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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Onium System for Separation, Preconcentration and Spectrophotometric Determination of Co (II), Via Cloud Point Extraction Methodology Faris H. Hayder
Journal of Global Pharma Technology Volume 09 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

According to the Onium system with application of Cloud point extraction (CPE) methodology coupled with spectroscopic method study the separation and the determination of  Cobalt(II), with limitation the optimum condition for higher extraction efficiency of Cobalt(II), by using (N-benzoyl-L-arginine ethyl ester hydrochloride)(N-BAEH) and non-ionic Surfactant (1% Triton X–100). Study appears the extracted species giving maximum absorbance at 294 nm, and these methods for separation need 0.8 M HCl in 10 mL aqueous solution. Contain 100 µg of Cobalt (II), as well as need heating at 85 °C for 15 minutes, in the presence of 0.5 mL of Surfactant in aqueous solution.Keywords: Cobalt(II), Cloud Point Extraction, Onium extraction, Halow complex, perconcentration.
Effect of Resistance Exercises by Means of Aids with Doses of Vitamin D3 in Some Biomechanical Variants to Develop the Spike Skill of Volleyball for Female Students Mohammed Jasim Mohammed Al-Khalidi
Journal of Global Pharma Technology .
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Abstract

The research focused on several axes focused on these axes to know the impact of resistance exercises using the aids with doses of vitamin D3 to develop the skill of beating overwhelming volleyball and try to reach the best achievement, as the use of different aids shapes and sizes, taking into account differences in lengths and abilities for sample members to help Students to master this skill as required. The experimental group was trained on the skill of beating overwhelming by using aids with a dose of (1g) daily of vitamin D3 within 6 weeks at the rate of two training units per week and after the end of this period the results were collected for the two groups and the comparison between them (experimental group, control group) The statistic exceeds the experimental group on the control group.Keywords: Resistance exercises, Vitamin D3, biomechanical variants and spike skill.
Nanotechnology Applications in the Single-Cell Analysis for Cancer and Therapy Ali Hamad Abd Kelkawi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Understanding the molecular, cell, genetic, and functional heterogeneity of tumors at the cell level has become a major challenge to cancer research. Microfluidic technology has emerged as an important tool that offers advantages in single-cell analysis with the ability to integrate labor-intensive, labor-intensive experimental procedures, such as single-cell capture into a single small device at ease and in high productivity. Single-cell processing and analysis can be performed within a microfluidic multifunctional device for various applications in cancer research. Here, we present recent developments in microfluidic devices for single-cell analysis related to cancer biology, diagnosis, and treatment. First, we briefly present several microfluidic pads used to analyze one cell, followed by different microfluidic techniques to manipulate a single cell. Next, we highlight their various applications in cancer research, with a focus on cancer biology, diagnosis, and treatment. Current limitations and potential trends of one microfluidic cell analysis are discussed in the end.Keywords: Microfluidic lab-on-a-chip, Single cell analysis, Cancer biology, Cancer diagnosis, Cancer therapy, Cancer research.
Molecular Docking of Benzoylurea Derivatives as Potential Anti-Breast Cancer Agent and Its Admet Profiles Siswandono Siswandono
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: At present therapy for breast cancer leads to target cell therapy. One of the compounds that can be developed as anti-breast cancer agents is benzoylurea. Benzoylurea has the same pharmacophore group with hydroxyurea as urea derivatives which have anticancer activity. This study aims to predict the anticancer activity and ADMET profile of seven benzoylurea-derived compounds as candidates cytotoxic agent for breast cancer. Method: Biological activity of benzoylurea derivatives is predicted through molecular modeling (in silico) using the Autodock program, ADME profiles and toxicity can be predicted using the pkCSM program and the Protox II online tool. In silico test was carried out by docking between benzoylurea derivatives and HER2 receptor targets, PDB ID. 3PP0. Result: All benzoylurea-derived compounds studied were compliant with Lipinski's 5 legal requirements. The 4-tertier butylbenzoylurea compound shows a  better ADME profile and its toxicity is predicted to have mutagenic properties but not hepatotoxic properties. The smallest docking score of seven benzoylurea derivatives is 4-tertier butylbenzoylurea, therefore the compound has the best cytotoxic activity. Conclusion: the 4-tertier butylbenzoylurea compound is chosen as the compound to be synthesized and further developed.Keywords : molecular docking; benzoylurea; anti-breast cancer; ADMET profiles
Isolation and Identification of Saprolegnia Parasitica and Other Fungi from Farms Fishes in the Province of Wasit / Iraq Isa S Touhali
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Background: Fungal infections are one of the main factors responsible for mortality and economic losses among the ornamental and food fish farming industries. The most commonly identified fungal pathogens of fish are water molds of Saprolegnia genus. Objective: The goal of this study was to determine the presence of Saprolegnia species in the fish farm by utilizing traditional and molecular strategies and contribute to the knowledge of fungal biodiversity in the province of Wasit. Methods: This study included a total of one hundred samples were collected during the six months from September -2016 to February -2017 from fish culture ponds. in the province of Wasit , Iraq. After isolation of fungi by culturing and examination under microscopic by used special stains was showed 42 (42%) samples were positive for fungal growth. Out of 42 fungal growths; 13 (31%) isolates were identified as Saprolegnia species were identified in this study. Also other fungi were isolated; 11(26.2%) isolates were identified as Aspergillus sp.; 8 (19%) isolates were identified as Penicillium sp.; 6 (14.3%) isolates were identified as Alternaria sp.; 4 (9.5%)  isolates were identified as Fusarium  sp. and used specific primers sequences (ITS1 and  ITS4) to detection Internal transcribed spacer (ITS) gene of Saprolegnia parasitica were used in conventional PCR. The results of the PCR amplification of (ITS) gene showed that, 8 samples out 13 samples Saprolegnia species were positive to Saprolegnia parasitica with a PCR product size of approximated 750 bp, while 5 samples out 13 samples Saprolegnia species showed negative results for the presence of this gene as indicated by the absence of the PCR products in their relevant lanes. In conclusion, the cultured fishes frequently suffer from fungal disease, especially during the months from early December to late February when water temperature falls below 10°C and  several species of Saprolegnia cause several damages in fishes and economic losses for the aquaculture industry. However, with early diagnosis by culturing and molecular technique and appropriate management, has a good prognosis.Keywords: Saprolegnia species, Saprolegnia parasitica, fish culture ponds, Internal transcribed spacer (ITS) gene.
Effect of Spraying Salicylic Acid and Collection Dates of Corn Silk (Zea mays L.) on Growth, Yield and Content of Some Antioxidant Compounds Maher H.S. Al-Mohammad
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

A filed experiment was conducted during the autumn season of 2016 to study the effect of foliar application salicylic acid (SA) at concentrations 0, 50, 100 and 200 mg.L-1 and collection dates (CD) at 14, 28 and 32 days after flowering and their interactions on growth parameters (plant length, total leaves number, leaf area and total chlorophyll), yield (Fresh and dry weight, plant yield and dry productivity) and some antioxidant compounds(total phenol compounds, flavonoids, anthocyanins, carotene, ascorbic acid and glutathione) of corn silk (Zea mays L.). Results of analysis of variance showed that SA affect were given increased   significantly impact (P<0.05)  when increased concentrations on all growth parameters of plant and yield, while late CD were increased leaf area, plant yield and dry productivity of corn silk, but the early CD decreased total chlorophyll and fresh weight of corn silk. The interaction between SA 200 mg.L-1×CD 14 days were given high amount of total phenol compounds, carotene, ascorbic acid and glutathione (140.53, 8.96 mg.Kg-1 DW, 115.34 and 16.71 mg.Kg-1 FW) respectively, and treat of SA 200 mg.L-1×CD 32 days were given high amount of total flavonoids and anthocyanin (48.57 and 5.93 mg.Kg-1 DW).  Keywords: Corn silk, Salicylic acids, Collection dates, Antioxidant compounds.
Study of Evolution of Multi Drug Resistance Protues spp. Isolated from Patient Suffering from UTI Ali Jaffar Saleem
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Clinical isolates of proteus spp. (30 isolates) were obtained from patients suffering from UTI from Baghdad Medical City hospital during the period between 1st December/2016 till 1st April 2017. The isolates were identified by culturing on MacConkey agar and blood agar then diagnosed by performing some morphological and biochemical tests. Proteus spp distributed in this study to P.mirabilis 23(76.6%) and P.vulgaris 7 (23.3%). In this study 17/30 (56.6%) of the sample were isolates from female and 13/30 (43.3%) isolates from male. Antibiotic susceptibility test for three antibiotics was performed using disc diffusion method. The percentage of highest resistance in proteus spp. isolates reached 80% (24/30) for Ampecillin and 76.6% (23) for Piperacillin while lower reached 50% (15/30) to Imipenim. Detect the resistance rates according to the sex of the patients showed significant differences for resistance to Imp in female 33.3% (10/30) compared with 16.6% (5/30) in male and for Amp, Pip in male 33.3% (10/30), 33.3% (10/30) compared with 46.6% (14/30), 43.3% (13/30) in female respectively.
Determinants of Stigma Attitude Among People Living with HIV Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: Human immunodeficiency virus / acquired immunodeficiency syndrome (HIV/AIDS) is still a stigma in the community and becomes a barriers in dealing with HIV. This study aimed to identify the determinants of stigma attitude among people living with HIV/AIDS (PLWHA).Methods: This study used a cross-sectional design. Sample collection was carried out by simple random sampling involving 135 Housewife suffered by HIV in Surabaya. The independent variables were policy support, patient characteristics (including age, sex, education level, marital status, occupation, HIV status, first being diagnosed with HIV), family factors (including family burden and family resilience). The dependent variables were stigma. Data were collected using a questionnaire. The analysis used binary logistic regression with a significance level of p ≤0.05. Results: The results showed there are five factors related to stigma in PLWHA, namely policy support (p = 0.019), marital status (p = 0.039), first being diagnosed with HIV (p = 0.006), family burden (p = 0.000) and family resilience (p = 0.041). Out of five variables, only four had a significant effect on stigma, namely marital status (OR = 0.009; 95% CI 0.000 – 0.697), first being diagnosed with HIV (OR = 7,464; 95% CI 1,820 - 30,617), family burden (OR = 0.075; 95% CI 0,017 - 0.329), and family resilience (OR = 0.010; 95% CI 0.000 - 0.381).Conclusion: The determinants of stigma attitude among PLWHA include policy support, marital status, first being diagnosed with HIV, family burdens and family endurance. Tackling stigma on HIV which involves various sectors including society, family, private and government.Keywords: HIV/AIDS; PLWHA, Stigma attitude.
Controlled Release of Cefixime using Sodium Carboxymethyl Cellulose Polymer Kawther Abd Alwahid
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Environmentally benign and efficient route of synthesis of   PAA-g-SCMC was prepared via irradiation (800W) using modified household microwave alone (without using initiator). PAA-g-SCMC polymer before and after loading with the drug was confirmed on FT-IR spectrophotometer and SEM.   SCMC polymer was also used to extend the release of antibiotic namely, Cefixime.  Buffer solutions of pH 7.2 and 1.2 were used as the medium for the release of drug to simulate the pH media of small intestine and stomach respectively. We used UV-visible spectrophotometer fo imbibing measuring solution of antibiotic for Cefixime respectively at 285 nm. The antibiotic release was done at different temperature (25 ⁰C, 37⁰C). Generally, the release was   increased at pH 7.2 and temperature at 37⁰C. The results obtained from the grafted polymers were better than the non grafted polymers concerning the controlled release of the drug.Keywords: Cefixime; SCMC polymer; Buffer solutions; Deionized water (D.W); Grafted polymer PAA-g-SCMC.
Synthesis of New Heterocyclic Derivatives from Thiophenol and Evaluation their Biological Activity Noor Y. Jaber
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

S-Chloroacetyl thiophenol (A) was synthesized by reaction of thiophenol with chloroacetyl chlorid, then the product (A) was reacted with hydrazine hydrate to give hydrazide derivative (B), which was introduced in different synthetic methods to produce either Schiff bases derivatives or to produce heterocyclic compounds. All compounds were confirmed by their melting point, FT-IR spectra, 1H-NMR, 13C-NMR spectrum and studying the possibility for their application as antibacterial and antifungal agents to some of them.Keywords: Thiopohenol, Hydrazen hydrate, Schiff bases.

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