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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Role of Pharmacognosists in Regulating Herbal Industry Chandrashaker K.S
Journal of Global Pharma Technology Volume 10 Issue 04: (2018) April 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Herbal medicines are widely used all over the world for the treatments of various diseases. Hence regulation is necessary for herbal medicinal products. Different countries have different regulation for herbal medicinal products. Standardization is an important part of regulation in which raw material and finished products specification, analytical and in process methods, stability study are required. In this article herbal products and its regulatory requirements are discussed. This is useful for marketing herbal medicinal products   particularly in India.Keywords: Herbal medicines, Chromatogram, Ayurvedic drugs.
An Overview of the Effectiveness of the Most Important Native Medicinal Plants of Iran on Hemorrhoid Based on Iranian Traditional Medicine Textbooks Mahnaz Mardani
Journal of Global Pharma Technology Volume 08 Issue 09: (2016) September 2016
Publisher : Journal of Global Pharma Technology

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Abstract

Hemorrhoid diseaseoccursfollowing the blood-filling of vascular structures of submucosal networks in the anal area. Patients usually feel no painsand the symptoms include a feeling of rectal congestion, mucus secretion, and bright red blood dripping. Surgical treatment is of the most common treatment methods of hemorrhoid. In addition to the usual treatments, classic therapies and complementary medicine are also applied. Medicinal herbs have been traditionally a source for the treatment of many diseases. Many native medicinal plants of Iran have had effective properties on hemorrhoid. Thus, in this review,the effective medicinal plants of Iranian ethnobotanical resources on hemorrhoid were reported. In this review study, a search for articles by the keywords hemorrhoid,ethnobotanical, and medicinal plants was done. A search on the databases, such as Scopus, ISI C, S ID, MegIran,and a number of other databases was performed. Based on the results obtained, 11 herbs from different parts of Iran are traditionally used to treat anorexia. Such medicinal plants as pistachio from mountainous trees, yarrow, camel thorn, etc. are of the effective herbs on hemorrhoid.Keywords: gastrointestinal tract, Hemorrhoid, Medicinal herb, Iranian ethnobotany.
Synthesis and Biological Activity Evaluation of New Imidazo and Bis Imidazo (1, 2-A) Pyridine Derivatives Naeemah Al-Lami
Journal of Global Pharma Technology .
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Abstract

A series of imidazo [1, 2-a] pyridine derivatives were obtained from the work that was conducted in this research. Firstly; reaction of 2-amino pyridine with (4-phenyl phenacyl bromide) or (4-bromo phenyl phenacyl bromide) to give 2-substituted imidazo [1, 2-a] pyridine as a starting compound (1a, 1b).Then reactions of compounds (1a, 1b) were carried out through two pathways: the first pathway involved condensation of two analogous of compounds (1a, 1b) with different aryl aldehyde to give bis imidazo [1, 2-a] pyridine (2a, 3a, 4a, 2b, 3b, 4b). While; the second pathway was introduced Carbaldehyde group at position-3 of prepared 2-substituted imidazo pyridine rings by Vilsmeier-Haack reaction, the produced was reacted with different aromatic amines to give Schiff bases of these derivatives. Then Schiff bases reacted with α-amino acid, monochloro acetic acid and phenyl isocyanate to give compounds (10a-15b). The new prepared compounds were identified by [FTIR, 1H-NMR and 13C-NMR] and their physical properties were measured. Furthermore, we have evaluated the effect of some prepared compounds on some bacterial and fungal strains. Keywords: Imidazo/pyridine, Bis imidazo, Aza-β-lactam, oxazolidin, imidazolinone.
Inducement of Agarwood Resin Using Various Chemical Formulation of Stem Tissue (Aquilaria malaccensis) Husni Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Agarwood is described as fragrance wood that is usually derived from the trunk of genus Aquilaria which have been infected by a particular disease. The main focus of this research is to study the effectiveness of four chemical inoculants applied into 6 year old karas tree (A. malaccensis) plantations in Slim River, Perak, Malaysia using dripping techniques. The inoculants used were labelled as A, B, C and D. Commercial inoculant, labelled as K, was used for comparison purposes and control labelled as N. After eight months of inoculation, the karas tree were cut down and discoloured tissue samples were collected.  Solvent extraction methods using dichloromethane (DCM) was carried out to obtain the resin crude extract from the plant tissue. Resin crude extract were then analysed using gas chromatography-mass spectrometry (GC-MS). The results showed that all chemicals successfully stimulated agarwood production. Inoculant A produced the highest crude extract recovery (8.63%) compared to inoculants B (7.45%), D (6.55%), C (5.95%), K (1.89%) and N (0.49%). GC-MS analysis revealed that aromatic compounds, sesquiterpenes, monoterpenes, sterols, alkanes and fatty acid methyl ester were identified from DCM extract. As an outcome, inoculant A is the best to be used as stimulant for agarwood due to product highest yield. This finding will hopefully contribute to new types of inoculants production in agarwood industries in Malaysia.Keywords: Agar wood, artificial inoculation, Chemical inducement, Aquilaria malaccensis, Malaysia
Significance of TLC and HPTLC in Phytochemical Screening of Herbal Drugs Anguraj Moulishankar; Prasanna Ganesan; Madhivanan Elumalai; Karthikeyan Lakshmanan
Journal of Global Pharma Technology Volume 13 Issue 01 (2021) Jan. 2021
Publisher : Journal of Global Pharma Technology

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Abstract

Plants provide the most of the pharmacologically active principles like alkaloids, anthraquinones, cardiac glycosides, coumarins, flavonoids, saponins, tannins, essential oils to humans. A large number of the medicinal plants were used by traditional and folk medicinal practitioners for various ailments. The active principles in them are detected by qualitative chemical tests for each category of phytoconstituents. Many chromatographic methods help in separation of the complex mixtures into individual phytoconstituent. Even though Thin Layer Chromatography (TLC) and HPTLC are rapid and easy methods, the selection of stationary phase and solvent system is always a time-consuming process. The general solvent systems for the specific category of secondary metabolites are available in various literatures, but for specific phytoconstituent one should do trial and error method to identify a suitable solvent system. This review article aims to minimize the valuable time of both beginning and experienced researchers by providing well-organized information about TLC and HPTLC in phytochemical screening. Keywords: TLC, HPTLC, Solvent system, Extraction, Phytochemical analysis, Herbal drugs.
Anti-Diarrheal Activity of Aqueous Extract Datura Innoxia Leaves in Rat Farrah R. Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Two experiments were performed, to study the therapeutic effect DI leaf extract against chemically induced diarrhea as well as anti-enter pooling effect induced by castor oil in two gatherings (T1&T2) Treated orally with (Datura innoxia leaves aqueous) extract at doses of 100 and 200 mg/Kg B.W. and compared with atropine sulphate treated group as standard drug and control one, each group consist of 6 albino rat. Exp-The results show significant decrease (P<0.05) in charcoal Intestinal travelling percent (ITP)in both DI extract doses in dose dependent manner T2 when compared to of atropine sulphate (1mg/kg BW) show similar result. While Ex-2 Nearly same patter results as in exp-1in which both orally treated DI extract doses and atropine(3mg/Kg BW) caused significant reduction (P˂0.05) in(enter pooling impact) on intestinal substance weight and volume in examination with the control gathering. The possibly because the DI extract may have another impact component next ant muscarinic impact cause its tropane alkaloids content. Inclusion, DI leaves aqueous   seem to cause anti-diarrheal effect and intestinal anti-propulsion effect positive correlated with extract dose.Keywords:  Aqueous extract, datura innoxia leaves, Anti-diarrheal Activity, Enteropooling, Rat.
Analyze the Relationship between QWL and Organizational Citizenship Behavior Zabol University Naser Khodizaee
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

A high quality of work life (QWL) is essential for all organizations to continue to attract and retain employees. Quality of work life is a comprehensive program which is designated to increase employee satisfaction. In today’s society, improving the working life has been one of the main goals of the organization and staff and their working environment. Today, in modern management concept of quality of work life around the world has become a major social issue. While in past decades only on working life in search of new systems to help staff between work life and personal life balance so that they can communicate. Any improvement in the quality of work life programs organizational culture that promotes the growth and excellence in the organization's staff .Organization citizenship behavior also is one important sociological dimension of organizations. The purpose of current study is Analyze the relationship between QWL and organizational citizenship behavior Zabol University. Using table of Morgan the sample volume was estimated 159 people. The SPSS and multiple linear regression and Pearson Tests were used for data analysis and responding to the hypotheses, respectively. Test show that there is meaningful relationship between six dimensions with quality of work life and organizational citizenship behavior.Keywords: quality of work life, organizational citizenship behavior.
Synthesis and Characterization of Some new 2,4-Thiazolidinedione Derivatives Zina. S. Hassan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The synthesized thiazolidinedione compounds were prepared from the condensation reaction between chloroacetic acid with thiourea in the presence of water. The yield of product was found to be in the range of 75-95%. The second-pot synthesized 2, 4-thiazolidinedione derivatives were prepared from the condensation reaction between thiazolidine ring with series of aldehydes aromatic (4-(Dimethylamino) benzaldehyde, 2, 3-Dimethoxybenzaldehyde, Terephathaldehyde, 2-Thiophenecarboxaldehyde, Isatin, Furfural) and confirmed by spectral data: FTIR and 1H-NMR Spectra.Keywords: 2, 4- thiazolidinedione; Characterization; Thiourea.
Investigation of Chitosan as Edible Coating on Storage of Star Apple (Chrysophyllum Cainino) Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Star apple or milk fruit (Chrysophyllum cainino) is a non climacteric fruit and is considered exotic. It has a very pleasant flavor and nice appearance because of its star shape when cut in half. It’s widely cultivated in South of Vietnam. The fruits are shining apple-sized berries. The immature fruits are astringent and contain sticky white latex. The fruit is bright green and greenish-yellow to red violet when ripe, and should be eaten when fully ripe. It has excellent health and medicinal benefits. Despite its food benefits, star apple is highly perishable due to its high moisture content which is susceptible to microbial action. Objective of this study focused on the chitosan edible coating affected to weight loss, protein, total soluble solid, vitamin A and vitamin C in star apple (Chrysophyllum cainino) fruits. Different concentrations of chitosan (0%, 0.25%, 0.5%, 0.75%, and 1%) were examined. Results demonstrated that star apple fruits which were coated with 0.75% chitosan still maintained shelf-life until 15 days of preservation. So the use of chitosan coating was one promising method to improve stability of star apple (Chrysophyllum cainino) fruits during storage and distribution.Keywords: Chrysophyllum cainino, Edible coating, Chitosan, Stability, Storage, distribution.
Synthesis and Characterizations of New Pyrazoles and Study the Toxic Effect of the Compounds in Hella and RD Cancer Cells lines Fadhil Lafta Faraj
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

New Pyrazole Derivatives have been synthesized by reaction of 2-(5-methoxy-3,3-dimethyl-1,3-dihydro-indol-2-ylidene)-malonaldehyde with hydrazine and substituted phenylhydrazine. The chemical purity of the new synthesized compounds was tested by TLC and the chemical structures were characterized by, FT-IR, 1H, and APT 13C NMR. The biological activity of the new synthesized compounds was conducted to investigate the toxic effect of these compounds on the growth of tumor cells represented by the line of HeLa cell line and the human muscle cancer RD in the laboratory. The study included exposure period 24 and 48 hours, and showed good and different results. Keywords: Pyrazole Derivatives, Hydrazine and substituted phenylhydrazine, Hella and RD Cancer Cells lines.

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