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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Sequencing of Proteus Toxic Agglutinin (Pta) Gene in Proteus Mirablis and Cytotoxic Effect of Pta on Human Colon Cancer Cell and Human Kidney Cell Lamees A. Abdul-Lateef
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Objective study the sequencing of Pta gene and the cytotoxic effect of pta gene on SW480 and ACHN cell line Material and method detection of pta gene by using PCR technique, detection of mutation in the Pta gene by used automated sequencing. Also the cytotoxic effect of Pta toxin on cell lines of SW480 and ACHN cell were used in vitro. Results the result was revealed that the Pta gene is present in 17 isolates (15 isolated from urine and 2 isolates from stool).  Sequencing of Pta gene from isolates of Proteus mirablis reveals of 43 mutations in five isolates and gives identity in percentage (92-95%) with standard strand in NCBI web site. However, the cytotoxic effect of Pta on cells line of SW480 and ACHN were used in vitro was also investigated. The result was shown that the effect of Pta toxin on SW480 lead to the proliferation of cell was significantly elevated when Pta toxin at 12.5%, 25%, and 50% concentrations. The concentration 50% of Pta toxin a significantly better effect on cell growth On the other hand, ACHN  cell  was gradually increase in growth at concentrations (6.25%, 12.5%%, 25%, and 50%)Keywords: Proteus toxic agglutinin gene, Sequencing, Human colon cancer cell line, Human kidney cell line.
Characteristics of Biocompatible Coatings on Dental Implants Alexei Yumashev
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

The purpose of this article is to give an overview of various biocompatible modifications of the implant surface and factors that mainly affect processes at the implant-bone interface. This review summarizes and explains the factors that are currently recognized as important for dental implants osseointegration: body materials and coatings, topography, hydrophilicity and polarity of the implant surface. Implant body materials (titanium, zirconium) are designed to provide mechanical stability. Their effect on bone cells can be improved with the help of surface treatment with various materials that include calcium phosphates, strontium, bio-glass, and diamond-like carbon. Surface topography can be changed using various methods, for example, plasma spraying, sandblasting, acid etching and microarc oxidation to increase bone contact with the implant. The hydrophilicity and polarity of the surface of the implants shows a significant cell adhesion effect. At the present time the currently used dental implant materials are showing satisfactory clinical results, ongoing research on innovative surfaces is necessary to improve and accelerate the of dental implant osseointegration.Keywords: Dental implants, Implant body materials, Biocompatible coatings, Osseointegration.
Zinc Oxide Nanoparticles by Biological Eco-Friendly Synthesis Matrixes for Antibacterial Applications Abdullah Hasan Jabbar
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

A zinc oxide nanoparticle (ZnONPs) is a prejudiced system because of utilizing into biomedical purposes such as mean conductivity, bacterial control, and lovely warmth resistance. The aims of this instruction are in imitation of synthesize nanoparticles on zinc oxide by biological techniques using a green method yet characterization over nanostructures. Many chemical or natural strategies have been utilized according to ZnO-NPs preparation, but organic techniques so inexperienced strategies among a range of substrates (eg enzymes, microorganisms, bacteria, or sow extracts) are probably to be dealt with as environmentally friendly alternatives in conformity with chemicals and/or applied sciences Physical properties. ZnO nanoparticles are nearly back in imitation of treat a difference about countless pores and skin illnesses and hold anticancer properties. ZnO nanoparticles hold featured so an appropriate meaning for offering medicine and senses. In it stricture article, we succinct the inexperienced synthesize of ZnO NPs or mentioned the antibacterial applications.Keywords: Nanotechnology, Zinc oxide nanoparticles, Green synthesis, biomedical applications.
In Silico Approach : Beta Glucan and AdhO36 Combinations enhance the Th1 immune response against Salmonella Typhi infection Hidajah Rachmawati
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Typhoid fever caused by Salmonella Typhi remains as an infectious disease that still becomes a health problem, especially in developing countries due to its fairly high morbidity. Vaccine development efforts, particularly about proteins that play a role in enhancing immunity, are adhesin protein (Protein AdhO36) and the addition of immunoadjuvant Beta Glucan that can improve the cellular immune system.Objective: This study was aimed to predict the ligand-receptor bonds (Dectin1-Beta Glucan; TLR2-Beta Glucan, TLR4-Beta Glucan) and the ligand-receptor bonds (Dectin1-AdhO36; TLR2-AdhO36, TLR4-AdhO36).Method: To determine the binding affinity of the bond between Beta-Glucan and Dectin1, TLR2, and TLR4, a molecular approach was specifically used using PyRx 0.8. Whereas to find out the interaction between Adh036 and target proteins Dectin1, TLR2, and TLR4, Patchdock software was used. The results of the interaction would be visualized using PyMol software. Amino acids involved in docking interactions were identified using KFC protein hotspots.Results and Conclusion: The result indicated  the binding affinity between receptor Dectin1-ligand Beta Glucan and Beta Glucan TLR2  was (-6.5 kcal/mol), and TLR4-Adh036 shown the highest interaction strength with global energy -1462.6.  This results shown the potential effect of AdhO36 and Beta Glucan combinations  enhanced cellular immunity against Salmonella Typhi infection.Keywords: AdhO36, Beta Glucan, TLR2, TLR 4, Dectin-1. In Silico
The Effect of Fetuin-A and Palmitate on the Translocation of Glucose Transporter-4 Through the Activation of Toll-Like Receptor 4 in Skeletal Muscle Cells Soebagijo Adi Soelistijo
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: Fetuin-A (FetA) is a 63 kD phosphorylated glycoprotein that relates to insulin resistance inhibits autophosphorylation and the activity of insulin receptor tyrosine kinase (IR-TK) at the receptor levels. FetA positively correlates with insulin levels, and homeostasis model of insulin resistance (HOMA-IR). However, the phenomenon is obtained from several studies; a decrease did not always follow the increase of FetA in glucose uptake in the tissue. Aim: To determine the impact of Fetuin-A and Palmitate on TLR4 mediated Glucose Transporter-4 translocation inhibition in normal glucose-tolerance human skeletal muscle cell (h-SkMC). Method: Normal h-SkMC culture were randomly divided into five arms and treated with human- insulin, and deoxy-glucose (GI arm), or human-insulin, deoxy-glucose, and FetuinA (GIF arm), or human-insulin, deoxy-glucose and Palmitate (GIP arm), or human-insulin, deoxyglucose, FetuinA and Palmitate (GIFP arm). The control arm was without any treatment. The effects of insulin, glucose, FetuinA, and Palmitate on the expression of TLR4, Akt, GLUT-4 were evaluated by immunofluorescence microscopy. The expression of TNF- and IL-6 were measured by ELISA assay, and glucose uptake was measured by spectrophotometry assay. The results were obtained and subject to comparative test and pathway analysis. Results: The treatment with glucose+insulin (GI), FetA (GIF), Palmitate (GIP), and Palmitate+FetA (GIFP) increased TLR4 expression significantly compared to control arm (p<0.05) and only treatment with GI and GIF significantly increased the expression of GLUT-4 compared to control arm (p<0.05). All treatment arms and control arms were not significantly different in altering glucose transport. The treatment with Palmitate significantly decreased GLUT-4 expression and independence of TLR4 expression. Conclusion: The treatment with FetA alone or in combination with Palmitate in normal h-SkMC significantly increases the expression of TLR4 but does not alter GLUT-4 translocation and glucose transport. These results provide novel evidence indicating that acute exposure of FetuinA and Palmitate on normal glucose-tolerance h-SkMC does not induce insulin resistance.Keywords: FetA, Palmitate, TLR4, GLUT-4, TNFα, IL-6, Glucose transport.
Prevention of Thrombotic Complications during Hysterectomy among Women with Uterine Fibroids M. Makarenko
Journal of Global Pharma Technology Volume 9 Issue 11
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Abstract

The aim of our study was to determine the state of hemostasis in women with benign tumors of the uterus during and after surgery. Thrombotic complication is one of the most dangerous problems in surgical, obstetrical and gynecological practice. In operative gynecology one of the most dangerous manifestations is thromboembolism, which can be met from 0, 5 to 6, 4% cases. We examined 153 women with the uterine fibroids. Main group consisted of 38 patients who were operated with the usage of the autologous plasma and control group consisted of 115 patients who were operated without the usage of the autologous plasma. We studied a condition of the system of a hemostasis of women of the main and control groups at all stages of supervision. The study found that women with uterine fibroids are at high risk of thrombotic complications during surgery and in the postoperative period. We came to the conclusion that using autoplasma in gynecological practice is economically beneficial and help to reduce the use of donor blood and its components during the surgical treatment of gynecological patients.Keywords: Uterine fibroids, Autologous plasma, Hemostasis system, Thrombotic complication.
Investigation of Herbal Tea Production from Perilla (Perilla Frutescens) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Perilla is an edible plant and has medicinal properties. The leaves have a very pleasant sweet taste and are used as a spice. Perilla seed and oil are rich sources of phenolic compounds, antioxidants, polyunsaturated fatty acids (α-linolenic acid, linoleic acid, oleic acid, and palmitic acid, omega-3 and omega-6 polyunsaturated fatty acids) and minerals. Perilla is commonly used to flavor the foods. Objective of the present study was focused on the effect of blanching, drying and storage of herbal tea produced from Perilla. Optimal results found that herbal tea would have stable antioxidant capacity while blanching at 95oC in 4 seconds with the presence of 4% CaCl2 submersed in blaching solution; drying at 40oC with 2.0 cm in dimenstion of Perilla; storage under vaccum in PET/AL/PE bag within 6 months without any deterioration.Keywords: Perilla, Herbal tea, Blanching, Drying, Storage, vacuum.
Association between inflammatory markers, BDNF, MCP-1 levels and insulin resistance in obese premenopausal women Moushira Zaki
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The present study deals with the investigation of serum TNF-α, IL-6, brain derived neurotrophic factor (BDNF), monocyte chemo-attractant and protein1 (MCP-1), fasting glucose and serum insulin levels of apparently healthy Egyptian premenopausal obese  women and compared with healthy non obese control women. This study aimed to determine assoction between inflammatory markers, BDNF, MCP-1, obesity measures and insulin resistance (IR) risk. The study included 120 apparently healthy Egyptian women, 60 obese and 60 non- obese. IR has been estimated by the Homeostasis Model Insulin Resistance (HOMA-IR). Results showed marked elevation in inflammatory markers and MCP-1 in obese women than controls. Significant reduction of BDNF levels was observed in obese cases with significant negative correlations with obesity measures and HOMA-IR and positive relations with TNF-α and MCP-1. In conclusion our data demonstrated increase of inflammatory markers and MCP-1 as well as decrease of BDNF levels in obese women, suggesting that these biomarkers might be positional candidate linking obesity markers that play important role for development of IR in apparently healthy Egyptian obese premenopausal women.
Community Satisfaction Survey in “Widodaren” Community Health Center Tutiek Herlina
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Community Health Center as health service unit that was the forefront of basic health services was expected to provide quality health services in accordance with community needs. Widodaren Community Health Center was one of Community Health Center in Ngawi Regency area which since 2015 has a full “BLUD” (Regional Public Service Agency) status, and all villages were still in pra advisory villages status. To saw how much quality of health services, it was necessary a Community Satisfaction Survey (CSS). The purpose of implementing CSS was to measure level of community satisfaction with basic health services by the Widodaren Community Health Center, Ngawi Regency in 2019. Community Health Center as health service unit that was the forefront of basic health services was expected to provide quality health services in accordance with community needs. Widodaren Community Health Center was one of Community Health Center in Ngawi Regency area which since 2015 has a full “BLUD” (Regional Public Service Agency) status, and all villages were still in pra advisory villages status. To saw how much quality of health services, it was necessary a Community Satisfaction Survey (CSS). The purpose of implementing CSS was to measure level of community satisfaction with basic health services by the Widodaren Community Health Center, Ngawi Regency in 2019. Methods: This research was survey. Samples were part of community who use health services at Widodaren Community Health Center who were selected by quota sampling technique. Variables studied were the level satisfaction of health services provided community health center. Collecting data with questionnaire. Data analysis with calculating the Community Satisfaction Index. Presentation of data in the form of tables and spider web diagrams. Results: The results showed that there was an influence of the physical activity model (Gambo Rasa) on blood glucose levels of type-2 diabetes mellitus. Results of this research are the service quality in all service units was above the target of 85, and an average of 88.187. Six service units were in excellent category and three service units in good category. Service quality based on service dimensions was above the target of 3,395 and an average of 3,530. Discussion and Conclusion: Four dimensions in excellent category and five dimensions in good category. The service quality of Widodaren Community Health Center in all service units and all dimensions are in good and excellent categories. As an effort to improve quality services, it is necesarry survey of needs or expectations of the latest, and satisfaction survey in 2020 as an evaluation of quality improvement efforts that have been made based on the results of CSS at 2019. Keywords: Survey, Satisfaction, Community, Service, Community Health Center
Comparative Evaluation of IL-1β levels in Gingival Crevicular Fluid (GCF) of the Teeth Supporting Porcelain Fused to Metal Crowns (P.F.M) Sirous Risbaf Fakour
Journal of Global Pharma Technology .
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Abstract

Background and Objective: Using fused to metal porcelain as crowns is the most common methods of replacing missing teeth.IL-1-beta plays a key role in immunity and inflammation. Gingival crevicular fluid (GCF) reflecting the periodontal inflammation was sampled in the same area. This study aimed to compare the amount of IL-1β in the GCF of porcelain -fused to metal crowns with that of healthy teeth. Method: This case-control study was performed on 16 people with porcelain- fused to metal crowns with clinically acceptable standards. The history of non-systemic disease, not smoking and taking any regular medications up to 6 past months was taken. Healthy teeth corresponding to veneered teeth in the opposite side of the jaw were selected as control group. After the initial sampling the teeth received a phase of a non-surgical dental treatment, and the sampling was repeated at 1 and 3 months after the initial sampling. After collecting data with SPSS23 statistical software the data was entered into computer.To compare the concentrations of IL-1β in the two groups Paired t-test was used. Results: The concentration of IL-1β at the all three intervals of testing in teeth with porcelain fused to metal crowns was higher than of it in the control group (P< 0.001). Furthermore, the concentration of IL-1β was decreased in both groups during the whole time. (P<0.001 & P<0.003). Conclusion: The concentration of IL-1β in GCF of teeth with porcelain- fused to metal crowns with clinically acceptable standards is higher than of that in healthy teeth. Porcelain- fused to metal crowns are involved in the production of IL-1β.Keywords: IL-1β, porcelain- fused to metal crowns, GCF, PFM.

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