20 software. Results: In this study, 180 patients with ischemic stroke were examined, which some of them were excluded from study due to lack of referring for follow-up or death after study. Finally, 75 patients were assigned to intervention group and 72 of them were included in control group. The mean of variables Breath holding index (BHI) and Apnea Mean flow velocity(MFV) in patients of intervention group increased significantly compared to the that in patients of control group (P = 0.049, P = 0.003). According to the results, the difference in increase of mentioned variables in the seventh day, and especially in the ninetieth day, after taking atorvastatin was more prominent, which it can be justified by mechanism of drug. Rest MFV patients in any of the two groups showed no significant difference, which suggests lack of the drug effect on the Rest MFV patients. Conclusion: This study found evidence of significant improved cerebrovascular reactivity of patients after taking Atorvastatin, which this process is independent from benefits caused by reduced blood fat following taking statins and it is created as result of self-regulation improvement of endothelial nitric oxide synthase enzyme.Keywords: Stroke, Atorvastatin, Cerebrovascular reactivity, BHI.
Synthesis of New 2, 4, 5-Triphenyl Imidazole Derivatives Derived from Benzoin and Studying their Biological Activity Rana S. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In this work a series of new 2, 4, 5-triphenyl imidazole derivatives were synthesized. In the beginning, compound [1] was formed from the reaction of benzoin and benzaldehyde in the presence of ammonia, which was reacted with sodium hydride in DMF to obtain imidazole salt. This salt was reacted with adipoyl chloride to give compound [2]. Acid hydrazide derivative [3] was obtained from the reaction of compound [2] with hydrazine hydrate. After that Shiff bases [4-9] have been synthesized from the reaction of compound [3] with different aromatic aldehydes. These new formed compounds were diagnosed by 13C-NMR, 1H-NMR for some of them (in Ahl-Albate University in Jordan) and FT-IR spectroscopy (In Baghdad University). All of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Imidazole, Shiffs bases, Biological activity.
The Removal of Pharmaceuticals and Personal Care Products (PPCPs) as Mixture from Water Stream by Ozonation: The Effect of pH and Retention Time on PPCPs Removal Hind M. Ewadh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Pharmaceuticals and personal care products (PPCPs) can be found in waste water and even sometimes in drinking water with increasing in the concentration especially within this last decade due to the high usage of medicines in daily life. Ketoprofen (KET) and Ibuprofen (IBU), as an anti-inflammatory drug, 17α- ethinylestradiol (EE2) as synthetic estrogen and Galaxolide (HHCB) as personal care products are found in many water sources with different concentration and they are unremovable by the conventional wastewater treatment and can be found in tap or drinking water. In this research, ozonation was used as removal technique to remove these PPCPs as a mixture by varying the ozonation contact between 15, 22.5 and 30 min and changing in pH value between 6, 7.5 and 9. After ozonation, the removal was recorded between (75-100%) for the selected PPCPs. During the ozonation pH was monitored decreasing in value and degradation occurred and transformed products were detected by GC/MS. Thus, ozonation can be used to remove the PPCPs from the water stream and the highest removal was conducted at pH= 9.Keywords: Pharmaceuticals and personal care products, Ibuprofen, Ketoprofen, 17α-ethinylestradiol, Galaxolide, Ozonation.
Detection the Infections with Viral Hepatitis C in Suwayrah / Wasit Governorate/ Iraq Humam Kasem Hussein
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Hepatitis C virus (HCV) is worldwide distributed virus which may lead to the death, its responsible for 15-20% of acute hepatitis. Then, most of these cases will progress to chronic infection. IL-8 considered as a good indicator of liver disorder such as liver carcinoma, which is one of the main complication of infection with HCV. Objective: This study was carried out to detect infection of HCV and its association with serum level of IL-8 by ELISA kits.  Materials and methods: Blood specimens were collected from suspected persons who visited Suwayrah General Hospital during the period from March 2018 to September 2018. Blood specimens (5 ml) were taken from them under aseptic conditions and left for 10 minutes for spontaneous clotting at room temperature before being centrifuged (6000 rpm) to separate the serum. Serum samples were kept frozen at –20°C for determination of HCV Abs and IL-8 levels. Results: The results showed that, this virus was detected in 14 male (58.3%) and in 10 female (41.7%). Most age period susceptible to HCV was 21-40 years 14 (58.3%). Level of IL-8 in HCV patients was (210±2.422 pg/ml) which significantly high (p<0.05) than healthy persons was (48±3.241 pg/ml).  Conclusions: Absence of prophylactic procedures especially vaccination make HCV highly infectious and fatal disease. Both genders are under attack of HCV infection. Age period of the individuals associated with the resistance to gain this virus. IL-8 is a good indicator to liver disease such as HCV.Keywords: Hepatitis C virus; Hepatic inflammation; Liver cirrhosis; Hepatocellular cancer and IL-8.

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