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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Characterization and Antibacterial Studies of Some New Imidazole Derivatives Saif M. Ali
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

In this work, imidazole derivatives were synthesized by the reaction of benzoyl thiourea with ethyl chloro acetate (1). Hydrolysis of ester for compound (1) was synthesized by reaction of Imidazole derivative (1) with KOH give 2-((1-benzoyl-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio)acetic acid (2),compound (1)treatment with aldehydes gave ethyl 2-((1-benzoyl (Arylidene)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio)acetate(3a-e). Hydrolysis of ester forcompound (3a-e)with KOH gives ethyl 2-((1-benzoyl (Arylidene)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)thio) acetic acid (4a-e),Compound (3a-e)reaction with thiourea and HCl concentration gives ethyl 2-((9-benzoyl-6-(phenyl)-2-thioxo-2,5,6,9-tetrahydro-1H-purin-8-yl)thio)acetate (5a-e). Compound (3a-e)reaction with hydrazine hydrate gives 2-((6-benzoyl-3-(phenyl)-3a,6-dihydroimidazo[4,5-c]pyrazol-5-yl)thio)acetohydrazide (6a-e).All imidazole derivatives have been characterized by 1H-NMR, IR, and mass spectroscopy.Keywords: Imidazolederivatives, Hydrolysis, Pyrimidine, Hydrazide.
Biochemical Observations in Patients Suffered From Acute and Chronic Kidney Diseases with Reference to Thyroxi Omar K Hassan
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Blood samples of acute kidney injury (AKI) patients (20) ;chronic kidney disease(CKD) patients (20) and normal persons(20), were collected from the central dialysis unit and private clinical diagnostic laboratories in Mosul city/Iraq during the period from (Jan. to March.2018), for investigation of blood urea, serum creatinine, serum thyroxin (T4) and serum total protein, Albumin and Globulin. Results reviled that only urea and creatinine were significantly reduced in AKI patients, but all studied parameters except albumin were significantly reduced in CKD patients in comparison with normal persons. Health significance of all parameter s levels was discussed.
Porphyromonas Gingivalis fim A Type I, II, III, IV, V and Ib Genotypes Distribution among Malay Chronic Periodontitis Patients Tara Bai Taiyeb Ali
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

III, IV, V and Ib genotypes in the Malay ethnic group and to relate their presence to chronic periodontitis. Design: A total of 30 Malay subjects (15 periodontitis and 15 periodontally healthy subjects) aged 25 years and above were selected. Clinical periodontal parameters were recorded for each subject. Subgingival plaque samples were collected from the deep pockets ≥5mm in periodontitis subjects and from subgingival areas in healthy subjects. Presence of P. gingivalis fimA types I, II, III, IV, V and Ib genotypes were identified by polymerase chain reaction followed by agarose gel electrophoresis.  Results: P. gingivalis was more prevalent in periodontitis subjects (53.33%) as compared to periodontally healthy subjects (13.33%). In periodontitis subjects, P. gingivalis fimA I, II, IV, V and Ib genotypes were detected in of 20%, 33.33% 20%, 6.67% and 13.33% respectively among periodontitis subjects. The frequency of genotype fimA type II was greater where plaque accumulation was >1. However, P. gingivalis fimA IV genotype followed by fimA Ib genotype were detected in higher percentages. Conclusion: P. gingivalis was detected in periodontally diseased and healthy subjects. P. gingivalis fimA genotype II, IV and Ib was identified in diseased subjects only. In conclusion, the prevalence of P. gingivalis especially fimA genotype II, IV and Ib can be used as indicator to differentiate between diseased and healthy subjects.Keywords: P. gingivalis, Chronic periodontitis, Genotypes.
The Effect of Dihydrotestosterone Hormone on the Sulfotransferase 1A1 Enzyme Level in the Scalp Hair Follicle in Patients with Androgenic Alopecia and its Effect on Response to Minoxidil Raghad NA
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective:  to evaluate the association between the dihydrotestosterone hormone level and the level of sulfotransferase 1A1 enzyme inside the scalp hair follicle in patients with androgenic alopecia. Method: The study was conducted with the participation of 67 androgenic alopecia patients (37 females and 30 males). The level of serum dihydrotestosterone hormone was estimated using enzyme linked immunosorbent assay. The sulfotransferase enzyme 1A1 was extracted from the plugged scalp hair follicle by sonication and estimated using enzyme linked immunosorbent assay. Results: In this study, it was found that there is a significant association between the level of serum dihydrotestosterone hormone and the level of sulfotransferase 1A1 enzyme inside the scalp hair follicle in patients of androgenic alopecia ( p-value< 0.001), which means that whenever the level of serum dihydrotestosterone hormone increases, the concentration of the sulfotransferase 1A1 enzyme inside the scalp hair follicle decreases, and probably it will affect the response of a patient toward the minoxidil. Conclusion:  reducing the level of serum dihydrotestosterone hormone, could increase the level of sulfotransferase 1A1 enzyme inside the scalp hair follicle and that concept can lead to modulate the treatment regimen of androgenic alopecia.
The Influence of the Musical Rhythm according to the Interactive Method of Learning the Top-down Passing Skills in the Volleyball for Students Saeed Gheni Noori
Journal of Global Pharma Technology .
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Abstract

The objective of the search is to identify the effectiveness of the use of musical tunes in the interactive method of learning the top-down passing skills in the volleyball, and the experimental method has been used to suit the nature of the problem. The research community has identified the fourth grade students of the Dar Al Salaam boys school in Misan governorate for the 2018-2017 school year, which totaled (72) students. (60) Students were randomly selected from the research community, who accounted for (83.3) of the community, and were divided into two groups, the control group was (30) students and the experimental group was (30) students. Thus, the researchers conducted parity between the two groups, and it took (5) weeks to implement the program by two educational units per week, and at a time of (45 minutes) per educational unit. The researchers used the method of application (SPSS) and some other statistical means. The researchers concluded the effectiveness of the program using the rhythms of music according to the method of exchange in learning the skills of passing up and down in the volleyball, and also concluded the speed in the acquisition of skills because of the adaptation of students with the program prepared for the duty sheet and feedback.Keywords: Music rhythm, Interactive mode, Skills of passing top and skill of passing from down.
Phytochemical Analysis and In Vitro Cytotoxicity of n-Hexane Extract of Kaempferia pandurata and its Nanoparticle to Breast Cancer MCF-7 Cells Fadilah Fadilah
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Background: Finger root (Kaempferia pandurata) is a medicinal herb which has shown anticancer activity as potential targeted-therapy towards estrogen receptor positive breast cancer. Objective: This research was conducted to analyze the phytochemical contents of n-hexane extract of Kaempferia pandurata and its nanoparticle to the growth of estrogen positive breast cancer MCF-7 cells. Methods: Kaempferia pandurata rhizome was extracted in n-hexane, and its phytochemical contents was analyzed by simple phytochemical test and thin layer chromatography. Nanoparticle was then synthesized from n-hexane extract of Kaempferia pandurata. Finally, the n-hexane extract of Kaempferia pandurata and its nanoparticle were then tested using MTT Assay to MCF-7 cells in order to determine their inhibition rate and IC50. Results:. The extraction of Kaempferia pandurata rhizome in n-hexane extract was conducted successfully. Through simple phytochemical testing, n-hexane extract of Kaempferia pandurata contained flavonoids, triterpenoids, and tannins. Thin layer chromatography using non-polar eluent (n-hexane : ethyl acetate = 5 :1) showed eight spots with Rf values of 0,12; 0,18; 0,23; 0,29; 0,41; 0,55; 0,62; 0,80. MTT assay resulted in IC50 value of 94.387 ± 11.667 μg/mL and 31,298 ± 0,242 μg/mL for n-hexane extract of Kaempferia pandurata and its nanoparticle respectively. Discussion: The phytochemical contents of n-hexane extract of Kaempferia pandurata (flavonoid, triterpenoid, tannin) was shown to have anticancer activities on breast cancer cells n-hexane extract of Kaempferia pandurata and its nanoparticle has moderately active anticancer activities towards estrogen positive breast cancer MCF-7 cells. Nanoparticle enhances n-hexane extract of Kaempferia pandurata’s entry to cancer cells. Conclusion: N-hexane extract of Kaempferia pandurata and its nanoparticle can be a potenial anticancer agent towards estrogen positive breast cancer.
Antibacterial Evaluation of Quassia Indica (Gaertn.) Nooteb. in Steenis Towards Bacteria Involved in Skin Diseases Kassim Ajeena P; Thomas Toji
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Quassia indica has been used as medication for a number of diseases in traditional systems of medicine. Leaves of Quassia indica evaluated for its antibacterial potential and phytochemical contents in various solvent extracts of the plant in increasing polarity towards pathogenic bacterial species involved in skin diseases in human beings. Antibacterial activity was evaluated by disc diffusion method. Petroleum ether and ethanol extracts were found to be active against Pseudomonas aeruginosa. The results indicated that the plant exhibited antibacterial activity especially towards single pathogen, Pseudomonas aeruginosa. Phytochemical analyses were performed to analyse the nature of compounds contained in the active extracts. Flavonoids, phenols, steroids were detected in petroleum ether and ethanol extracts. Alkaloids were not detected in any of the extracts. Active ethanol extract of the plant exhibited minimum inhibitory concentration as well as minimum bactericidal concentration of 31.25mg/ml towards Pseudomonas aeruginosa. The study revealed that the active ethanol extract possessed some antibacterial compounds, which could be isolated from the ethanol extract. Keywords: Quassia indica,Simaroubaceae, antibacterial, disc diffusion, MIC
Analysis of 4-Hydroxy-N-Desmethyltamoxifen and Tamoxifen in Dried Blood Spot of Breast Cancer Patients By Liquid Chromatography – Tandem Mass Spectrometry Yahdiana Harahap
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Tamoxifen is the first line hormonal therapy for breast cancer patients as their adjuvant therapy. The antiestrogen effect of tamoxifen is highly determined by its active metabolite, endoxifen. A simultaneous quantification method of tamoxifen and endoxifen in dried blood spot (DBS) using LC-MS/MS had been fully validated in this study. Extraction the analyte and metabolite from DBS card were conducted using methanol-acetonitrile (50:50). The separation was performed on UPLC Class BEH C18 column using 0.2% formic acid - acetonitrile as the mobile phase in gradient elution mode at 0.2ml/min. The detection of the mass was performed on Waters Xevo TQD using positive electrospray ionization for tamoxifen, endoxifen, and clomiphene as the internal standard with m/z value: 372.22>72.22; 374.29>58.2; 406.28>100.17, respectively. This method was linear in the range concentration of 5-200 ng/ml for tamoxifen and 1-40 ng/ml for endoxifen with r value 0.99. The method was applied to 40 breast cancer patients, where the results lied between 40.28 and 194.10 ng/ml for tamoxifen, meanwhile for endoxifen was 1.25 and 18.02 ng/ml. It showed that there were 4 patients received less effective tamoxifen therapy based on the endoxifen threshold in DBS sample, which was 3.3 ng/ml. This method has prospect future to optimize tamoxifen therapy by measuring tamoxifen and endoxifen concentration. Keywords: Breast cancer; Dried blood spot; Endoxifen; Tamoxifen; Clomiphene; Analysis;  LC-MS/MS; Validation.
Effects Cytokinin in Seed Germination Indexes Psyllium Plantago Psyllium Mohammad Amin Noorani
Journal of Global Pharma Technology .
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Abstract

Seed priming technique by which seeds under controlled conditions before being placed in their original context and this treatment before planting the exposure seeds ecological condition of the environment, physiological andbiochemical preparations not find germination This improves germination, initial establishment of the plant,earliness quality and as defense mechanisms of plants conditions. Seed dormancy treatments include the use concentrations (100, 50, 0) and kinetin concentrations (100, 50, 0) ppm. Percentage and speed of germination, germination efficiency, mean germination time, germination index, vigor index, the value germination, seedling length were measured. The results showed that in the psyllium for 100 with Kinetin Minimum germination in the passion is the same treatments. The lowest percentage in the psyllium kinetin 50.Keywords: seed dormancy, gibberellic acid, kinetin
Detection of the Effectiveness Metabolic Production of Pseudomonas Fluorescence towards Inhibition of Growth Fusarium Graminearum and Production to Zeralenone Wisam Jasim Abed Ali
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The study aimed to conduct a survey of fungi associated with the rice crop and focus on Fusarium graminearum and the detection of its ability to produce of zeralenone. 50 samples of local and imported rice were collected in the city of Diwaniyah. The results showed a wide spread of fungi in local and imported rice samples, where the fungi are isolated Aspergillus spp, Fusarium spp., Alternaria spp. , Penicillium spp., Rhizopus spp. and Mucor spp. by ratio (32,24,20,8,8,8) %. Results of ELISA examination were shown four species of Fusarium graminearum were produced of zeralenone by rate 33.3%. The results showed the effectiveness of metabolic products of bacteria showed high efficacy to inhibit the growth of F. graminearum and inhibit the production of zeralenone at four concentrations of metabolic products from Pseudomonas fluorescence (250, 500, 750, 1000) mg/l.Keywords: Fusarium graminearum, Zeralenone, Pseudomonas fluorescence.

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