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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Pumpkin Concentrate on Alloxan Induced Diabetic Rats Ashish Baldi
Journal of Global Pharma Technology Volume 02 Issue 10: (2010) Oct.2010
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Abstract

Effect of Pumpkin Concentrate on Alloxan Induced Diabetic Rats
A Novel Anti-bacterial, Histopathological and Immunomodulatory Effect of Lactobacillus Reuteri and Exopolysaccharide in Pneumonia Model Likaa Mahdi
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Objective: The current study aimed to evaluate the antibacterial activity of exopolysaccharide (EPS) against multidrug resistant Klebsiella pneumoniae isolated from blood cultures in vitro and evaluate the potential antibacterial, histopathological and immunomodulatory efficacy of Lactobacillus reuteri and EPS against K.pneumoniae in-vivo. Materials and methods: purification and characterization of EPS produced from L.reuteri.BALB mice were injected with   K. pneumoniae, and treated with either L. reuteri or EPS, bacteriological, histopathological and cytokine production were determined. Results: Antibacterial activity of purified EPS was higher than crude P<0.05. In-vivo L. reuteri and EPS  demonstrate a significant decreasing in the number of bacteria in liver and spleen, while complete clearance of K. pneumoniae  in lung comparing with control P<0.05  and accelerated recovery of the defense mechanisms against K. pneumoniae by inducing two types of  cytokines. These cytokines would be involved in the improvement of the immune response and limiting the injury caused by infection. Succeeded to eradicate K. pneumoniae infection improves histological patterns of the lung, spleen and hepatic tissues. Conclucion: L. reuteri and EPS, they could be novel therapeutic agents for prevention and treatment of pneumonia infection and   introduced as potential novel candidates that have to be subjected for more in vivo and application studies for treatment and control of resistant K. pneumoniae.                                                                                  Keywords: L. reuteri, Exopolysaccharide, Immunomodulatory, Antibacterial, K. pneumoniae.
The Cognition of Sensory-Motor and Its Correlation to Some of Physical Fitness Elements and Skill Traits for the Player's Epee Mohamed Abdulrahman Mohamed
Journal of Global Pharma Technology .
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The game of fencing with the epee passed through a great development in the performance of skill and plan through the increased attention given to it by specialists and interested of trainers and researchers, as well as conducting research and studies that have a major role. In upgrading the game for the better. The importance of this research is evidenced by the linking of skills to some sensory abilities - the movement and the elements of physical fitness and motor skills may help in obtaining factors that contribute to the development of learning and training development of the game of fencing with many aspects of epee, hence, the researcher noted that many of the trainers focus in their training on the elements of fitness and motor skills without taking into account the importance of cognitive abilities - sense of movement and its relationship to these elements and skills played by the player in the stadium. And the relationship between some cognitive abilities of the sense of movement and some elements of fitness and skill qualities of the game of fencing with the epee. The sample of the research was chosen in a deliberate manner, the number of (24) players representing the clubs of Baghdad and the provinces of the game of duel with epee, (4) players for each club and the researcher used the statistical bag for social sciences (SPSS) to address the findings. The most important conclusion was the weakness of the accuracy of the stab, which indicates the weakness of the sense of precision of the weapon (tool) to the legal targets of the competitor. The researcher recommended emphasizing the development of training programs that work on the development and development of flexibility and agility and speed of movement of motorists fencing with epee.Keywords: Cognition, Kinetic sensation, Physical fitness and epee.
Molecular Detection of Some Virulence Genes of Salmonella Typhymurium and Salmonella Enteritidis Isolated from Patients Suffering Watery Diarrhea Lamees A. Abdul-Lateef
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Salmonella enterica virulence factors can be divided into chromosomal, plasmid and bacteriophages encoded virulence factors. Many of the Salmonella virulence factors, such as adhesion, invasion, and toxin genes are clustered in certain areas of the chromosome known as “Salmonella pathogenicity islands” (SPI). A total of 200 clinical stool samples were collected during this study which obtained from patient Suffering from watery diarrhea who a dmintted to three main hospitals of Babylon Governorate: Merjan Medical city, Al-Hillah Surgical Teaching Hospital and Babil Teaching Hospital for Women and Children during a period of three months (from july 2018 to September 2018). Out of 200 specimens 35(17.5%) were detected by culture and vitek2 compact, 24 (12%) of them were confirmed by PCR using target gene, (17) Salmonella typhimurium and (7) Salmonella enteritidis. PCR was conducted to determine the some virulence genes of the isolates by using primers inv A, sdiA and sifA. The PCR amplification products were visualized by electrophoresis on 1% agarose gels for 35min at 70v. The sizes of the amplicons were determined by comparison to the 200 bp allelic ladder. Among isolates studies it was found that invA gene present in 13(54)% isolates of S. enterica ,(9) isolates of S. typhimurium and (4) isolates of S. enteritidis , sdiA gene it was found in all isolates (100)% while sifA gene it was found in all isolates only isolate number 18 not contained this gene 23(96)%.Keywords: Salmonella typhimurium, S. enteritidis, invA, sdiA and sifA.
The Comparison of Macular Thickness in Diabetic Patients without Proliferative Diabetic Retinopathy using Optical Coherence Tomography (OCT) at Prof. Dr. R D Kandou General Hospital, Manado, Indonesia Ade John Nursalim
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Macular thickening that occurs in diabetic retinopathy has been known as one of the primary causes of vision loss functions in patients with diabetic retinopathy. In order to prevent further complications due to macular thickening, Optical Coherence Tomography (OCT) has been used as a diagnostic tool in diabetic retinopathy. This study aims to evaluate the importance of OCT in promoting early detection in retinal thickening as diagnostic tools and proper exams to diminish the chance of visual acuity related to diabetic retinopathy. Method: A case-control observational study was conducted among 22 subjects with Diabetes Mellitus Type-2 (DM-2) from the medical record of the Ophthalmology-Vitreoretinal Division at Prof. dr. R.D. Kandou State General Hospital, Manado from March-December 2018 period. They were divided into 11 patients with mild and moderate non–proliferative diabetic retinopathy (NPDR) and 11 non-diabetic patients’ group. OCT was used to evaluate the macular thickness in both groups. Data were analyzed using SPSS version 20 for Windows. Result: Most of subjects were female (59.1%), age 45-50 years (31.8%), ≥ 10 years duration of DM-2 (63.6%), refractive errors of 0.00-(-3.00) and 0.00-(+3.00) (33.3%), and HbA1c levels ≥6.5 % (54.5%). There was a statistically significant difference of the central macular thickness between NPDR (257.32±76.94 µm) and non-NPDR patients (213.14±19.23 µm) (p=0.006) by using OCT. Conclusion: Optical Coherence Tomography (OCT) could be used to compare the significant differences of macular thickness between diabetic patients without proliferative diabetic retinopathy at Prof. Dr. R D Kandou General Hospital, Manado, Indonesia. Keywords: Macular Thickness, Diabetic Retinopathy, Optical Coherence Tomography.
Equilibrium, Thermodynamic and Kinetic Study of the Adsorption of a New Mono Azo dye onto Natural Iraq Clay Alya Khider Abaas
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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In the present work, bentonite clay was used as an adsorbent for the removal of a new prepared mono azo dye, 4-[6-bromo benzothiazolyl azo] thymol (BTAT) using batch adsorption method. The effect of many factors like adsorption time, adsorbent weight, initial BTAT concentration and temperature has been studied. The equilibrium adsorption data was described using Langmuir and frundlich adsorption isotherm. Based on kinetics study, it was found that the adsorption process follow pseudo second order kinetics. Thermodynamics data such as Gibbes Free energy ∆Gᵒ, entropy ∆Sᵒ and ∆Hᵒ were also determined using Vant Hoff plot.Keywords: Adsorption, Azo dye, Bentonite, Isotherm, kinetic.
High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth   is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.
Study of Some Biochemical and Blood Parameters as Screening Markers for Breast Cancer Patients before Adjuvant Therapy in Thi Qar Government-Southern Iraq Jamal Harbi Hussein Alsaadi
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Breast cancer is the most common malignancy disease in women. The study includes Eighty-three  cases were divided according age into women (patients and healthy ) average age more than forty five( Age > 45 year)   Fifty - five confirmed  subject of breast cancer patients (n = 42), healthy as control group (n=18) and women (patients and healthy) average age less than forty five Age (< 45 year) twenty three distributed to(2) groups too  .The first  group  confirmed (n=13)cases of breast cancer patients  and  second group (n=10)as control group. They were evaluated for blood parameters and some biochemical parameters that are associated with breast cancer occurring in Thi-Qar Government .Iraq. study has revealed that  significant decreasing (p<0.001) observed in  HB , PCV, RBC  and  WBC   levels  and a significant increasing  (P < 0.05) Platelets   , ESR   and  Monocyte retrospectively  in cancer patients comparison to normal control subjects and significant correlation (P< 0.05) between Neutrophil and Lymphocyte  , rates of NLR and PLR were significantly higher in breast cancer patients compared to control group   at  Age  > 45 year .While  the results showed for women   mean Age (< 45 year). The mean haemoglobin (Hb) , packed cell volume( PCV)  and  Red blood cells  (RBC) levels in the patient group were a significantly and lower than the control group at (p>0.05). There was high significant differences in WBCs   neutrophils, lymphocytes, monocytes also significant difference ESR (p>0.01) compared with healthy female .The values of NLR and PLR were showed significantly but no high   in the patients compare   with   healthy group. In this study  biochemical Parameters(lipid profile ) ,were showed  a significant decreasing at (p>0.01) for ;lipid profile parameters (Cholesterol, T.G, HDL and LDL) compared with  biochemical Parameters measurement  values of  female control mean  Age  > 45 year , while results showed  that significant increasing at (p>0.05)in  some lipid profiles in breast cancer patients compared with healthy control group  in women Age (<45 year).Keywords: Breast cancer, Lipid profile, Blood Parameters.
The Impact of Extraintistinal amobiosis on TP53 Gene in Patients with Hepatocellular Carcinoma Basheer. Abd. Nasralla
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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In this study, 20 serum samples and 8 liver abscess biopsy specimens were taken from 20 hepatocellular carcinoma and E. histolytica infected patients. Laboratory findings of patients with liver abscess showed increased total white blood cell count (WBC), increased C-reactive protein, (AST), (ALT), alkaline phosphatase (ALP), gamma-glutamyl  transpeptidase (GGT) and bilirubin. The result of PCR performed on liver abscess patients was positive for the DNA of E.histolytica infected patients and 8 biopsy liver abscess patients. To detect TP 53 gene in hepatocellular with liver abscess of all 8(100%), mutation occurred in sequences of TP53, and there were changes in several locations on the exons. Nucleotides changes were shown in TP53 gene Exon 147,152,160.203 and 235amplified from tumor liver cancer samples. The mutation occurred on nucleotides TCC, GGT, ACT, CGC and ATC of TP53 gene.Keywords: Extra intestinal amebiasis. TP53 gene, Hepatocellular carcinoma.
Determination of Hormones profile and Semen Parameters for Infertility of Men at Al-Husain Hospitals, Thi-Qar City, Iraq and Effect the Age and Type of Diagnosis Enas Abdul Kareem Jabbar
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Male factor is responsible for the infertility in about 50% of cases. The people’s perception of infertility varies from culture to culture. So this work amid to determine the prevalence and pattern of endocrinological abnormalities and semen parameters in patients investigated for male infertility in our environment, and any associated between semen’s and hormones’ results. This work included 89 infertility men and 11 healthy as control group. Their age was ranged between 20-50 years old. The volume, concentration and movement of seminal fluid patterns were examined. Then patients were divided to four groups: Azospermia, Oligospermia, and Normospermia poor movement. Follicle-stimulating hormone FSH, luteinizing hormone LH, Prolactin, and Testosterone were determined. The endocrinological diagnosis was done.  The highest frequency % of cases was normospermia with poor movement and the lowest was azospermia. The mean of patients’ age was about 34.5 years. The frequencies% of infertility was significantly higher within 25-40 age group. The semen volume was significantly lower in Azospermia and Oligospermia groups. The normal shape sperm and the sperm concentration were lower in all patients groups. FSH, LH, and prolactin levels increased in Azospermia and Oligospermea groups compared to normospermia and control groups. The highest frequency of cases with high FSH, LH, and Prolactin was in Azospermea, and lowest in normospermia while the frequency of cases with high testosterone frequency was (0) in Azospermea and only (1) in Oligospermea, and Normospermea. In Azospermia and Oligospermia, the significantly highest endocrinological diagnosis was germinal epithelial failure. This study reported the significance of proper endocrinological work-up in evaluating patients with infertility where appropriate because these cases may be identifiable endocrine disorders that may be correctable, and that in our environment, endocrine dysfunction is common cause of male infertility. It also reported the frequencies of different endocrine abnormalities, some of which can be successfully processed. We conclude that hormonal evaluations should be performed in the assessment of infertility in males in our environment.

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