cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
I Wayan Sudarsa
Contact Email
sudarsa@unud.ac.id
Phone
-
Journal Mail Official
globalpharmatechnology@gmail.com
Editorial Address
India
Location
Kota denpasar,
Bali
INDONESIA
Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
 211   212   213   214   215 
Evaluation of Crestal Bone Resorption around Dental Implants In Flapped and Flapless Surgical Techniques Depending on Cone Beam CT Scan (Comparative Study) Mustafa Abdul Hussein Al Najjar
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

around the implants. Some initial loss of bone around dental implants is generally expected. There is reason to believe that reflecting a mucoperiosteal flap promotes crestal bone loss in the initial phase after an implant has been inserted. The surgical placement of a dental implant fixture is constantly changing and in recent years, there has been some interest in developing techniques that minimize the invasive nature of the procedure, with flapless implant surgery being advocated. The purpose of this study was to compare the radiographic level of the peri- implant bone after implant placement between traditional flapped surgery and flapless approach depending on CBCT during 24 weeks healing period.  Materials and Methods: A total of 25 Iraqi patients with 46 implants aged 20-60 years .Were randomized into two groups: control group which involved 27 implants inserted by conventional flapped surgical approach and study group which involved 19 implants inserted by flapless surgical approach. The bone level was measured by CBCT for each implant at buccal and palata/ lingual sides at two times, immediately after implant placement (base line data), and after 24 weeks healing period. Results: There was no significant difference between study (flapless) and control (flapped) groups in the mean of total crestal bone resorption for buccal and palatal sides. Conclusions: Bone resoption around dental implants placed with conventional flap surgery compared to flapless surgery does not seem to be influenced during the healing period before implant loading.
Psychogenic Depression Depending on Gender and Age Differentiation Alena Gura
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of the study is to analyze the factors that can be predictors of the development and progression of psychogenic depressions, as well as establish age and gender characteristics of their clinical options. The study included 140 people (70 females and 70 males) aged 30-70. Patients were divided into 2 groups: group 1 - 70 people diagnosed with psychogenic depression, aged 30 to 50, Group 2 - 70 people diagnosed with psychogenic depression, aged 50-70. In males of the younger age group, anxious (in 10 (28.7%) men) and dysphoric (in 13 (37.1%) men) variants of psychogenic depression were typical. In females, adynamic (in 14 (40%) females) and dysthymic (in 12 (34.2%) females) predominated. In patients of a older age, the gender differentiation of clinical variants of depression disappears, however, in this age group, both among males and females, the proportion of people with the hypochondriacal variant of psychogenic depression significantly increased by 2.6 times (OR = 3.32, 95% CI [1.36- 8, 14]). Thus, we established the presence of significant gender and age differences in the clinical course of psychogenic depressions and the frequency of factors that create the basis for the occurrence of depressive disorders, which should be taken into account when conducting appropriate complex therapy of the disease. Keywords: Gender characteristics of psychogenic depression, Clinical variants of psychogenic depression, Age-related features of psychogenic depression, Trigger factors of psychogenic depression.
Ciprofloxacin Increased Cytotoxicity of Normal Bone Marrow Stem Cells in Mice Treated With Cyclophosphamide and Etoposide Suhool Kareem
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The effects of ciprofloxacin (Cipx) on the cytotoxicity of cyclophosphamide (CP), etoposide (VP-16), and combinations thereof on normal bone marrow stem cells in mice were studied. Cipx was administered prior to or after treatment with CP and VP-16. Chromosomal aberration (CA), micronucleus (MN) and mitotic index (MI) were used as markers.  CP, VP-16 and Cipx and their combinations were injected intraperitoneally at concentrations of 2, 20, 9.5 mg/kg, respectively. Control groups were injected with normal saline and DMSO solution. Cytogenetic analyses were carried out after 24 hrs of treatment. CP and VP-16 reduced MI and increased CA and MN; while Cipx did not produce significant cytotoxic effects when used alone. Additional cytotoxic effects were seen when Cipx was injected before CP and VP-16 combination.  Highest effect was observed when Cipx was injected after injecting combination of CP and VP-16 (p≤0.05).In conclusion; Cipx increased the cytotoxic effects of CP and VP-16 when used before and after treatments with combinations of CP and VP-16.Keywords: Cyclophosphamide; Etoposide; Ciprofloxacin; bone marrow; chromosomal aberration; micronucleus; Mitotic index; cytotoxicity.
Effectiveness of Mindfulness-based Cognitive Therapy (MBCT) on Martial Adjustment among Women Shahrbanoo Ghahari
Journal of Global Pharma Technology Volume 08 Issue 02
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background and goal: marital adjustment is one of the most important issues has been considered in societies. Mindfulness-based cognitive therapy is an effective method in increase of marital adjustment; hence, the purpose of this study is to determine effectiveness of mindfulness-based cognitive therapy on marital adjustment among women. Materials and method: the plan of research is experimental with type of pretest and posttest with control group. Statistical population of this study included all persons who had referred to two Counseling Centers in Rasht City, Iran in 2015. Qualified persons to enter into the study filled out Dyadic Adjustment Scale (DAS) and 30 members were randomly chosen out of 50 members who had gained the lower score than cut off point of marital adjustment (100) and then placed into two test and control groups. Experimental intervention (mindfulness-based cognitive therapy) was implemented on test group and post test was conducted for both groups after the end of intervention. The obtained data from Multivariate Analysis of Covariance (MANCOVA) were analyzed through SPSS 22 software. Findings: The obtained results indicated mindfulness training had a significant effect on marital adjustment among women (P<0/01).Conclusion: according to the obtained results, it can be stated that mindfulness-based cognitive therapy would lead to increase in marital adjustment of women.
Application of Soy Protein Isolate Edible Coating for Mangosteen (Garcinia Mangostana) Storage Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Recently, the mangosteen has been noted to be an abundant source of a class of polyphenols known as xanthones It has a variety of health promoting properties including anti-inflammatory, anti-oxidant, and anti-cancer activity. Mangosteen fruits have a storage and marketable postharvest life of not more than one week under tropical conditions. In order to have supply of this fruit between harvest seasons, which ranges from two to four months depending on local production, it is necessary to use postharvest techniques for the extension of mangosteen shelf life. Application of soy protein isolate as edible coating could be considered as a useful approach to maintain its product quality during preservation. Ojective of the present study focused on the effect of soy protein isolate coating on some physicochemical, microbial and sensory characteristics of mangosteen during preservation. Optimal results showed that weight loss, pH, total soluble solids, titratable acidity and ascorbic acid; total plate count; sensory characteristics could be maintained at appropriate levels by coating mangosteen with 1.5% soy protein isolate.Keywords: Mangosteen, Soy protein isolate, Coating, Preservation, Physicochemical, Microbial, Sensory.
Efficacy and Safety of Canagliflozin Compared to Sitagliptin and Glimepride as Add- on Therapy in T2DM Yazan A. Bataineh
Journal of Global Pharma Technology Volume 11 Issue 07
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes type II is a progressive disease and associated with many complications. Metformin is the first-line pharmacological therapy for type II. However, there is a second anti-diabetic drug can be added for patients who do not achieve sufficient glycemic control with metformin. In this study, we assess the efficacy and safety of newly approved anti-diabetic drugs Canagliflozin compared to Sitagliptin and Glimepiride patient with type II diabetes. Basically, 210 diabetic patients have received Canagliflozin 300 mg or Sitagliptin 100 mg or Glimepiride 4 mg for at least 16 weeks. Previously, the patient's glycemic state was uncontrolled by Metformin monotherapy. Glycated hemoglobin and Fasting blood glucose changes were used as an efficacy assessment from the baseline after metformin discontinuation. The safety profile was determined by comparing patient’s lipid profile, renal function, BUN, renal function and uric acid. Our results had shown a significant reduction in HBA1c and FBS in the three groups after 4 months of treatment (p <0.05). However, there was no significant change in the reducing effect between the three drugs (p= 0.704, 0.521). Canagliflozin and Glimepiride produce more reduction in triglycerides than Sitagliptin through the treatment period, although it is not significant, the change in the effect was significantly higher in Canagliflozin and Glimepiride comparing to Sitagliptin. Unlike Canagliflozin, Glimepiride and Sitagliptin produce a significant reduction in LDL after 4 months of treatment (p = 0.0318, 0.047) and significant difference in the effect (p = 0.042). Canagliflozin cause a significant elevation in LDL after the initiation of therapy (p= 0.034). The effect of Canagliflozin was significantly higher on HDL comparing to Glimepiride and Sitagliptin throughout the treatment (p = 0.048) and as a difference in the effect (p =0.043). Canagliflozin and Glimepiride produce a significant elevation in BUN comparing to Sitagliptin (p = 0. 004, 003), whereas, Canagliflozin and Sitagliptin produce a higher reduction in GFR than Glimepiride. Glimepiride is significantly elevates serum uric acid comparing to Canagliflozin and Sitagliptin with p= 0.0406. Conclusion: Canagliflozin, Sitagliptin, and Glimepiride are effective add-on therapy with metformin for proper control of blood glucose in T2DM. Canagliflozin and Glimepiride improve TGs and LDL greater than Sitagliptin. Sitagliptin produces less elevation in BUN than Canagliflozin and Glimepiride. Canagliflozin and Sitagliptin required renal monitoring throughout treatment.
Preparation and Characterization of Nano Hybrid Antifungal from Amphotericin B and Evaluation its Inhibitory Efficiency against Candidaalbicans Mays Ibrahim Al-Wakeel
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Direct ion exchange method was used to prepare a nanohybrid antifungal from Amphotericin B (AmB) and layered double hydroxides (LDH).The new nanoantifungal was subjected to identification .FT-IR spectroscopy revealed the appearance of new chemical groups in the prepared antifungal which indicates the formation of new compound. The X-Ray Diffraction (XRD) spectrum revealed the appearance of new diffraction planes in the nanohybrid antifungal in compare with the spectrum of layered double Hydroxides. The two and three dimensional image of the above compound obtained from atomic force microscope confirmed the formation of new antifungal with nanodimensions. The antifungal activity of prepared compound was evaluated against Candida albicans isolated from mouth and vagina.Keywords: Amphotericin B, Nanohybrid antifungal, FTIR, XRD, Controlled release, Antifungal activity
Effectiveness of Ethanolic Propolis Extract (EPE) Administration in Ameliorating Diabetic Mice Model Muhaimin Rifa’i
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (DM) is a group of metabolic disorder characterized by hyperglycemia resulting from defects in insulin action, insulin secretion, or both. Many efforts have been made to overcome this disease but until now has not been fully successful. This study aimed at examining CD34+, TER119+VLA4+, B220+  cell population,  and stromal cell-derived factor 1 (SDF-1) expression in an attempt to correct homeostasis indiabetic mice model with active disease.Three different EPE doses were tested (50, 100, and 200 mg/kg BW).  The oral administration of EPE was conducted for 14 days. On day 15, the bone marrow cells were isolated and then subjected to flow cytometry analysis, and data was processed by One-way ANOVA (p < 0.05) and Tukey test using SPSS 16.0 for Windows. The results showed that administration of EPE with the doses of 50 and 100 mg/kg BW) potentially increased cell proliferation. In contrast, the doses of 200 mg/kg BW seem to be in potentially suppressing cell proliferation. Taken together, propolis, which is involved in the induction of proliferation, show a rather in low doses, while high dose will give a suppression effect on cell proliferation and differentiation. Therefore, the use of propolis for treatment should consider the appropriate dose.  Keywords: B220, CD34, Diabetes mellitus, SDF-1, TER-119+VLA-4+.
Multibasillary Leprae Lepromatous Leprosy Type Relaps with Erythema Nodosum Leprosum Reaction: Establishing the Diagnosis Ria Margiana
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Leprosy or Morbus Hansen is a disease caused by infection with Mycobacterium Leprae with manifestations in the skin and peripheral nerves that can cause neuropathy or disability. The case of relapse in leprosy is a condition in which patients who have successfully completed the MDT (multi drug therapy) program with complete and appropriate but there are new symptoms of the disease either during the monitoring period or after. ENL reactions can occur at any time, namely before, during and after MDT therapy. Case: A woman aged 43 years comes to Dermatovenereology clinic with complaints of red bumps accompanied by pain in the face and extremities. On physical examination fromt the facial, superior and inferior limbs appear multiple erythematous nodules with partial hyper pigmented, multiple, indistinct boundaries. Investigation in the form of an AFB test indicates the presence of IB + 3 and IM 0% which previously earned IB +1 IM 2.09%. Histopathological examination revealed an ENL reaction with a red acid-resistant bacillus. The patient is diagnosed with leprosy MB type LL RFT1, 5 years relapsed with ENL Discussion: Relapse or recurrence in leprosy can occur due to a variety of factors, one of which is due to the presence of persistent leprosy bacilli, Becx-Bleumink criteria can be used as a reference for diagnosing relapse that includes clinical features, BTA examination and histopathological features.Keywords: Erythema nodosum leprosum, Leprosy, Relapse.
Ferric (III) Chloride-Catalyzed Synthesis of 3, 4-Dihydropyrimidine-2(1H) Ones / Thiones for Biginelli Reaction and Characterization of Their Anticancer Activity Mahmood Shakir Magtoof
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

We describe the syntheses of  3,4-Dihydropyrimidine-2(1H)Ones/Thiones by a one-pot cyclocondensation of urea or thiourea, aldehydes and ethylacetoacetates using Ferric (III) Chloride as catalyst, this method has the advantage of excellent yields (55–93%) and short reaction time (6-7 hours). Furthermore, we have studied the antioxidant activities of these synthesized 3,4-Dihydropyrimidine-2(1H)Ones/Thiones. Some the synthesized compounds appear the Important antioxidant properties, these properties studied by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. The cellular toxicity of the compound 1 was studied on (MCF7) cell lines using MTT assay that revealed the presence of a toxic effect of the cells with the highest activity of the compound 1 on (MCF7) cell lines. This indicates that compound 1 has an antioxidant and anticancer effect and can be used as a new chemical compound but this needs further investigation in vivo to confirm our results in vitro. The compounds were established on the basis of the spectral studies using IR,1H-NMR, 13C-NMR, and Mass spectra.Key words:  Aldehydes, urea/thiourea, Ethyl acetoacetates, Anticancer, Antioxidant, MCF7.

Page 213 of 244 | Total Record : 2439

 211   212   213   214   215 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Volume 18 Issue 01 (2026) Jan. 2026 Volume 17 Issue 12 (2025) Dec. 2025 Volume 17 Issue 11 (2025) Nov.2025 Volume 17 Issue 10 (2025) Oct. 2025 Volume 17 Issue 04 (2025) April 2025 Volume 17 Issue 03 (2025) March 2025 Volume 17 Issue 02 (2025) Feb. 2025 Volume 17 Issue 01 (2025) Jan 2025 Volume 16 Issue 12 (2024) Dec. 2024 Volume 16 Issue 11 (2024) November 2024 Volume 16 Issue 10 (2024) October 2024 Volume 16 Issue 09 (2024) September 2024 Volume 16 Issue 08 (2024) August 2024 Volume 16 Issue 07 (2024) July 2024 Volume 16 Issue 06 (2024) June 2024 Volume 16 Issue 05 (2024) May 2024 Volume 16 Issue 04 (2024) April 2024 Volume 16 Issue 03 (2024) March 2024 Volume 16 Issue 02 (2024) February 2024 Volume 16 Issue 01 (2024) January 2024 Volume 14 Issue 05 (2022) May 2022 Volume 13 Issue 05 (2021) May 2021 Volume 13 Issue 04 (2021) April 2021 Volume 13 Issue 03 (2021) March 2021 Volume 13 Issue 02 (2021) Feb. 2021 Volume 13 Issue 01 (2021) Jan. 2021 Volume 12 Issue 12 (2020) Dec. 2020 Volume 12 Issue 11 (2020) Nov. 2020 Volume 12 Issue 10 (2020) Oct. 2020 Volume 12 Issue 09 (2020) Sept. 2020 Volume 12 Issue 08 (2020) Aug. 2020 Volume 12 Issue 07 (2020) July 2020 Volume 12 Issue 06 (2020) June 2020 Volume 12 Issue 05 (2020) May 2020 Volume 12 Issue 04 (2020) April 2020 Volume 12 Issue 03 (2020) March 2020 Volume 12 Issue 02 (2020) Feb. 2020 Volume 12 Issue 01 (2020) Jan. 2020 Volume 12 Issue 08 Volume 11 Issue 12 (2019) December 2019 Volume 11 Issue 11 (2019) November 2019 Volume 11 Issue 10 (2019) October 2019 Volume 11 Issue 09 (2019) September 2019 Volume 11 Issue 09: (2019) September 2019 Volume 11 Issue 08 (2019) Aug. 2019 Volume 11 Issue 07 (2019) July 2019 Volume 11 Issue 06 (2019) June 2019 Volume 11 Issue 05 (2019) May 2019 Volume 11 Issue 04 (2019) April 2019 Volume 11 Issue 03 (2019) March. 2019 Volume 11 Issue 02 (2019) Feb. 2019 Volume 11 Issue 01 (2019) Jan. 2019 Volume 11 Issue 2: 2019 Volume 10 Issue 12. Volume 11 Issue 6. Volume 10 Issue 12 (2018) December 2018 Volume 10 Issue 11 (2018) November 2018 Volume 10 Issue 10 (2018) October 2018 Volume 10 Issue 09: (2018) September 2018 Volume 10 Issue 08: (2018) August 2018 Volume 10 Issue 07: (2018) July 2018 Volume 10 Issue 06: (2018) June 2018 Volume 10 Issue 05: (2018) May2018 Volume 10 Issue 04: (2018) April 2018 Volume 10 Issue 02: (2018) Feb 2018 Volume 10 Issue 01: (2018) Jan. 2018 Volume 10 Issue 10: 2018 Volume 10 Issue 01 Volume 09 Issue 12 Volume 09 Issue 11 Volume 9 Issue 11 . Vol. 9 Issue 7 : 2017 Volume 9 Issue 10 Volume 09 Issue 09 Volume 09 Issue 08 Volume 9 Issue 07 Volume 09 Issue 05 Volume 09 Issue 04 Volume 09 Issue 03 Volume 09 Issue 02 Volume 08 Issue 11 Volume 08 Issue 07 Volume 08 Issue 06 Volume 08 Issue 05 Volume 08 Issue 04 Volume 08 Issue 03 Volume 08 Issue 02 Volume 08 Issue 01 Volume. 9 Issue 6 Volume 08 Issue 10: (2016) October 2016 Volume 08 Issue 09: (2016) September 2016 Volume 12 Issue 01 Volume 11 Issue 07 Volume 11 Issue 05. Volume 11 Issue 04. Volume 11 Issue 03 Volume 11 Issue 01. Volume 08 Issue 08 Volume 04 Issue 02: (2012) February 2012 Volume 03 Issue 06: (2011) June 2011 Volume 03 Issue 04: (2011) April 2011 Volume 02 Issue 10: (2010) Oct.2010 Volume 02 Issue 07: (2010) July 2010 Volume 02 Issue 05: (2010) May 2010 Volume 02 Issue 03: (2010) March 2010 More Issue