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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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A Physiological Study of Albumin Level for Patients with Non-Hodgkin Lymphomas Samer N. Khalaf
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Cancers cause increases in mortality in different countries each year. The late diagnosis of cancers contributes to patient death significantly. Recently, the efforts of scientists began towards examining several markers that help in early detection. This paper aims to monitor the relationship between serum albumin level and NHL beside some variables such as weight, age, sex and several other diseases. The demographic data and samples were collected from people with and without NHL. Then, the albumin concentration was assessed using the biochemical tests. After that, the data were analyzed statically using Minitab-16 program, T-test and ANOVA. The results showed a significant difference (P≤ 0.05) in albumin level between control and the patients with NHL. The same pattern was for patients with NHL and other diseases. In contrast, there was no considerable difference between male and female with NHL. Furthermore, the findings illustrated a decrease in albumin concentration for old patients' less than young patients. On the other hand, the overweight patients revealed more albumin level that the patients with normal weight. Serum albumin is considered an important sign for the early detection of NHL. This early diagnosis will play a good role beside the chemotherapy and other kind of treatment. This will help to reduce the risk and mortality because of cancers worldwide.   Keywords: Non-Hodgkin lymphomas (NHL), Serum albumin level, Cancer, Overweight.
Effect of Cranberry in Enhancing Oral Hypoglycemic Agents in Uncontrolled Type-II Diabetic Patients Atheer Majid Rashid Al-Juhaishi
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Diabetes mellitus (DM) is one of the most common metabolic disorders associated with morbidity and mortality. Type II diabetes may be due to peripheral insulin resistance, defected insulin secretion or both. Cranberries are an evergreen class of midget sapling in the subgenus Oxycoccus of genus Vaccinium and have many pharmacological effects including antibacterial, antioxidant, cardio protective activity, anticancer, and hypoglycemic effects. The aim of this study is to assess the effect of cranberry in enhancingoral hypoglycemic agents in uncontrolled type II diabetic patients. The population sample consists of 60 type II diabetic patients aged between 35 and 63 years who met the diagnostic criteria of type II DM. Each patient was assessed individually using a case sheet that including age & sex, medical history and medication history. They were divided into two groups; the 1st group was treated with metformin and sulfonylurea alone, the 2nd group were treated with those agents plus cranberry capsules as add on treatment. The results showed significantly decline in blood glucose & glycated hemoglobin (HbA1c) which was changed from uncontrolled level 9.51% to controlled level 6.97% with aid of cranberryin group 2 in comparison with its change from 9.38% to 7.65% with oral hypoglycemic agents alone in group1 (p-value <0.0001). In conclusion, cranberry has a good hypoglycemic effect in treatment of type II DM and enhancing the effect of oral hypoglycemic agents.Keywords: Cranberry, Type II diabetes, FBS, HbA1c.
Spectrophotometric Determination of Sulphameter with N-1-(Naphthyl) Ethylenediamine Reagent by Using Diazotization Coupling Reaction Amal H. Mhemeed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Cutting edge method of spectrophotometric for the assay of micro amount of sulphameter  The method is based  on the reaction of sulphameter in acidic medium with sodium nitrite to form the diazonium  ion which is coupled with N-1-(naphthyl) ethylenediamine to form a stable a pinkish- red  azo dye which shows maximum absorption at 503 nm. Beer’s law is obeyed over the concentration range 0.2 – 14 ppm. The molar absorptivity is (5.21 ´ 104) l.mol-1.cm-1, Sandal sensitivity index of (5.23 ´ 10-3) mg.cm-2. With a relative error of (-0.05% - + 2.3%) and relative standard deviation of (± 0.02% - ± 1.5%). The present method requires neither temperature control nor solvent extraction step.Keywords: Sulphameter drug, N-1-(naphthyl) ethylenediamine, Spectrophotometric Determination.
Seasonal Variation, Antibiotic Resistance of Some Sewage Bacteria from Hamdan Waste Water Treatment Plant in Basrah City-Iraq Maytham A. Al-Hamdani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Seasonal variation and antibiotic resistance pattern of some sewage bacteria have been studied during the period of at Hamdan wastewater treatment plant in basrah city-Iraq. The results obtained revealed that there is a seasonal variation in the number of bacteria studied. The bacterial taxa in the present study found to resist several antibiotics. The isolated bacteria are multidrug resistant bacteria.  Higher percentage of antibiotic resistance was recorded for bacteria from raw sewage that decreased during the subsequent treatments. Sewage bacteria showed different antibiotic resistance patterns. The effluents to Shatt al-Basrah still contain multidrug resistant bacteria that cause a big health problem through dissemination of multidrug resistant bacteria to the area around.
Study of Bio Film Formation by Sphingomonas Paucimobilis Isolates and In-vitro Inhibition of Bio Film by Iraqi Probiotics Shahrazad Najem Abdu-Allah
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Five clinical and environmental Sphingomonas paucimobilis isolates were isolated from two hospitals in Baghdad through a period extended for nine months and the identification of isolates to species level was done by Vitek-2 system. Out of 5 isolates, 2 (40%) were isolates from blood, one (20%) isolate from ear swab and 2(40%) isolates from hospital environment. The isolates showed high resistant rates 5(100%) to Ampicillin followed by Cefazolin 4(80%), while the highest sensitivity rate was 5 (100%) to Trimethoprim/Sulfamethoxazole followed by 4(80%) to Ceftazidime, Cefepime, Imipenem, Ertapenem, Ceftriaxone and Levofloxacin. Four (80%) isolates out of 5 Sphingomonas paucimobilis, were positive (+) for slime layer production while only 1(20%) isolates was negative (-) for slime layer production. Our results showed that 3(60%) Sphingomonas paucimobilis isolates (Sph2, Sph3 and Sph4) were achieved the highest thickness of biofilm forming, while 2(40%) isolates (Sph1 and Sph5) were non biofilm forming when compared with the optical density (OD) of the control by polystyrene microtitre plate method. The in vitro inhibitory effect of Iraqi probiotics (Bacillus subtilis, Lactobacillus acidophilus, Lactobacillus spp. and Saccharomyces cerevisiae) was investigated against the three highest thickness biofilm forming Sphingomonas paucimobilis isolates (Sph2, Sph3 and Sph4) and the results revealed that the absorbance (OD) of the Sphingomonas paucimobilis biofilm was declined in comparison with the data of the biofilm before the treatment with Iraqi probiotics. From the results we noticed that Iraqi probiotics were effective against the biofilm formation in all the concentrations under study and the first two concentrations (10-2 and 10-3) were the most effective. Keywords: Sphingomonas paucimobilis, Bio film formation, Bio film inhibition and Iraqi probiotics.
A Training Program to Develop the Endurance Strength and Effect of the Enzyme Sgot and the Level of Some Performance Some of the Complex Skills in the Basketball for Youth Hasan Saleh Mahdi Al-Okbi
Journal of Global Pharma Technology .
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Abstract

The objective of the research is to prepare a training program to develop the endurance of the strength, as well as to know the effect of this program on the enzyme SGOT and the level of performance of some skills in the basketball youth. The study sample consisted of (12) players, selected from the total community of (14) players, has been excluded (2) player for the purpose of conducting the exploratory experiment, and the experimental method was used to suit the nature of the research procedures. After the tests were carried out and the application of the training program was carried out the post-test to obtain the results through which the most important conclusions were reached. The researchers concluded that there was a significant effect of the training curriculum in the development of strength endurance of the muscles of the arms, increased rates of SGOT enzyme, and the emergence of a significant development in the level of performance of offensive youth composite basketball skills.Keywords: Endurance strength, Enzyme (SGOT), Complex offensive skills and basketball.
Synthesis and Characterization of Some New Quinolinic acid Derivatives Haneen Nazar Wahab Al-Issawi
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Preparation of some non-homogeneous cyclic compounds starting with Quinolic acid .A different N-heterocyclic substituted derivative of quinolone has been synthesized. The nitrogen atoms have been alkylated first to form N-carboxymethyl followed by cyclization reaction to form heterocyclic/substituted aryl groups. All the synthesized compounds have been identified using FT-IR, 1H NMR spectrum.Keywords: Quinolinic acid, 1, 3-Oxazole, Imidazol, 1, 2, 4-Triazole, 1, 3, 4- thiadiazol, diazetidin, diazepines.
Clopidogrel as an Oral Antiaggregant in Ischemic Heart Disease Truong Dinh Cam
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

The use of antiaggregant in preventing cardiovascular diseases remains an important therapeutic approach. The research aims to perform a comparative analysis of the effect of acetylsalicylic acid (aspirin) and clopidogrel monotherapy or their combination on platelet aggregation applying the method of impedance aggregometry. The study was carried out in 2018-2019 in Grozny (Russia) and in Ho Chi Minh (Vietnam) based on the past medical histories of 557 patients diagnosed with ischemic heart disease in 3 primary health-care facilities. The acetylsalicylic acid monotherapy in amount 100 mg per day was used for the treatment of 367 patients comprising Group I, another 147 patients (Group II) received clopidogrel in a dosage 75 mg per day, and the rest 43 patients (Group III) took both drugs. The method of impedance aggregation with the estimation of three parameters, such as platelet aggregation time, aggregation amplitude, and the area under the aggregation curve, was applied after the introduction of two inducers, namely, collaagen and ADP. In Group I, the use of collagen as an inducer resulted in prolonged platelet aggregation period and reduction of area under the curve (correlation -0.80 (p ≤0.05)). In Group II, the influence of clopidogrel on both inducers was reported. In the case of ADF-initiated platelet aggregation, a positive correlation between amplitude and area under the aggregation curve of 0.98 (p ≤ 0.01) was recorded. A correlation of 0.77 (p ≤ 0.05) was noted between the platelet aggregation extension and the area under the collagen-induced process curve. The results obtained through this research in the opposite correlation coefficients for Group I and Group II show the mechanisms of acetylsalicylic acid and clopidogrel action. The applied methodology allowed establishing qualitative and quantitative changes occurring in the aggregation of platelets with the addition of ADP and collagen as inducers. Keywords: ADP; Antiaggregant; Acetylsalicylic acid (ASA); Clopidogrel; Collagen; Ischemic heart disease.
Effect of Force Molting on Blood Parameters of Broiler Breeder Hens Khalid Hamid Hassan
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The study was conducted in the poultry house of animal production Department, College of Agriculture, University of Diyala, during the period 1st Oct. 2016 to 22 June 2017. The aim of the study was to determine the effect of force molting by fasting program of Ross 308 and Arbor Acres broiler breeder hens on blood parameters. The experiment consists of four groups (each group consist of 15 hens) namely Ross molting (Rm), Ross control (Rc), Arbor Acres molting (Am), and Arbor Acres control (Ac). The blood samples performed with three replications. The results were indicated that there is a significant higher heterophil cell count of Am compared with Rm, while there is higher Base cell and H/L of Am compared with other groups. Also, there is a significant superiority of Am and Rm in PCV and Hb values compared with other groups. There is a superiority of Ac and Rc in blood glucose, protein and globulin compared with other groups. There is a significant increase of WBC, Heterophil, Basophils, H/L, Hb in molting groups compared with control group, while there is a significant superiority of control groups compared with molting groups in glucose, albumin, cholesterol, GPT, GOT and uric acid.                                                                                                                             Keywords: Force molting, Arbor Acres, Ross 308, Blood parameters.
The Relationship between Sarcoidosis of Intrathoracic Lymph Nodes and Digestive System Diseases: A Comparative Observation A.V. Medvedev
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Background: The cases of sarcoidosis of intrathoracic lymph nodes often accompanied by various digestive system diseases have not received enough attention in medical publications. Therefore, the objective of this study is to explore the interrelatedness between the development of gastrointestinal disorders and pulmonary pathology. Materials and methods: The study included 79 patients with sarcoidosis of intrathoracic lymph nodes (ITLN), mean age 46.4±0.9, disease duration 6.8±0.4 years. The patients studied were divided into two groups: patients with ITLN sarcoidosis with gastrointestinal (GI) tract diseases, and people with ITLN sarcoidosis with no symptoms of gastrointestinal tract diseases. All patients underwent laboratory and instrumental examination. Results: Diseases of the digestive system were found in 19 patients with ITLN sarcoidosis. Newly diagnosed digestive system diseases were observed in four patients: one patient with duodenal ulcer, three patients with gastroesophageal reflux disease (GERD). Exacerbation of previously diagnosed diseases was recorded in fifteen patients; most often it was exacerbation of chronic gastritis and chronic duodenal ulcer (five cases each), in three patients it was exacerbation of chronic cholecystitis, in two patients exacerbation of chronic pancreatitis and chronic gastric ulcer was detected. Conclusion: The development of gastrointestinal diseases coincides in time with the development of sarcoidosis or occurs under conditions of its treatment. In patients with sarcoidosis who underwent therapy of this disease, gastrointestinal diseases were observed in 55.5% of patients, in patients with recurrent, progressive course of sarcoidosis they were observed 1.4 times more often than in those with steady course of sarcoidosis. Keywords: Sarcoidosis of Intrathoracic Lymph Nodes (ITLN Sarcoidosis) – Gastrointestinal Diseases-Digestive System Pathology.

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