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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Characterization of Some New Heterocyclic Derivatives Asstabraq Mohsin Yasir
Journal of Global Pharma Technology .
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Abstract

The newly compounds containing a seven-member ring oxazepane and five-member ring tetrazole derivatives were prepared starting schiff bases. Synthesized by percyclic reactions of imine group with phthalic anhydride resulted the formation of 1,3-oxazepane-4,7dione derivatives (S1, O). The new tetrazole derivatives were obtained from treatment of each prepared schiff bases S and S1 with sodium azide to give derivatives (S2, T). Finally derivatives have been characterized by melting points, FT.IR and 1H-NMR spectroscopy.Keywords: Phathalic anhydride, Sodium azide, Tetrazole, Oxazepane-4,7dione.
Metastatic Breast Carcinoma on Diffuse Spine Metastatic Process Using Augmented Exoskeleton Cement: Proposing a New Technique Tjokorda Mahadewa GB
Journal of Global Pharma Technology .
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Abstract

Metastatic breast cancer (MBC) to the cervicothoracic area of the spine is very rare cases. In this case report, we describe a case for this rare lesion. Case: a thirty-nine-year-old female with a history of weakness of the legs and pain in the upper back spine came to the hospital with history of breast biopsy with result of adenocarcinoma and positive long tract signs. On whole-spine MRI, it is shown the bone metastatic process on C5-7, T3, T5-7, T9-10 with bony destructions and extradural mass around T5-7 and T9-10. Two stages of surgery were planned for this patient. The first operation was addressed to cervical metastatic process through the posterior approach, in the form of a cervical fusion with laminectomy biopsy. The second step was via posterior approach for thoracic decompression and fusion. Since the Karnovsky score was 60 and single step surgery was chosen, led to cervicothoracic decompression fusion at single stage using augmented exoskeleton cement technique. During follow-up, the patient was neurologically improved on the both legs function significantly, though gait was still tolerable and recovery program was still ongoing in outpatient department. MBC treatment for long spine involved lesions can also be handled via a single posterior approach with good results especially for case with cervicothoracic metastatic process.Keywords: Metastatic breast cancer, Posterior approach, Cervicothoracic fusion, Exoskeleton.
Flagellin Immunization against Urinary Tract Infection Caused by p. Mirabilis Astabraq A. Al-Sodanii
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective Proteus mirabilis is dimorphic a (gram negative bacteria that alternates between a rod –shaped swimmer stage and multinucleate, highly elongated swarming stage. Methods  Urine Samples collected from three hospitals in Baghdad city from adult and child patients Suffering from urinary tract infections for 6 months .The samples get reached 1152 distributed among the patients old between few days to 80 years most patients living in hospital with urinary tract catheter , 56 samples of Proteus mirabilis were identified after isolation and diagnosis of bacterial species in different methods because there different complications in UTIs Patients specially Stone formation ,  catheter obstruction , and renal damage. Results these bacteria were diagnosis in api 20 E and vitek2 system and one isolate of Proteus mirabilis was selected for the study according to distance movement by measurement (swarming motility). Flagellin which is the flagella protein was extracted and predicated, followed by SDS-polyacrylamide gel electrophoresis for protein molecular weight estimation and  concentration of protein counted by Bradford method ,then immunization protocol were tested in Albino rabbits in different concentrations 10,20,40 microgram from flagella protein then immunoglobulin antibody IgG ,IgM in serum were tested by single radial immunoglobulin diffusion plate , positive results  showed raised the concentrations of these antibodies with high significant differences .Immunized  females rabbits was tested to ascending urinary tract infection challenge by inoculation 145×107">  cfu from P.mirabilis and tested in 1 , 3 , 7 , 14 days , any  females rabbits didn’t show urinary tract infection by P.mirabilis  when urine culture tested and, the concentration of IgG , IgM  antibody in balance also showing white blood cells in normal range .While rabbits females that inoculated by 145×107">  cfu in positive control group showed urinary tract infection by P. mirabilis  after 7 days post inoculation the tested urine culture showed raised in IgG , IgM and white blood cells concentration. Conclusions In the present study, flagellin protein immunization in rabbit showed that there are rising in IgM and IgG titers. After challenging by ascending urinary tract infection, we showed neutralization of IgG and IgM and white blood cells.Keywords: Flagellin, P. Mirabilis, UTI, Vaccine.
Estimation of Adiponectin Hormone and Antioxidants Levels in Type 2 Diabetic Patients in Dhiqar Province Ahmed Abdul Redha Jallod
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The present study was aimed to investigate the changes associated with type II diabetes in the level of adiponectin and antioxidants: (Catalase, Glutathione, Superoxide dismutase and Vitamin C). Seventy Samples (taken from male patients) were collected in cooperation with the Specialized Center for Diabetes and Endocrinology in the Directorate of Health in Thi-Qar Governorate. The numbers of healthy samples were 30. The results  showed a significant decrease (P≤ 0.05) in the level of adiponectin and antioxidants (catalase, glutathione and vitamin C) in diabetic patients, while it was observed that there was a significant increase in the level of antioxidant superoxide dismutase in diabetic compared with the control group. Moreover, the effect of both the smoking and age on the level of adiponectin and antioxidants was studied. The results showed a significant decrease in the level of adiponectin and catalase in smoking diabetic patients compared to non-smokers. On the other hand, the study showed that there was a significant increase in the level of superoxide dismutase in smoking patients compared to non-smokers.  As for the effect of age, the results showed a significant increase in superoxide dismutase with aging in patients with diabetes, while there was a significant decrease in the levels of both glutathione and vitamin C with aging.Keywords: Diabetes mellitus, Adiponectin, Antioxidants.
Detection of Isotope Stable Radioactive in Soil and Water Marshes of Southern Iraq Reyam Naji Ajmi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

This study was conducted to indicate Isotopic Stable Radioactive element (ISRe) of the Iraqi marshes by using Geographic Information Systems (GIS) to implement the comparing these elements with World Health Organization elements (WHO), and the Food and Agriculture Organization (FAO), this study achieved in several phases: Work included access to geographical data in six main stations of the Missan governorate (Al- Auda Marsh, Al- Battat Marsh ) during October 2016 period and selection of environmental factors Water and Soil . Results of water in all stations under study showed low concentrations of ISRe Pb212, Pb214,Pb138  and the remaining elements varied and mostly similar limited factors with natural boundaries of water bodies, A little increase come from of some pollutants that are discharged from the water drainage or waste populated .The soil samples showed ISRe, Pb214, Pb212, Pb138 , this may be due to the disintegration of the former previous radioactive element in the same region after wars or explosions , the remaining elements were found in variable concentrations . This database considered as a very important for environmental risks and health in aquatic environmental of marsh which can be updated through a unified future other periodic data. It is one of the method efforts of research for the Iraqi marshes because it represents the concept of ecological zones are covering relatively large areas in southern Iraq, which have a distinctive character of the natural geography of different types so there is a relationship between organisms and their environment an important in an aquatic ecosystem of the food chain.Keywords: Iraqi marsh, Pollution, Bioindicator, Isotopic Stable Radioactive.
Knowledge, Attitude and Doubts of Parents about HEXA Vaccine Newly Introduced in Expanded Program of Immunization in Iraq Hadeel Fadhil Farhood
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background a significant number of new effective vaccines against infectious diseases have become available ,some of these vaccines are given in combination as one vaccine , HEXA vaccine is one of these vaccines .the success of vaccination services is dependent not only on vaccines provision but ,also on other factors including parents; knowledge , attitude and also their doubts about the vaccines. Objectives To assess parents' knowledge and attitude about HEXA vaccine newly introduced in expanded program of immunization in Iraq and to identify  its parents' doubts .Methods Across sectional interview based  study of Iraqi parents in six health sectors in Babylon province -Iraq , during the period of the 1st of March to the 1st of July 2016 ,including (92) parents who had  at least one child eligible to be vaccinated with HEXA vaccine (born after 24/11/2015).Parents were interviewed to assess their Knowledge ,Attitude and Doubts about the HEXA vaccine.  Results The study found that (38% ) of parents had good Knowledge,(90.2%)had positive attitude,    (59.8 %) had doubts  about HEXA vaccine.(70.9%) parents had vaccinated their children and they were unsure about the vaccine safety or effectiveness,(29.9 %) parents had delayed their children vaccination ,the main reasons of parents' doubts were Child was ill (44.4%) and(21.8%)don't know enough information about the HEXA vaccine .Conclusions Majority of  parents had moderate (fair) knowledge and excellent positive attitude about HEXA vaccine. Most of parents had doubts about HEXA vaccine.Keywords: Knowledge, Attitude, Doubts parents, Expanded program of immunization.
Synthesis, Characterization and Antibacterial Studies of Some Transition Metal Complexes Containing New Dithiocarbamate Ligand Ahmed Thabitnuman Dhuha
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The synthesis of some transition metal complexes with dithiocarbamate as a ligand of general formula [M (L) 2] where M = Mn (II), Co (II) and Ni (II). The dithiocarbamate ligand and its complexes were described by FT-IR, UV-Vis and 1H, 13C-NMR, Mass spectra, elemental micro analysis C.H.N.S., magnetic susceptibility, molar conductivity, melting points, and atomic absorption. The antibacterial Studies of synthesized compounds were studied versus [Escherichia coli (gram negative) and Staphylococcus aureus (gram positive)]. The conductivity data affirm the nonelectrolyte nature of the complexes.Keywords: Dithiocarbamate (Dtc), 4-aminophenazone, Transition metal.
Study the Ascorbic Acid Levels, Lipoprotein Ratio and Hypocholesterolemia Action of Dry Okra Extract on Experimental Model of Locally Male Rabbits Hamzah H. Kzar
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Okra (Abelmoschus esculentus) is a flowering plant in the mallow family. Okra is important for its edible green and dry seed pods. The plant is cultivated in tropical, subtropical and warm temperate regions around the world. The geographical source of okra now is very available in Iraq. The rabbit rapidly develops severe hypercholesterolemia and decrease in levels of ascorbic acid and increase in ratio of bad cholesterol to good cholesterol in response to dietary manipulation. The results of this study showed that, there was a significant decrease in serum total cholesterol  and lipoprotein ratio for groups of rabbits that administrated with dry okra aqueous extract with its seeds (0.5g/kg) (DOE+ cholesterol oil-fed) as compared to control group( not administrated) at the end of six week of experiment (398±4.0) vs. (175± 5) (P < 0.05). On the other hand, a significant difference in the level of serum total cholesterol (P<0.05) starts in control group treated with cholesterol-oil fed at the end of six week of experiment as compared to cholesterol+ DOE group  (398±4) vs. (543±4). The aqueous extract of dry okra may be enhancing the conversion of cholesterol to bile acids in the liver by activation of an enzyme α-hydroxylase. DOE may be having inhibition action on HMG-COA synthase that responsible on endogenous synthesis of cholesterol in liver. Keywords: Dry okra extract, Induce cholesterol. Lipoprotein ratio, Ascorbic acid.
Grafting onto Different Rootstocks Influences Yield, Quality, Chemical Composition, and Bioactivities of Tomato Fruits under Greenhouse Conditions Howaida I. Abd-Alla
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: Grafting is a possible chemical free solution that shows several changes in plants, with the aid of vigorous rootstock. Methods: The influence of grafting on the yield and fruit quality of tomato cultivars grown under greenhouse condition was conducted during two successive seasons of 2016 and 2017. The metabolic composition of fruits of tomato Solanum lycopersicum L. Nefret hybrid (T1) grafted onto four rootstocks were identified by gas chromatography coupled to mass spectrometry (GC-MS). The levels of aspartate and alanine aminotransferases and alkaline phosphatase were analyzed for the determination of liver functions. The levels of oxidative stress markers; malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined in the rat's liver tissue. Kidney function parameters of serum urea and creatinine levels were also measured. Histologic examinations of the liver and kidney tissues were also performed. Results: The effects of grafting on the vegetative growth, yield, and fruit quality characteristics, i.e., fruit weight, length, diameter, total soluble solids content and titratable acidity of T1, grafted onto four rootstocks have showed great variability.  The vegetative growth, i.e., plant height of T2, was increased when S. lycopersicum L. var. VFN (T2) was used as a rootstock.  T2 has showed no adverse effects in all biochemical parameters under investigation compared by the other treatments. Aldehydes, ketones, esters, fatty acids, terpenoids, carotenoids, phenolics and alkaloids were the main identified components and the major compound was β-ionone (13.37%) in T2. Conclusion: The nutritional content of T2 and that it has showed no alteration in oxidative stress markers, liver and kidney function tests and their histopathological patters support its safety. While, un-grafting or grafting onto Solanum melongena L. cv. Balady (T3) may be a tool to improve the crop quality. Keywords: Greenhouse-grown tomato, Grafting, GC-MS, Carotenoids, Lycopene, Polyphenols, Liver, Kidney, Histopathology.
The Role of Career Path Management in Nurses’ Succession Planning Abdolali Keshtegar
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Background and purpose: Nurses are ones of service organizations’ forces who are in direct contact with clients. So, they must have special mastery in their work. Therefore, nurses’ career path and process of their succession is very important. This research aimed to study the relationship between career path management and succession of nurses. Study method: The present research was descriptive-correlation. The present research’s statistical population included 280 nurses working in Iranshahr hospitals selected by census method as statistical sample and the questionnaires including succession Rothwell (2006) and career path management Delong (1982) were distributed among them. Formal validity was used to determine questionnaires validity and Cronbach’s alpha was used to determine reliability which was 0.84 for succession questionnaire and it was 0.85 for career path. Data was analyzed by Pearson correlation inferential test and simple regression in SPSS21software.  Findings: The variables of career path management and succession were in a good position. At 99% significant level, correlation coefficient of career path management and succession and its dimensions including succession planning assessment, filing the educational vacancy, personal performance assessment, current work requirements and making a commitment to systematic succession planning) were 0.65, 0.784, 0.72, 0.682, 0.570, 0.178, -0.352 and -0.203, respectively. According to regression results, 42.3 percent of succession changes can be explained based on career path management. Conclusions: Career path management appropriately explains succession system. A more worthy succession system will be established through career path management. So, we will enjoy the existence of qualified nurses in positions by a special consideration to career path management.Keywords: Nurse, Succession, Career path management.

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