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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Investigation of Tumor Necrosis Factor-Alpha (TNF A) Gene Polymorphism in Patients with Hypertension in Al-Diwaniyah City, Iraq Ghaidaa Raheem Lateef Al-Awsi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
Publisher : Journal of Global Pharma Technology

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Abstract

A study was conducted on 100 in the outpatient whom consulted Al-Diwaniyah Teaching Hospital in Al-Diwaniyah City in the period between October 2017 to April 2018.One hundred blood samples (50 experimental and 50 controls) were collected under the supervision of the treating physician. TNF-α, which is an abbreviation of “tumor necrosis factor alpha”, is one of the key distinctive pro-inflammatory cytokines emerging evidence have confirmed the vital role of TNF-α in the progress of hypertension. The genotyping regarding (TNF a) were carried out through utilizing polymerase chain reaction, commonly denoted as (PCR), along with (RFLP), which is an abbreviation of “restriction fragment length polymorphism”. We aimed at determined vital variations within the genotype frequencies of (TNF a) among control and experimental sample groups.Keywords: Hypertension, RFLP, TNF A, SNPs. Polymorphisms, Diwaniyah, Iraq
Feasibility of Composite Edible Coating Derived from Chitosan and Carboxymethyl Cellulose on Star Apple Quality during Post-harvest Preservation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Star apple (Chrysophyllum cainito) is well known as non climacteric fruit with high antioxidant capacity, high nutritional and health benefit. Its pulp is very sweet with glucose as the main sugar. This fruit has a short shelf life due to its perishable nature. Edible coatings have been extensively applied in the fruit preservation as an alternative method to preserve foodstuffs, improve shelf life and control loss of firmness and moisture in fresh fruits. Hence, purpose of this research penetrated on the efficiency of composited edible coating film prepared from chitosan and carboxymetyl cellulose (CMC) in different formulas to preserve star apple fruit. Weight loss (%), firmness (N), total soluble solid (oBrix), and vitamin C were the key indicators used to monitor during 15 days of preservation. After chitosan-CMC coating, the weight loss rate was restrained, and higher firmness, total soluble solid, and vitamin C were reserved. Our finding revealed that chitosan 2.0% combined with CMC 1.0% was appropriate for extending self-life of this valuable fruit. There has been a great demand of emerging fruit packaging from chitosan-CMC composited coating as antibacterial and barrier film. Composited chitosan-CMC coating would have wide prospect in the preservation of other post-harvest fruits and vegetables.Keywords: Chrysophyllum cainito, Chitosan, CMC, Coating, Weight loss, Firmness, Soluble solid, Vitamin C.
Synthesis of New γ-Lactam Derived from 3-Chlorobenzo [b] Thiophene and Evaluation of Anti Bacterial Activity Zainab B Hashim
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

New hetero cyclic, compounds derived from cinnamic acid was synthesized. 3-Chlorobenzo[b]thiophene-2-carbonyl (Z1) was synthesized from cinnamic acid and thionyl chloride . Carbohydrazide (Z2) was obtained by the reaction of 3-Chlorobenzo [b]thiophene-2-carbonyl chloride (Z1) with hydrazine hydrate. treatment of (Z1)with ethylene di amine to give  (Z3) .(Z2,Z3) undergo condensation reaction with different aromatic aldehyde in absolute ethanol gave the Schiff′s bases (Z4-Z19) new γ- lactams (Z20- Z35)  derivatives have been synthesized by reacting of succinic anhydride with Schiff’s bases These compounds were evaluated of the anti- bacterial activitiesKeyword: benzo[b]thiophene, γ- lactams, Schiff′s bases.
Comparative Anatomical and Histological Study of the Liver in Three Species of Wild Birds in Iraq Hussein A. Al-hamadawi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The present study aims to know the morphological description and histological structure of the liver for three species of Iraqi wild birds (Laughing dove, White-throated Kingfisher and Common Kestrel) which represent different modes of feeding habits. To make this purpose a 24 sexually mature healthy birds were hunted from different areas of Al-shamyia city in Al-Qadisiyah province (8 birds from each species) , all birds were anesthetized and sacrificed after catch directly. The results of anatomical study showed that the liver for three species of birds were located in the middle of coelom cavity and it composed of two lobes, large right lobe and small left lobe in Laughing dove and White-throated Kingfisher ; But the left lobe is bigger than right lobe in Common Kestrel. On the other side the results showed a significant difference (P<0.05) between width of right lobe and width and length of left lobe of Common kestrel compared with White throated kingfisher and Laughing dove. While there was no significant difference (P>0.05) between the length and width of the right and left lobes in throated Kingfisher compared with Laughing dove. The color of liver was light brown-drak red in Laughing dove and light red in White-throated Kingfisher while dark brown-red in Common Kestrel. The percentage of the liver weight in laughing dove represents the higher rate when it compared with Common Kestrel and White-throated Kingfisher. In histological study, our results explained that the liver in the three species of birds were surrounded by a thin layer of dense connective tissue called Glissons capsule. It divided into unclear and irregular lobules and the central vein represent the core of each lobule. From the central vein, the hepatic laminae which consist of one to two layers of hepatic cells were branched, anatomizing, and radically extend to the periphery of the lobule blood sinusoids lining with endothelium and few number of large. The lobules surrounded by portal are a peripherally which made from dense connective tissues , it constitutes of portal vein, hepatic artery, and bile duct, in addition to lymphatic vessels which lining by endothelium.­­­­­­­­­­­­­­­­­­­­­­­­Keywords: Liver, Common Kestrel, White-throated Kingfisher and Laughing dove.
Phytochemical screening and assessing the bioactive constituents of Lepisanthes tetraphylla (vahl) radlk through GC-MS analysis Sudha Kesavarthini P; Rani S; Vishwanath B A
Journal of Global Pharma Technology Volume 11 Issue 02 (2019) Feb. 2019
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Abstract

The present study was carried for the preliminary phytochemical analysis of the ethanolic extract of the plant Lepisanthes tetraphylla (vahl) radlk belongs to the family Sapindaceae. Bioactive constituents in the ethanolic extract of Lepisanthes tetraphylla was analysed by GC-MS analysis. Phytochemical screening revealed the presence of carbohydrates, proteins and amino acids, saponins, tannins, flavonoids, gums. In GC-MS analysis, around one hundred and seventeen compounds were present, in which many compounds where not reported for their biological properties. The presence of various bioactive compounds confirms the application of Lepisanthes tetraphylla for various diseases by traditional use.
Malondialdehyde and Antioxidant Vitamins in Breast Cancer Iraqi Patients Firas A. Hassan
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present research was proceeded to explore the situation of plasma anti-oxidative vitamins (E andC) and lipid peroxidation on sixty no patronize breast cancer patients and 30 salutary women. Alteration in the standard for “total antioxidant capacity”, malondialdehyide (MDA), Nitreic oxide (NO) were temperate in specimen patients influenced through breast tumor. The effect detected that plasma vitamin E and vitamin E regulated for the aggregated of cholesterol and triglycerides diminished significantly in patients group (p 0.01). The grade of (MDA) increment significantly in patients as contract to the control. considerable variation were also spotted amidst patients together (non-metastatic and metastatic) breast cancer according  respects specimen(NO) that were minimize in metastatic by contrast together non-metastatic breast tumor.Keywords: Vitamin C, Lipid peroxide, Total Antioxidant capacity, Nitric oxide.
Salmonella enterica Serovar Enteritidis and Typhymurium: Phenotypic, Molecular Detection and Sequencing of Quorum Sensing Zainab Adil Ghani Chabuck
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Bacterial messaging and chatting, or Quorum sensing (QS) is a way that permitting the coordination behaviors of groups between many common bacterial pathogens. Objectives: Phenotypic detection of Quorum sensing production followed by Molecular Detection and Sequencing of its gene sdiA. Materials and Methods: A primers pair for PCR detection of sdiA gene of Salmonella enterica serovar enteritidis and typhymurium had been designed for its detection and followed by its sequencing for detection of mutation using automated sequencing. These were preceded by phenotypic detection of QS. Results: Quorum sensing produced by S. enterica was studied. Results revealed that homoserine lactone production causes the appearance of bacterial cells aggregation, which appears best after 4hours of incubation where it is representing a maximum concentration of homoserine lactone. In addition, sdiA gene is present in all isolates. Sequencing of sdiA gene from isolates of Salmonella enterica serovar enteritidis and typhymurium propose that there were 8 mutations in three isolates, also gave identity in a percentage of (98-99%) with standard strand according to NCBI web site. Keywords: Quorum sensing, Salmonella enterica, sdiA, sequencing.
Molecular Diagnostic of Treponema pallidum in Blood Specimens of Donors Using Simple PCR and Real-Time PCR in Thi-qar Province, Iraq Kamil M. Al-Jobori
Journal of Global Pharma Technology .
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Abstract

Syphilis is a   perplexing infection; it is a complex multistage disease responsible for a range of severe clinical manifestations when untreated or as a result of treatment failure in its sole human host.  The objective of current study was    to diagnostic of Treponema pallidum in blood specimens of donors using molecular methods. A total of 150 samples (25 serums, 25 plasma and 100 whole blood) were used for this purpose. Samples were analyzed using   simple PCR and RT-PCR by amplifying 16Sr and polA genes).During the study period, out of 150 samples of serum, plasma and whole blood collected from males and females, whole blood samples of 14 male and 1 female gave positive result for DNA extract , and and only 15 samples were positive for simple PCR  and RT-PCR for the 16Sr gene . But polA gene   not succeeded to amplify by simple PCR, however, succeeded to amplified 15 samples using RT-PCR. In conclusion, Blood samples, regardless of the compartment (serum, plasma or whole blood) used for testing, appear to be unsuitable for PCR analysis. However, from blood compartment whole blood was the best sample for spirochete detection of syphilis infection   than from serum and plasma samples.Keywords: Blood donors, Syphilis, Treponema pallidum, 16Sr gene, polA gene, Simple PCR, RT-PCR.
Removal of Hexavalent Chromium from Aqueous Solutions Using Azolla Plant Leaf Mojtaba Afsharnia
Journal of Global Pharma Technology .
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Abstract

Soluble hexavalent chromium Cr is one of the most important and most dangerous toxic and carcinogenic heavy metals. This metal in accordance with health organizations has been classified as one of six probably carcinogenic agents through ingestion. This study was conducted to evaluate the level of removal of hexavalent chromium from aqueous solutions using Azolla plant leaf. In this experimental study, the effect of influencing variables was analyzed, including pH (2, 3, 5, 7, 8, 10 and 12), contact time (5 to 120 minutes), adsorbent dosage (0.1, 0.3, 0.5, 0.7, 0.9, 1 and 1.5 g/l) and initial phenol concentration (10-200 mg). Adsorption isotherms were studied using Langmuir, Freundlich and Temkin isotherms. The results showed that acid- heat- modified Azolla plant leaf had greater potential for absorption of chromium in comparison with washed with distilled water or unmodified conditions, so that the absorption rate was about 53% in pH 2 with an hour contact time. Also according to the results, the absorption rate in pH 2 was greater than in pH 4. Therefore, Azolla plant leaf compared with some adsorbents investigated so far is considered as an effective, suitable and inexpensive adsorbent for removal of Cr from aqueous solutions.Keywords: Hexavalent Chromium, Adsorption, Azolla, Aqueous Solutions, Adsorbent
Synthesis and Antibacterial Activities of New β-Lactam and Imidazole Derivatives Hind J. Shawkat
Journal of Global Pharma Technology .
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Abstract

New β-lactam, imidazole, oxazole and amide derivatives were synthesized with good yields using simple methodology. Thiosemicarbazide derivatives 2(a-f) were treatment with ethyl chloro acetate to give compounds 1-((arylidene) amino) 2-thioxoimidazolidin-4-one 3(a-f), then3 (a-f) were converted to oxazole derivatives have β-lactam moiety by reaction with chloro acetyl chloride. Amide derivatives were synthesized by convertion 3(a-f) with acid chloride (acetyl chloride and benzoyl chloride).Structural of all derivatives have been confirmed with IR, H1 NMR and some of them with mass spectroscopy .These derivatives were tested for invetro antibacterial against Staphylococcus aureus, Pseudomonasaeruginosa Kelebsiella pneumonia and Escherichia Coli.Large number of compounds showed high inhibition zone (mm) against different bacterial species.Keywords: Imidazole, Oxazole,β-lactam, Amide, Antibacterial activity.

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