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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Selenium Linked to Increased Antioxidant Levels and Decreased Free Radicals in Lung Tissue of Wistar Rats Exposed to E-Cigarette Smoke Bambang Wirjatmadi
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Objective: This study aimed to find out whether selenium could increase levels of antioxidants and decrease free radicals in lung tissue of Wistar rats after exposure to e-cigarette smoke. Methods: This study used an experimental method with control group design. Male Wistar rats with criteria aged 2–3 months, weighing 200-250 grams were used as animal models in this study to assess cell damage through the expression of Superoxide Dismutase, Glutathione Peroxidase and Malondialdehyde in the lung tissue using immunohistochemical staining. E-cigarette smoke containing 6 mg of nicotine was given to each group of animal models with differences in the amount and duration of time. The adaptation process in experimental animals was carried out for approximately 5 days. Results and Conclusion: Selenium has been shown to increase the expression of antioxidant superoxide dismutase and glutathione peroxidase, and decrease the levels of malondialdehyde in cells following oral administration of selenium in Wistar rats (p <0.05). In addition, selenium also reduced the amount of free radical in the cells; when it was given before exposed to e-cigarette smoke. It can be concluded that oral selenium can increase antioxidants levels and decrease free radicals in lung tissue cells due to exposure to e-cigarette.
Investigating the Challenges of Developing Sports among the Elder Lies in Hamedan Province and Presenting Practical Solutions Rasul Monem
Journal of Global Pharma Technology .
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Abstract

The aim of this study was to determine the challenges of developing sports among the elderlies in Hamadan Province and their problems with exercising as well as providing practical solutions for developing recreational sports for this group of people in Hamadan Province. In order to investigate the research question, elder lies above 60 in 2014 were chosen as the statistical population. The sampling method was cluster-random and the data collection instrument was a researcher-made questionnaire which its face and content validity were tested and confirmed by a group of authorities. The reliability was calculated using cronbach-α (α=0.87).Data analysis indicated that there are significant relationships. between monthly income and engaging in sports activities, between elder lies` satisfaction from leisure time activities and the kind of activity, and  between quality of life and doing sports among the elderlies at α= 0.05. Findings of the present study indicated that lack of sufficient recreational and sports facilities, low level of education, low income, physical weakness, cultural factors, mental features, family , and proper education about advantages of sports and physical activity, and spending leisure time have prominent roles in proper use of sports and leisure time. Authorities in Hamadan province should take some serious steps including creating sports-recreational spaces and places in order to remove obstacles the elder lies face to increase elder lies` tendencies to sports.Keywords: Leisure Time, Sports Activity, The elderly.
Sperm DNA Fragmentation and Chromatin Maturation of Prepared Sperm with ALA Supplementation: The Effect of Embryo Development Quality silvia werdhy lestari; aucky hinting; Petrus Supardi; anom Bowolaksono; asmarinah asmarinah
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Abstract: This study was aimed to determine the differences in embryo quality between spermatozoa with good or poor of DNA fragmentation index and chromatin maturation, through spermatozoa preparation with the addition of ALA. This experimental study compared the quality of embryos that fertilized by spermatozoa with DNA fragmentation and chromatin maturation, with and without ALA supplementation. In this study semen samples from 20 patients were collected, which were then prepared and examined for DNA fragmentation index (DF) and chromatin maturation (CM). Then the sample was divided into 4 groups, namely the good DF - good CM, good DF - poor CM, poor DF - good CM and poor CM - poor CM, further divided again with and without treatment (ALA supplementation). After injection of spermatozoa into the oocyte, the development of embryo was observed in each group. In the group without treatment, significant differences in embryo quality were obtained between groups of good DF - good CM with poor DF - good CM, good DF - good CM with poor DF - poor CM, good DF - poor CM with poor DF - good CM and good DF - poor CM with poor DF - poor CM (p <0.05). In the treatment group, there were not significant difference in the quality of the embryo between treatment groups, namely with or without ALA, in the group with good or poor DF, and with good or poor CM (p> 0.05). Embryo fertilized by spermatozoa with good or poor DF and with good or poor CM, with the supplementation of ALA, the quality was not significantly better than without the supplementation of ALA.    Keywords: spermatozoa DNA fragmentation, spermatozoa chromatin maturation, ALA, in vitro fertilization, embryo quality 
The Incidences of Use the Over Counter Drugs Abeerfadhil Ibraheem
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Importance of the study:  over-the-counter (OTC) medication is commonly used, among older, adults and children. They can be dangerous because their side effect, interactions with other medication and allergic reactions. The most OTC medications frequently utilized worldwide are Paracetamol (acetaminophen), Non-steroidal anti-inflammatory drugs (NSAID), stomach upset, antitussive, allergy and skin rashes and itching medications. Objectives:  To determine the misused practice of over-the-counter medications, to assess the common use of the over-counter medication and to assess patient's information about commonly used over-the-counter (OTC) medication. Design, Setting, and Participants:  Descriptive analyses study, the sample was (100) participants, conducted from community-dwelling from 21 to 61and over years old male and female. Using assessment tool instructed from literature review from1/2/2018-1/3/2018, the reliability of the questionnaire through the use of Cronbach's Alpha was (.846). Results:  the study revealed that the lowest mean score (1.53) for knowing how much weights before giving these medicines. The lowest mean score (1.73) for they check with care provider before taking an (OTC) when having a long-term medical problem or are taking prescription medicines, the lowest mean score (1.3) for they taking acetaminophen every 4 to 6  to relieve headache, fever & pain. Conclusions : the most  of study sample didn’t aware about the weight  and the dose of taking medication, check with care physician before taking an over-the-counter drugs when having a long-term medical treatment or dealing with prescription therapies and when they taking acetaminophen every 4 to 6  to relieve headache, fever & pain .Keywords:  Over counter medication (OTC), Misuse, Non-steroidal anti-inflammatory drugs (NSAIDs) and stomach upset.
Investigation of Drug-Excipients Compatibility for Colloidal Delivery of Therapeutic Chondroitinase Krishnamoorthy Kannan
Journal of Global Pharma Technology Volume 11 Issue 06 (2019) June 2019
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Abstract

Objective: Proteins and enzymes are marginally stable macromolecules along with certain additives for converting them into suitable drug formulation. The research in pharmaceuticals claims the suitability of wide and variety range of micelles, reverse micelles, unsaturated fatty acids and their esters with glycols act as a protective fence for such therapeutic macromolecules against denaturants in colloidal form. The present study, address preformulation and compatibility study of different additives with bioenzyme- chondroitinase for futuristic colloidal microemulsion formulation. Methods: Initially the solubility of chondroitinase with excipients was determined to obtain suitable aqueous, oil and surfactants phase. FTIR spectra of individual chondroitinase and along with each additive in binary blend form were compared to retain characteristic bands of native protein. It was followed with non-denaturing SDS-PAGE to ensure native conformation of enzyme on gel in presence of additives. Circular dichroism technique was used to investigate stability of primary and secondary structure of enzyme in these binary mixtures. The control and accelerated studies were performed by spectroscopy. Results: Chondroitinase solubility was observed as: phosphate buffer > propylene glycol > glycerol > Tween 80 > Oleic acid. FTIR spectra retained characteristic bands of chondroitinase in binary blends. SDS-PAGE ensured no signs of protein fragments, aggrega­tion or degradation on gel. CD spectra revealed no major loss of enzyme activity. Control and accelerated studies confirmed concentration and purity of enzyme in binary blends in accepted limit. Conclusion: These results demonstrated that the excipients employed in this study were safe as additives with chondroitinase for colloidal formulation. Keywords: Circular Dichroism, FTIR-ATR, SDS-PAGE, Preformulation, Enzyme-additive compatibility, Therapeutic chondroitinase.
Antibacterial Activity of Synthesized Graphene Oxide Modified Nickel Phthalocyanine Saad Abbas Jasim
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The antimicrobial properties of Graphene Oxide Modified Nickle Phthalocyanine were evaluated against Staphylococcus aureus, Gram-positive bacterium and sydomonus, Gram-negative one.. Bacteriological tests were performed in Muller Hinton solid agar plates with different concentrations of graphene oxide particles. The inhibition zones as a function of added graphene oxide where studied ,the results show that as the concentration of graphene oxide increased the inhibition zone increased also against both types of bacteria. Whene the ratio of added graphene oxide was (15%) maximum inhibitionzone hase been calculated.Keywords: Graphene oxide; Nickle Phthalocyanine; Antimicrobial.
The Relationship of Organizational Justice with Organizational Commitment, Organizational Trust, and Job Satisfaction of Employees of Sistan and Baluchestan Education Office Abdol Ali Keshtegar
Journal of Global Pharma Technology .
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Organizational justice refers to employee's feeling and understanding about fairness and equity in work behaviors and relationships. Various researches show that the increase of justice affects different aspects of organizational behavior. Based on this, current research tries to examine how the aspects of organizational justice and dimensions of its subset (including distributional, procedural, and relational justice) affect job satisfaction, organizational commitment, and organizational trust. Statistical population of current research is 120 employees of schools of Sistan and Baluchestan education organization. Standard questionnaires were distributed randomly among 40 statistical samples by using Cochrane formula. Niehoff and Moorman questionnaire was used for measuring aspects of organizational justice, Minnesota's questionnaire (MSQ) for job satisfaction was used for measuring job satisfaction of employee, Meyer, Allen, and Smith questionnaire was used for measuring organizational commitment, and Ellonen et al questionnaire (ot) was used for measuring organizational trust. Data analysis with SPSS software showed that the distribution of data is normal and therefore, Pearson correlation test was used for determining the relationship of variables. Results showed that all hypotheses of research are supported and there is a positive and significant relationship between organizational justice and job satisfaction, organizational commitment, and organizational trustKeywords: Organizational justice, Job satisfaction, Organizational commitment, Education organization, Sistan and Baluchestan. 
The Effect of Nutritional State on Immune Response for Adults Patients with Tuberculosis Mohammed A.K. Alsaadi
Journal of Global Pharma Technology .
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Malnutrition is observed frequently in patients with pulmonary tuberculosis (TB), but their nutritional status, especially of micronutrients, is still poorly documented. The objective of this study was to investigate the nutritional status of patients with active TB compared with that of healthy controls in Babylon providence. In a case-control study, 50patients aged 18–75 y with untreated active pulmonary TB was compared with 40 healthy controls. Anthropometric and micronutrient status data were collected. Compared with the controls, TB patients had significantly lower body mass index and concentrations of serum albumin, andplasma zinc and vitamin C. And studying the factors that affecting the cell mediated immunity including phagocytic index, CD56  and IFN-γ for TB patients.Blood samples were collected from patients group and control group to estimate phagocytic index, interferon gamma (IFN-γ), CD56 and Vitamin C by ELISA (Enzyme linked immunosorbent assay) method and to estimate zinc and Albumin level were also estimated by using  spectrophotometer. The cell mediated parameters showing that there is a significantly decreased (p< 0.05) in phagocytosis activity of neutrophils in  TB  patients (6.04%)  compared  to  control group (11.70%)  and there is no significantly increased (p> 0.05) of IFN-γ level in the TB patients (0.159) IU/ml compared  to  control group (0.157) IU/ml .CD56 level in TB patient (78.043)IU/ml compared to control group (74.473) which was with no significantly increased (p > 0.05). The level of zinc in serum is significantly decreased (p<0.05) in the TB patients (51.18) g/dl compared with control (113.44) g/dl and albumin level in serum is a significantly increased (p<0.05) in the TB patients (38.973) g/dl compared with control (50.2) g/dl.Keywords:  TB. Tuberculosis. IFN-γ. Malnutrition
Identification of Some New Tetrazole and Thiazolidine Derivatives Synthesized From 4-Chlorobenzoic Acid and Evaluation Their Antibacterial Effect Maysoon Tariq Tawfiq
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The research  includes  the synthesis of some new derivatives of  tetrazole and thiazolidine  rings from the reactions of  2- (4-chlorophenyl)-5-hydrazinyl- 1,3,4-oxadiazole [4] with various substituted aromatic aldehydes  in absolute ethyl alcohol as  a  solvent and presence of glacial acetic acid as a catalyst to form Schiff's  bases [5-10]. The prepared new Schiff's bases [5 -10] reacted with sodium azide , and mercaptoacetic acid in THF to yield five membered rings  (tetrazole ring) [11-15], and (thiazolidine ring) [16-20]  in good products. The  spectral  methods  of  the   prepared  compounds  were  characterized  by FT.IR, and 1HNMR for compounds [9,13,14,and 19] , besides melting points were recorded , and the purity was checked through T.L.C. technique. Antibacterial activities for some of the synthesized compounds were examined.Keywords: Heterocyclic compounds, 4-Chlorobenzoic acid, Acid hydrazide, Oxadiazole, Schiff’s bases, Tetrazole, Thiazolidine, Biological activity.
Drug Use Evaluation in the Pediatrics Admitted with Severe Respiratory Tract Infections Vineela Chadalavada; Triveni P; Hameeda Begum Md; Pujitha S
Journal of Global Pharma Technology Volume 12 Issue 08 (2020) Aug. 2020
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The objective of the present study is to evaluate drug prescribing patterns in children admitted with respiratory tract infections into pediatric ward. This is a prospective cross-sectional study conducted for a period of one year at a tertiary hospital located in a city of Andhra Pradesh, South India. The study was done by using prescribing indicators from the World health organization (WHO) manual for the conduction of drug use evaluation studies. The prevalence of respiratory tract infections, particularly lower respiratory tract infection is high among children less than 5 years. 54.39% of drugs are prescribed with brand names, of which the majority of drugs are administered through parenteral route (58.26%). Antibiotics (34.7%) are highly prescribed in all the cases followed by other category drugs. A significant difference was found in the evaluation of prescribed daily dose and standard dose. The profile of drug use in the present study was similar to previous Indian studies. Most of the prescribing encounters are parental forms and band names that need exploration of the present treatment trends. The present baseline data can serve for the development of national Pediatric prescribing guidelines in the future.

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