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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Implementation of Total Ergonomics Approach through Multidisciplinary Sciences for the Improvement of Workers’ Health Quality: Literature Review Doctoral Dissertation Udayana Bali-Indonesia Wahyu Susihono
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Total Ergonomics Approach is application of SHIP (Systemic, Holistic, Interdisciplinary and Participatory) through appropriate technology consideration in conducting design of working condition, work attitude and work system. The Total Ergonomics Approach model has been implemented in various disciplines such as Industrial, Agriculture, Fisheries, and Computer design, Education, Health, Hospitality, Building and Religious. Since 2006 to 2016 (10 years) was found nine scientific sectors that apply the concept of Total Ergonomics Approach. The results of the implementation indicate an incensement in the quality of workers’ health through the reduction of musculoskeletal complaints, fatigue, workload and some other complaints as an impact of ergonomic intervention. The science of ergonomics can be applied to solve various problems in a multidisciplinary range of sciences. Ergonomic improvements take account of human abilities, skills and limitations. Humans become the main factor in every design and improvement work.Keywords: Total Ergonomics, quality of work health, SHIP.
The Impact of Smoking, Including Hookah, on the Human Body Elena Emelina
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Smoking is a social problem in society. For smokers, the problem is to quit smoking, for non-smokers-to avoid the influence of smokers and not "catch" their habit, and also-to maintain their health. Tobacco use is the only truly avoidable cause of death worldwide, with approximately half of all long-term smokers dying. World Health Organization (WHO) estimates that there are 1.3 billion people who smoke in the world and forecasts that the number of people who smoke will increase to 1.6 billion by 2025. Currently, 47% of men and 12% of women consume tobacco globally, while only in Europe about 30% of the adult population smokes. In recent decades, the growth of the tobacco epidemic is mainly due to an increase in the proportion of people who smoke in developing countries. At the same time, the smoking epidemic is growing among women and the younger generation. In Russia, the prevalence of smoking is one of the highest in the world. The increase in the prevalence of tobacco smoking in recent years in our country has been facilitated by freer trade in cigarettes, low prices for them and aggressive, widespread, large-scale advertising of tobacco products in all media.Keywords: Tobacco smoking, Hookah smoking, Health, Safety, Smoker.
Assessment of NT-ProBNP and Troponin T in Sera of Iraqi Patients with Renal Failure Nour Saeed Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Background: Patients with renal failure have high risk of cardiovascular disease which is a leading cause of morbidity and mortality among these patients. This study aimed to evaluate the effect of renal failure on the cardiac system by measuring the following markers (NT-ProBNP and Troponin T) and compared with healthy subjects. Method: This study consists of a total (90) subjects, among them (60) patients with end stage renal failure and (30) healthy persons that served as control group. This study has been carried out in AL-Yarmok Teaching Hospital and AL-Karama Teaching Hospital in Baghdad for the period from February 2017 till May 2017. Serum (NT-ProBNP and Troponin T) were done by enzyme-linked immunosorbent assay (ELISA). Results: this study showed an increasing significant in the levels of NT-Pro BNP and Troponin T for patients with renal failure compared with control group.  Conclusion: Renal failure was affected on cardiac system as the cardiac markers (NT-ProBNP &troponin T) levels were increased significant. Keywords: NT-ProBNP, Troponin T, Renal failure.
Feasibility of Pickling from Common Bean (Phaseolus vulgaris) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Common bean (Phaseolus vulgaris) is often a main source of protein, dietary fiber and minerals in diet offering benefits for human health. With the purpose of accelerating the commercial value of this vegetable, objective of this study focused on the lactic acid fermentation of the common bean into pickle. Different technical parameters such as blanching time and temperature, calcium chloride concentration in soaking, salt sugar percentage submersion affecting to fermentation were examined. This research was conducted in 2019 in the Labone Scientific laboratory. Results showed that 95oC in 6 seconds were suitable for blanching of common bean. The optimal calcium chloride concentration for soaking was recorded at 0.2% for soaking of common bean. The optimal salt: sugar was noticed at 7.5%:2.5% adequately for pickling in 14 days.  As a result from pickling process, common bean will get a longer shelf life, translucent appearance, firm texture and pickle flavor. Pickled common bean was ideal for promoting the positive health image of probiotics. The findings of this investigation help diversifying the multiuse of common bean in food processing enterprises.Keywords: Common bean, Phaseolus vulgaris, Pickling, Blanching, Soaking, Calcium chloride.
Cleavage of Mucin and Salivary Agglutinin by Partiallypurified Protease from Native Strain of Streptococcus Mutansan67 Mayssaa E Abdalah
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Streptococcus mutansAN67 is olatecommensal species of the human oral cavity and their role as a major causative agent associated with dental plaque.S.mutansAN67 was selected as the most active isolate for protease production. Separation and purification of Streptococcusmutans AN67 proteolytic enzyme was done by 0-70% (w:v) saturated ammonium sulfate and ion-exchange chromatography on the DEAE-cellulose column. Partiallypurified protease by ion-exchange chromatography was given an activity of 24 Unit/ml, protein concentration of 0.038 mg/ml, specific activity of 631.5 Unit/mg with purification fold of 2.8and a yield of42 %. Determination of molecular weight for partially purified protease from S. mutans AN67 was elucidated by the use of gel filtration on Sepharose-6B column, which determined as 134000Da.Partially purified protease was tested for cleavage of mucin and agglutinin proteins by gel filtration chromatography on Sepharose-6B column. Partially purified protease was able to cleave mucin protein substrate into three fractions; also it’s cleaving agglutinin protein into three fractions.Keywords: Streptococcusmutans, Protease, Mucin, Agglutinin.
Synthesis and Characterization of Some New Ni, Cu and Co Complexes with Azo-Shciff Base Ligand Mosa Jaafar Mosa
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Azo-schiff base lig and prepared by other obvious studies but we use special amine compound amino acid lysine, bath of azo and schiff base were characterized by FT-IR and H1NMR spectroscopy to notice the different resulting from condensation reaction [Co (AHDB)2] +2,[ Co (AHDB)2] +2 and [ Ni (AHDB)2] +2 complexes with a two molecules of bidentate ligand were synthesized  and identified by using various spectroscopic techniques. Obtained difference in UV-Vis spectrum between ligand and complexes indicates on successful of complication reaction appearance of band belong to d-d transition and didn’t found in ligand spectra, another indication of complication is the H1NMR spectrum show the same chemical shifts in both ligand and complexes cases with small shifting in ppm region which is expected result.Keywords: Azo-schiff base ligand, Cobalt tetra coordinate complexes, Amino acid schiff base.
The Effect of the Complementary Enzyme Q10 in Improving Some Functional Variables of Disabled Basketball Players Sahar Hur Majeed
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Basketball for disabled players is regarded as a game that requires many functions, and this is attributed to the nature of the game itself that forces the disabled player to do moves recognized with high strength and special tempo in a short time. Therefore, the functional side is regarded as one of the fundamental demands for the occurrence of the necessary functional adaptations that might differ in degree from other sport games, and this is done through studying the biological variables because they are important and necessary since they have a great effect on the athletic performance and the physical capacities that are essential for the basketball game in general, and basketball for disabled players in particular because of its great importance in the basketball match especially they, functional variables, occur under the anaerobic  lactic system where the player should have the ability to do his skills in a high speed and frequently in the match. The research aims at preparing anaerobic exercises through taking the Q10 enzyme to improve some of the functional variables of the disabled basketball players. The research also aims to identify the effects of the anaerobic exercises by taking Q10 enzyme, the experimental method was used by taking the Iraqi disabled basketball team as a specimen. 18 players were divided randomly into three groups (experimental 1, experimental 2, and control group) each group consisted of 6 players. The (experimental 1) group had to do the anaerobic exercises prepared by the researchers with doses of the coenzyme Q10; (experimental 2) group had to do anaerobic exercises prepared by the researchers, whereas the (control) group had to do special exercises. Based on the above plan, the coenzyme was used as capsules (100 mg.) taken daily before breakfast, the total enzyme dosage becomes (60 gm.) equivalent to (3gm.). The study concluded that exercises with the use of the complementary Q10 enzyme lead to improve heartbeat ratio before and after exertion, as well as improve the level of lactic acid before and after exertion. Furthermore, it improved the level of V2 Max of the research specimen.Keywords: Enzyme, Functional Variables and Basketball.
The Alteration of SNAIL2 and MMP-9 Protein Expression of JEG-3 Choriocarcinoma Cell by Methanolic Extract of Tamarindus Indica Fruit Candra Rini Hasanah Putri; Sutiman Bambang Sumitro; Setyawati Soeharto; Karyono MIntaroem
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: Tamarindus indica is one of the famous natural plant that has various effects on health. Recent research has begun to examine the effect of Tamarindus indica on cell malignancy. One of the things that happens in cell malignancy is an increasing ability of cell migration, which is characterized by increasing expression of Snail2 and MMP-9. This study was conducted to determine the effect of extract of Tamarindus indica Fruit Extract (TIFE) towards Snail2 and MMP-9 expression in JEG-3 cells.Methods :.TIFE were extracted by using methanol. JEG-3 cells were grown in culture medium treated with TIFE (at 0, 25, 50 and 100 µg/ml). Immunofluorescence staining was carried out, and observed under Confocal Laser Scanning Microscope.Result: Snail2 expression after treatment with TIFE 50 and 100 µg/ml higher than control- (P=0.015 ; P=0.001) whereas at MMP-9 expression there was a biphasic pattern, in which the MMP-9 expression peaked at concentration of 50 µg/ml (P=0.002), then MMP-9 expression decreased at 100 µg/ml concentration. Conclusion : The expression of Snail2 influence MMP-2 expression after treat with TIFE, so it might increase the potential for JEG-3 cell migration Keywords : Methanolic extract, Tamarindus indica, Snail2, MMP-9
Molecular Modeling of Anti-Alopecia Compounds Found in Sauropus Androgynus Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

People in the village of Mak Kemas, Malaysia use the katuk leaves (Sauropus androgynus) to prevent anti-alopecia. It was thought that katuk leaves have secondary metabolites which could accelerate the growth of new hair. The objective of this study was to determine the molecular modeling of compounds contained in katuk leaves (Sauropus androgynous) providing docking and ADMET information in silico as anti-alopecia drugs. In this study, receptors were used (PDB code: 4K7A) derived from protein data banks (http://www.rscb.org/pdb) and visualized with Discovery Studio and tested 10 compounds that had the potential as ligands to prevent baldness. Molecular modeling of bioactive compounds was carried out by molecular docking computation using AutodockTools 1.5.6 and Pre-Admet to determine absorption, distribution, and toxicity. The results were an amino acid residue that showed the place-bound to the receptor, inhibitory constant (Ki), and free energy bonds (∆ G). Of the 11 compounds studied, 3 were 5-Alpha-Dihydrotestosterone; Finasteride; and Pyrene interacts well so that it could prevent baldness. From the results of docking and pre-admet that had been done, it concluded that the compounds contained in katuk leaves could be used as candidates for anti-alopecia drugs.Keywords: Anti-alopecia, ADMET, In-silico, Katuk Leaf, Sauropus androgynus.
Molecular Identification and Phenotypic Detection of Some Virulence Factors among Aeromonas hydrophila Isolated from Diarrhea Cases (Iraq) Ilham A. Bunyan
Journal of Global Pharma Technology .
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Abstract

The present study included the detection of Aeromonas hydrophila in clinical samples were taken from patients suffering from diarrhea during the period from July (2017) to October (2017). A. hydrophila isolates which were diagnosed by four different methods (Culture media, biochemical tests, Api20E system and Polymerase chain reaction (PCR). Api20E kit was the important method for diagnosis of bacteria, which has led to isolate and, diagnosis of (35) isolates of A. hydrophila, but the PCR method of gene (16S rRNA) was more accurate method for diagnosis, which has led to isolate and diagnosis as (16) clinical isolates. The virulence factors of bacteria were detected, and showed that all isolates have ability to produce, heamolysin, protease, lipase, and capsule formation but have no ability to produce siderophores. In addition, A. hydrophila have the ability to adhere to uroepithelial cells of human and have strong biofilm formation.Keywords: Aeromonas hydrophila, 16S rRNA gene Capsule, Sidrophore, hemolysin, and Lipase.

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