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Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 187 Documents
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ANALISIS PERBANDINGAN METODE TAM DAN METODE UTAUT 2 DALAM MENGUKUR KESUKSESAN PENERAPAN e-Puskesmas DI PUSKESMAS KABUPATEN GROBOGAN Ferika Indrasari; Windy Nur Lestari; Agus Sulaeman
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.863

Abstract

The application of information technology in the health sector, especially the e-Puskesmas system, is intended to improve the quality of services at the Grobogan Regency Community Health Center. The main objective of the study was to analyze the comparison between two models: the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2). The study was conducted at the Grobogan Regency Community Health Center from January to March 2025. The population in this study was pharmaceutical personnel at the Grobogan Regency Community Health Center, and the sample in the study consisted of 90 people. The method in this study was comparative quantitative, with data quality testing using validity tests, reliability tests, and one-way ANOVA tests. The results of the one-way ANOVA test showed no significant difference between the TAM method and the UTAUT 2 method, with a sig value of 0.773 > α (0.05), which means there was no significant difference between the TAM method and the UTAUT 2 method in measuring the success of the implementation of the Puskesmas at the Grobogan Regency Community Health Center. This study canit can be concluded that in this study there is no significant difference between the TAM Method and the UTAUT 2 Method in measuring the success of the implementatione-Puskesmasat the Community Health Centers in Grobogan Regency.
Investigasi Potensi Antiviral Ekstrak Biji Kopi Robusta Temanggung Dalam Menghambat Virus Dengue (DENV) Rizky Ardian Hartanto Sawal; Ayu Ina Solichah; Ismi Puspitasari; Felina Daiman
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.883

Abstract

Dengue Hemorrhagic Fever (DHF) is a significant health issue in tropical and subtropical regions. The discovery of new antiviral agents is crucial due to the lack of effective treatment or vaccines. This study aims to explore the potential of Temanggung robusta coffee bean extract as an anti-DENV agent. The coffee beans were extracted through maceration using 96% ethanol, followed by phytochemical screening to identify active compounds such as alkaloids, flavonoids, saponins, and tannins. Anti-DENV activity and Vero cell cytotoxicity tests were conducted to evaluate the extract's effectiveness and safety. Results indicated that robusta coffee extract exhibited anti-DENV activity with an EC50 of 88.51 µg/ml and a Selectivity Index (SI) of 9.82. The antiviral activity is attributed to bioactive compounds like alkaloids, flavonoids, saponins, and tannins that inhibit DENV replication. Although the extract demonstrated cytotoxicity at high concentrations with CC50 of 869.7 µg/ml, it still holds potential as a therapeutic anti-DENV agent with relatively low toxicity risks. This research opens opportunities for developing robusta coffee-based therapies for DENV infection control in the future.
Eksplorasi Penggunaan Tanaman Obat untuk Pengobatan Jerawat di Desa Bukian, Payangan-Bali Ni Putu Sucitariningsih; Ida Ayu Manik Partha Sutema; Ni Putu Aryati Suryaningsih; I Putu Riska Ardinata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.365

Abstract

Acne is a common dermatological condition affecting up to 85% of the global population, primarily triggered by hormonal fluctuations that increase sebum production and promote the proliferation of Cutibacterium acnes. The management of excessive sebum has become a crucial strategy in acne treatment, alongside conventional therapies such as antibiotics, including minocycline and doxycycline. Historically, prior to the development of synthetic pharmaceuticals, natural remedies played a significant role in acne treatment and continue to be widely used today, particularly in rural communities. Objective: This study aimed to explore the types of medicinal plants traditionally used as anti-acne treatments by the community of Bukian Payangan Village, Bali. Methods: This research employed a quantitative descriptive design. Sampling was conducted using the snowball sampling technique. Data were collected from 100 respondents using a structured checklist. Results: There were 13 types of anti-acne plants including Jackfruit, Fern, Lime, Teki Grass, Aloe Vera, Chinese Betel, Tomato, Moringa, Turmeric, Red Bean, Cucumber, Pepper, and Sandalwood, where Jackfruit (Artocarpus heterophyllus) had a Use Value the highest (0.44) came from the yard of the house (39%). The most widely used parts of the plant are leaves (64.30%) by processing, namely squeezed (54.95%) and used by pasting (87%) on acne-prone facial areas. The most felt benefits related to reducing oily skin. Conclusion: There are as many as 13 plants as anti-acne, with the dominance of use on the leaves and having the main effect of sebum control.
Tren Kepatuhan Pelaku Usaha Bidang Kosmetik di Indonesia Sri Astuti; Tina Wikara; Sri Nurhayati; Evi Ratna Sari; Rotua Uli Carolina; Galuh Zhafirah Rahmita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.741

Abstract

Compliance of business actors with regulations and standards such as the Good Manufacturing Practice (GMP) and regulations on the distribution, advertising and labelling of cosmetics is a crucial aspect in ensuring the safety and quality of cosmetic products to protect public health. This study aimed to assess the level of compliance of cosmetics business actors with regulations and standards in Indonesia. This quantitative study analyzed secondary data from the Indonesian FDA (BPOM)’s risk-based supervision of production and distribution facilities, advertising, and labelling across 34 provinces from 2019–2023. Each year, 4270–7,054 facilities were inspected and classified as compliant or non-compliant, and compliance proportions were calculated. The results were weighted using the Analytical Hierarchy Process (AHP) to produce a compliance index categorized into four levels: excellent (90.01–100), good (66.67–90), fair (33.34–66.66), and poor (0–33.33). The results of the analysis showed that the compliance index of cosmetics businesses for five years ranged from 71.62 to 83.79 and was classified as good: 82.79 (2019), 80.96 (2020), 75.41 (2021), 71.62 (2022), and 83.79 (2023). The index trend showed a fluctuating pattern from year to year, with the highest value recorded in 2023.
Peran Ekstrak Kunyit dan Pegagan dalam Modifikasi Ekspresi Gen eNOS: Implikasi Terhadap Gangguan Ginjal pada Obesitas Agus Sulaeman; Eci Perayani; Soni Muhsinin; Nita Selifiana; Elis Susilawati; Marita Kaniawati; Aghnia Nurvianti Nafilah; Hendra Mahakam; Putra Putra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.763

Abstract

Obesity is a global health problem closely associated with endothelial dysfunction, oxidative stress, and renal impairment, where endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) levels serve as critical biomarkers for endothelial function. This study aimed to evaluate the effects of turmeric (Curcuma longa) extract, pegagan (Centella asiatica) extract, and their combination on body weight, organ index, fat index, blood biomarkers, and renal eNOS gene expression in obese rats. Male white rats were randomly divided into six groups: normal control, negative control (high-fat diet), positive control (orlistat 10.8 mg/kgBW), turmeric extract (200 mg/kgBW), pegagan extract (200 mg/kgBW), and a combination of turmeric–pegagan extracts (200:100 mg/kgBW). Treatments were administered for 60 days, and parameters assessed included body weight, organ index, fat index, blood biomarkers (ITT, creatinine, NO, elastin), and renal eNOS expression using PCR. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. The results demonstrated that the combination of turmeric and pegagan extracts significantly reduced body weight, liver, kidney, and heart indices, as well as visceral fat index, while improving blood biomarkers through the reduction of creatinine levels, along with an increase in NO serum approaching normal compared with the negative control group; the respective mean values were -10.14±0.57%, 5.52±0.73%, 1.23±0.21%, 0.64±0.06%, 1.35±0.05%, 0.33±0.06 mg/dL, dan 5.14±0.58 mmol/L. Renal eNOS expression exhibited an increasing trend in the combination group, although not statistically significant. In conclusion, the combination of turmeric and pegagan extracts exerts synergistic effects in improving endothelial dysfunction and renal impairment in obesity through lipid profile modulation, reduction of organ damage biomarkers, and enhancement of NO bioavailability.
Cost-Effectiveness of Meropenem Versus Ceftriaxone for the Treatment of Sepsis at Dr. Tadjuddin Chalid Hospital Makassar Anshar Saud; Alfira Mutmainnah; Bustanul Arifin
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.909

Abstract

Sepsis is a critical condition arising from the body's response to an infection. In Indonesia, the incidence of sepsis remains notably high, with mortality rates reaching 49%. At Dr. Tadjuddin Chalid Hospital Makassar, meropenem and ceftriaxone are extensively utilized as empirical therapies. Conducting a cost-effectiveness analysis is essential for ensuring rational and efficient decision-making in the selection of appropriate antibiotic therapy. This study aimed to compare the cost-effectiveness of meropenem versus ceftriaxone in treating patients with sepsis in the inpatient ward of Dr. Tadjuddin Chalid Hospital Makassar. A retrospective cross-sectional design was employed, utilizing the medical records of patients with sepsis. Data were analyzed using the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER) to ascertain the economic value of both antibiotics. The results indicated that the ACER value of meropenem was IDR 731,180.68, which was lower than that of ceftriaxone (IDR 775,021.41), suggesting that meropenem was more cost-effective. The incremental cost of IDR 667,206 indicates the additional expenditure required for meropenem to achieve a 1% increase in the proportion of patients with a length of stay of less than 17.4 days. The sensitivity analysis results align with the ICER analysis, which identified meropenem as more cost-effective, enabling robust conclusions. Treatment costs emerge as the key variable affecting the ICER, requiring primary consideration when interpreting cost-effectiveness results. In conclusion, meropenem is more cost-effective than ceftriaxone and can be recommended as an alternative antibiotic therapy for patients with sepsis from a pharmacoeconomic perspective.
Kromatografi Lapis Tipis Video Densitometri sebagai Alternatif Analisis Simultan Rifampisin dan Isoniazid dalam Sediaan Kombinasi Fauzan Zein; Yusril Panji; Deden Indra Dinata
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.1018

Abstract

Rifampicin and isoniazid are first-line antituberculosis drugs widely used in tuberculosis therapy. Simultaneous determination of both compounds is required to ensure the quality and safety of pharmaceutical preparations. This study aimed to develop a Thin-Layer Chromatography (TLC) Video Densitometry method as an alternative approach for the simultaneous analysis of rifampicin and isoniazid in combination tablets. Separation was performed using silica gel GF254 as the stationary phase and methanol:ammonia (10:1) as the mobile phase. Spot visualization was carried out under UV light at 254 nm and analyzed using ImageJ software to obtain the area under curve (AUC) values. Method validation included selectivity, linearity, sensitivity, accuracy, and precision tests. The results showed that the Rf values of rifampicin and isoniazid were 0.78 and 0.66, respectively, with a selectivity factor of 1.18. The calibration curves demonstrated good linearity with determination coefficients of 0.9987 for rifampicin and 0.9992 for isoniazid. The recovery values ranged from 99.20–99.70% for rifampicin and 99.56–99.80% for isoniazid, while the %RSD values were less than 2% for both compounds. The assay results of combination tablets showed rifampicin levels of 82.42–82.46% and isoniazid levels of 78.00–78.47%. Based on the validation results, the TLC video densitometry method fulfilled the validation parameters and can be used as an alternative method for the simultaneous analysis of rifampicin and isoniazid in combination preparations.
Validitas dan Reliabilitas Kuesioner Kidney Knowledge Survey (KiKS) Bahasa Indonesia pada Pasien Penyakit Ginjal Kronik Tigo Ramansyah Prawira Negara; Hadi Sunaryo; Siti Fauziyah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.373

Abstract

Background: Indonesia's chronic kidney disease population reached 638.178 people in 2023. Assessing patients’ knowledge regarding chronic kidney disease is essential to evaluate their understanding, which will affect self-management behavior and patient therapy outcomes.  Objective: This study aims to prove the validity of the Kidney Knowledge Survey Questionnaire (KiKS) as a theory-based self-management intervention instrument for the Indonesian population. Method: This study began with permission from the questionnaire authorization holder, forward translation, back translation, expert team assessment (content validity), verification, and reconciliation by the authority holder. It was then continued with construct validity and reliability tests on outpatients with chronic kidney disease. Results: The forward translation stage involved an independent language institution (previously unfamiliar with the KiKS questionnaire) and back translation by a translator whose mother tongue is English. Assessment of the back translation showed that the adaptation into Indonesian was valid. The content validity test gave an I-CVI value of 1 and a CVR of 1, except for question no. 9 was declared invalid (I-CVI value = 0.5 and CVR = 0). Construct validation and reliability tests on 30 chronic kidney disease patients showed that each question in the Indonesian version of the KiKS was valid with r> 0.306 and Cronbach's alpha of 0.819.  Conclusion: The Indonesian language version of the KiKS questionnaire instrument is valid and reliable in determining the level of knowledge of chronic kidney disease in chronic kidney disease patients.
Perbandingan Rituksimab dan Biosimilarnya dalam Regimen Kemoterapi pada Pasien Limfoma Non-Hodgkin di RS Persahabatan Dendhi Bagus Andriyanto; Nadia Farhanah Syafhan; Fitri Nurhayati
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.488

Abstract

Non-Hodgkin lymphoma (NHL), particularly diffuse large B-cell lymphoma (DLBCL), represents a significant global and Indonesian health burden. The R-CHOP regimen serves as the standard first-line therapy, with rituximab proven to enhance its efficacy. Following patent expiry, biosimilar rituximab became available. However, real-world effectiveness and safety comparisons, especially within the Indonesian population, remain limited. This retrospective comparative study, conducted at Rumah Sakit Persahabatan, involved NHL patients who received R-CHOP between 2019 and 2024. Medical record data were collected for patients treated with reference rituximab (n=60) and biosimilar rituximab (n=56). Patient characteristics, treatment response based on RECIL 2017 criteria, and adverse events (AEs) based on CTCAE were compared using Chi-Square or Mann-Whitney U tests, with statistical significance set at p<0.05. Baseline patient characteristics were found to be statistically comparable between both groups. Efficacy analysis revealed Complete Response (CR) was numerically higher in reference group (75% vs 58.9% CR), although the difference was not statistically significant (p=0.194). The safety profile generally showed no significant differences for most AEs. However, the incidence of Grade ≥ 3 Herpes was significantly higher in the Biosimilar group (8.3%) compared to the Reference group (0%) (p=0.024). In conclusion, biosimilar rituximab demonstrates comparable efficacy to its reference product in treatment response for NHL patients receiving R-CHOP. Its safety profile is largely comparable, although a notable increase in Herpes incidence was observed in the biosimilar group. These findings support the use of biosimilar rituximab as an effective alternative while underscoring the importance of monitoring specific AEs, particularly Herpes reactivation.
Pengaruh Edukasi dan Homecare Terhadap Pengetahuan, Kepatuhan, Outcome Terapi Pasien DM di Puskesmas Tebet Arinda Utami; Siska Siska; Muhamad Syaripuddin; Numlil Khaira Rusdi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.552

Abstract

Increasing knowledge and compliance of type 2 DM patients must be supported by pharmaceutical services by pharmacists in the form of education and homecare. This study aims to determine the effect of pharmacist services on knowledge, compliance and clinical outcomes in the form of blood glucose levels of type 2 DM patients. This study is prospective with a pretest and posttest control group design plan randomly or Randomized Controlled Trial, Respondents numbered 108 people divided into 3 groups: the control group, the education group which was given education twice using booklet media, and the education and homecare group which was given education and homecare by pharmacists twice each. The results showed that in the control group, Fasting Blood Glucose levels decreased from an average of 146.28 mg/dL to 136.89 mg/dL (p<0.05) which indicated a significant decrease. However, the increase in compliance scores from 3.94 to 4.50 (p>0.05) and knowledge scores from 59.86 to 60.72 (p>0.05) were not statistically significant. The conclusion of the study is that educational interventions, either alone or combined with homecare, significantly increased patient compliance and knowledge, although fasting blood glucose levels did not show a significant decrease

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