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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Characterization of Some New Di-amines Derived from Di-amines Supplemented with Di-heterocyclic Five Membered Rings and Some Aromatic Aldehydes Noor S. Noori
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

It has been documented that imines and heterocyclic compounds with five membered rings and their derivatives, have enormous biological activity in various area as medicinal and pharmaceutical. Therefore, supplementing the di imines with five -membered heterocyclic rings, perhaps enhance the biological activity characters of the resulting products. Consequently, the target of present work involve the developing of new imines derived from selected di amines after connecting a five membered heterocyclic rings of the type di thiazole and di oxazole to the parent molecules via the reaction of the previous di amines with chloroacetyl chloride yield the corresponding amides [A1-A3] , then subsequent reaction of the later  with of thiourea and urea give substantially new di thiazol [th1-th3] and di oxazole [Ox1-Ox3] respectively .Reaction of these new developed di amines with selected aromatic aldehydes result a pavantly in the formation of the desired bis imines [Sc1-Sc10]. On the other hand the structures of all the synthesized compounds were confirmed by their physical properties, such as colors and melting points and spectroscopic measurements FT-IR, 1H-NMR and 13C-NMR for selected compounds.Keywords: Di imines, Chloroacetyl chloride, Thiazole-2, 4-diamines, oxazole-2, 4-diamines.
Risk Behavior of Tiom Community Related with Helminthiasis at Lanny Jaya District, Papua Province, Indonesia Gurendro Putro
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Helminthiasis is an infectious disease which is one of the severe health problems in Indonesia. The worm can reduce intelligence, inhibit the growth of children, and even cause death. The behavior of a clean and healthy life is expected to be able to encourage the community to improve the quality of daily health behaviors to cope with helminthiasis. Objective: to assess risk factors in healthy hygiene behaviors that has the potential to cause helminthiasis. Method: A descriptive retrospective research. The material is interviews form and library data assessment. Data collection is done by listening, direct recording, recording audio, and video provided. Data retrieval is done by the time-limited sampling method. The data obtained were processed and analyzed descriptively. Results: It was found that the community consisted of local communities and migrants. The risk factors for clean and healthy living that have the potential to cause helminthiasis are divided into two, namely: (1) Hygiene and living environment sanitation (2) Personal hygiene and sanitation which includes; the habit of washing hands is still low, not wearing footwear, the practice of cutting nails that are still weak, open defecation habits, bathing habits that are very rarely done, drinking water and eating raw food (3) Risk of eating pork at a "barapen" stone grilling ceremony. Conclusion: Risk factors in healthy hygiene behavior that have the potential to cause helminthiasis are health sanitation of residential, inadequate personal hygiene, and cooking pork at a "barapen" stone grilling ceremony, which is considered insufficient to kill worms. Keywords: Clean and healthy lifestyle, Helminthiasis, Tiom, “Barapen” Ceremony, Tiom, Papua Indonesia.
Cytotoxicity of Xanthium Strumarium against Breast Cancer Cell Lines Atheer S. Alsabah
Journal of Global Pharma Technology .
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Abstract

Objective: This study aimed to investigate the possible in vitro cytotoxicity of Xanthium strumarium.  Methods: The dried leaves powder was extracted with chloroform. Extract alone and combined with Doxorubicin have been evaluated by MTT assay for cytotoxicity against AMN3, AMJ13, MCF7 breast cancer cell lines and normal REF cell line.   Results: Chloroform extract has potent cytotoxicity in a dose dependent manner, against AMN3, AMJ13, MCF7 cell lines and less toxic effect on normal REF cell line; where IC50 (2.93µg/ml), (2.99µg/ml), (2.67µg/ml), and (15.84µg/ml) respectively. The cytotoxicity of extract combined with Doxorubicin showed a synergistic activity on AMN3, AMJ13, MCF7 cell lines, and dose dependent effect on normal REF cell line (synergism at 3.125-6.25µg/ml, addition at 12.5µg/ml, and antagonism at 25-100µg/ml). Conclusion: Chloroform extract has potent cytotoxicity against breast cancer cell lines and less toxic effect on normal REF cell line. In addition to synergistic activity in combination with Doxorubicin on breast cancer cell lines and dose dependent effect on REF cell line.  Keywords: Chloroform extract, Xanthium strumarium, Cytotoxicity, MTT assay, cell line.
Investigating the Staff Agility and the Role of Empowerment in their Improvement Mohammad Mostafa Dahmardeh
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

Staff ability is not used efficiently in most organizations and managers are not able to get their potential capacities. The aim of this study is to investigate the role of the staff agility and the role of empowerment in their improvement. The study is practical according to purpose and is descriptive survey based on the method of gathering data. To collect theoretical foundations and history in this study, the library studies, articles and academic journals have been used. Also field research and search in statistical population were used to collect statistical information to test research hypotheses. A psychological empowerment questionnaire (Spreitzer) and organizational agility (Zhang and Sharifi) have been used to collect information in this study. The statistical population consists of all the employees of the Social Security Organization in Zabol. The sample size was selected using Morgan table. SPSS software was used for data analysis. Descriptive tests of frequency, mean and standard deviation are used for demographic variables and key variables and also inferential tests such as Pearson correlation, and stepwise linear regression and Friedman test have been used to rank the components of psychological empowerment. Data results indicate that there is a significant relationship between the components of psychological empowerment and staff organizational agility.Keywords: organizational agility, Psychological empowerment, Social security organization, Staff, Organization
Removal of Pharmaceutical (Paracetamol) by using CNT/ TiO2 Nanoparticles Aseel M. Aljeboree
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Paracetamol has been the highly usage drug in the world which increased environmental pollution, it has been effected in human life, flora and fauna in the world. Adsorption technique was used to remove paracetamol from water using CNT/TiO2 nanoparticles; the TiO2 was developed from CNT/TiO2 nanoparticles. The experiments were carried out to drug uptake by CNT/TiO2 nanoparticles and effect of some experimental factors like temperature, initial drug concentration, adsorbent dosage, , and particle size in solution, also the adsorption equilibrium was characterized using Langmuir and Freundlich isotherm models. The results have shown immense potential, it was found that correlation coefficient value deal with of the drug, while Langmuir equation was found a good correlation of drug.Keywords: Adsorption, Pharmaceutical, Paracetamol, TiO2, Isotherm models, CNT.
Spin Compensation Temperatures in the Mean-field Theory of a Mixed Spin-3/2 and Spin-7/2 Blume-Capel Ising Model Hadey K. Mohamad
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

In this research it has been constructed the ground-state phase diagram of a mixed spin-3/2 and spin-7/2 Blume-Capel Ising system on a square lattice in theplane. Magnetic phase transitions, in a molecular based magnet, are tested using mean field method (MFM). The equilibrium magnetizations can be achieved by minimizing the free energy which is vital for locating and spin compensation points as well. By utilizing mean field theory (MFT) on principles of Bogoliubov inequality of the free energy, it has been investigated the spin compensation phenomena. In particular, characteristic ferrimagnetic features have been shown depending on the negative values of the different single-ion anisotropies, acting on the atoms and atoms, respectively.Keywords: Blume-Capel Ising model; Ground-state phase diagram; Compensation temperature; Magnetic free energy.
Safety and Gastro protective Activity of Graviola Seeds Extract against Acidified Aspirin Induced Gastric Ulceration Mays Ali Fadhel
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Peptic ulcer disease attacks millions of people yearly around the globe, affecting both quality and quantity of life. There are many different causes responsible for the etiology of this disease; one of the most common causes is non-steroidal anti-inflammatory drugs (NSAIDs) through different mechanisms. Annona muricata have been found to have antioxidant effects, along with a good protective effect against inflammation in rats, making it a good candidate as a potential gastro protective agent. So, this study is designed to evaluate this possible pharmacological activity. Annona muricata seeds were extracted; chemical analysis of the extract has been done, acute toxicity study has been performed using different doses of ethanolic seed extract of Annona muricata (ESAM) 500, 2000, and 5000 mg/kg, the extract demonstrated relative safety at doses up to 2000mg/kg. The gastro protective effect of ethanol seeds extract of Annona muricata (ESAM) has been investigated using two doses of ESAM 250 and 500mg/kg of ESAM, using ranitidine 50mg/kg,  as a reference, ulcer was induced by acidified aspirin solution after 7 days. The extract caused reduction in the gastric content volume, ulcer index and TNF-α, and a significant elevation in the gastric PGE2 and SOD levels in dose dependent manner showing a good preventive index in compare to the acidified aspirin group. Gastro protective effect of ESAM was prevented by pretreatment with sulfhydryl alkylating group (NEM) and NOS inhibitor group (L-NNA) approving the involvement for sulfhydryl (SH) group and endogenous nitric oxide (NO) in the gastro protective effect of Annona Muricata seeds.  Immunohistochemical staining showed pretreatment with ESAM caused upregulation of HSP70. So, this study suggests that the seeds extract of Annona muricata is relatively safe. Its gastroprotective activity attributed to its antisecretory; cytoprotective; antioxidant and anti-inflammatory effects.Keywords: Acute toxicity, Annona muricata seed extract, Gastro protective, Non-steroidal anti-inflammatory drugs.
Evaluation of Possible Toxic Effects of Thymus vulgaris leave Extract on Thyroid Function and Fertility in Male Rats Noori Mohammed Luaibi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Thyme has been used for thousands of years for a myriad of indications. This experiment was conducted to evaluate the effects of thyme leave extracts on some rat organs and hormones such as TSH, T3, T4 and Testosterone after serial period times of injection with different concentrations. 75 Spargue-Dawley albino adult male rats were randomly distributed into five groups of control and treated groups. Each group had 15 rats, group1 for the negative control, group 2 for the positive control, group 3, 4, and 5 were treated with thyme in the concentration of (500, 750and1000) mg/kg of body weight by injection for 10,20, and 30 days subsequently. According to statistical analysis revealed that the level of T3, T4 and testosterone were decreased in treated groups in comparison with control groups and the decreasing value of these hormones were continuing to occur in high concentrations with long period of time injecting with thyme leave extract, While the level of TSH illustrated increment in high concentrations and long periods of time exposing to thyme leaves extract.Keywords: TSH, T3, T4 ,Testosterone, Thymus vulgaris.
Evaluation of the Effectiveness of Olive (Olea europaea) Leaf and Pomegranate (Punica granatum) Flower Extracts in the Viability of the Protoscolices of Echinococcus granulosus In Vitro Zainab Ali Hussein
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The present study was conducted for the period from 1/10/2017 up to 1/3/2018 at the Department of Biology - College of Education for Girls-Kufa University. It aims to assess the effectiveness of ethanolic extracts for olive (Olea europaea) leaf and pomegranate (Punica granatum) flower in the viability of protoscolices of Echinococcus granulosus parasite in vitro. The results demonstrated that the ethanolic extracts for olive leaf and pomegranate flower are very effective in the devastation of the protoscolices, and that the mortality rate increases with concentration and duration of exposure to both extracts .The results showed that the ethanolic extracts for olive leaf was more powerful than the ethanolic extracts for pomegranate flower in the mortality of protoscolices, where the LC50 for the mortality of the protoscolices was (9.7) mg/ml and (11.1) mg/ml, respectively, following 15 minutes of exposure to the extracts, while the LC50 for the mortality of the protoscolices (5.9) mg/ml and (6.6) mg/ml respectively, after 60 minutes of exposure to the extracts. The results also showed that the ethanolic extract for olive leaf led to the decimation of the protoscolices in less time than the ethanolic extract for pomegranate flower when exposed to the concentration of (4) mg / ml, where the LT50 of the protoscolices of (44.6) minutes and (79.4) minutes, respectively, while exposed to the concentration of (16) mg/ml, where the LT50 of the protoscolices of (15.7) minutes and (18.3) minutes, respectively. The conclusion from this study that leaves of olive plant and pomegranate flowers as natural materials can be used to kill the protoscolices of the E. granulosus parasite before a surgical procedure to remove the hydatidcysts .Keywords: Olive leaf, Pomegranate flower, Ethanolic extracts, Protoscolices, Echinococcus granulosus, In vitro.
Evaluating the Efficacy of Bio-Sanitizer S1 in Disinfecting Contaminated Elastomeric Chains Mohammed Nahidh
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Background: Special consideration for the elastomeric chains must be paid in order to prevent their contamination. The purpose of this study was to test the efficacy of Bio-sanitizer S1 in disinfection the contaminated elastomeric chains.  Materials and methods: Three types of elastomeric chains of short types from three companies were utilized in this study. The as-received elastomeric chains were checked for bacterial and fungal growth using Blood, MacConkey and Sabouraud dextrose agars. Elastomeric chains contaminated by saliva of orthodontic patients were checked for bacterial and fungal growth using the same media. After disinfecting the contaminated elastomeric chains, they were cultured again in the same agars to test the efficacy of Bio-sanitizer S1 as compared to chlorhexidine 0.2%. One-way ANOVA test was used for comparison. Results: As-received elastomeric chains from all companies were free from bacterial and fungal contaminations. The contaminated chains had no growth at all after disinfection with Bio-sanitizer S1 and chlorhexidine. Conclusions: Bio-sanitizer S1 acts as efficacious as chlorhexidine in disinfecting the contaminated elastomeric chains with the disadvantages of longer immersion time associated with the latter.Keywords: Elastomeric chain, disinfection, colony forming units.

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