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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
Perioperative outcome between open renal stone-removal surgery and PCNL in patients with staghorn stones Gede Wirya Kusuma Duarsa
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Background: Percutaneous nephrolithotomy (PCNL) has become the treatment of choice for staghorn stones, replacing open stone surgery. However, in a developing country, open stone surgery is still the treatment of choice due to its nature for not requiring endourology devices, it can be performed by a general surgeon, and it is financially acceptable.Objective: This study aims to compare the cost-related outcome between PCNL and open renal stone surgery in patients with staghorn stones.Method: Data were collected retrospectively, taken from patients’ medical records who underwent PCNL and open stone surgery in three hospitals from 2016-2017. Seventy-eight patients were divided equally into PCNL group and open surgery group. Data of the hospital length of stay, the volume of blood loss during surgery, stone-free rate, and post-operative additional procedures were recorded.Outcome Measurements and Statistical Analysis: The data were analyzed using SPSS version 23.0 for Windows.Results: The hospital length of stay was shorter in PCNL compared to open stone surgery (3 vs. 4 days, p<0.001). The post-operative stone-free rate was lower in PCNL compared to open stone surgery (48.7 vs. 92.3%, p<0.001). More post-operative additional procedures were found in PCNL compared to open stone surgery (p<0.001). There was no significant difference in the amount of blood loss during surgery in both groups (p=0.102).Conclusions: PCNL is a minimally invasive procedure that is effective and safe for treating staghorn stones. Nevertheless, in places where PCNL is unavailable, open stone surgery can still be a choice for treatment. 
Effect of Exam Stress of 1-4 Year Student on the Human Body Aminet Askerovna Pseunok
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The research was performed by the authors to study the effect of exam stress on the respiratory system of 1-4 year students. The experiment was carried out in the longitudinal regime for two years with the participation of the same students. Healthy students participated in the experiment voluntarily. We surveyed 89 1-4 year students, of which were 30 boys and 59 were young females aged 18-22 years. The survey was conducted during the intersessional period and on the day of the exam. To study the functional state of external respiration in the examined students, a pneumotachometric type spirometer with a SPIRO-SPECTR calibration syringe was used. The measurements were carried out from 9 to noon since during this period of the day the studied parameters are the most stable. The experiment took into account gender characteristics. Two age groups were formed: 18-19 years old (1-2 years of education) and 20-22 years old (3-4 years of education). Analysis of the research results showed that in the time course of learning from 1 to 4 years, students' adaptive capacity of the respiratory system increases, resulting in increased efficiency and effectiveness of regulatory mechanisms.Keywords: Longitudinal studies, Psycho-emotional stress, Examination stress, Functionality, Respiratory system.
Response of Freesia Hybrida Plant to Spraying with Roselle Calyx Extract (Hibiscus Sabbdariffa L.) and Vitamin B1 Extract in Growth Characteristics Arshad Naji Alhasnawi
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

An experiment was conducted at the nursery of Agriculture Faculty during growing season 2014 – 2015 to study the effect of spraying Roselle extract and vitamin B1 on growth and flowering characteristics of freesia plant. Experiment was adopted a Randomized Complete Block Design (R.C.B.D) with three replicates in two factors, First three concentration of spraying Roselle calyx extract i.e. (0, 5 and 10) g.L-1. Second three concentration of vitamin B1 i.e. (0, 20 and 40) mg. L-1. Means were compared by using Least Significant Difference (L.S.D) test at a probability of 0.05.   Results showed that spraying Roselle calyx extract at a concentration 10g.L-1 and vitamin B1 at concentration 20mg. L-1 increased the number of leaves per plant significantly to 8.67, shoot dry weight to 4.66g, content of chlorophyll A,B and Total in leaves to 56.01,25.00 and 68.09mg. 100g-1 fresh weight, inflorescence stalk length to 26.67cm, diameter of floret to 4.67cm, number of floret to 11.67floret, inflorescence -1, and number of corm to 3.67corm. plant-1, diameters of corm to1.63cm and decreased number of day to flowering time to 125.00 day, compared to the control which gave the lowest values( 3.87life. plant-1, 1.26g, 42,44, 12.51 and 53.0409mg. 100g-1 fresh weight, 14.40cm, 2.67mm,4.67 floret. inflorescence -1, 2.00corm. plant-1 and 1.03cm) and increased number of days  to flowering time to 140 days.                                                                                                                                  Keywords: Freesia Hybrida, Vitamin B1 (Thiamin), Roselle Plant (Hibiscus Sabbdariffa L.) Extract.             
Seminal Oxidative Stress Markers and Fertilization Rate in Sub fertile Male Undergo Assisted Reproductive Technique Ban J. Edan
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objectives: The aim of this research is to examine effect oxidative stress in seminal plasma on fertilization rate in assisted reproductive technique (ART) Methods 70 men attended to fertility center in Al-sadder teaching hospital were rolled in this study .semen analysis was done according to the WHO 2010 guidelines. After analysis the results of SFA were classified as the nospermia, Oligospermia, Oligoasthenospermia and normospermia. Seminal free radicals and antioxidants were measured by spectrophotometric absorbance assay. Results MDA was insignificantly and negatively associated with sperm concentration and highly active motile sperm while CAT and GSH was insignificantly and positively associated with sperm concentration and highly active motile sperm (p>0.05). Oxidative stress parameters in different SFA abnormality shows MDA level insignificantly elevated in sub fertile men with abnormal SFA than normal one. Whereas CAT and GSH were in significantly lesser in sub fertile men with abnormal SFA than normal one. Patients with normal SFA had about five time more fertilization rate than patients with abnormal SFA (odds ratio= 5.585 (CI .529 -59.003)). Universal regression analysis was done to show the effect of measured factors on fertilization rate, count and percentage of active sperm was the most effective factor on FR. Conclusion Inadequate antioxidant protection and elevated oxidative stress destruction effect on semen quality and ultimately o fertilization rate and ART outcome.Keywords: Malondialdehyde (MDA), Antioxidant Enzymes, Reduced Glutathione (GSH), Catalase (CAT), Seminal fluid analysis (SFA), Fertilization rate (FR) and assisted reproductive technique (ART).
Biochemical Investigation in Blood Serum of Female Patients in Type-2 Diabetes Alaa Abbas Fadhel
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Type-2 diabetes mellitus (DM) is considered as a chronic defect of glucose metabolism linked to deficiency of insulin or and resistance to the insulin action. This cross-section study includes forty-three female patients in type-2DM (50 ± 7 years old), with diabetes duration of10±4 years and thirty-six healthy subjects matched in the age and sex with patients as control. Fasting blood specimens were collected from both patients and healthy control. Serum blood level of zinc, magnesium, manganese, triglyceride (Tg), total cholesterol (Tc), alanine amino transferase (ALT), and g-glutamyl transpeptidase (GGT) were evaluated and investigated. The results indicated that there is a significant decrease in Zn, Mg, and Mn serum concentration levels in female type-2 DM compared to control group (p £ 0.05) which supports the close association of the above elements with glucose metabolism. Serum triglyceride (Tg), and total cholesterol (Tc) levels were significantly higher compared with the healthy control subjects (p £ 0.05). while the results concerning to liver enzymes showed significant elevation in the mean level of ALT and GGT enzymes in compared with healthy subjects. The achieved results might be functioned as predictors for coronary heart disease and suggest that the measurement of serum liver enzymes could be signed as a biomarker for type-2 diabetes mellitus disease.Keywords: Type-2 diabetes, Trace elements, Lipid parameters, ALT, GGT,
Fabrication and Study the Structure, Optical and Dispersion Parameters of PMMA with InCl3 Additive Nadir Fadhil Habubi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Polymethyl methacrylate films are prepared by casting method with various content of InCl3 (2, 4%). X-ray diffraction (XRD) and optical microscope are used to determine the structural properties. Transmittance that determined using UV-Visible spectrophotometer and optical parameters also calculated. Urbach energy values increase with the increasing of InCl3 and energy gap decreased from 3.849 eV of pure PMMA films to 3.230 eV of PMMA-4% InCl3. Dispersion parameters are determined using Wemple-DiDomenico model. Refractive index data at infinite wavelength was found to obey single oscillator model.Keywords: PMMA, Dispersion parameters, Composite, Optical properties.
The Correlation between Masculinity and Smoking Behavior among Adolescent in Surabaya Setho Hadisuyatmana
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Smoking behavior is one of the risky health behaviors adopted by adolescents in Indonesia. The behavior was commonly recognized as a masculine among male adolescents. The label of man identity called masculinity influences this condition. This study investigated the association of masculinity as ideology, masculinity norms, and gender role conflict and its correlation with smoking behavior in male adolescents who lived in Surabaya. This study used a descriptive correlative method and involved 314 adolescent males aged 15-18 years old in Surabaya as participants. We employed univariate analysis to identify predictors, including the ideology of masculinity (MNRI-SF), masculinity norms (CMNI-46), and gender role conflict (GRCS-I); and a dependent variable: male adolescents’ smoking behavior. The data were collected electronically, following waived written consents. Bivariate analyses were conducted to investigate each of the predictor's questionnaires and dependent variables using chi-square with the level of significance of p<0.05. Adolescents as participants in this study have low levels of ideological masculinity, high norms of masculinity and gender role conflict in the moderate category. The results indicated that ideology masculinity, masculinity norms, and gender role conflicts are positively associated with smoking behavior (p=0,001, p=0,029, and p=0,001 respectively). The findings of this study suggested that smoking behavior was constructed as an element to the idea of masculinity in the perspective of male adolescents in Surabaya, despite the available warning to prevent the circulation of tobacco products to adolescents. Thus, this study recommends the need for reinvention around tobacco-products circulation as not to involve the youth. Keywords: Adolescent, Gender role conflict, Masculinity, Smoking behavior.
Structure of Groups with At Most Six Character Degrees Mohammad Hosein Salmani Yengejeh
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Let a, b, c and d be relatively prime integers greater than 1 and cd(G) be the set of all irreducible complex character degrees of a finite group G. Mark Lewis in [4] proved that every group G with  cd(G) = {1,  p, q, r, pq, pr},where p, q and r are distinct primes, is the direct product of two groups H and K with cd(H)={1, p, q} ; cd(K)={1, p, r} and so is solvable. We try to use classification of finite groups and drop the primness hypothesis and show that the same result holds in a special case. In fact we show that if a, b, c and d be relatively prime integers greater than 1 and cd(G) 14⊆"> {1, a, bd, cd, abd, acd}, then G is solvable. Also as an interesting application of this theorem we prove that there is no group G with cd(G) = {1, a,  bd,  cd}, where a, b, c and d be relatively prime integers greater than 1.Keywords: Character degree, Solvable group, Irreducible character degree set, Degree graph. 2010 AMS Mathematics Subject Classification: 20C15; 20D05.
Antioxidant Activity and Properties of Walnut Brown Seed Coat Extract Majid Asadi Samani
Journal of Global Pharma Technology Volume 08 Issue 11
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Abstract

To date, there are few studies about the properties of walnut brown seed coat. The antioxidant activity and properties of walnut brown seed coat was considered in this study and the amounts of carotenoids, chlorophylla, chlorophyllb, vitamin E were determined. The antioxidant activity was determined by cupric assay, DPPH, and measurement of oxidative stability in sunflower oil against Copper sulfate. Walnut brown seed coat at 1% was effective antioxidant in comparison to BHT in inhibition of lipid peroxidation. This extract presented the highest vitamin E level (1.4± 0.042 mg/g). DPPH assay showed the extract had the high radical scavenging ability. The results of this study showed the walnut brown seed coat possessed strong antioxidant properties in vitro, hence it might be beneficial in human health. Keywords: Walnut, Antioxidant activity, Vitamin E, Cartenoids, Chlorophylls.
Novel Unsaturated Intermediates (Aldehyde, Polyolefin, Pheromone and Fatty Acid) Synthesized using Wittig Reaction Hussein Habeeb Mustafa
Journal of Global Pharma Technology .
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Abstract

In this study novel unsaturated compounds could be prepared with the required skip-conjugated (Z,Z)-double bonds configuration using  a traditional Wittig reaction. This reaction depends on a coupling of aldehydes with phosphonium salt. Must products do not appear to have been prepared before, and these products were diagnosed by using NMR spectrum, infrared (IR) and mass spectrometer techniques. It is concluded that these products could widely be used as a fatty acid and a useful intermediates in the synthesis of pheromones instead of insecticides, and several chemical reactions.Keywords: Witting reaction, Unsaturated fatty acid, Skip-conjugated alkenes, Pheromone.

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