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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Phytotherapy for Insomnia: A Review of the Most Important Effective Medicinal Plants in Treating Insomnia According to References of Iran Abdolrahim Kazemi Vardanjani
Journal of Global Pharma Technology Volume 08 Issue 09: (2016) September 2016
Publisher : Journal of Global Pharma Technology

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Abstract

Sleep is a complex biological pattern and one of the circadian rhythm. Insomnia referring to difficulty falling asleep or staying asleep, or lack of sleep, which is tonic and refreshing, is one of the most common disorders of this pattern. Some of the complications of sleep deprivation are weakened immune system, reduced glucose tolerance, reduced hypothalamic-pituitary-adrenal axis activity during subsequent days, hypertension, decreased level of maximum ability to exercise, non-dependently increased risk of cardiovascular events, and talent. In the light of the significance of sleep, appropriate treatment of insomnia, and high prevalence of insomnia in the community, a strategy to treat insomnia can be development of a specific therapeutic strategy and nature-based, complementary medicines. This review article seeks to report the effective medicinal plants on insomnia according to the ethnobotanical references of Iran. According to the findings, 17 plant species from 11 families have been used for prevention and treatment of insomnia n Iran.
Synthesis and Characterization of Some Bis Heterocyclic Compounds from (Dapson and 3-Amino Phenol) Faez Abdul-Hussein Al-Rammahi
Journal of Global Pharma Technology .
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Abstract

This study involves synthesized of diheterocyclic compounds of the reaction of (4,4-diamino diphenylsulphon (DDS) and 3-Aminophenol with (benzoin, 2-Hydroxy-1,2-diphenylethanone); These compounds were characterized by melting point and FT-IR spectroscopy and the biologicl activity was evaluated against four kinds of bacteria two positive and two negative.Keywords: Heterocyclic compounds, Schiff base, Oxazepine, Imidazolidine, benzoin, Dapson.
Corrosion Protection of Stainless Steel by Electro Polymerization of 4- (2-Hydroxy Benzamido) -4- Oxobut- 2 -Enoicacid and Study its Biological Activity Sana A. Habeeb
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Poly4-(2-hydroxy benzamido)-4-oxo but-2-enoi cacid (PHOE) was prepared by the electrochemical polymerization of 4-(2-hydroxy benzamido)-4-oxobut-2-enoicacid (HOE) monomer on stainless steel (St.S)   asanti -corrosion coating.  Atomic Force Microscope (AFM), Fourier transform infrared techniques (FTIR) and cyclic voltammetry were used to characterize the properties and the structure of the polymer layer.  The corrosion behavior of  uncoated and coated  St.S were estimated from Tafels plots using Potentiostatic  technique in 0.2 M HCl solution as  corrosive environment  at temperature range( 293 – 323) K. Nanomaterials such as  graphene and Nano ZnO in the different concentrations were added to monomer solution to improve the corrosion resistance  of  St.S surface so that  the results showed  that the values of  corrosion  protection efficiency  for  polymeric  coating increase with adding Nanomaterials . In addition the kinetics and thermodynamics parameter were calculated for St.S corrosion   before and after polymeric coating in the acidic medium, moreover, the influence of the prepared polymer on some strains of bacteria was studied.Keyword: Anti-corrosion, Electrochemical polymerization, Stainless steel, Coating, Antibacterial activity.
The Influence of Health Education and Simulation Methods on The Improvement of Mother’s Knowledge and Skill in Handling Injury Toward Children at Home Abd. Hady J; Andi Agustang; Arlin Adam; Simunati Simunati; Hariani Hariani; Nuraeni Mustari
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

This research aimed to analyze the influence of providing health education and simulation method on the mothers’s knowledge and skill in handling first aid toward children at home. This research was a quasi-experimental research by utilizing two group pretest-posttest design. The sample size were 65 mothers, selected using purposive sampling. Data collection was carried out in the pre test and post test phases. In this case, the data were collected through questionnaires, observations and interviews. After the data has been collected, then analyzed using paired sample t-test. Regarding the knowledge, the statistical test result was obtained p-value of 0.000 (
Synthesis, Characterization and Investigation Liquid Crystalline, Properties of 1, 2, 3-triazole Derivatives via Cycloaddition Reaction Nisreen H Karam
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The new of compounds synthesized by sequence reactions starting from a reaction of 3-phenylenediamine  or 4-phenylenediamine  with chloroacetyl chloride to produce the compounds [I]a,b, then the compounds[I]a,b reacted with sodium azide to yield compounds[II]a,b that reacted 1,3-dipolarcycloaddition reaction  with   acrylic acid to give compounds [III]a,b these compounds reacted with  methanol led to ester compounds[IV]a,b then reacted with  hydrazine to give acid hydrazide [V]a,b . Finally compounds [V]a,b reacted with   aromatic aldehydes to product shiff bases derivatives. The compounds characterized by mp. , IR, 1HNMR in addition to mass spectroscopy for some of them the liquid crystals properties were studied by using polarized optical microscope (pom) and deferential calorimetry (DSC).    Keywords: Liquid crystal, 1, 2, 3-triazole ring, Clicks reaction.
CPCR Results in Cardiac Arrested Patients in Motahari Hospital Affiliated to Jahrom University of Medical Sciences, Iran, 2011-2015 Mohsen Hojat
Journal of Global Pharma Technology .
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Abstract

Introduction Cardiopulmonary resuscitation (CPR) in hospital has received much attention over the last decade. Computing international indices of CPR in hospital can be a guideline for researchers and managers in determining the executive and research priorities. So this study was designed and implemented to evaluate the results of CPR in Motahari Hospital in Jahrom. Materials and Methods this study was a cross-sectional and analytic study that designed and implemented in Motahari Hospital affiliated with the Jahrom University of Medical Sciences during 2011-2015. All patients receiving resuscitation were evaluated each year and in each section as the census regardless of the background factors; and information was collected through cardiopulmonary resuscitation checklist which was filled by clinical supervisor and hospital resident doctor per shift. Content and face validity was calculated according to opinion of 5 professors, content validity index (0.77), and the content validity ratio (0.83); reliability of the tool was calculated through education of clinical supervisors and acquisition of Kappa coefficient to researchers (96%). Data were analyzed by SPSS16 software. Results In this study, resuscitation was annually performed on 353 patients from 389 cases during 2011-2015, that the patients were 78.61% males and 21.39% females with an age range of 1-98 years and an average age of 55.6 years. Of the total cases conducted resuscitation, successful resuscitation was 56.29% at 24 hours and return of spontaneous blood circulation was 63.03% at first 20 minutes. Average total of duration of resuscitation was reported 59.58 minutes. Conclusion the results of this study are consistent with the results of European and America countries. It also shows that the faster resuscitation start and quick and correct use of defibrillator can improve short-term and long-term indicators of resuscitation.Keywords: Cardiopulmonary resuscitation (CPR), ROSC - S to D.
Evaluation of Antioxidant and Anticancer Activity of Kohautia Aspera (Heyne Ex Roth) Bremek Kavitha G; Sivakkumar T; Elessy Abraham
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

The purpose of present study was to investigate the antioxidant and anticancer activities of selected extracts of Kohautia aspera (Heyne ex Roth) Bremek. The chloroform, water and ethanolic extracts which are rich in phytoconstituents were subjected to DPPH photometric assay and standard MTT assay. The percentage of growth inhibition in antioxidant study increased with increasing concentration of extracts. The ethanolic extract showed better antioxidant activity followed by other extracts. The anticancer potential of plant was investigated by standard MTT assay against SK-MEL 28 skin cancer cells. In vitro cytotoxic activity of plant increased with increasing concentration of extracts. The results clearly indicated that the extracts of the study species has potential inhibition of free radicals and powerful anticancer activity against skin cancer cells.
Informed Consent to Clinical Trial as Factor Determining Participation Igor Mareev
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The informed consent (IC) form and the doctor involved in the research are the major sources of information for participants in clinical trial (CT). Thereby, they are directly influencing the perception of possible participants and they decisions about participation. However, significance of these factors for the participants in the BE study remains unclear. The leading method applied was a questionnaire survey: a volunteer (n=137), who has already experienced the practice of participation in clinical trial and satisfies the selection criteria, was once asked to fill in the questionnaire on his own. As the research progressed, all the respondents were divided into two groups: participants who got acknowledged about the IC by a doctor and independently. In the group of respondents, who read IC independently, students dominated. The significance of factors influencing the decision to participate in clinical trial was assessed on a five-point scale. Respondents noted the following as the most significant motivators: a cash reward, regular health observation and observation by professional experts. Negatively colored factors were the risk of side effects, adherence to restrictions, and the use of a new drug. Thus, research results showed that volunteers adequately assess the risks of participation in clinical trial. Material affluence plays a key role in motivation and determines the ‘professionalization’ of volunteers in the BE study. This factor is undoubtedly the leading risk of ethics violation.Keywords: Clinical trials, Bioequivalence, Informed consent, Perception, Motivation, Decision-making.
Clinical Study for Oxidative Stress and Lipid Profile Levels in Patients with Cardiac Arrhythmias Mohammed. L. A. Al-Baaj
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Cardiac arrhythmia is a disturbance heart rhythm. Most types of arrhythmia are not serious, while there are some that types can be life threatening promptly because it impacts the pumping action of the heart substantially, enough to disrupt blood supply to the body, potentially leading to sudden cardiac death. The present study is designed to determine the levels of (MDA) (malondialdehyde) as a marker for lipid peroxidation , in addition, measurement  the level of lipid profile (cholesterol TCH, triglyceride TG, high density lipoprotein HDL, low density lipoprotein LDL, very low density lipoprotein vLDL, in patients of cardiac arrhythmia. The study includes (110) subjects with average age (62.0±3.0) years and the average of BMI was (27.80 ± 3.0 kg/m2) which were divided into five groups: (20) patients of (AF), (17) Patients of (SVT), (20) patients of (VT), (18) patients of (PVCs) and (35) clinically healthy subjects, who were attend blood bank to blood donation as control groups. The study aims to shed a light on the correlation between oxidants and lipid profile  in patients with cardiac arrhythmia .The results show that there were a significant increases in serum concentrations of  each of (MDA) ,(TCH), (TG), (LDL) and (vLDL)  in all  of patients groups in comparison with control group (P≤0.05), as for level of (HDL) there was a significant reduction (P≤0.05) In patients of AF in comparison with each one of study groups, also there was a significant increase in concentrations of  MDA of  patients of  VT compared with each of AF, SVT, PVCs (P≤0.05) and non-significant increase in serum concentrations of MDA  between SVT and AF ,while there was slightly significant increase  between each of AF and SVT compared with PVCs(P≤0.05). On the other hand Pearson’s correlation coefficient analysis showed a positive correlation between MDA level and each lipid profile parameter, except HDL which showed a negative correlation in all groups of cardiac arrhythmia.Key words: Arrhythmia, AF, SVT, PVCs, VT, Oxidative stress and MDA.
Substantiation of use of Photodynamic Therapy in Experimental Research in Vitro with Strains of Periodontopathogenic Bacteria and Fungi Candida Vadim O. Samusenkov
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Photodynamic therapy is used for the treatment of inflammatory periodontal diseases. This study was aimed at determining the effectiveness of the treatment of periodontitis and gingivitis with the use of a photosensitizer that interacts with the light flux, has the ability to adsorption on the surface of the bacterial cell. To determine the sensitivity of photodynamic effects, the following priority strains of microorganisms were selected: Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida glabrata. For the cultivation of microorganisms in the bioreactor, two types of tubes were used: 50 ml tubes with a membrane filter (TubeSpin) and 50 ml tubes of Falcon type with a lid without a membrane. 20 ml of nutrient medium was added to each tube. A. actinomycetemcomitans (37°C; RPM: 500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 1 sec.; volume: 15-16 ml; λ: 850 nm); S. constellatus (37°C; RPM: 1500 min‒1; measurement freq.: 3 h-1; Rev. spin period: 2 sec.; volume: 15-16 ml; λ: 850 nm); C. albicans (37°C; RPM: 1300min‒1; measurement freq.: 3 h-1; Rev. spin period: 3sec.; volume: 15-16 ml; λ: 850 nm). After bacterial suspension inoculations, the samples were irradiated with semiconductor laser devices with different wavelengths-630 nm and 662 nm, at a power of 100 j/cm2. The basis of experimental studies was automated cultivation of isolated strains of microorganisms with control of growth curves of microbial populations using different modes of exposure and photosensitizers.Keywords: Periodontopathogenic microorganisms, Photodynamic effects, Photosensitizers, Gingivitis, periodontitis.

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