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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Prospects for the Use of the Herb Chamomile in the Manufacture of Dietary Supplements Аngelina V. Streljaeva
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Chamomile flowers is a widely studied pharmaceutical raw material, however, pharmaceutical herb chamomile herbal raw material practically has not been studied, but in practice is an interesting and promising item for further study. The objective of the study was carrying out of the analysis of the herb chamomile raw material (two types-fresh and dried). Method: In accordance with the Russian SP (State Pharmacopoeia) procedures, there were produced etheroleum and alcohol extract. Moisture content was determined as for dried raw material: 14.00±0.74%, for fresh raw material: 71.40±2.23%. Quantitative and qualitative composition was assessed by GLC (gas-liquid chromatography, mass detector) and HPLC (high-performance liquid chromatography) methods. Results: As of comparative analysis of etheroleum and alcoholic extract from herb chamomile, it should be pointed out that azulene derivatives were present in etheroleum and in alcoholic extract; however, chamazulene as such was identified just in etheroleum. In alcoholic extract there was no chamazulene. In alcohol extract there were identified vitamins, flavonoids (kaempferol is the important one), phenol compounds, coumarins, organic acids-ferulic acid and its derivatives, peptides and sugars. Conclusion: The herb chamomile is both a promising dietary food supplement, and a pharmaceutical preparation. There are a lot of studies concerning the determination of herbal`s bioactive components. This process is important for quality control of herbs and its products.Keywords: Herb chamomile, Chamazulene, Matricin, Kaemferol, Ferulic acid.
Detection of Metallo β-lactamase Class among Carbapenem Resistant Acinetobacter baumannii (CRAB) Isolates in Hilla / Iraq Rabeea Abdulelah Al-Hindawi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

During the period between April 2016 and January 2017, a total of 1100 clinical specimens (burns, wounds, throat, urine, blood) were collected from two hospitals in Babylon province Al-Hillah Teaching Hospital and Medical City of Mirjan Hospital. All specimens were cultured and 17 Acinetobacter baumannii isolates were obtained from clinical specimens in a percentage of (1.5%) distributed in burn 11 (2.8%), wound 1 (0.6%), throat 1 (2%), urine 3 (0.7%) and blood 1 (0.9%).This study was conducted to determine the presence of carbapenem resistance Acinetobacter baumannii (CRAB) isolates and the prevalence of Ampc gene responsible for carbapenem-resistance among clinical isolates of A. baumannii collected from two hospitals in Hillah City. Isolates were identified according to VITEK2 system and further confirmed using PCR technique depending on housekeeping genes. Antibiotics susceptibility was assayed by using disks diffusion method according to CLSI recommendations and it’s found 8 isolates was carbapenem resistant. The Carbapenem resistance Acinetobacter baumannii (CRAB) isolates were subjected to monoplex PCR targeting ampC gene, PCR experiments showed that seven (87.5%) isolates were harbored ampC gene. These results revealed that CRAB isolates constitute 47% of all A. baumannii that had been isolated from Al-Hillah Teaching Hospital and Medical City of Mirjan Hospital in Babylon province. This underlies the importance of their accurate identifications and reporting to prevent the emergence of complete resistance to the most potent drugs against A. baumannii in Babylon province.  Keywords:  CRAB, A. baumannii, Carbapenem.
The Effectiveness of the M.U.R.D.E.R Strategy to Solve Problems in Learning Skills of Top and Bottom Facing Service for Student in the Volleyball Saeed Gheni Noori
Journal of Global Pharma Technology .
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Abstract

The study aimed at identifying the efficacy of the murder strategy to solve problems in learning the top-down and bottom-up service skills of volleyball, and researchers have identified the research community of fifth graders, the bio branch of the Rafidain preparatory boys' school in Baghdad governorate for the 2017-2018 school year, the number (86) students, 36 students were selected as a random search sample, divided into two female and experimental groups of 15 students per group and the rest of the students selected for the exploratory experiment, the experimental group exercised a murder strategy to solve the problems, while the officer group exercised the traditional method, the program was applied by two educational units per week for 6 weeks, and in light of the findings of the two researchers, they concluded that the murder strategy to solve the problems had a positive impact on the speed of learning the artistic performance and the accuracy of the service skills facing The top and bottom of the trial group, and the use of this strategy for this group was more influential than in the security group method of learning the performance of the top-down and bottom-facing service skills.Keywords: M.U.R.D.E.R strategy, Top and bottom facing service.
Development of Biocompatible Coatings for Dental Implants Based on Transition Metal Nitrides Alexei Yumashev
Journal of Global Pharma Technology Volume 11 Issue 05 (2019) May 2019
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Abstract

Nitrides are nitrogen (N) compounds with other chemical elements, in particular with transition metals. For transition metal nitrides, the main ones are properties such as homogeneity of the material of nitride products, high electrical conductivity, and high melting points, with hardness exceeding most other known materials. As experimental samples we used ready transition metals alloys from cylinders, 10 mm in diameter, and 20 mm in height. 10 cylinders for each alloy were used. Heating to the required temperatures was carried out using an induction heating furnace. Temperatures were measured with a DT model pyrometer, the measuring range of which ranges from -50 to + 110 °C, with an error of one tenth of a °C. Alloys were studied using electron microscopy, and the hardness of the resulting alloy was also measured. In addition to the samples of implants with a nitride coating, samples of cast products (implants) were produced. 10 samples of each type were made. The nitride film present almost doubled the hardness indices of metals and their alloys. The smallest wear out was observed for gold and platinum samples, the largest - for zirconium, titanium and nickel, 2-3 times more (p≤0.05). The presence of even the thinnest titanium nitride film changed these indicators, as a result of which the wear out level became even lower than that of gold (p≤0.05). The present nitride film prevents the formation of an adsorption layer. Such implants wear out will be slowed down in comparison with metal ones, but without a nitride film, on which an adsorption layer is formed. Along with the preference of titanium physical and chemical properties over other metals and their alloys, the deposition of a titanium nitride film is a necessary property to improve. Titanium has several advantages over other metals, including lower thermal conductivity and resistance to corrosion changes. Titanium nitride gives maximum hardness and maximum wear resistance. Nitride film implants acquire no damage; moreover, nitride spraying can also be used with other types of implants, for example, ceramics. The nitride film gives the metal base additional stability properties, creating a protective layer. The combined use of a titanium implant with titanium nitride spraying (layer thickness no more than 0.1 mm) increases the properties of hardness and wear resistance of implants.Keywords: Nitrogen (N) compounds; Transition metals alloys; Electrical conductivity; Dentistry; Dental implants.
The Study of Subjective Assessment of the Safety and Efficacy of Antihypertensive Drugs from the Group of Beta-Blockers and Calcium Antagonists Tetiana Nehoda
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Introduction: In order to study in more detail the subjective assessment of the effectiveness of antihypertensive monotherapy, the questionnaires of patients were structured. They were divided into groups according to the drugs used by patients belonging to a particular clinical and pharmacological group: beta-blockers and calcium antagonists. The purpose of this study was to study of subjective factual and prognostic assessment of patients' effectiveness of treatment. Materials and methods: Methods such as: questionnaires of patients (content analysis of case histories) were used. Data processing was performed using statistical and mathematical methods and graphical analysis. Results and discussion: There were some patterns of lowering blood pressure in patients on the background of monotherapy of hypertension and patients following the doctor's instructions for treatment. Conclusions: As a result of the study, it was found that most patients follow the recommendations of doctors on the appointment of antihypertensive drugs.
A Simple Data Mining Model for Heart Disease Prediction Santhosh Kumar Sundar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The large amounts of data require information retrieval techniques to extract useful information. Medical data is generally complex and in large volumes.  Data mining techniques are widely used in medical field for various purposes. One of the important applications in medical data analysis is the prediction of diseases. Non Communicable Diseases (NCD) is known as life style disease which requires the medical history of patient. Among other diseases in NCD, Heart disease is the leading cause of death in the world. Heart disease affects the normal functionality of heart. The health care industry gives the huge amount of the health care data and that need to be mined to ascertain hidden information. With the help of data mining and medical history, the early prediction of heart disease can be possible. This paper focuses about the early prediction of heart disease using data mining techniques. For that classification and clustering algorithms are used.Keywords: Non Communicable Disease, Heart Disease, Medical Data Mining, Clustering, Classification.
The Effect of Complex Exercises Using the Strategy of Pressure Game to Develop the Energy Expended for the Heart and the Speed of the Skilled Performance of the Football Players Nabhan Hamid Ahmed
Journal of Global Pharma Technology .
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Abstract

The aim of the research is to identify the effect of the combined exercises using the play method of the pressure to develop the energy released to the heart and the speed of the skill performance of football players. As for the sample of the research, it included the players of the club of 22 players and the Anbar Youth Club participating in the 2016 league championship Results of the study showed that there were significant differences between the results of the research in the post tests of the control group and experimental and for the benefit of the experimental group. The findings of the researchers that the exercises combined with play pressure has a positive effect on the sample research Follicular and through the conclusions were to reach the most important recommendations, including the adoption of complex exercises in the training units and in the special stage of preparation and in a high-intensity interval training and repetitive because of its role in the development of research variables.Keywords: Complex exercises, Strategy, Pressure game, Energy expended, Heart and football players.
Synthesis and Characterization of Some Heterocyclic Compounds and Evaluation of their Antioxidant Activity Auhood Kadhim Zaid
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This study is concerned with the synthesis and characterization of five derivatives of two groups of heterocyclic compounds, dihydroprimidine (DHPM) and imidazole. The DHPM derivatives were [benzyl 6-methyl-4-(naphthalen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (1a)], [benzyl 6-methyl-4-(naphthalen-2-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (2a)] and [benzyl 4-(1-hydroxynaphthalen-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (3a)] and the imidazole compounds were [1,4-bis(4-(4-bromophenyl)-1-(3-chlorophenyl)-1H-imidazol-2-yl) benzene (1b)] and [1,4-bis(4-(4-bromophenyl)-1-phenyl-1H-imidazol-2-yl)benzene (2b)]. Biological testing revealed the prepared compounds to have antioxidant properties. Keywords: Antioxidants, Heterocyclic compounds, Dihydroprimidine, Imidazole, Biological activity.
Effectiveness of Fining Agents for Wax Apple (Syzygium samarangense) Wine Clarification Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Waxe apple fruits are rich sources of nutrition with water, carbohydrate, protein, vitamins, and minerals, along with some medicinal properties. This fruit is highly perishable because of its thin skin and can be easily damaged. The processing of wax apple juice into wine could enhance the value of the fruit. However, turbidity in waxe apple wine is a major problem limiting its contribution to international commercialization. Wine clarification is a widely applicable procedure that involves an agent or a mixture being supplemented to clarify, stabilize or modify the sensory wine attributes. Objective of this study focused on the feasibility of different fining agents such as gluten, gelatin, maize zein, casein, bentonite for clarification of waxe apple wine. This research also examined if there was any synergistic effect while combining gluten with gelatin to improve their fining capability. Our results revealed that 5.0:3.0 g/hL (gluten: gelatin) was adequate to control the haze cloud or turbidity after 3rd week racking of waxe apple wine.Keywords: Waxe apple, Wine, Fining, Clarification, Turbidity, Gluten, Gelatin.
Evaluation the Effect of Treatment on Melatonin Levels among Male with Nephrolithiasis Omar Khalid Suhail
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Kidney stone formation is the source of the common disease nephrolithiasis. Oxidative stress has been increasingly linked to the high incidence of this disease. The hormone melatonin (MLT) is a biogenic amine, plays a role in the human body as an antioxidant and anti-inflammatory parameter; also it could be effective in preventing cell damage. In this study fifty-five male with nephrolithiasis with age and gender-matched (30) apparently, healthy individuals were involved. Twenty0-two of the patients treated with Tamsulosin hydrochloride and potassium citrate treatments were also comprised. Determination of sera and urine contents of urea, creatinine, electrolytes, and MLT levels were carried out. The urea and creatinine concentrations reveal significant increases in sera of patients in comparison to that of control.  A decrease in serum MLT concentration was observed in patients groups in comparison to those of control, while a highly significant diminution in urine MLT concentration was indicated in patients groups after treatment in comparison with that of other groups. As a conclusion the MLT  concentrations were altered in nephrolithiasis patients in comparison with its concentrations in both patients after treatment and healthy subjects, that proved the important role of  MLT as an antioxidant and anti-inflammatory parameter in nephrolithiasis; as well increasing MLT dietary intake or on supplementation was recommend. Keywords: Treatment, Melatonin Levels, Nephrolithiasis.

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