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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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The Study of A Linear and Non-Linear Optical Property for PMMA Thin Films Doped with the Rhodamine B Laser Dye and Ag Nano Particles are Used in Medicine Mithaq M. Mehdy Al- Sultani
Journal of Global Pharma Technology .
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Abstract

Four different mixtures of ( 10-3 mol/l Rhoda mine B laser dye , 0.1 gm PMMA and one of Ag nano particles weights ( 0.02 gm ,0.04 gm , 0.06 gm and 0.08 gm ) )   had been prepared using chloroform solvent .Four different thin films had been made from these mixtures  using drop casting method .The absorption   spectrums of  these thin films had been taken . The absorption spectral properties as (peak wave length, peak absorbance and frequency difference at half absorbance maximum) had been measured depending on the absorption spectrums for thin films. The non- linear optical properties as (Transmittance difference )  ,Non –linear phase shift    , Non-linear Refractive index  , Minimum normalized transmittance  and  Non-linear absorption coefficient ) were calculated according to normalized transmittance data obtained from Z—scan setup with closed and open aperture .The main conclusion is that the Ag nano particles causes a shift of  the absorption wavelengths  to longer wavelengths ( red shift ) , so this helps in choosing the medium and nano particles with appropriate excitation wavelengths .Keywords: Rhoda mine B laser dye, Ag nano particles, Linear, Non-linear, Properties. 
Prevalence of Pediculosis Capitis and its Risk Factors in Elementary School Students I Made Sudarmaja
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Pediculosis capitis or head-lice infestation is a health problem, especially in children in developing countries. Transmission of pediculosis capitis is also fast, causing a high-incidence in an area. This study was conducted to determine the prevalence of pediculosis capitis and the relationship between risk factors for its infestation. Methods: This is a descriptive study with a cross-sectional design. The data was collected from elementary school students in Tenganan village, Bali, Indonesia in September 2018. The sampling technique was a voluntary sampling method with a sample of 141 elementary school students. Data analysis was carried out with the SPSS with univariate and bivariate analysis. Results: The prevalence of pediculosis capitis in elementary school children in Tenganan Village is 69.5%. Factors related to pediculosis capitis infestation are sex (PR=2.235, p <0.001), long-hair (PR=2.015, p <0,001), shared hair-accessories (PR=1.450, p=0.004), and lived with people infected with head lice (PR=1.692, p <0.001). Conclusion: The prevalence of pediculosis capitis in elementary school children in Tenganan Village is 69.5% with gender as the most influential risk factor for infestation.Keywords:  Pediculosis capitis, Prevalence, Risk factors.
The Cognitive Achievement of the Physical Management Material and its Relation to the Organizational Deviations of the Training from the Point of View of the Students Jassem Jaber Mohammed
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The introduction and the importance of research included that the level of sport needs to be built on and the most important of these foundations is the administrative aspect which is the cornerstone of the sport process in all its aspects and this aspect needs an in-depth study that adopts the researcher and the university professor to communicate it to the students and the extent The relationship of the student's cognitive achievement to this information with the organizational deviations of the teacher the problem was formulated in the form of several questions. The most important of which was to remove the organizational deviations of the teacher as a function of predicting the educational achievement of students of the fourth stage of the Faculty of Physical Education and Sports sciences at the University of Babylon Sports management, and there are several objectives, the most notable of which is the prediction of the achievement of the students of the fourth stage of the material of sports management in terms of the organizational deviations of the material teacher from the point of view of the students and the researcher used the descriptive curriculum for the suitability and nature of the study and through the results of the research was Several conclusions, including that the ratio of organizational deviations of the teacher from the point of view of students varies among them where there were several directives and proposals, the most important of which was to rely on the predictive equation produced by this study in other samples.Keywords: Cognitive achievement, Physical management, Material, Training and point of view
Analysis of Genetic Distance and Similarity in Some Radish Cultivars (Raphanus sativus L.) by Random Amplified Polymorphic DNA (RAPD) Markers A. K. H. Al-Tufaili
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The random amplified polymorphic DNA (RAPD) assay is a useful method for to Detection Genetic Distance and Similarity among cultivars. In the present study, The DNA of the five Radish genotypes were screened with 5 primers generated reproducible and easily storable RAPD profiles with a number of amplified DNA fragments ranging from 9 to 12. The number of polymorphic ranged from 5 to 9 with an average reached 7.4 fragments ̸ primers with the polymorphic percentage ranged from 41.66%to 90%. The number of monomorphic ranged from 0  to 5  and was total of the monomorphic 10 with an average reached 2 fragments ̸ primers with the monomorphic percentage was 0% to 41.66%. A maximum genetic distance value was obtained in Local white radish and white radish Hybrid F1 reached 0.662. While a minimum genetic distance value was seen between Local red radish and Local white radish reached 0.458. The least genetic similarity was between the two cultivars Local red radish and Local white radish 40%. This study shows that the genetic diversity among radish cultivars can be used to improve plant growth, especially medical active compounds production in addition to increasing the plant yield and improve the quality. Keywords: Radish, Genetic Diversity, Molecular marker, RAPD.
Family Caregiver’s Perception and Comprehension toward Pressure Injury Prevention in Bedridden Patients after Discharge from Hospitals Martono .
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objectives: Perception and understanding of pressure injury care is an important basis for family caregivers in preventing pressure injuries in stroke paralysis patients.The aims of this study to assess the caregiver family's perceptions and comprehension in preventing pressure injury. Methods: The design of this study was cross sectional. The survey was conducted on 357 family caregivers in nursing homes, Indonesia. Potential participants were recruited from Family Caregiver who treated stroke paralysis patients who were bedridden after being discharged from the hospital in a nursing home. Predictor variables (independent) of this study consisted of perception and comprehension and the dependent variable of this study was prevention of pressure injuries. Data were collected using a questionnaire: The analysis used linear regression with a significance level of p ≤0.05. Results: Simultaneously, 36.1% of perception and comprehension explained the prevention of pressure injury as evidenced by the value R2 = 0.361; p (F test) = 0.049. Partially, 19.4% perception of the prevention of pressure injury prevention was proven to be p (t-test) =0.016; R2=19.4% and 12.2% comprehension explained the prevention of pressure injury as evidenced by the value of p (t-test) = 0.019; R2=12.2% with a confidence interval of 95%. Conclusion: Family caregiver’s comprehension of the prevention of pressure toward pressure injury prevention in bedridden patients after discharge from hospitals was low. Perceptions and comprehension factors of family caregivers contribute to the prevention of pressure injury in stroke paralysis patients who are bedridden.Keywords: Caregivers, Perception, Comprehension, Pressure injury.
Determination of Neutron Flux of Isfahan ZPR in Different Level of Energy by MCNP COD for Investigate of BNCT Eghbali Borujeni Akram
Journal of Global Pharma Technology Volume 10 Issue 01
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Abstract

Relating to deaths caused by cancers, we have tried to investigate the type of the cancers, and common method used for their treatments. Then we have evaluated the advantage and disadvantage of different methods, in regarding with the type of cancers, aiming to proof, that BNCT method can be the most appropriate methods for treatment of cancer in comparison with the other methods available. Now of days, advanced method of BNCT use a thermal (E n < 0.5 eV), or epithermal (0.5 eV < E n < 10 keV), neutron beam in conjunction with tumor- targeting boron compound for irradiation of glioblastoma and metastatic melanomas. In conjunction with, a systematic Mont carlo N-particle (MCNP) investigation of the different level of energy for neutron in ZPR (Zero Power Reactor) has been performed.  We did calculated with MCNP code, on neutron flux in ZPR, for different level of energies, and to complete the work, we compared the results with neutron flux requirements in BNCT cancer treatments. We believe that in future, BNCT can pursue its way as one of the safest and fastest method of brain cancers treatment, and we hope that in the near future, an appropriate (bed) will be established, for research and development of this method in our country, so that this method can become Vastly available to those patients, who are hopelessly seeking, a safer methods of brain cancer treatment.  Keywords: BNCT, Cancer therapy, Neutron source, Neutron flux, MCNP, ZPR.
Morphological Description and Histological Structure of Kidney in (White Breasted King Fisher) Halcyon Smyrnensis (Linnaeus, 1758) Isrra Adnan Auda Khadhim
Journal of Global Pharma Technology .
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Abstract

The result of anatomical examination indicated that the bird of the current study has a pair of kidney that take asymmetrical position on both side of vertebral column in a bony depression called renal fossa within the synsacrum, each kidney composed of three lobes, cranial, middle and caudal lobe, the result of present study indicate that there is a difference in the location of the cranial lobe of left kidney between male and female, whereas the caudal lobe is the largest kidney lobe. The kidney surrounded by a thin capsule of connective tissue, the basic unit of the kidney is the lobule , each lobule consist of cortical and medullary tissue, the lobules looks pear shape and surrounded from two side by interlobular vein and the intralobular vein located in the center of lobule , the kidney consist of two areas cortex and medulla, the cortex occupies more space than the medulla, the cortex contain glomerulus , proximal convoluted tubules and distal convoluted tubule , while the medulla contain thin and thick of Henle,s loop, collecting tubule and collecting duct.Keywords: Kidney, White breasted king fisher, Morphological description, Histological structure.
Assessing Levels of Domestic Violence among Secondary-School Students in Al-Nasiriya City/ Iraq Maan Hameed Ibrahim Al-Ameri
Journal of Global Pharma Technology Volume 11 Issue 07
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Introduction: Violence is the intentional use of physical force against oneself, another person, or groups that result in injury, death, psychological harm, mal-development or deprivation(1). Domestic violence (also named domestic abuse or family violence) is a pattern of behavior which involves violence or other abuse by one person against another in a domestic setting. Child exposure to domestic violence constitutes a prevalent concern nationwide. Over 15 million children are estimated to live in households in the U.S. in which at least one incident of physical domestic violence has occurred in the previous year. Lifetime of childhood exposure rates to physical domestic violence in the U.S. have been projected at approximately 16% (2). Family violence described by the law on protection and treatment of child abuse in the United States which was issued that the abuse and neglect. Minimum is any act of talk or failed to act the part of a parent or caregiver that result in death, harm physical, verbal violence, emotionally dangerous, sexual abuse, sexual exploitation and any act or failure to act resulting in imminent danger of serious harm(3). Objectives: The purpose of the study is to assessing levels of domestic violence among secondary-school students in the Al-Nasiriya city and to find out any association between levels of domestic violence and some demographic characteristics. Methodology: A descriptive study was achieved from October, 20th, 2017 to July, 1st, 2018. A non-probability (purposive) sample of 600 students with age ranged between12 and 18 year was chosen from ten secondary schools (simple random sampling). A designed questionnaire was used for the study and it consists of two parts:  part one contains demographic characteristics of the students which include age, gender, class, residency, income, house, level of education and occupation of father and mother, number of kids and order of kid; part two is the scale domestic violence (Zahra Abdel-Hamezah Hadi, 2013). This part is composed of (39) item and is divided into (3) sections domains; they are verbal violence which is composed of (10) items; Physical violence which is composed of (13) items and psychological violence which is composed of (16) items. The statistical analysis was achieved by using the descriptive statistics: frequency, percentage, distribution and inferential analysis such as Chi2.  Results: Six hundred questionnaires were completed.  60.0% of sample is intermediate. 66.8% of sample is male, 25.3% of the students are in first class, 78.8% of sample is city, 46.3% of sample is monthly  income almost enough, 27.7% of father is secondary graduate and  42.5 of mother is illiterate, 60.2% of sample occupation of father is free work and 88.7% of mother is house keeper. The severity of domestic violence of the participants ranged from mild 54.7% of the verbal violence; moderate 39.3% of physical violence; and mild 34.2%of psychological violence.  Conclusion: The present study revealed that more than half of student are intermediate, and also more than half of the student are male, less than half of student are first class, more than half of student are city, less than half of income are almost enough, less than half of education father are secondary graduate and mother education are illiterate, more than half job of father are free work and job of mother are house keeper. 54.7% more than half of student are verbal violence, 39.3% less than half of physical violence and 34.2% of psychological violence. Recommendation: Necessity to provide for the services rehabilitation victims of domestic violence by supporting the role of social researcher in school and at home. Intensifying programs related to family guidance in order to increase family awareness through the various media. Urge concerned parties to establish laws legislation and deterrent systems to deal with cases of domestic violence. To spread awareness among the members of the community about the seriousness of this phenomenon.Keywords: Domestic violence, Student, School, Nasiriya city.
Investigation of Binding Efficacy of Pectin Isolated from Solanum betaceum Cav using Tabletting Technology Benedict Jose C
Journal of Global Pharma Technology Volume 12 Issue 12 (2020) Dec. 2020
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Abstract

Pectin’s are widely used in food industry and Pharmaceutical industry. It is also a natural part of the human diet. The current research work deals with the isolation and preliminary characterization of pectin from tree tomato (Solanum betaceaum Cav) and further to evaluate its binding property with starch and Poly Vinyl Pyrollidone (PVP). The pectin was subjected to phytochemical and physicochemical characterization and its suitability to use as binding agent. FT-IR spectroscopy, DSC studies were performed for drug, Solanum betaceaum Cav pectin (SBP) powder and the tablets were prepared with isolated pectin and other binders. Paracetamol tablets were prepared by wet granulation method containing mannitol and microcrystalline cellulose as diluents, using 4%, 8% and 12 %w/w of SBP, starch and PVP as binding agents in the tablet formulation. Precompressional properties of granules and tablets such as Carr’s index, Hausner’s ratio and angle of repose and quality control tests like weight variation, thickness, friability, hardness and disintegration time were determine and found satisfactory. The in vitro release studies shows that release rate of drug is decreased with increase in the SBP percentage in the formulation. Solanum betaceaum Cav pectin powder showed good binding. The binding efficiency of Solanum betaceaum Cav pectin was comparable with binding character of starch 12% and PVP 8%. The pectin isolated from Solanum betaceaum Cav can be used as binder in the formulation of tablets. Keywords: Solanum betaceaum Cav pectin, Fruit pectin, Tree tomato, Tamarillo pectin, Natural binder, Natural excipients.
Chemical Composition and Bioactivity Characteristics of Pimpinella Anisum Essential Oil against Trichophyton rubrum Ali Jalil Obaid
Journal of Global Pharma Technology .
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Background: The present study was conducted to assess the phytochemical and bioactive characteristics of anise oil on metabolic activity of Trichophyton rubrum. Methods: Essential oil was extracted from anise seeds using a Clevenger-type apparatus. Phyto chemical analysis of active material was carried out, through TLC accompanied autoradiography, high performance liquid chromatography (HPLC) and GC-MS analyses were proceeded to relate the chemical profile with their antifungal activity. Minimum inhibitory concentrations were determined using the micro wells dilution method. Inhibitory effect of crude anise oil and anethole was investigated against T. rubrum. Cytotoxic effects of anise oil and anethole was concluding using MTT assay. Effects and interaction of anethole with ergosterol of fungi cell membrane was assayed. Results: Qualitative TLC, HPLC analysis revealed the present of anethole in the essential oil from anise seeds. One volatile compound in the extracts of anise oil sample was identified as anethole under the chromatographic conditions. GC-MS analysis revealed that anethole is the major compound in essential oil of P. anisum, in which trans-anethole was 96.8%, then Himachalene (1.84%), other components were also present but less than 1% e.g. Estragole, cyclohexene and 2-Methoxy-5-(1-propenyl) phenol. The tested strains of this fungus revealed substantial sensitivity pattern to assayed anethole. Results showed that there was total growth inhibition of the dermatophytes isolates at minimal inhibitory concentrations (MIC) between 15.6 μ g/m L for crude oil and 7.5 μ g/m L  for anethole. MTT assay revealed that anethole is safe as phototherapeutic agents, when it is having no effects on normal cell, but shown anticancer activity against cancer cell. Conclusions: The obtained results suggested that essential anise oil and anethole might be a potential source of new antimicrobial agents and could be valuable as an alternative drug against T. rubrum.Keywords: Trichophyton rubrum, Anise essential oil, TLC-bio autography, HPLC, GC-MS, Antifungal activity.

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