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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Biological Activity of Extraction of Protein Compound From Metapenaeus on Giardia Lamblia Shatha Khudhaier Abbas
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The study includes the extraction of whole bodies of local shrimp from Shatt Al-Arab during Jun 2012 on Giardia lambia which collected  sample from Ibn Al-Balady hospital in Baghdad from patients clinic. The result of study the extract caused all effect was killed of parasite on sixth day followed by  shrimp extract and then  shrimp extract and cyst continue to decline until it reached  in seventh day and (WBC) in  extractwas  and  in  extract compare with control group  and Flagel group , and the result found MLC in  killed the parasite in seventh day.Keywords: Giardia lamblia, Metapenaeus, Red blood cells, White blood cells, Hemoglobin, Packed cell volume.
Histological and Immunological Study of Daily Supplement of Aqueous extract of Thymus vulgaris Leaf in Mice Challenged with Vibrio alginolyticus Ali. M. Al-Dahbi
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The aim of current study was evaluation the potential effects of daily supplement of aqueous extract of thymus vulgaris leaf on immunity system and some of total serum proteins performances in mice was challenged with V. alginolyticus, a total of 20 mice was divided into four group, group I:(Normal saline), group II: injected subcutenously V. alginolyticus, group III administrated orally for 14 day with 400µgkg of aqueous extract Thymus vulgaris leaf. Finally group IV injected subcutenously with V.alginolyticus and administrated orally for 14 day with 400 µg/kg of aqueous extract Thymus vulgaris leaf. The results of phagocytic activity reported there were significant differences (P≤0.05) between group IV (3.90±0.24) and (2.77±0.24); group II (2.65±0.24), while there was no highly significant difference (P≤0.05) between groups II, group III. In other hand lymphocytes proliferation results were revealed group III, group IV (0.380±0.020, 0.400±0.08) were recorded highly significant differences with Group II (2.65±0.24).In addition,  the  total serum proteins  were  showed the highest value was recorded in group III and group IV at day  10 and day 14 with highly significant differences (P≤0.05), Furthermore For  delayed type hypersensitivity (DHT), the  results were revealed  group IV had the highest value after 48, 72  hr, (3. 6±0.33) and recorded a highly significant difference (P≤0.05) with group III, group II after 48, 72 hr. Finally the histopathological examinations of small intestines were showed changes in group II like losing of mucous membranes, damaging in villa, moreover in group IV there were presence of inflammatory cells in damaged area also there were villi partially damaged. This study was revealed depending on the results, the daily supplement of aqueous extract thymus vulgaris leaf (400 µg /kg) had positive effects on the immune response, total serum protein, and showed positive effects in histological examinations through protection the small intestine from V. alginolyticus invasion.Keywords: Aqueous extract of Thymus vulgaris leaf, Histological changes, Immunological response, V.alginolyticus.
The Brain Management of Time and it's Correlative to the Creative Leadership of The Heads Of Scientific Departments in the Faculties of Physical Education and Sports Sciences in Iraq Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The current research problem was identified by answering the following question:Is there a relationship between the effectiveness of time management, and the level of creative leadership of the heads of departments, in the faculties of physical education and sports sciences from the perspective of the members of the faculty and the objectives of the research was to identify the effectiveness of time management and creative leadership of the heads of departments in the faculties of physical education and sports sciences and identify the Iraqi The relationship between the degree of effectiveness of time management and creative leadership of heads of departments in the faculties of physical education and sports sciences in Iraq. The researchers used the descriptive approach in the two methods of surveying and inter relationships. The research community was determined by the professors of faculties of physical education and sports sciences in Iraq. The sample was randomly selected from the (Universities of Muthanna, Babel, Kufa, Karbala, Dhiqar, Missan, Kut, and Qadisiyah) as indicated in the table below. Characterization of research measures Since the current research aims to define the management of time and its relationship to the level of creative leadership of the heads of the scientific departments in the faculties of physical education and sports sciences of Iraq, it was necessary to achieve the objectives of the research tool to develop time management, by defining time management areas from the perspective of members of the Commission Teaching, and preparing a tool for the level of creative leadership by defining its areas from the point of view of faculty members as well .Defining the concept of the study variables: time management and creative leadership. Defining areas of time management and creative leadership as follows: The brain management of time: Planning - Organization - Human Relations - Decision Making - Follow-up and Evaluation .Creative Leadership Scale. The most important conclusions: The philosophy of department heads and their approach to time management and creative production as important elements in the management process is weak. There is a correlation between time management and positive creative leadership through the answers of faculty member’s .The main reasons that limit the professional level of the departments of the academic departments where the recommendations are the limited training courses in the field of management. And the need to prepare a guide to knowledge and guidance in the field of time management, and the creative capabilities of employees in the university institution .The availability of spatial and physical facilities to help prepare for the change process to ensure the sustainability and continuity of the work of faculties of physical education and sports sciences.Keywords: Brain management, Time, Creative, and leadership.
Silver Nanoparticles Synthesized from Citrus aurantium L. & Citrus sinensis L. leaves and Evaluation the Antimicrobial Activity Zina K. Albahadly
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The increases in incidence of drug resistance among pathogenic fungi have made the search for new anti-microorganism inevitable. Nowadays, the synthesis of metal nanoparticles by using green methods is increased rapidly. We synthesized Silver nanoparticles from Citrus aurantium L. and Citrus sinensis L. leaves. AgNPs biosynthesized were characterized by particle analyzer, zeta potential, Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD), and UV-Vis spectroscopy to study the diameter of particles, structure properties of samples, and optical spectroscopy properties respectively. The results obtained revealed that size of AgNPs were 60.5 and 31.72 nm for Citrus aurantium L. and Citrus sinensis L. leaves respectively, with crystallized face-centered cubic structure. The AgNPs biosynthesis showed effective inhibitory antifungal activity against Candida albicanns.Keywords: Biophysics, Antibacterial test, Physical properties.
Toxoplasmosis: A Review Sadiya A. Anah
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Toxoplasmosis one of the common human-animal diseases (Zoonotic diseases) caused by a parasite belongs to the group of coccidian, class of sporozoa known as the Toxoplasma gondii, an intracellular obligate parasite, especially in nucleic cells, as noted inside the nucleus.Keywords: Human-animal diseases; Zoonotic diseases; Parasite; Tissues.
Analytical Method Development for Simultaneous Estimation of Cobicistat and Darunavir by RP-HPLC Method A. Sindhuja
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

A new method was established for simultaneous estimation of Cobicistat and Darunavir by RP-HPLC method.  The chromatographic conditions were successfully developed for the separation of Cobicistat and Darunavir by using Xterra C18 5µm (4.6*250mm) column, flow rate was 1ml/min, mobile phase ratio was Phosphate buffer (0.05M) pH 4.6: ACN   (30:70%v/v)   (pH was adjusted with orthophosphoric acid), detection wave length was 255nm. Five trails have been done with various composition of mobile phase. Among them the mobile phase composition Acetonitrile and phosphate buffer in the ratio of 70:30 (trail no 5), using C18 column as stationary phase and detection at 255nm has produced a well resoluted peak. The no of theoretical plates was 5105, 3788 with a tailing factor of 1.3, 1.4. The peak retention time was 2.399, 3.907 with a peak area of 946124, 11541. The results shown that developed method is rapid, specific for the simultaneous estimation of cobicistat and darunavir in combined dosage form.Keywords: Cobicistat,Darunavir, RP-HPLC, Phosphate buffer, ACN
Application of Agar/ Glycerol as Biodegradable Coating on Storage of Star Apple (Chrysophyllum Cainito) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Star apple (Chrysophyllum cainito) is a non climacteric fruit, with high antioxidant capacity and high nutritional and health benefit. The flesh of star apple is very sweet with glucose as the main sugar. The fruit is very susceptible to water loss so they are easily shrinkage and fruit softening during storage, resulting in the decrease of their commodity value. The major postharvest losses of star apples are due to fungal infection, physiological disorders, and physical injuries. The prevalent method of preservation of postharvest star apples is the use of moderately low temperatures and high humidity. However, low temperatures induce chilling injury. Edible film is environmentally friendly and safe for human health since it is made from natural ingredients. One of the marine polysaccharide used as base material for edible film preparation is agar. Glycerol is also the most widely used plasticizer in edible film making. An investigation on coating of star apples by using agar/glycerol was investigated. Star apples which were coated with 2.75% agar and 6.8% glycerol still maintained good quality until 30 days of preservation. Application of edible coating on star apple is able to reduce quality changes and slow down moisture loss by controlling and modifying the internal atmosphere of the individual fruits. The great benefit conferred by edible coatings is that these are natural biodegradable products.Keywords: Star apple, Agar, Glycerol, Biodegradable, Coating, Storage, Shelf-life.
Synthesis, Electro Conductivity, Thermal Stability and Antibacterial Activity of New Bis 1, 3, 4-Oxadiazole Copolymers Munged Jabbar Mohsin
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

A series of bis oxadiazole copolymer were synthesized. The first series was synthesized by the reaction the resorcinol with ethylbromacetate to obtain diethyl 2,2'-[benzene-1,3-diylbis(oxy)]diacetate (1). Compound 1 was converted to their corresponding di hydrazide (2). This compound was reacted with oxalyl chloride in pyridine and N-Methyl-2-pyrrolidone (NMP) to obtained P1. This polymer was converted to P2 by cyclized it in the presence of polypesporic acid (PPA) as dehydrating agent to obtain P2 as bis oxadiazole copolymer. P3-P7 was synthesized by the reaction of compound 2 with five various di carboxylic acid in PPA as depicted in Scheme 1. These copolymers were characterized by IR and 1H-NMR. The electro conductivity of synthesized copolymer were tested at 20, 20000 Hz at 25, 35, 45, 55, 65, 75, 85 and 95 ̊C. Various positive and negative conductivity were recorded in most copolymers at different temperature. Thermal stability was studied for all copolymers. Copolymers 6 and 7 exhibited significant stability at 450 C. The antibacterial activity for these copolymers was tested against gram negative and gram positive bacteria. Copolymer P1, P2, P5, P6 and P7 showed antibacterial activity against all bacteria under test and P5 exhibited highest inhibition zone (23 mm) against Shigella dysentery, while P7 showed same inhibition against Bacillus subtilis. Furthermore, P7 exhibited inhibition zone equal 19 mm against Esherichia Coli.Keyword: Copolymer, Bis oxadiazole, Electro conductivity thermal.
Systemic Corticosteroids are Effective in about a Half of pemphigus Patients Anfisa Lepekhova
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Systemic corticosteroids (CS) can control flare-ups of the disease and remain the mainstay of treatment. However, even high doses of CS sometimes fail to produce adequate symptom control. We retrospectively analyzed the rate of CS efficacy in 123 pemphigus patients seen at our Department over 16-year period. Our research shows that half (54/123) of patients with pemphigus had lack of response to treatment. PNP was noted only in CS resistant patients (8/54). Also, higher mortality, at least one exacerbation a year and exacerbation during 2-5 year of the disease associated with reduction of CS dose were significantly more frequent in the group of CS resistant patients than in CS sensitive one.We showed that half of patients had a lack of response to CS. However, we found in pemphigus onlyclinical severity subdivision by frequency and clinical manifestations of steroid resistance useful in adjuvant therapy. Adjuvant therapy can beused to treatpemphigus vulgaris to reduce sideeffects of CS or when these therapies are ineffective to achieve a complete remission.Therefore, it is important to investigate a potential molecular biomarkers of CS resistance in patients with pemphigus and other bullous disorders. Keywords: Pemphigus, Steroid insensitivity, Potential biomarkers, Criteria of steroid insensitivity, Severity, Treatment.
Phytonanotechnology Synthesis and Characterization of Silver Nanoparticles using Methanolic Extract of L. Inermis: A Study of the Effect of Temperature, Ph on the Rate of Synthesis and Biochemical Properties Hiba Adnan
Journal of Global Pharma Technology .
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Abstract

Phytonanotechnology synthesis methods are environmentally friendly, readily available, safe and nontoxic. In this study, methanolic extract of Lawsonia inermis has been used for the synthesis of silver nanoparticles. To improve the biological composition of natural nanoparticles, many parameters were investigated, and these were concentration of the extract, pH and temperature of the reaction. The characterization process was performed using techniques of UV-visible spectroscopy, Energy Dispersive X-Ray (EDX) and scanning Electron Microscopy (SEM).  The results illustrated that silver nanoparticles had a size of (150-600) nm and a spherical shape, showed SPR sharp peak between 390- 451 nm and EDX attested that Ag, W, Ru, Cl and C elements exhibited weight percentages of 69 %, 17%, 7.5%, 5.3% and 1.2 % respectively. The antibacterial activity was examined against two Gram positive bacteria (S. aureus and S. pneumoniae) and two Gram negative bacteria (E.coli and P. aeruginosa) by using the agar disk diffusion method , showed that silver nanoparticles had a strong effect against Gram positive bacteria and it is more than Gram negative bacteria. Antioxidant activity was also tested by DPPH test. The % inhibition values were found to be 82.66, 75.43, 71.57 and 62.67μg/ml for Ag NPs, ascorbic acid, L. inermis and BHA respectively at100 μg/ml.Key words: Silver nanoparticles, Law Sonia inermis, Antibacterial and Antioxidant activity.

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