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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Antibacterial Activity of Aquatic Zea Mays L. Hairs Extract against Different Bacteria in Babylon Province: An In-Vitro Study Rasha Hadi Saleh
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background Zea Mays L. has been frequently used as a therapeutic agent used for treatment of various diseases .Objective A evaluation the antibacterial, anti-biofilm, adherence and swarming in hibitory activities of   Zea   Nujm mays L. hair extract against different bacteria. Methods: Well diffusion method, bio film inhibition test using a tissue culture plate, adherence and swarming inhibition assays were done for estimation and evaluation the anti-bacteriala activity of Zea mays L against a number of bacteria. Results: The result showed that Zea Mays L hair extracts the vying potent antibacterial activity. It’s also inhibiting adherence to epithelial cells and biofilm formations of the bacteria. The result shows that the extract has high anti-swarming activity .Conclusions: The extract has marked antibacterial activity. It can inhibit biofilm formation, swarming to ility, and bacterial cell adherence to oral epithelial cells. Keywords:  Biofilm, Bacterial adherence, Swarming.
Histomorphological Study of the Ovaries and Follicles Growth in Adult Female Albino Rats Saif M. Haibet
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
Publisher : Journal of Global Pharma Technology

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Abstract

The Ovary plays a vital role in the reproductive process and this study was carried out in order to investigate the structure of ovaries of the female mature rat Ovaries were obtained by direct incision on the abdominal cavity and were then divided into two sections and fixed in buffered formalin. The sections (5-7 μm) were cut in paraffin blocks, stained with Mayer’s haematoxylin stain, periodic acid Schiff (PAS) technique. In histological examinations it was composed of two main zones, cortex and medulla. The surfaces of the ovaries were wavy and lined by simple cuboidal or columnar epithelium. The tunica albuginea consisted of connective tissue fibres. There were connective tissue cells in the cortex, as well as interstitial cells containing. Primordial, primary, secondary, tertiary follicles, corpus luteum and atretic follicles were seen in the cortex of ovaries. Mean diameters of these follicles varied between 80 and 1600 μm. Medulla consisted of loose connective tissue which contained blood and lymph vessels of varying sizes. The diameter of ovarian follicles in the cortex was measured as primordial 36.5±1.31µm, primary single layer 60.58±2.68µm, primary multi-layer 167.84±5.59µm, secondary with C-shaped antrum 193.83 ± 75.71 µm and graafian 389.62±9.55mm.
Application of Chitosan Coating for Quail (Coturnix Coturnix) Egg Preservation Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Quails are becoming more popular as a source of meat and egg because of their small body size, rapid generation turnover and high egg production. Quail eggs are the good source of nutrients for human health, being one of the best and most economical sources of high quality protein. Although quail eggs are small in size, their nutritional value is three to four times greater than chicken eggs and is packed with vitamins and minerals. Quail eggs are becoming more and more popular as they fulfill the criteria of a product with traits of functional food. Objective of this research focused on the effect of different chitosan concentrations (0%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%), effect of storage temperature condition (4oC, 28oC) to quail egg quality. Results showed that coating 2.5% of chitosan and preserving at 4oC could extend quail egg quality for 60 days.Keywords: Quai egg, Coating, Chitosan, Concentration, Temperature, Preservation.
The Epidermal Growth Factor Receptor Expression in Leptin-Treated Traumatic Oral Ulcer in Rats Sabreen S. Abed
Journal of Global Pharma Technology Volume 11 Issue 03
Publisher : Journal of Global Pharma Technology

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Abstract

Back ground: The injured tissues need to activate their cellular responses in order to restore their normal histological architecture. Leptin has a significant effect on wound healing by enhancing the expression of many biological molecules and cytokines. The present study   aimed to evaluate the effect of topical application of recombinant leptin on induced traumatic oral ulcer healing by mean of immunohistochemical localization of EGF-R. Materials and methods:  Forty eight male Albino rats with body weight between (200 -270 gm) and age between 2-3 months, were subjected to traumatic ulcer with 8 mm diameter by surgical blade no.15 on the right side of the buccal mucosa. The animals divided into two groups; control group: the ulcer treated daily with sterilized distilled water, the experimental group: the ulcer treated daily with 10µl of 1 µg/ml recombinant leptin. The rats were sacrificed at 3,7,10 days. The specimens were taken for immunohistochemical study to detect the expression of EGF-R in both control and study groups. Results: The present study showed that the recombinant leptin increased the expression of EGF-R in the ulcer area only at 3rd day of ulceration by both epithelial and mesenchymal cells with highly significant differences than control group. Conclusion: leptin accelerated the healing process in oral mucosal ulcer by increase the expression of EGF-R in early healing period than control.Keywords: leptin, Oral mucosa, Ulcer, EGF-R.
Interleukin (IL) 18 and Its Relation with Diabetes Mellitus and Chronic Periodontitis Kavitha J
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
Publisher : Journal of Global Pharma Technology

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Abstract

 IL-18 is a member of the IL-1 family of cytokines. IL-18 demonstrates a unique function by binding to a specific receptor expressed on various types of cells. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Metabolic abnormalities in carbohydrates, lipids, and proteins result from the importance of insulin as an anabolic hormone. Chronic periodontitis, also known as adult periodontitis, is an infectious inflammatory disease caused by the bacteria of the dental plaque, resulting in the progressive destruction of the tissues that support the teeth, i.e. the gingival, the periodontal ligament, cementum, and the alveolar bone. Chronic periodontitis can also play a role as a metabolic stress or for diabetes control. In this review article, we will focus on the unique features of Interleukin (IL) 18 and its relation with diabetes mellitus and chronic periodontitis.
Effect of Regular Sports Activity in the Salivary Glands in Short and Long Distance Sprinters for Track and Field Games Hayder Flayyih Hasan
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

Saliva is produced in salivary gland and the human saliva consists of 99.5% water but contains many important substances such as electrolytes. Mucus antibodies to bacteria and various organisms. This study was studied by enzymes which are biological catalysts of different chemical structures. And affect the speed of some reactions without consumption. The importance of this research lies in the role of these enzymes, which are studied in the health of teeth and mouth “isosomiee, hactoferin, Bromine, globin alga” and the percentage of the concentration of these enzymes. Which are of the quantity and quality of saliva produced from the salivary glands? The latter is an acquired by adapting the activity of the sports activity with the training intensity. Such as long - term diseases of the field work of these glands in secretion is very important in the durability of motor performance such as sports activities. By moisturizing the mouth and facilitating the process of breathing and swallow saliva especially that such sports activities rely on the energy … so the study assumes that the long-distance runners have a quality and the amount of salivary secretion useful more than short- distance runners during periods of rest or practice of normal daily life because the saliva of the mouth decreases during the exercise of violent physical exercise this necessarily means that long - distance sprinters enjoy the health of teeth and mouth over short runners to contain their saliva on an enzymatic con centration.Keywords: Regular sports, salivary glands, short and long distance and sprinters. 
Synthesis and Characterization of new Schiff base Derived from Benzothiazole with (Salicyldehyde and Saccharin) and Complexes for some Metal Ions (Co, Ni, Cd and Hg) Luay Ali Dhahi
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

This research including preparation new derivatives for heterocyclic compounds are (1,3 benzothiazole), process synthesis in us research divided into two major pathways: First , synthesis 2- amino benzothiazole derivatives ethyl 2-aminobenzo[d]thiazole-6-carboxylate (HL).Second pathway ,reaction of salicyldehyde and saccharin with amine group of benzothiazole (HL) produced  of Schiff's base compounds(HL1,HL2). The compound was characterized by FT-IR, UV-Vis and 1H, 13C-NMR spectra. The complexes of the bivalent ions (M+2 =Co, Ni, Cd and Hg) with Schiff bases derived to give ligands (HL1, HL2) were prepared and then reacted with metal salts in ethanol as a solvent in (1:2) ratio (M: L). the complexes which have the general formula [M (HLn) 2Cl2] when (n=1, 2). Have been prepared and characterized by FT-IR, UV-Vis spectra, conductivity measurements, magnetic susceptibility. The proposed geometrical structures for all complexes were octahedral.Keywords: ligand, Benzothiazole, Salicyldehyde, Saccharin, Schiff bases, Complexes.
Investigation of Melanin in Dermatophytes that Isolated from Primary Schools Students Abbas Abdel Hussein Mohi
Journal of Global Pharma Technology Volume 11 Issue 05.
Publisher : Journal of Global Pharma Technology

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Abstract

The study was conducted on four types of dermatophytes, including Trichophyton rubrub, T. mentagrophytes, Microsporium audouinii and M.canis. For isolated samples from primary school students under the age of sixteen, samples were collected from different areas of tinea capitis, tinea corporis and then identified the fungal infections to distinguish it from, other infections, such as eczema and traditional sensitivity, the diagnosis was done by direct examination of 10% KOH and then SDACC to observe the fungal structures where Morphological Description was identified. The fungus stimulated the production of melanin dye using a PDA medium for the four species. Melanin was detected in two ways copper silver sulfide (AgCuS) and light microscopy where the melanin was presented in the fungal structures of the hyphae and Conidial. The second method was grown for twenty-one days. Melanin was extracted and the melanin concentrations and carefully were observed using the scanning electron microscopy.Keywords: Melanin; Primary school; and Dermatophytes
Awareness of Chronic Kidney Disease among General Adult Population in Indonesia Susi Ari Kristina; Laksmy Anggun Larasati; Suci Hanifah
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Chronic kidney disease (CKD) is rapidly becoming a major problem for developing countries such as Indonesia in terms of complicated management such as hemodialysis, continuous ambulatory peritoneal dialysis (CAPD) or high-cost renal transplantation. In its initial stages, early diagnosis and management of CKD may help avoid or delay disease progression. This study aimed to assess CKD's awareness and knowledge in Indonesia's general population. Methods: Cross-sectional research design was performed among the general adult population in Yogyakarta province. Recruiting participants using a convenience sample. A pre-validated questionnaire consisted of two parts, demographic features and CKD information. A logistic bivariate regression was used to identify independent CKD predictors, and p-value
Synthesis, Characterization, Antimicrobial Activity and Antioxidant of Azo Schiff Bases Containing Sulfanilamide Bushra K. AL-Salami
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Some new azo Schiff bases (SH1-SH6, SH14) were prepared in good yields by reaction of Sulfanilamide with 2, 4-dihydroxy-5-(phenyldiazyl) benzaldehyde and its substituted derivatives (Z1-Z6, Z14).  The structures of azo and azo-azomethine compounds were determined by FT-IR, 1HNMR spectroscopic techniques, EI-mass and elemental analysis.  The azo-azomethine compounds have been tested in vitro against Pseudomonas aeruginosa (-Ve) gram and Staphylococcus sciuri (+ Ve) gram in order to assess their antibacterial characteristic. Antioxidant efficiency of the azo-azomethine compounds examined.Keywords: Azo-azomethine, Azo compound, antioxidantand antibacterial activity, Sulfanilamide.

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