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MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation
Published by PT. RADJA INTERCONTINENTAL PUBLISHING
ISSN : -     EISSN : 29867754     DOI : https://doi.org/10.59733/medalion
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation | ISSN (e): 2986-7754 is a peer-reviewed, open access journal which publishes original research articles and review articles in all areas of nursing and midwifery, research and education. The aim of the journal is to contribute to the growing field of nursing practice and provide a platform for researchers, physicians and healthcare professionals. Topics of interest include: Nursing education Community nursing Specialist nursing topics Policies in nursing and healthcare Ethical issues Healthcare systems Healthcare management Pediatrics nursing
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 279 Documents
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IN SILICO STUDY OF PHYSALIS ANGULATA COMPOUNDS AS POTENTIAL THERAPEUTICS FOR ECZEMATIC SKIN DISEASES Yan Martin Witantra
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.21322464

Abstract

Eczema, a broad term encompassing a number of chronic inflammatory skin disorders, is typically characterized by symptoms such as redness (erythema), itching (pruritus), dryness, thickening of the skin due to repeated scratching (lichenification), and the possible appearance of fluid (exudation) or small blisters (vesicles). IL-4 and IL-13 activate the JAK-STAT pathway through the IL-4Rα and IL-13Rα1 receptors, which promotes STAT6 activation and the inflammatory response in atopic dermatitis, thus providing the basis for the use of upadacitinib as a selective JAK1 inhibitor that is effective in alleviating the symptoms of the disease. The aim of this study was to explore potential therapeutic pathways, with particular attention to compounds present in Physalis angulata , including the withanolide group such as withangulain B, physagulin C, and withanolide, which is one of 41 groups of compounds that have been identified in Physalis angulata . In addition, this study also evaluated the control drug upadacitinib, which is designed to target the IL-4Rα and IL-13Rα1 receptors, which play a key role in the type 2 (Th2) immune response. The study utilized several computational techniques, including data mining, biological activity analysis, ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling, molecular mapping, and in silico studies. The results showed that the binding energies of the ligands (Physagulin C and Withangulatin B) with the IL-4Rα receptor were -12.6 kcal/mol and -12.7 kcal/mol, respectively. Similarly, Withanolide and Withagulatin B were identified as the top candidate compounds for the IL-13Rα1 receptor, with binding energies of -11.5 and -11.5 kcal/mol, respectively. The interactions above are the most beneficial for the development of eczematic disease therapy. The overall results of this study demonstrate great potential, indicating that the withanolide compounds, physagulin c, and withangulatin B derived from Physalis angulata offer an alternative pathway in targeting immune cells (Th2) through JAK-STAT activation and STAT6 translocation to the nucleus. Therefore, this study opens up opportunities for the development of innovative therapies in the treatment of eczematic diseases.
BILATERAL PNEUMOTHORAX AS A COMPLICATION OF PULMONARY TUBERCULOSIS: A RARE AND LIFE-THREATENING CASE Amiruddin; Muhammad Rizky Assilmy Lubis
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Introduction: Bilateral spontaneous pneumothorax secondary to pulmonary tuberculosis is an uncommon but life-threatening complication characterized by the rupture of subpleural TB cavities with simultaneous air accumulation in both pleural spaces. It predominantly occurs in patients with advanced cavitary disease or immunocompromise and carries high morbidity and mortality without prompt recognition and management. Early imaging and combined emergency thoracic intervention with anti-tuberculosis therapy are essential to improving patient outcomes. Case Illustrations: A 46-year-old male presented with two months of progressive dyspnea, productive cough, weight loss, night sweats, and acute chest pain. Chest radiography confirmed bilateral pneumothoraces. Bilateral chest tubes were placed, and sputum GeneXpert detected rifampicin-sensitive Mycobacterium tuberculosis. Anti-tuberculosis therapy (Category I regimen) was initiated concurrently. By day 12, air leaks resolved, chest tubes were removed on day 13, and the patient was discharged in stable condition under outpatient TB follow-up. Discussion: Bilateral TB-related pneumothorax arises from cavitary rupture or bronchopleural fistula formation. Although unilateral pneumothorax is well described in TB, bilateral presentation remains rare. Management requires immediate needle decompression or chest tube insertion, high-flow oxygen, nutritional and analgesic support, and prompt initiation of rifampicin-based anti-tuberculosis therapy to address the underlying infection and facilitate cavity healing. Persistent air leaks may necessitate video-assisted thoracoscopic surgery with chemical or mechanical pleurodesis. Close radiological and microbiological monitoring during treatment minimizes recurrence risk. Conclusion: This case underscores the critical need for rapid diagnosis and integrated medical-surgical management of bilateral pneumothorax in pulmonary tuberculosis. Timely chest drainage combined with effective anti-tuberculosis therapy can lead to full lung re-expansion and favorable outcomes, even in resource-limited settings.
RELATIONSHIP BETWEEN WIDAL TITER WITH C-REACTIVE PROTEIN (CRP) LEVELS AND SEGMENTED NEUTROPHIL PERCENTAGE IN CHILDREN WITH TYPHOID FEVER AT GRAHA MEDIKA MARTAPURA CLINIC, BANJAR DISTRICT Eka Wahyuni; Puspawati; Muhammad Arsyad; Syihab Fayumi
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Typhoid fever is an infectious disease that remains a public health problem in Indonesia, particularly among children. Infection with Salmonella typhi can trigger an inflammatory response characterized by elevated C-reactive protein (CRP) levels and changes in the percentage of segmented neutrophils. The Widal test is still widely used to aid in the diagnosis of typhoid fever because it is simple, rapid, and cost-effective. This study aimed to determine the relationship between Widal titers and CRP levels and the percentage of segmented neutrophils in pediatric typhoid fever patients at the Graha Medika Martapura Clinic, Banjar Regency. This study employed an observational analytical method with a cross-sectional design. The data used were secondary data from the medical records of pediatric typhoid fever patients from January 2025 to March 2026. The study sample consisted of 206 patients selected using total sampling. Data analysis was performed using the Spearman rank correlation test. The results showed that the majority of patients had a Widal titer of 1/640 (65.5%), elevated CRP levels (59.7%), and a normal percentage of segmented neutrophils (84.5%). The correlation test results showed no significant association between the Widal titer and CRP levels (r=0.073; p=0.296) or the percentage of segmented neutrophils (r=0.064; p=0.361). It was concluded that the Widal titer is not associated with CRP levels or the percentage of segmented neutrophils in pediatric patients with typhoid fever.
THE INFLUENCE OF FAMILY SUPPORTIVE ORGANIZATIONAL CULTURE ON WORK-FAMILY CONFLICT IN WORKING MOTHERS Liandra Khairunnisa; Hafiz Nurdiansyah
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

The increasing participation of women in the workforce has expanded the role of mothers as individuals responsible not only for their families but also for the demands of their jobs. This condition increases the risk of work-family conflict (WFC), a conflict that arises from a misalignment between the demands of work and family life. This conflict has been identified as a critical issue in industrial and organizational psychology because it affects psychological well-being, job satisfaction, organizational commitment, productivity, and employee turnover intentions. One organizational factor believed to be able to reduce work-family conflict is family supportive organizational culture (FSOC), an organizational culture that supports a balance between work and family through policies, values, norms, and support from leaders and colleagues. This conceptual article aims to examine the relationship between family supportive organizational culture and work-family conflict in working mothers through a synthesis of theories and the results of recent empirical research. The study was conducted using a narrative literature review method by examining various scientific articles published in accredited national journals and reputable international journals in the fields of psychology, organizational behavior, and human resource management. The study results show that a family-friendly organizational culture acts as an organizational resource capable of reducing work-family conflict through work flexibility, supervisor support, coworker support, easy access to family-friendly policies, and reduced stigma against employees who carry out family responsibilities. Based on Conservation of Resources Theory , Role Theory , and Spillover Theory , FSOC contributes to creating a balance between work and family roles so as to improve the psychological well-being of working mothers. This article emphasizes that strengthening a family-friendly organizational culture is an important strategy in supporting work-family balance and sustainable organizational performance and serves as a foundation for future empirical research.
IMPLEMENTATION OF HOT BATH HYDROTHERAPY AND MOIST WOUND HEALING INNOVATIONS IN NURSING CARE FOR SKIN INTEGRITY DISORDERS IN TYPE 2 DM PATIENTS IN THE ORCHID ROOM OF SUNGAILIAT REGIONAL GENERAL HOSPITAL IN 2026 Mega Artika; Shindi Hapsari
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Background: Type 2 Diabetes Mellitus often causes diabetic ulcers that cause impaired skin integrity and increase the risk of infection, amputation, and decreased quality of life. The combination of Hot Bath Hydrotherapy and Moist Wound Healing is a nursing innovation that has the potential to support wound healing. Objective: To describe the application of Hot Bath Hydrotherapy and Moist Wound Healing innovations in nursing care for type 2 Diabetes Mellitus patients with impaired skin integrity in the Anggrek Ward, Bakti Timah Hospital, Sungailiat in 2026. Method: The study used a descriptive design with a descriptive case study approach. The study subjects were 10 type 2 Diabetes Mellitus patients with diabetic ulcers who met the inclusion criteria. Data were collected using a nursing assessment format, wound development observation sheet, Bates-Jensen Wound Assessment Tool or Pressure Ulcer Scale for Healing, documentation, interviews, observations, and physical examinations. Data analysis was carried out descriptively by comparing the patient's condition before and after the intervention. Results: All patients showed improvement in wound condition in the form of reduced exudate and necrotic tissue, increased granulation tissue, decreased pain, reduced signs of infection, and increased mobility after 3 x 24 hours of intervention. Conclusion: The combination of Hot Bath Hydrotherapy and Moist Wound Healing has the potential to be an evidence-based nursing intervention that supports the healing of diabetic ulcers and improves the quality of nursing care.
POTENTIAL OF FARNESOL AS A MAO-A INHIBITOR CANDIDATE FOR THERAPY OF MENTAL HEALTH DISORDERS: AN IN SILICO STUDY Hafidz Ardan Kaizar; Yennie Agnes Pranata
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.21501856

Abstract

Mental health disorders, particularly depression, remain a global problem with a high prevalence among university students. Conventional therapy using chemical antidepressants is often limited by side effects, delayed onset of action, and limited effectiveness. Farnesol, a sesquiterpene found in essential oils, has been reported to exhibit biological activity in the central nervous system. This study aims to explore the potential of farnesol as a candidate Monoamine Oxidase-A (MAO-A) inhibitor through an in silico approach. Docking studies were performed on 5HT1A, 5HT2A, GABA, and MAO-A receptors using SwissDock, with the ligand prepared from the PubChem database. Binding interactions were visualized using ChimeraX and LigPlot, while toxicity evaluation was analyzed using SwissADME and ADMETlab 2.0. The results showed that farnesol had the best binding energy toward the MAO-A receptor (-8.43 kcal/mol) compared with the control compound phenelzine (-6.62 kcal/mol). Farnesol also showed good blood-brain barrier penetration ability and a low toxicity profile. Therefore, farnesol has the potential to be developed as a natural antidepressant candidate derived from essential oils. Further in vitro and in vivo studies are required to verify these findings.
RELATIONSHIP BETWEEN EFFECTIVENESS AND VARIATIVENESS OF BRONCHIAL ASTHMA MEDICATION WITH CLINICAL IMPROVEMENT OF BRONCHIAL ASTHMA Natalia Kristina Br Sinaga
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Background: Bronchial asthma is a chronic inflammatory airway disease that is highly heterogeneous, both in terms of pathophysiology and response to therapy. The availability of various drug classes ranging from inhaled corticosteroids (ICS), bronchodilators, allergen immunotherapy (AIT), to various biologic agents does not necessarily guarantee uniform clinical improvement in every patient due to variability in endotypes, biomarkers, and treatment adherence. Objective: This review aims to analyze the relationship between the effectiveness and variability of various bronchial asthma drug classes with clinical improvement outcomes, including reduced exacerbations, improved lung function, and quality of life. Methods: A narrative literature review was compiled based on three main articles on allergen immunotherapy, targeted biologic therapy, and tezepelumab in severe asthma, supplemented by additional literature searches on therapy adherence and predictive biomarkers. Results and discussion: The effectiveness of conventional pharmacotherapy is strongly influenced by variability in patient adherence, with the average objective adherence to ICS ranging from 22 - 70% of the prescribed dose. Allergen immunotherapy has demonstrated consistent preventive and therapeutic effects in mild-moderate allergic asthma, but its benefits depend on dose, duration, and patient phenotype. Biologic therapy (anti-IgE, anti-IL-5/IL-5Rα, anti-IL-4Rα) significantly reduced exacerbations, particularly in the type 2-high phenotype with eosinophilia, while tezepelumab, a TSLP inhibitor, demonstrated efficacy across phenotypes, including type 2-low, with annual exacerbation reductions of up to 56–71%. This variability in response underscores the need for biomarker-guided approaches and combination therapies to optimize clinical improvement. Conclusion: The effectiveness of bronchial asthma medications is closely linked to the variability of disease endotypes, patient biomarkers, and therapy adherence; optimal clinical improvement is achieved through a personalized approach based on phenotypes and biomarkers, rather than a single, uniform treatment strategy.
HEALTH RISK ANALYSIS OF LEAD (Pb) HEAVY METAL CONTENT IN DRINKING WATER IN FLOOD-PRONE AREAS Fitriani; Syamsul Bahri; Husna Maulida; Muhammad Syahrul Manzili; Faiza Humaira
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 6 No. 4 (2025): December
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Floods are hydrometeorological disasters that have the potential to reduce drinking water quality through the mobilization of environmental pollutants, including heavy metals such as lead (Pb). This study aims to analyze lead content in drinking water and assess the level of public health risks due to exposure through the ingestion pathway. The study uses an environmental health risk analysis approach by calculating non-carcinogenic intake (Ink) and Risk Quotient (RQ) based on the rate of water consumption, duration of exposure, frequency of exposure, and body weight of respondents. The research method uses a descriptive survey with a cross-sectional approach conducted in Peunayan Village, Nisam District, North Aceh Regency. The research sample consisted of 50 respondents with a random sampling technique. The results showed that the lead concentration was 0.0010 mg/L and this value is still below the maximum limit stipulated in the Regulation of the Minister of Health of the Republic of Indonesia Number 492/MENKES/PER/IV/2010, which is 0.01 mg/L for lead parameters in drinking water. The calculation of non-carcinogenic intake showed a real-time value of 0.000053 mg/kg/day with a Risk Quotient (RQ) of 0.014, indicating that non-carcinogenic health risks are still in the safe category (RQ≤1). Long-term exposure projections showed an increase in intake and RQ values to 0.67 in the 50-year estimate, but remained below the risk limit. These findings indicate that although lead concentrations still meet safety standards, the potential for long-term exposure accumulation requires attention. Therefore, regular water quality monitoring, public education, and the implementation of simple water treatment technologies are important steps in preventing environmental health risks
THE RELATIONSHIP BETWEEN GADGET USE AND SOCIAL DEVELOPMENT EMOTIONAL BEHAVIOR OF SCHOOL-AGE CHILDREN AT SDN 3 MINDAHAN Ahsanu Nadya Zidni Ilma; Indanah; Anny Rosiana Masithoh
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

The increasing use of gadgets among school-aged children raises concerns about their social-emotional development, particularly regarding their ability to interact socially, manage emotions, and behave prosocially. This study aims to analyze the relationship between gadget use and the social-emotional development of school-aged children at SDN 3 Mindahan, Batealit District, Jepara Regency. This study used a quantitative approach with a cross-sectional design. Sampling was conducted using a total sampling technique, so that the entire population of 119 students was used as the research sample. Data collection was carried out using a gadget use questionnaire and the Strengths and Difficulties Questionnaire (SDQ). Data analysis included univariate and bivariate analysis using the Spearman's Rho test. The results showed that 48% of respondents had low gadget use, 43% had moderate use, and 9% had high use. Most children had normal social-emotional development (90%). There was a significant relationship between gadget use and social-emotional development on the difficulty scale (p=0.000; r=0.559) with a positive direction and moderate strength. Furthermore, there was a significant negative correlation between gadget use and social-emotional development on the strength scale (p=0.010; r=-0.256). The study concluded that higher gadget use led to higher levels of social-emotional difficulties and lower prosocial behavior in school-aged children.
EFFECTIVENESS OF PELVIC FLOOR MUSCLE EXERCISES ON QUALITY OF LIFE IN ELDERLY ELDERLY WITH URINARY INCONTINENCE: LITERATURE REVIEW Ni Kadek Diahwinny Indrayani; Ni Putu Geg Mas Widya Candra Pinasthy; Made Juliani; Ni Wayan Dewi Tarini; Made Ririn Sri Wulandari
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

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Abstract

Background:Urinary incontinence in the elderly has serious physical, psychological, and social impacts, and reduces quality of life. Pelvic Floor Muscle Exercise (PFME) is recommended as an effective non-pharmacological intervention, but its implementation is still limited. Objective: To evaluate the effectiveness of PFME on quality of life in elderly with urinary incontinence. Methods: A systematic literature review based on PRISMA guidelines of 15 primary articles published between 2014–2024, with inclusion criteria focusing on the elderly, PFME interventions, and quality of life measurements. Results: PFME consistently reduced the frequency of incontinence, increased voiding control, and improved physical and psychological quality of life. In elderly women, PFME reduced the frequency of incontinence by 74% (p > 0.05); in post-prostatectomy men, the combination of PFME with an oscillating rod increased the continence rate from 43% to 74% (p < 0.01). PFME was also effective in older adults with mild cognitive impairment, reducing daily episodes from 3.3 to 1.7 (p < 0.001), as well as increasing self-efficacy and decreasing depression scores (p < 0.01). Online approaches such as “teleGROUP” also showed positive long-term results (73% symptom reduction, p < 0.001). Conclusion: PFME has been shown to be an effective, safe, and adaptive intervention for the management of urinary incontinence in older adults, with a significant impact on quality of life. Educational support, technology, and an individualized approach can enhance its successful implementation.

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